PubMed:7641692 JSONTXT

{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":0,"end":9},"obj":"DNA"},{"id":"T2","span":{"begin":25,"end":35},"obj":"protein"},{"id":"T3","span":{"begin":55,"end":59},"obj":"protein"},{"id":"T4","span":{"begin":99,"end":113},"obj":"protein"},{"id":"T5","span":{"begin":133,"end":154},"obj":"protein"},{"id":"T6","span":{"begin":251,"end":264},"obj":"protein"},{"id":"T7","span":{"begin":266,"end":270},"obj":"protein"},{"id":"T8","span":{"begin":299,"end":320},"obj":"cell_type"},{"id":"T9","span":{"begin":334,"end":338},"obj":"protein"},{"id":"T10","span":{"begin":454,"end":458},"obj":"protein"},{"id":"T11","span":{"begin":486,"end":496},"obj":"protein"},{"id":"T12","span":{"begin":497,"end":520},"obj":"protein"},{"id":"T13","span":{"begin":525,"end":529},"obj":"protein"},{"id":"T14","span":{"begin":561,"end":565},"obj":"protein"},{"id":"T15","span":{"begin":605,"end":628},"obj":"protein"},{"id":"T16","span":{"begin":669,"end":685},"obj":"protein"},{"id":"T17","span":{"begin":690,"end":704},"obj":"protein"},{"id":"T18","span":{"begin":728,"end":752},"obj":"protein"},{"id":"T19","span":{"begin":794,"end":798},"obj":"protein"},{"id":"T20","span":{"begin":814,"end":824},"obj":"protein"},{"id":"T21","span":{"begin":952,"end":956},"obj":"protein"}],"text":"IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase.\nActivation of the CD28 surface receptor provides a major costimulatory signal for T cell activation resulting in enhanced production of interleukin-2 (IL-2) and cell proliferation. In primary T lymphocytes we show that CD28 ligation leads to the rapid intracellular formation of reactive oxygen intermediates (ROIs) which are required for CD28-mediated activation of the NF-kappa B/CD28-responsive complex and IL-2 expression. Delineation of the CD28 signaling cascade was found to involve protein tyrosine kinase activity, followed by the activation of phospholipase A2 and 5-lipoxygenase. Our data suggest that lipoxygenase metabolites activate ROI formation which then induce IL-2 expression via NF-kappa B activation. These findings should be useful for therapeutic strategies and the development of immunosuppressants targeting the CD28 costimulatory pathway."}

{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":114},"obj":"Sentence"},{"id":"S2","span":{"begin":115,"end":295},"obj":"Sentence"},{"id":"S3","span":{"begin":296,"end":541},"obj":"Sentence"},{"id":"S4","span":{"begin":542,"end":705},"obj":"Sentence"},{"id":"S5","span":{"begin":706,"end":836},"obj":"Sentence"},{"id":"S6","span":{"begin":837,"end":979},"obj":"Sentence"}],"text":"IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase.\nActivation of the CD28 surface receptor provides a major costimulatory signal for T cell activation resulting in enhanced production of interleukin-2 (IL-2) and cell proliferation. In primary T lymphocytes we show that CD28 ligation leads to the rapid intracellular formation of reactive oxygen intermediates (ROIs) which are required for CD28-mediated activation of the NF-kappa B/CD28-responsive complex and IL-2 expression. Delineation of the CD28 signaling cascade was found to involve protein tyrosine kinase activity, followed by the activation of phospholipase A2 and 5-lipoxygenase. Our data suggest that lipoxygenase metabolites activate ROI formation which then induce IL-2 expression via NF-kappa B activation. These findings should be useful for therapeutic strategies and the development of immunosuppressants targeting the CD28 costimulatory pathway."}

{"project":"genia-medco-coref","denotations":[{"id":"C13","span":{"begin":0,"end":20},"obj":"NP"},{"id":"C11","span":{"begin":25,"end":46},"obj":"NP"},{"id":"C3","span":{"begin":55,"end":59},"obj":"NP"},{"id":"C5","span":{"begin":99,"end":113},"obj":"NP"},{"id":"C1","span":{"begin":394,"end":430},"obj":"NP"},{"id":"C2","span":{"begin":431,"end":436},"obj":"NP"},{"id":"C4","span":{"begin":454,"end":459},"obj":"NP"},{"id":"C9","span":{"begin":525,"end":540},"obj":"NP"},{"id":"C6","span":{"begin":690,"end":704},"obj":"NP"},{"id":"C7","span":{"begin":762,"end":775},"obj":"NP"},{"id":"C8","span":{"begin":776,"end":781},"obj":"NP"},{"id":"C10","span":{"begin":794,"end":809},"obj":"NP"},{"id":"C12","span":{"begin":814,"end":835},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-relat","subj":"C2","obj":"C1"},{"id":"R2","pred":"coref-ident","subj":"C4","obj":"C3"},{"id":"R3","pred":"coref-ident","subj":"C6","obj":"C5"},{"id":"R4","pred":"coref-relat","subj":"C8","obj":"C7"},{"id":"R5","pred":"coref-ident","subj":"C10","obj":"C9"},{"id":"R6","pred":"coref-ident","subj":"C12","obj":"C11"}],"text":"IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase.\nActivation of the CD28 surface receptor provides a major costimulatory signal for T cell activation resulting in enhanced production of interleukin-2 (IL-2) and cell proliferation. In primary T lymphocytes we show that CD28 ligation leads to the rapid intracellular formation of reactive oxygen intermediates (ROIs) which are required for CD28-mediated activation of the NF-kappa B/CD28-responsive complex and IL-2 expression. Delineation of the CD28 signaling cascade was found to involve protein tyrosine kinase activity, followed by the activation of phospholipase A2 and 5-lipoxygenase. Our data suggest that lipoxygenase metabolites activate ROI formation which then induce IL-2 expression via NF-kappa B activation. These findings should be useful for therapeutic strategies and the development of immunosuppressants targeting the CD28 costimulatory pathway."}

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