PubMed:7641692 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	0-9	DNA	denotes	IL-2 gene
T2	25-35	protein	denotes	NF-kappa B
T3	55-59	protein	denotes	CD28
T4	99-113	protein	denotes	5-lipoxygenase
T5	133-154	protein	denotes	CD28 surface receptor
T6	251-264	protein	denotes	interleukin-2
T7	266-270	protein	denotes	IL-2
T8	299-320	cell_type	denotes	primary T lymphocytes
T9	334-338	protein	denotes	CD28
T10	454-458	protein	denotes	CD28
T11	486-496	protein	denotes	NF-kappa B
T12	497-520	protein	denotes	CD28-responsive complex
T13	525-529	protein	denotes	IL-2
T14	561-565	protein	denotes	CD28
T15	605-628	protein	denotes	protein tyrosine kinase
T16	669-685	protein	denotes	phospholipase A2
T17	690-704	protein	denotes	5-lipoxygenase
T18	728-752	protein	denotes	lipoxygenase metabolites
T19	794-798	protein	denotes	IL-2
T20	814-824	protein	denotes	NF-kappa B
T21	952-956	protein	denotes	CD28

Id	Subject	Object	Predicate	Lexical cue
S1	0-114	Sentence	denotes	IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase.
S2	115-295	Sentence	denotes	Activation of the CD28 surface receptor provides a major costimulatory signal for T cell activation resulting in enhanced production of interleukin-2 (IL-2) and cell proliferation.
S3	296-541	Sentence	denotes	In primary T lymphocytes we show that CD28 ligation leads to the rapid intracellular formation of reactive oxygen intermediates (ROIs) which are required for CD28-mediated activation of the NF-kappa B/CD28-responsive complex and IL-2 expression.
S4	542-705	Sentence	denotes	Delineation of the CD28 signaling cascade was found to involve protein tyrosine kinase activity, followed by the activation of phospholipase A2 and 5-lipoxygenase.
S5	706-836	Sentence	denotes	Our data suggest that lipoxygenase metabolites activate ROI formation which then induce IL-2 expression via NF-kappa B activation.
S6	837-979	Sentence	denotes	These findings should be useful for therapeutic strategies and the development of immunosuppressants targeting the CD28 costimulatory pathway.

Id	Subject	Object	Predicate	Lexical cue
C13	0-20	NP	denotes	IL-2 gene expression
C11	25-46	NP	denotes	NF-kappa B activation
C3	55-59	NP	denotes	CD28
C5	99-113	NP	denotes	5-lipoxygenase
C1	394-430	NP	denotes	reactive oxygen intermediates (ROIs)
C2	431-436	NP	denotes	which
C4	454-459	NP	denotes	CD28-
C9	525-540	NP	denotes	IL-2 expression
C6	690-704	NP	denotes	5-lipoxygenase
C7	762-775	NP	denotes	ROI formation
C8	776-781	NP	denotes	which
C10	794-809	NP	denotes	IL-2 expression
C12	814-835	NP	denotes	NF-kappa B activation
R1	C2	C1	coref-relat	which,reactive oxygen intermediates (ROIs)
R2	C4	C3	coref-ident	CD28-,CD28
R3	C6	C5	coref-ident	5-lipoxygenase,5-lipoxygenase
R4	C8	C7	coref-relat	which,ROI formation
R5	C10	C9	coref-ident	IL-2 expression,IL-2 expression
R6	C12	C11	coref-ident	NF-kappa B activation,NF-kappa B activation

Id	Subject	Object	Predicate	Lexical cue
T1	0-9	DNA_domain_or_region	denotes	IL-2 gene
T2	25-35	protein_molecule	denotes	NF-kappa B
T3	55-59	protein_molecule	denotes	CD28
T4	99-113	protein_molecule	denotes	5-lipoxygenase
T5	133-137	protein_molecule	denotes	CD28
T6	197-214	other_name	denotes	T cell activation
T7	251-264	protein_molecule	denotes	interleukin-2
T8	266-270	protein_molecule	denotes	IL-2
T9	276-294	other_name	denotes	cell proliferation
T10	299-320	cell_type	denotes	primary T lymphocytes
T11	334-338	protein_molecule	denotes	CD28
T12	394-423	inorganic	denotes	reactive oxygen intermediates
T13	425-429	inorganic	denotes	ROIs
T14	454-458	protein_molecule	denotes	CD28
T15	486-496	protein_molecule	denotes	NF-kappa B
T16	497-501	protein_molecule	denotes	CD28
T17	525-529	protein_molecule	denotes	IL-2
T18	561-565	protein_molecule	denotes	CD28
T19	605-628	protein_family_or_group	denotes	protein tyrosine kinase
T20	669-685	protein_molecule	denotes	phospholipase A2
T21	690-704	protein_molecule	denotes	5-lipoxygenase
T22	728-740	protein_molecule	denotes	lipoxygenase
T23	762-765	inorganic	denotes	ROI
T24	794-798	protein_molecule	denotes	IL-2
T25	814-824	protein_molecule	denotes	NF-kappa B
T26	873-895	other_name	denotes	therapeutic strategies
T27	919-937	other_name	denotes	immunosuppressants
T28	952-956	protein_molecule	denotes	CD28