PubMed:7617032 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/7617032","sourcedb":"PubMed","sourceid":"7617032","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/7617032","text":"Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor.\nThe crystal structure of interferon-gamma bound to the extracellular fragment of its high-affinity cell-surface receptor reveals the first view of a class-2 cytokine receptor-ligand complex. In the complex, one interferon-gamma homodimer binds two receptor molecules. Unlike the class-1 growth hormone receptor complex, the two interferon-gamma receptors do not interact with one another and are separated by 27 A. Upon receptor binding, the flexible AB loop of interferon-gamma undergoes a conformational change that includes the formation of a 3(10) helix.","tracks":[{"project":"AIMed","denotations":[{"id":"T1","span":{"begin":39,"end":55},"obj":"protein"},{"id":"T2","span":{"begin":121,"end":137},"obj":"protein"},{"id":"T3","span":{"begin":307,"end":323},"obj":"protein"},{"id":"T4","span":{"begin":424,"end":440},"obj":"protein"},{"id":"T5","span":{"begin":558,"end":574},"obj":"protein"}],"attributes":[{"subj":"T1","pred":"source","obj":"AIMed"},{"subj":"T2","pred":"source","obj":"AIMed"},{"subj":"T3","pred":"source","obj":"AIMed"},{"subj":"T4","pred":"source","obj":"AIMed"},{"subj":"T5","pred":"source","obj":"AIMed"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"AIMed","color":"#eca793","default":true}]}]}}