PubMed:7617032 JSONTXT

{"project":"AIMed","denotations":[{"id":"T1","span":{"begin":39,"end":55},"obj":"protein"},{"id":"T2","span":{"begin":121,"end":137},"obj":"protein"},{"id":"T3","span":{"begin":307,"end":323},"obj":"protein"},{"id":"T4","span":{"begin":424,"end":440},"obj":"protein"},{"id":"T5","span":{"begin":558,"end":574},"obj":"protein"}],"text":"Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor.\nThe crystal structure of interferon-gamma bound to the extracellular fragment of its high-affinity cell-surface receptor reveals the first view of a class-2 cytokine receptor-ligand complex. In the complex, one interferon-gamma homodimer binds two receptor molecules. Unlike the class-1 growth hormone receptor complex, the two interferon-gamma receptors do not interact with one another and are separated by 27 A. Upon receptor binding, the flexible AB loop of interferon-gamma undergoes a conformational change that includes the formation of a 3(10) helix."}