PubMed:7605997
Annnotations
DisGeNET
{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":23,"end":27},"obj":"gene:6886"},{"id":"T1","span":{"begin":70,"end":105},"obj":"disease:C1961099"},{"id":"T2","span":{"begin":255,"end":259},"obj":"gene:6886"},{"id":"T3","span":{"begin":169,"end":204},"obj":"disease:C1961099"},{"id":"T4","span":{"begin":487,"end":491},"obj":"gene:6886"},{"id":"T5","span":{"begin":520,"end":525},"obj":"disease:C1961099"},{"id":"T6","span":{"begin":556,"end":560},"obj":"gene:6886"},{"id":"T7","span":{"begin":618,"end":623},"obj":"disease:C1961099"},{"id":"T8","span":{"begin":813,"end":817},"obj":"gene:6886"},{"id":"T9","span":{"begin":843,"end":848},"obj":"disease:C1961099"},{"id":"T10","span":{"begin":760,"end":764},"obj":"gene:6886"},{"id":"T11","span":{"begin":843,"end":848},"obj":"disease:C1961099"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"},{"id":"R4","pred":"associated_with","subj":"T6","obj":"T7"},{"id":"R5","pred":"associated_with","subj":"T8","obj":"T9"},{"id":"R6","pred":"associated_with","subj":"T10","obj":"T11"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"Does activation of the TAL1 gene occur in a majority of patients with T-cell acute lymphoblastic leukemia? A pediatric oncology group study.\nAlmost 25% of patients with T-cell acute lymphoblastic leukemia (T-ALL) have tumor-specific rearrangements of the TAL1 gene. Although TAL1 expression has not been observed in normal lymphocytes, TAL1 gene products are readily detected in leukemic cells that harbor a rearranged TAL1 allele. Hence, it has been proposed that ectopic expression of TAL1 promotes the development of T-ALL. In this report, we show that TAL1 is expressed in the leukemic cells of most patients with T-ALL, including many that do not display an apparent TAL1 gene alteration. A polymorphic dinucleotide repeat in the transcribed sequences of TAL1 was used to determine the allele specificity of TAL1 transcription in primary T-ALL cells. Monoallelic expression of TAL1 was observed in the leukemic cells of all patients (8 of 8) bearing a TAL1 gene rearrangement. In the leukemic cells of patients without detectable TAL1 rearrangements, TAL1 transcription occurred in either a monoallelic (3 of 7 patients) or a biallelic (4 of 7 patients) fashion. Thus, TAL1 activation in these patients may result from subtle alterations in cis-acting regulatory sequences (affecting expression of a single TAL1 allele) or changes in trans-acting factors that control TAL1 transcription (affecting expression of both TAL1 alleles)."}
jnlpba-st-training
{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":23,"end":32},"obj":"DNA"},{"id":"T2","span":{"begin":255,"end":264},"obj":"DNA"},{"id":"T3","span":{"begin":275,"end":279},"obj":"protein"},{"id":"T4","span":{"begin":316,"end":334},"obj":"cell_type"},{"id":"T5","span":{"begin":336,"end":354},"obj":"protein"},{"id":"T6","span":{"begin":379,"end":393},"obj":"cell_type"},{"id":"T7","span":{"begin":408,"end":430},"obj":"DNA"},{"id":"T8","span":{"begin":487,"end":491},"obj":"protein"},{"id":"T9","span":{"begin":556,"end":560},"obj":"protein"},{"id":"T10","span":{"begin":581,"end":595},"obj":"cell_type"},{"id":"T11","span":{"begin":672,"end":681},"obj":"DNA"},{"id":"T12","span":{"begin":760,"end":764},"obj":"protein"},{"id":"T13","span":{"begin":813,"end":817},"obj":"protein"},{"id":"T14","span":{"begin":835,"end":854},"obj":"cell_type"},{"id":"T15","span":{"begin":882,"end":886},"obj":"protein"},{"id":"T16","span":{"begin":907,"end":921},"obj":"cell_type"},{"id":"T17","span":{"begin":957,"end":966},"obj":"DNA"},{"id":"T18","span":{"begin":989,"end":1003},"obj":"cell_type"},{"id":"T19","span":{"begin":1035,"end":1039},"obj":"protein"},{"id":"T20","span":{"begin":1056,"end":1060},"obj":"protein"},{"id":"T21","span":{"begin":1174,"end":1178},"obj":"protein"},{"id":"T22","span":{"begin":1246,"end":1277},"obj":"DNA"},{"id":"T23","span":{"begin":1305,"end":1323},"obj":"DNA"},{"id":"T24","span":{"begin":1373,"end":1377},"obj":"protein"},{"id":"T25","span":{"begin":1422,"end":1434},"obj":"DNA"}],"text":"Does activation of the TAL1 gene occur in a majority of patients with T-cell acute lymphoblastic leukemia? A pediatric oncology group study.\nAlmost 25% of patients with T-cell acute lymphoblastic leukemia (T-ALL) have tumor-specific rearrangements of the TAL1 gene. Although TAL1 expression has not been observed in normal lymphocytes, TAL1 gene products are readily detected in leukemic cells that harbor a rearranged TAL1 allele. Hence, it has been proposed that ectopic expression of TAL1 promotes the development of T-ALL. In this report, we show that TAL1 is expressed in the leukemic cells of most patients with T-ALL, including many that do not display an apparent TAL1 gene alteration. A polymorphic dinucleotide repeat in the transcribed sequences of TAL1 was used to determine the allele specificity of TAL1 transcription in primary T-ALL cells. Monoallelic expression of TAL1 was observed in the leukemic cells of all patients (8 of 8) bearing a TAL1 gene rearrangement. In the leukemic cells of patients without detectable TAL1 rearrangements, TAL1 transcription occurred in either a monoallelic (3 of 7 patients) or a biallelic (4 of 7 patients) fashion. Thus, TAL1 activation in these patients may result from subtle alterations in cis-acting regulatory sequences (affecting expression of a single TAL1 allele) or changes in trans-acting factors that control TAL1 transcription (affecting expression of both TAL1 alleles)."}
DisGeNET5_gene_disease
{"project":"DisGeNET5_gene_disease","denotations":[{"id":"7605997-0#23#27#gene6886","span":{"begin":23,"end":27},"obj":"gene6886"},{"id":"7605997-0#70#105#diseaseC1961099","span":{"begin":70,"end":105},"obj":"diseaseC1961099"}],"relations":[{"id":"23#27#gene688670#105#diseaseC1961099","pred":"associated_with","subj":"7605997-0#23#27#gene6886","obj":"7605997-0#70#105#diseaseC1961099"}],"text":"Does activation of the TAL1 gene occur in a majority of patients with T-cell acute lymphoblastic leukemia? A pediatric oncology group study.\nAlmost 25% of patients with T-cell acute lymphoblastic leukemia (T-ALL) have tumor-specific rearrangements of the TAL1 gene. Although TAL1 expression has not been observed in normal lymphocytes, TAL1 gene products are readily detected in leukemic cells that harbor a rearranged TAL1 allele. Hence, it has been proposed that ectopic expression of TAL1 promotes the development of T-ALL. In this report, we show that TAL1 is expressed in the leukemic cells of most patients with T-ALL, including many that do not display an apparent TAL1 gene alteration. A polymorphic dinucleotide repeat in the transcribed sequences of TAL1 was used to determine the allele specificity of TAL1 transcription in primary T-ALL cells. Monoallelic expression of TAL1 was observed in the leukemic cells of all patients (8 of 8) bearing a TAL1 gene rearrangement. In the leukemic cells of patients without detectable TAL1 rearrangements, TAL1 transcription occurred in either a monoallelic (3 of 7 patients) or a biallelic (4 of 7 patients) fashion. Thus, TAL1 activation in these patients may result from subtle alterations in cis-acting regulatory sequences (affecting expression of a single TAL1 allele) or changes in trans-acting factors that control TAL1 transcription (affecting expression of both TAL1 alleles)."}
pubmed-sentences-benchmark
{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":106},"obj":"Sentence"},{"id":"S2","span":{"begin":107,"end":140},"obj":"Sentence"},{"id":"S3","span":{"begin":141,"end":265},"obj":"Sentence"},{"id":"S4","span":{"begin":266,"end":431},"obj":"Sentence"},{"id":"S5","span":{"begin":432,"end":526},"obj":"Sentence"},{"id":"S6","span":{"begin":527,"end":693},"obj":"Sentence"},{"id":"S7","span":{"begin":694,"end":855},"obj":"Sentence"},{"id":"S8","span":{"begin":856,"end":981},"obj":"Sentence"},{"id":"S9","span":{"begin":982,"end":1167},"obj":"Sentence"},{"id":"S10","span":{"begin":1168,"end":1436},"obj":"Sentence"}],"text":"Does activation of the TAL1 gene occur in a majority of patients with T-cell acute lymphoblastic leukemia? A pediatric oncology group study.\nAlmost 25% of patients with T-cell acute lymphoblastic leukemia (T-ALL) have tumor-specific rearrangements of the TAL1 gene. Although TAL1 expression has not been observed in normal lymphocytes, TAL1 gene products are readily detected in leukemic cells that harbor a rearranged TAL1 allele. Hence, it has been proposed that ectopic expression of TAL1 promotes the development of T-ALL. In this report, we show that TAL1 is expressed in the leukemic cells of most patients with T-ALL, including many that do not display an apparent TAL1 gene alteration. A polymorphic dinucleotide repeat in the transcribed sequences of TAL1 was used to determine the allele specificity of TAL1 transcription in primary T-ALL cells. Monoallelic expression of TAL1 was observed in the leukemic cells of all patients (8 of 8) bearing a TAL1 gene rearrangement. In the leukemic cells of patients without detectable TAL1 rearrangements, TAL1 transcription occurred in either a monoallelic (3 of 7 patients) or a biallelic (4 of 7 patients) fashion. Thus, TAL1 activation in these patients may result from subtle alterations in cis-acting regulatory sequences (affecting expression of a single TAL1 allele) or changes in trans-acting factors that control TAL1 transcription (affecting expression of both TAL1 alleles)."}
genia-medco-coref
{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":19,"end":32},"obj":"NP"},{"id":"C4","span":{"begin":70,"end":105},"obj":"NP"},{"id":"C3","span":{"begin":56,"end":105},"obj":"NP"},{"id":"C2","span":{"begin":42,"end":105},"obj":"NP"},{"id":"C6","span":{"begin":169,"end":212},"obj":"NP"},{"id":"C5","span":{"begin":155,"end":212},"obj":"NP"},{"id":"C7","span":{"begin":251,"end":264},"obj":"NP"},{"id":"C8","span":{"begin":379,"end":393},"obj":"NP"},{"id":"C9","span":{"begin":394,"end":398},"obj":"NP"},{"id":"C10","span":{"begin":487,"end":491},"obj":"NP"},{"id":"C11","span":{"begin":520,"end":525},"obj":"NP"},{"id":"C12","span":{"begin":556,"end":560},"obj":"NP"},{"id":"C14","span":{"begin":618,"end":623},"obj":"NP"},{"id":"C13","span":{"begin":599,"end":623},"obj":"NP"},{"id":"C15","span":{"begin":635,"end":639},"obj":"NP"},{"id":"C16","span":{"begin":640,"end":644},"obj":"NP"},{"id":"C17","span":{"begin":760,"end":764},"obj":"NP"},{"id":"C18","span":{"begin":813,"end":831},"obj":"NP"},{"id":"C19","span":{"begin":882,"end":886},"obj":"NP"},{"id":"C20","span":{"begin":1007,"end":1054},"obj":"NP"},{"id":"C21","span":{"begin":1056,"end":1074},"obj":"NP"},{"id":"C22","span":{"begin":1193,"end":1207},"obj":"NP"},{"id":"C23","span":{"begin":1339,"end":1359},"obj":"NP"},{"id":"C24","span":{"begin":1360,"end":1364},"obj":"NP"},{"id":"C25","span":{"begin":1373,"end":1391},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C6","obj":"C4"},{"id":"R2","pred":"coref-ident","subj":"C5","obj":"C3"},{"id":"R3","pred":"coref-ident","subj":"C7","obj":"C1"},{"id":"R4","pred":"coref-relat","subj":"C9","obj":"C8"},{"id":"R5","pred":"coref-ident","subj":"C10","obj":"C7"},{"id":"R6","pred":"coref-ident","subj":"C11","obj":"C6"},{"id":"R7","pred":"coref-ident","subj":"C12","obj":"C10"},{"id":"R8","pred":"coref-ident","subj":"C14","obj":"C11"},{"id":"R9","pred":"coref-ident","subj":"C13","obj":"C2"},{"id":"R10","pred":"coref-relat","subj":"C16","obj":"C15"},{"id":"R11","pred":"coref-ident","subj":"C17","obj":"C12"},{"id":"R12","pred":"coref-ident","subj":"C19","obj":"C17"},{"id":"R13","pred":"coref-ident","subj":"C21","obj":"C18"},{"id":"R14","pred":"coref-ident","subj":"C22","obj":"C20"},{"id":"R15","pred":"coref-relat","subj":"C24","obj":"C23"},{"id":"R16","pred":"coref-ident","subj":"C25","obj":"C21"}],"text":"Does activation of the TAL1 gene occur in a majority of patients with T-cell acute lymphoblastic leukemia? A pediatric oncology group study.\nAlmost 25% of patients with T-cell acute lymphoblastic leukemia (T-ALL) have tumor-specific rearrangements of the TAL1 gene. Although TAL1 expression has not been observed in normal lymphocytes, TAL1 gene products are readily detected in leukemic cells that harbor a rearranged TAL1 allele. Hence, it has been proposed that ectopic expression of TAL1 promotes the development of T-ALL. In this report, we show that TAL1 is expressed in the leukemic cells of most patients with T-ALL, including many that do not display an apparent TAL1 gene alteration. A polymorphic dinucleotide repeat in the transcribed sequences of TAL1 was used to determine the allele specificity of TAL1 transcription in primary T-ALL cells. Monoallelic expression of TAL1 was observed in the leukemic cells of all patients (8 of 8) bearing a TAL1 gene rearrangement. In the leukemic cells of patients without detectable TAL1 rearrangements, TAL1 transcription occurred in either a monoallelic (3 of 7 patients) or a biallelic (4 of 7 patients) fashion. Thus, TAL1 activation in these patients may result from subtle alterations in cis-acting regulatory sequences (affecting expression of a single TAL1 allele) or changes in trans-acting factors that control TAL1 transcription (affecting expression of both TAL1 alleles)."}
GENIAcorpus
{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":23,"end":32},"obj":"DNA_domain_or_region"},{"id":"T2","span":{"begin":56,"end":64},"obj":"multi_cell"},{"id":"T3","span":{"begin":70,"end":105},"obj":"other_name"},{"id":"T4","span":{"begin":109,"end":139},"obj":"other_name"},{"id":"T5","span":{"begin":155,"end":163},"obj":"multi_cell"},{"id":"T6","span":{"begin":169,"end":204},"obj":"other_name"},{"id":"T7","span":{"begin":206,"end":211},"obj":"other_name"},{"id":"T8","span":{"begin":218,"end":247},"obj":"other_name"},{"id":"T9","span":{"begin":255,"end":264},"obj":"DNA_domain_or_region"},{"id":"T10","span":{"begin":275,"end":279},"obj":"protein_molecule"},{"id":"T11","span":{"begin":316,"end":334},"obj":"cell_type"},{"id":"T12","span":{"begin":336,"end":345},"obj":"DNA_domain_or_region"},{"id":"T13","span":{"begin":379,"end":393},"obj":"cell_type"},{"id":"T14","span":{"begin":408,"end":430},"obj":"DNA_family_or_group"},{"id":"T15","span":{"begin":465,"end":483},"obj":"other_name"},{"id":"T16","span":{"begin":487,"end":491},"obj":"protein_molecule"},{"id":"T17","span":{"begin":520,"end":525},"obj":"other_name"},{"id":"T18","span":{"begin":556,"end":560},"obj":"protein_molecule"},{"id":"T19","span":{"begin":581,"end":595},"obj":"cell_type"},{"id":"T20","span":{"begin":604,"end":612},"obj":"multi_cell"},{"id":"T21","span":{"begin":618,"end":623},"obj":"other_name"},{"id":"T22","span":{"begin":672,"end":676},"obj":"protein_molecule"},{"id":"T23","span":{"begin":760,"end":764},"obj":"protein_molecule"},{"id":"T24","span":{"begin":791,"end":809},"obj":"other_name"},{"id":"T25","span":{"begin":813,"end":817},"obj":"protein_molecule"},{"id":"T26","span":{"begin":835,"end":842},"obj":"cell_type"},{"id":"T27","span":{"begin":843,"end":848},"obj":"other_name"},{"id":"T28","span":{"begin":856,"end":878},"obj":"other_name"},{"id":"T29","span":{"begin":882,"end":886},"obj":"protein_molecule"},{"id":"T30","span":{"begin":907,"end":921},"obj":"cell_type"},{"id":"T31","span":{"begin":929,"end":937},"obj":"multi_cell"},{"id":"T32","span":{"begin":957,"end":961},"obj":"protein_molecule"},{"id":"T33","span":{"begin":989,"end":1003},"obj":"cell_type"},{"id":"T34","span":{"begin":1007,"end":1015},"obj":"multi_cell"},{"id":"T35","span":{"begin":1035,"end":1039},"obj":"protein_molecule"},{"id":"T36","span":{"begin":1056,"end":1060},"obj":"protein_molecule"},{"id":"T37","span":{"begin":1116,"end":1124},"obj":"multi_cell"},{"id":"T38","span":{"begin":1149,"end":1157},"obj":"multi_cell"},{"id":"T39","span":{"begin":1174,"end":1178},"obj":"protein_molecule"},{"id":"T40","span":{"begin":1199,"end":1207},"obj":"multi_cell"},{"id":"T41","span":{"begin":1246,"end":1277},"obj":"DNA_family_or_group"},{"id":"T42","span":{"begin":1305,"end":1311},"obj":"DNA_domain_or_region"},{"id":"T43","span":{"begin":1312,"end":1316},"obj":"protein_molecule"},{"id":"T44","span":{"begin":1373,"end":1377},"obj":"protein_molecule"},{"id":"T45","span":{"begin":1422,"end":1426},"obj":"protein_molecule"}],"text":"Does activation of the TAL1 gene occur in a majority of patients with T-cell acute lymphoblastic leukemia? A pediatric oncology group study.\nAlmost 25% of patients with T-cell acute lymphoblastic leukemia (T-ALL) have tumor-specific rearrangements of the TAL1 gene. Although TAL1 expression has not been observed in normal lymphocytes, TAL1 gene products are readily detected in leukemic cells that harbor a rearranged TAL1 allele. Hence, it has been proposed that ectopic expression of TAL1 promotes the development of T-ALL. In this report, we show that TAL1 is expressed in the leukemic cells of most patients with T-ALL, including many that do not display an apparent TAL1 gene alteration. A polymorphic dinucleotide repeat in the transcribed sequences of TAL1 was used to determine the allele specificity of TAL1 transcription in primary T-ALL cells. Monoallelic expression of TAL1 was observed in the leukemic cells of all patients (8 of 8) bearing a TAL1 gene rearrangement. In the leukemic cells of patients without detectable TAL1 rearrangements, TAL1 transcription occurred in either a monoallelic (3 of 7 patients) or a biallelic (4 of 7 patients) fashion. Thus, TAL1 activation in these patients may result from subtle alterations in cis-acting regulatory sequences (affecting expression of a single TAL1 allele) or changes in trans-acting factors that control TAL1 transcription (affecting expression of both TAL1 alleles)."}