PubMed:7604283 JSONTXT

{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":25,"end":28},"obj":"protein"},{"id":"T2","span":{"begin":28,"end":33},"obj":"protein"},{"id":"T3","span":{"begin":45,"end":52},"obj":"cell_type"},{"id":"T4","span":{"begin":249,"end":289},"obj":"cell_type"},{"id":"T5","span":{"begin":318,"end":331},"obj":"protein"},{"id":"T6","span":{"begin":333,"end":337},"obj":"protein"},{"id":"T7","span":{"begin":410,"end":414},"obj":"protein"},{"id":"T8","span":{"begin":440,"end":451},"obj":"protein"},{"id":"T9","span":{"begin":452,"end":456},"obj":"protein"},{"id":"T10","span":{"begin":461,"end":465},"obj":"protein"},{"id":"T11","span":{"begin":509,"end":531},"obj":"protein"},{"id":"T12","span":{"begin":532,"end":537},"obj":"protein"},{"id":"T13","span":{"begin":542,"end":547},"obj":"protein"},{"id":"T14","span":{"begin":565,"end":579},"obj":"cell_type"},{"id":"T15","span":{"begin":595,"end":599},"obj":"protein"},{"id":"T16","span":{"begin":656,"end":680},"obj":"cell_line"},{"id":"T17","span":{"begin":685,"end":723},"obj":"cell_line"},{"id":"T18","span":{"begin":745,"end":749},"obj":"protein"},{"id":"T19","span":{"begin":763,"end":767},"obj":"protein"},{"id":"T20","span":{"begin":849,"end":852},"obj":"protein"},{"id":"T21","span":{"begin":852,"end":857},"obj":"protein"}],"text":"Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I.\nHuman T cell lymphotropic virus I (HTLV-I) is the etiological agent for adult T cell leukemia and tropical spastic paraparesis (also termed HTLV-I-associated myelopathy). HTLV-I-infected peripheral blood T cells exhibit an initial phase of interleukin-2 (IL-2)-dependent growth; over time, by an unknown mechanism, the cells become IL-2-independent. Whereas the Jak kinases Jak1 and Jak3 and the signal transducer and activator of transcription proteins Stat3 and Stat5 are activated in normal T cells in response to IL-2, this signaling pathway was constitutively activated in HTLV-I-transformed cells. In HTLV-I-infected cord blood lymphocytes, the transition from IL-2-dependent to IL-2-independent growth correlated with the acquisition of a constitutively activated Jak-STAT pathway, which suggests that this pathway participates in HTLV-I-mediated T cell transformation."}

{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":77},"obj":"Sentence"},{"id":"S2","span":{"begin":78,"end":248},"obj":"Sentence"},{"id":"S3","span":{"begin":249,"end":427},"obj":"Sentence"},{"id":"S4","span":{"begin":428,"end":681},"obj":"Sentence"},{"id":"S5","span":{"begin":682,"end":954},"obj":"Sentence"}],"text":"Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I.\nHuman T cell lymphotropic virus I (HTLV-I) is the etiological agent for adult T cell leukemia and tropical spastic paraparesis (also termed HTLV-I-associated myelopathy). HTLV-I-infected peripheral blood T cells exhibit an initial phase of interleukin-2 (IL-2)-dependent growth; over time, by an unknown mechanism, the cells become IL-2-independent. Whereas the Jak kinases Jak1 and Jak3 and the signal transducer and activator of transcription proteins Stat3 and Stat5 are activated in normal T cells in response to IL-2, this signaling pathway was constitutively activated in HTLV-I-transformed cells. In HTLV-I-infected cord blood lymphocytes, the transition from IL-2-dependent to IL-2-independent growth correlated with the acquisition of a constitutively activated Jak-STAT pathway, which suggests that this pathway participates in HTLV-I-mediated T cell transformation."}

{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":70,"end":76},"obj":"NP"},{"id":"C9","span":{"begin":45,"end":76},"obj":"NP"},{"id":"C2","span":{"begin":78,"end":120},"obj":"NP"},{"id":"C3","span":{"begin":124,"end":247},"obj":"NP"},{"id":"C4","span":{"begin":249,"end":256},"obj":"NP"},{"id":"C5","span":{"begin":318,"end":339},"obj":"NP"},{"id":"C6","span":{"begin":410,"end":415},"obj":"NP"},{"id":"C7","span":{"begin":595,"end":599},"obj":"NP"},{"id":"C8","span":{"begin":656,"end":663},"obj":"NP"},{"id":"C10","span":{"begin":656,"end":680},"obj":"NP"},{"id":"C11","span":{"begin":685,"end":692},"obj":"NP"},{"id":"C12","span":{"begin":745,"end":750},"obj":"NP"},{"id":"C13","span":{"begin":763,"end":768},"obj":"NP"},{"id":"C14","span":{"begin":822,"end":865},"obj":"NP"},{"id":"C18","span":{"begin":803,"end":865},"obj":"NP"},{"id":"C19","span":{"begin":867,"end":872},"obj":"NP"},{"id":"C15","span":{"begin":887,"end":899},"obj":"NP"},{"id":"C16","span":{"begin":916,"end":923},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C2","obj":"C1"},{"id":"R2","pred":"coref-ident","subj":"C3","obj":"C2"},{"id":"R3","pred":"coref-ident","subj":"C4","obj":"C2"},{"id":"R4","pred":"coref-ident","subj":"C6","obj":"C5"},{"id":"R5","pred":"coref-ident","subj":"C7","obj":"C6"},{"id":"R6","pred":"coref-ident","subj":"C8","obj":"C4"},{"id":"R7","pred":"coref-ident","subj":"C10","obj":"C9"},{"id":"R8","pred":"coref-ident","subj":"C11","obj":"C8"},{"id":"R9","pred":"coref-ident","subj":"C12","obj":"C7"},{"id":"R10","pred":"coref-ident","subj":"C13","obj":"C12"},{"id":"R11","pred":"coref-relat","subj":"C19","obj":"C18"},{"id":"R12","pred":"coref-ident","subj":"C15","obj":"C14"},{"id":"R13","pred":"coref-ident","subj":"C16","obj":"C11"}],"text":"Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I.\nHuman T cell lymphotropic virus I (HTLV-I) is the etiological agent for adult T cell leukemia and tropical spastic paraparesis (also termed HTLV-I-associated myelopathy). HTLV-I-infected peripheral blood T cells exhibit an initial phase of interleukin-2 (IL-2)-dependent growth; over time, by an unknown mechanism, the cells become IL-2-independent. Whereas the Jak kinases Jak1 and Jak3 and the signal transducer and activator of transcription proteins Stat3 and Stat5 are activated in normal T cells in response to IL-2, this signaling pathway was constitutively activated in HTLV-I-transformed cells. In HTLV-I-infected cord blood lymphocytes, the transition from IL-2-dependent to IL-2-independent growth correlated with the acquisition of a constitutively activated Jak-STAT pathway, which suggests that this pathway participates in HTLV-I-mediated T cell transformation."}

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