PubMed:7575565 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/7575565","sourcedb":"PubMed","sourceid":"7575565","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/7575565","text":"HMG-I binds to GATA motifs: implications for an HPFH syndrome.\nWe have examined binding of the nuclear protein HMG-I to the human gamma-globin promoter. We find that HMG-I binds preferentially to the more 3' of a pair of GATA motifs in the gamma-globin promoter; this paired motif is bound by the erythroid factor GATA-1. A naturally occurring mutation (-175 T-C) in the area bound by HMG-I results in overexpression of gamma-globin in adult red blood cells (HPFH) and up-regulation of the gamma-globin promoter in in vitro expression assays; HMG-I does not bind to this mutant sequence. A survey of GATA motifs from other globin cis-elements demonstrates HMG-I binding to most of them. These findings implicate HMG-I in the HPFH phenotype; we speculate that it may participate in the formation of multiprotein complexes that regulate globin gene expression.","tracks":[{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":15,"end":19},"obj":"gene:55278"},{"id":"T1","span":{"begin":48,"end":52},"obj":"disease:C0271994"},{"id":"T2","span":{"begin":0,"end":5},"obj":"gene:3146"},{"id":"T3","span":{"begin":48,"end":52},"obj":"disease:C0271994"},{"id":"T4","span":{"begin":0,"end":5},"obj":"gene:10354"},{"id":"T5","span":{"begin":48,"end":52},"obj":"disease:C0271994"},{"id":"T6","span":{"begin":712,"end":717},"obj":"gene:3146"},{"id":"T7","span":{"begin":725,"end":729},"obj":"disease:C0271994"},{"id":"T8","span":{"begin":712,"end":717},"obj":"gene:10354"},{"id":"T9","span":{"begin":725,"end":729},"obj":"disease:C0271994"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"},{"id":"R4","pred":"associated_with","subj":"T6","obj":"T7"},{"id":"R5","pred":"associated_with","subj":"T8","obj":"T9"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T0","pred":"source","obj":"DisGeNET"},{"subj":"T1","pred":"source","obj":"DisGeNET"},{"subj":"T2","pred":"source","obj":"DisGeNET"},{"subj":"T3","pred":"source","obj":"DisGeNET"},{"subj":"T4","pred":"source","obj":"DisGeNET"},{"subj":"T5","pred":"source","obj":"DisGeNET"},{"subj":"T6","pred":"source","obj":"DisGeNET"},{"subj":"T7","pred":"source","obj":"DisGeNET"},{"subj":"T8","pred":"source","obj":"DisGeNET"},{"subj":"T9","pred":"source","obj":"DisGeNET"}]},{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":0,"end":5},"obj":"protein"},{"id":"T2","span":{"begin":15,"end":26},"obj":"DNA"},{"id":"T3","span":{"begin":95,"end":110},"obj":"protein"},{"id":"T4","span":{"begin":111,"end":116},"obj":"protein"},{"id":"T5","span":{"begin":124,"end":151},"obj":"DNA"},{"id":"T6","span":{"begin":166,"end":171},"obj":"protein"},{"id":"T7","span":{"begin":221,"end":232},"obj":"DNA"},{"id":"T8","span":{"begin":240,"end":261},"obj":"DNA"},{"id":"T9","span":{"begin":297,"end":320},"obj":"protein"},{"id":"T10","span":{"begin":385,"end":390},"obj":"protein"},{"id":"T11","span":{"begin":420,"end":432},"obj":"protein"},{"id":"T12","span":{"begin":436,"end":457},"obj":"cell_type"},{"id":"T13","span":{"begin":459,"end":463},"obj":"cell_type"},{"id":"T14","span":{"begin":490,"end":511},"obj":"DNA"},{"id":"T15","span":{"begin":543,"end":548},"obj":"protein"},{"id":"T16","span":{"begin":571,"end":586},"obj":"DNA"},{"id":"T17","span":{"begin":600,"end":611},"obj":"DNA"},{"id":"T18","span":{"begin":623,"end":642},"obj":"DNA"},{"id":"T19","span":{"begin":656,"end":661},"obj":"protein"},{"id":"T20","span":{"begin":712,"end":717},"obj":"protein"},{"id":"T21","span":{"begin":725,"end":729},"obj":"cell_type"},{"id":"T22","span":{"begin":798,"end":820},"obj":"protein"}],"attributes":[{"subj":"T1","pred":"source","obj":"jnlpba-st-training"},{"subj":"T2","pred":"source","obj":"jnlpba-st-training"},{"subj":"T3","pred":"source","obj":"jnlpba-st-training"},{"subj":"T4","pred":"source","obj":"jnlpba-st-training"},{"subj":"T5","pred":"source","obj":"jnlpba-st-training"},{"subj":"T6","pred":"source","obj":"jnlpba-st-training"},{"subj":"T7","pred":"source","obj":"jnlpba-st-training"},{"subj":"T8","pred":"source","obj":"jnlpba-st-training"},{"subj":"T9","pred":"source","obj":"jnlpba-st-training"},{"subj":"T10","pred":"source","obj":"jnlpba-st-training"},{"subj":"T11","pred":"source","obj":"jnlpba-st-training"},{"subj":"T12","pred":"source","obj":"jnlpba-st-training"},{"subj":"T13","pred":"source","obj":"jnlpba-st-training"},{"subj":"T14","pred":"source","obj":"jnlpba-st-training"},{"subj":"T15","pred":"source","obj":"jnlpba-st-training"},{"subj":"T16","pred":"source","obj":"jnlpba-st-training"},{"subj":"T17","pred":"source","obj":"jnlpba-st-training"},{"subj":"T18","pred":"source","obj":"jnlpba-st-training"},{"subj":"T19","pred":"source","obj":"jnlpba-st-training"},{"subj":"T20","pred":"source","obj":"jnlpba-st-training"},{"subj":"T21","pred":"source","obj":"jnlpba-st-training"},{"subj":"T22","pred":"source","obj":"jnlpba-st-training"}]},{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":0,"end":5},"obj":"NP"},{"id":"C2","span":{"begin":91,"end":116},"obj":"NP"},{"id":"C3","span":{"begin":120,"end":151},"obj":"NP"},{"id":"C4","span":{"begin":166,"end":171},"obj":"NP"},{"id":"C5","span":{"begin":211,"end":232},"obj":"NP"},{"id":"C6","span":{"begin":236,"end":261},"obj":"NP"},{"id":"C7","span":{"begin":263,"end":280},"obj":"NP"},{"id":"C9","span":{"begin":385,"end":390},"obj":"NP"},{"id":"C8","span":{"begin":322,"end":390},"obj":"NP"},{"id":"C10","span":{"begin":486,"end":511},"obj":"NP"},{"id":"C11","span":{"begin":543,"end":548},"obj":"NP"},{"id":"C12","span":{"begin":566,"end":586},"obj":"NP"},{"id":"C13","span":{"begin":600,"end":642},"obj":"NP"},{"id":"C14","span":{"begin":656,"end":661},"obj":"NP"},{"id":"C15","span":{"begin":681,"end":685},"obj":"NP"},{"id":"C16","span":{"begin":712,"end":717},"obj":"NP"},{"id":"C17","span":{"begin":759,"end":761},"obj":"NP"},{"id":"C18","span":{"begin":798,"end":820},"obj":"NP"},{"id":"C19","span":{"begin":821,"end":825},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C2","obj":"C1"},{"id":"R2","pred":"coref-ident","subj":"C4","obj":"C2"},{"id":"R3","pred":"coref-ident","subj":"C6","obj":"C3"},{"id":"R4","pred":"coref-ident","subj":"C7","obj":"C5"},{"id":"R5","pred":"coref-ident","subj":"C9","obj":"C4"},{"id":"R6","pred":"coref-ident","subj":"C10","obj":"C6"},{"id":"R7","pred":"coref-ident","subj":"C11","obj":"C9"},{"id":"R8","pred":"coref-ident","subj":"C12","obj":"C8"},{"id":"R9","pred":"coref-ident","subj":"C14","obj":"C11"},{"id":"R10","pred":"coref-pron","subj":"C15","obj":"C13"},{"id":"R11","pred":"coref-ident","subj":"C16","obj":"C14"},{"id":"R12","pred":"coref-pron","subj":"C17","obj":"C16"},{"id":"R13","pred":"coref-relat","subj":"C19","obj":"C18"}],"attributes":[{"subj":"C1","pred":"source","obj":"genia-medco-coref"},{"subj":"C2","pred":"source","obj":"genia-medco-coref"},{"subj":"C3","pred":"source","obj":"genia-medco-coref"},{"subj":"C4","pred":"source","obj":"genia-medco-coref"},{"subj":"C5","pred":"source","obj":"genia-medco-coref"},{"subj":"C6","pred":"source","obj":"genia-medco-coref"},{"subj":"C7","pred":"source","obj":"genia-medco-coref"},{"subj":"C9","pred":"source","obj":"genia-medco-coref"},{"subj":"C8","pred":"source","obj":"genia-medco-coref"},{"subj":"C10","pred":"source","obj":"genia-medco-coref"},{"subj":"C11","pred":"source","obj":"genia-medco-coref"},{"subj":"C12","pred":"source","obj":"genia-medco-coref"},{"subj":"C13","pred":"source","obj":"genia-medco-coref"},{"subj":"C14","pred":"source","obj":"genia-medco-coref"},{"subj":"C15","pred":"source","obj":"genia-medco-coref"},{"subj":"C16","pred":"source","obj":"genia-medco-coref"},{"subj":"C17","pred":"source","obj":"genia-medco-coref"},{"subj":"C18","pred":"source","obj":"genia-medco-coref"},{"subj":"C19","pred":"source","obj":"genia-medco-coref"}]},{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":62},"obj":"Sentence"},{"id":"S2","span":{"begin":63,"end":152},"obj":"Sentence"},{"id":"S3","span":{"begin":153,"end":321},"obj":"Sentence"},{"id":"S4","span":{"begin":322,"end":587},"obj":"Sentence"},{"id":"S5","span":{"begin":588,"end":686},"obj":"Sentence"},{"id":"S6","span":{"begin":687,"end":858},"obj":"Sentence"}],"attributes":[{"subj":"S1","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S2","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S3","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S4","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S5","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S6","pred":"source","obj":"pubmed-sentences-benchmark"}]},{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":0,"end":5},"obj":"protein_molecule"},{"id":"T2","span":{"begin":15,"end":26},"obj":"DNA_domain_or_region"},{"id":"T3","span":{"begin":48,"end":61},"obj":"other_name"},{"id":"T4","span":{"begin":95,"end":110},"obj":"protein_family_or_group"},{"id":"T5","span":{"begin":111,"end":116},"obj":"protein_molecule"},{"id":"T6","span":{"begin":124,"end":151},"obj":"DNA_domain_or_region"},{"id":"T7","span":{"begin":166,"end":171},"obj":"protein_molecule"},{"id":"T8","span":{"begin":221,"end":232},"obj":"DNA_domain_or_region"},{"id":"T9","span":{"begin":240,"end":261},"obj":"DNA_domain_or_region"},{"id":"T10","span":{"begin":297,"end":313},"obj":"protein_family_or_group"},{"id":"T11","span":{"begin":314,"end":320},"obj":"protein_molecule"},{"id":"T12","span":{"begin":344,"end":352},"obj":"other_name"},{"id":"T13","span":{"begin":385,"end":390},"obj":"protein_molecule"},{"id":"T14","span":{"begin":420,"end":432},"obj":"protein_family_or_group"},{"id":"T15","span":{"begin":436,"end":457},"obj":"cell_type"},{"id":"T16","span":{"begin":459,"end":463},"obj":"cell_type"},{"id":"T17","span":{"begin":490,"end":502},"obj":"protein_family_or_group"},{"id":"T18","span":{"begin":515,"end":541},"obj":"other_name"},{"id":"T19","span":{"begin":543,"end":548},"obj":"protein_molecule"},{"id":"T20","span":{"begin":571,"end":586},"obj":"DNA_domain_or_region"},{"id":"T21","span":{"begin":600,"end":611},"obj":"DNA_domain_or_region"},{"id":"T22","span":{"begin":623,"end":642},"obj":"DNA_domain_or_region"},{"id":"T23","span":{"begin":656,"end":661},"obj":"protein_molecule"},{"id":"T24","span":{"begin":712,"end":717},"obj":"protein_molecule"},{"id":"T25","span":{"begin":725,"end":729},"obj":"cell_type"},{"id":"T26","span":{"begin":798,"end":820},"obj":"protein_complex"},{"id":"T27","span":{"begin":835,"end":841},"obj":"other_name"},{"id":"T28","span":{"begin":842,"end":857},"obj":"other_name"}],"attributes":[{"subj":"T1","pred":"source","obj":"GENIAcorpus"},{"subj":"T2","pred":"source","obj":"GENIAcorpus"},{"subj":"T3","pred":"source","obj":"GENIAcorpus"},{"subj":"T4","pred":"source","obj":"GENIAcorpus"},{"subj":"T5","pred":"source","obj":"GENIAcorpus"},{"subj":"T6","pred":"source","obj":"GENIAcorpus"},{"subj":"T7","pred":"source","obj":"GENIAcorpus"},{"subj":"T8","pred":"source","obj":"GENIAcorpus"},{"subj":"T9","pred":"source","obj":"GENIAcorpus"},{"subj":"T10","pred":"source","obj":"GENIAcorpus"},{"subj":"T11","pred":"source","obj":"GENIAcorpus"},{"subj":"T12","pred":"source","obj":"GENIAcorpus"},{"subj":"T13","pred":"source","obj":"GENIAcorpus"},{"subj":"T14","pred":"source","obj":"GENIAcorpus"},{"subj":"T15","pred":"source","obj":"GENIAcorpus"},{"subj":"T16","pred":"source","obj":"GENIAcorpus"},{"subj":"T17","pred":"source","obj":"GENIAcorpus"},{"subj":"T18","pred":"source","obj":"GENIAcorpus"},{"subj":"T19","pred":"source","obj":"GENIAcorpus"},{"subj":"T20","pred":"source","obj":"GENIAcorpus"},{"subj":"T21","pred":"source","obj":"GENIAcorpus"},{"subj":"T22","pred":"source","obj":"GENIAcorpus"},{"subj":"T23","pred":"source","obj":"GENIAcorpus"},{"subj":"T24","pred":"source","obj":"GENIAcorpus"},{"subj":"T25","pred":"source","obj":"GENIAcorpus"},{"subj":"T26","pred":"source","obj":"GENIAcorpus"},{"subj":"T27","pred":"source","obj":"GENIAcorpus"},{"subj":"T28","pred":"source","obj":"GENIAcorpus"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"DisGeNET","color":"#c193ec","default":true},{"id":"jnlpba-st-training","color":"#93eca7"},{"id":"genia-medco-coref","color":"#ec9398"},{"id":"pubmed-sentences-benchmark","color":"#93b2ec"},{"id":"GENIAcorpus","color":"#ccec93"}]}]}}