PubMed:7565415 JSONTXT

Annnotations TAB JSON ListView MergeView

    Inflammaging

    {"project":"Inflammaging","denotations":[{"id":"T1","span":{"begin":0,"end":136},"obj":"Sentence"},{"id":"T2","span":{"begin":137,"end":371},"obj":"Sentence"},{"id":"T3","span":{"begin":372,"end":509},"obj":"Sentence"},{"id":"T4","span":{"begin":510,"end":783},"obj":"Sentence"},{"id":"T5","span":{"begin":784,"end":923},"obj":"Sentence"},{"id":"T6","span":{"begin":924,"end":1101},"obj":"Sentence"},{"id":"T7","span":{"begin":1102,"end":1262},"obj":"Sentence"},{"id":"T8","span":{"begin":1263,"end":1360},"obj":"Sentence"},{"id":"T9","span":{"begin":1361,"end":1539},"obj":"Sentence"},{"id":"T10","span":{"begin":1540,"end":1679},"obj":"Sentence"},{"id":"T11","span":{"begin":1680,"end":1906},"obj":"Sentence"},{"id":"T12","span":{"begin":1907,"end":2018},"obj":"Sentence"},{"id":"T13","span":{"begin":2019,"end":2142},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":136},"obj":"Sentence"},{"id":"T2","span":{"begin":137,"end":371},"obj":"Sentence"},{"id":"T3","span":{"begin":372,"end":509},"obj":"Sentence"},{"id":"T4","span":{"begin":510,"end":783},"obj":"Sentence"},{"id":"T5","span":{"begin":784,"end":923},"obj":"Sentence"},{"id":"T6","span":{"begin":924,"end":1101},"obj":"Sentence"},{"id":"T7","span":{"begin":1102,"end":1262},"obj":"Sentence"},{"id":"T8","span":{"begin":1263,"end":1360},"obj":"Sentence"},{"id":"T9","span":{"begin":1361,"end":1539},"obj":"Sentence"},{"id":"T10","span":{"begin":1540,"end":1679},"obj":"Sentence"},{"id":"T11","span":{"begin":1680,"end":1906},"obj":"Sentence"},{"id":"T12","span":{"begin":1907,"end":2018},"obj":"Sentence"},{"id":"T13","span":{"begin":2019,"end":2142},"obj":"Sentence"}],"text":"Regulation of human immunodeficiency virus type 1 and cytokine gene expression in myeloid cells by NF-kappa B/Rel transcription factors.\nCD4+ macrophages in tissues such as lung, skin, and lymph nodes, promyelocytic cells in bone marrow, and peripheral blood monocytes serve as important targets and reservoirs for human immunodeficiency virus type 1 (HIV-1) replication. HIV-1-infected myeloid cells are often diminished in their ability to participate in chemotaxis, phagocytosis, and intracellular killing. HIV-1 infection of myeloid cells can lead to the expression of surface receptors associated with cellular activation and/or differentiation that increase the responsiveness of these cells to cytokines secreted by neighboring cells as well as to bacteria or other pathogens. Enhancement of HIV-1 replication is related in part to increased DNA-binding activity of cellular transcription factors such as NF-kappa B. NF-kappa B binds to the HIV-1 enhancer region of the long terminal repeat and contributes to the inducibility of HIV-1 gene expression in response to multiple activating agents. Phosphorylation and degradation of the cytoplasmic inhibitor I kappa B alpha are crucial regulatory events in the activation of NF-kappa B DNA-binding activity. Both N- and C-terminal residues of I kappa B alpha are required for inducer-mediated degradation. Chronic HIV-1 infection of myeloid cells leads to constitutive NF-kappa B DNA-binding activity and provides an intranuclear environment capable of perpetuating HIV-1 replication. Increased intracellular stores of latent NF-kappa B may also result in rapid inducibility of NF-kappa B-dependent cytokine gene expression. In response to secondary pathogenic infections or antigenic challenge, cytokine gene expression is rapidly induced, enhanced, and sustained over prolonged periods in HIV-1-infected myeloid cells compared with uninfected cells. Elevated levels of several inflammatory cytokines have been detected in the sera of HIV-1-infected individuals. Secretion of myeloid cell-derived cytokines may both increase virus production and contribute to AIDS-associated disorders."}

    jnlpba-st-training

    {"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":82,"end":95},"obj":"cell_type"},{"id":"T2","span":{"begin":99,"end":113},"obj":"protein"},{"id":"T3","span":{"begin":114,"end":135},"obj":"protein"},{"id":"T4","span":{"begin":137,"end":153},"obj":"cell_line"},{"id":"T5","span":{"begin":202,"end":221},"obj":"cell_type"},{"id":"T6","span":{"begin":242,"end":268},"obj":"cell_type"},{"id":"T7","span":{"begin":387,"end":400},"obj":"cell_type"},{"id":"T8","span":{"begin":529,"end":542},"obj":"cell_type"},{"id":"T9","span":{"begin":573,"end":590},"obj":"protein"},{"id":"T10","span":{"begin":701,"end":710},"obj":"protein"},{"id":"T11","span":{"begin":873,"end":903},"obj":"protein"},{"id":"T12","span":{"begin":912,"end":922},"obj":"protein"},{"id":"T13","span":{"begin":924,"end":934},"obj":"protein"},{"id":"T14","span":{"begin":948,"end":962},"obj":"DNA"},{"id":"T15","span":{"begin":977,"end":997},"obj":"DNA"},{"id":"T16","span":{"begin":1141,"end":1162},"obj":"protein"},{"id":"T17","span":{"begin":1163,"end":1172},"obj":"protein"},{"id":"T18","span":{"begin":1230,"end":1240},"obj":"protein"},{"id":"T19","span":{"begin":1298,"end":1307},"obj":"protein"},{"id":"T20","span":{"begin":1388,"end":1401},"obj":"cell_type"},{"id":"T21","span":{"begin":1424,"end":1434},"obj":"protein"},{"id":"T22","span":{"begin":1574,"end":1591},"obj":"protein"},{"id":"T23","span":{"begin":1633,"end":1643},"obj":"protein"},{"id":"T24","span":{"begin":1654,"end":1662},"obj":"protein"},{"id":"T25","span":{"begin":1751,"end":1759},"obj":"protein"},{"id":"T26","span":{"begin":1846,"end":1874},"obj":"cell_line"},{"id":"T27","span":{"begin":1889,"end":1905},"obj":"cell_type"},{"id":"T28","span":{"begin":1934,"end":1956},"obj":"protein"},{"id":"T29","span":{"begin":2032,"end":2062},"obj":"protein"}],"text":"Regulation of human immunodeficiency virus type 1 and cytokine gene expression in myeloid cells by NF-kappa B/Rel transcription factors.\nCD4+ macrophages in tissues such as lung, skin, and lymph nodes, promyelocytic cells in bone marrow, and peripheral blood monocytes serve as important targets and reservoirs for human immunodeficiency virus type 1 (HIV-1) replication. HIV-1-infected myeloid cells are often diminished in their ability to participate in chemotaxis, phagocytosis, and intracellular killing. HIV-1 infection of myeloid cells can lead to the expression of surface receptors associated with cellular activation and/or differentiation that increase the responsiveness of these cells to cytokines secreted by neighboring cells as well as to bacteria or other pathogens. Enhancement of HIV-1 replication is related in part to increased DNA-binding activity of cellular transcription factors such as NF-kappa B. NF-kappa B binds to the HIV-1 enhancer region of the long terminal repeat and contributes to the inducibility of HIV-1 gene expression in response to multiple activating agents. Phosphorylation and degradation of the cytoplasmic inhibitor I kappa B alpha are crucial regulatory events in the activation of NF-kappa B DNA-binding activity. Both N- and C-terminal residues of I kappa B alpha are required for inducer-mediated degradation. Chronic HIV-1 infection of myeloid cells leads to constitutive NF-kappa B DNA-binding activity and provides an intranuclear environment capable of perpetuating HIV-1 replication. Increased intracellular stores of latent NF-kappa B may also result in rapid inducibility of NF-kappa B-dependent cytokine gene expression. In response to secondary pathogenic infections or antigenic challenge, cytokine gene expression is rapidly induced, enhanced, and sustained over prolonged periods in HIV-1-infected myeloid cells compared with uninfected cells. Elevated levels of several inflammatory cytokines have been detected in the sera of HIV-1-infected individuals. Secretion of myeloid cell-derived cytokines may both increase virus production and contribute to AIDS-associated disorders."}

    genia-medco-coref

    {"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":82,"end":95},"obj":"NP"},{"id":"C2","span":{"begin":315,"end":370},"obj":"NP"},{"id":"C3","span":{"begin":372,"end":400},"obj":"NP"},{"id":"C4","span":{"begin":425,"end":430},"obj":"NP"},{"id":"C5","span":{"begin":529,"end":542},"obj":"NP"},{"id":"C6","span":{"begin":573,"end":649},"obj":"NP"},{"id":"C7","span":{"begin":650,"end":654},"obj":"NP"},{"id":"C8","span":{"begin":686,"end":697},"obj":"NP"},{"id":"C9","span":{"begin":799,"end":816},"obj":"NP"},{"id":"C10","span":{"begin":912,"end":922},"obj":"NP"},{"id":"C11","span":{"begin":924,"end":934},"obj":"NP"},{"id":"C12","span":{"begin":1137,"end":1178},"obj":"NP"},{"id":"C13","span":{"begin":1298,"end":1313},"obj":"NP"},{"id":"C14","span":{"begin":1388,"end":1401},"obj":"NP"},{"id":"C15","span":{"begin":1521,"end":1538},"obj":"NP"},{"id":"C16","span":{"begin":1633,"end":1678},"obj":"NP"},{"id":"C17","span":{"begin":1751,"end":1775},"obj":"NP"},{"id":"C18","span":{"begin":1846,"end":1874},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-pron","subj":"C4","obj":"C3"},{"id":"R2","pred":"coref-ident","subj":"C5","obj":"C1"},{"id":"R3","pred":"coref-relat","subj":"C7","obj":"C6"},{"id":"R4","pred":"coref-ident","subj":"C8","obj":"C5"},{"id":"R5","pred":"coref-ident","subj":"C9","obj":"C2"},{"id":"R6","pred":"coref-ident","subj":"C11","obj":"C10"},{"id":"R7","pred":"coref-ident","subj":"C13","obj":"C12"},{"id":"R8","pred":"coref-ident","subj":"C14","obj":"C5"},{"id":"R9","pred":"coref-ident","subj":"C15","obj":"C9"},{"id":"R10","pred":"coref-ident","subj":"C17","obj":"C16"},{"id":"R11","pred":"coref-ident","subj":"C18","obj":"C3"}],"text":"Regulation of human immunodeficiency virus type 1 and cytokine gene expression in myeloid cells by NF-kappa B/Rel transcription factors.\nCD4+ macrophages in tissues such as lung, skin, and lymph nodes, promyelocytic cells in bone marrow, and peripheral blood monocytes serve as important targets and reservoirs for human immunodeficiency virus type 1 (HIV-1) replication. HIV-1-infected myeloid cells are often diminished in their ability to participate in chemotaxis, phagocytosis, and intracellular killing. HIV-1 infection of myeloid cells can lead to the expression of surface receptors associated with cellular activation and/or differentiation that increase the responsiveness of these cells to cytokines secreted by neighboring cells as well as to bacteria or other pathogens. Enhancement of HIV-1 replication is related in part to increased DNA-binding activity of cellular transcription factors such as NF-kappa B. NF-kappa B binds to the HIV-1 enhancer region of the long terminal repeat and contributes to the inducibility of HIV-1 gene expression in response to multiple activating agents. Phosphorylation and degradation of the cytoplasmic inhibitor I kappa B alpha are crucial regulatory events in the activation of NF-kappa B DNA-binding activity. Both N- and C-terminal residues of I kappa B alpha are required for inducer-mediated degradation. Chronic HIV-1 infection of myeloid cells leads to constitutive NF-kappa B DNA-binding activity and provides an intranuclear environment capable of perpetuating HIV-1 replication. Increased intracellular stores of latent NF-kappa B may also result in rapid inducibility of NF-kappa B-dependent cytokine gene expression. In response to secondary pathogenic infections or antigenic challenge, cytokine gene expression is rapidly induced, enhanced, and sustained over prolonged periods in HIV-1-infected myeloid cells compared with uninfected cells. Elevated levels of several inflammatory cytokines have been detected in the sera of HIV-1-infected individuals. Secretion of myeloid cell-derived cytokines may both increase virus production and contribute to AIDS-associated disorders."}

    pubmed-sentences-benchmark

    {"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":136},"obj":"Sentence"},{"id":"S2","span":{"begin":137,"end":371},"obj":"Sentence"},{"id":"S3","span":{"begin":372,"end":509},"obj":"Sentence"},{"id":"S4","span":{"begin":510,"end":783},"obj":"Sentence"},{"id":"S5","span":{"begin":784,"end":923},"obj":"Sentence"},{"id":"S6","span":{"begin":924,"end":1101},"obj":"Sentence"},{"id":"S7","span":{"begin":1102,"end":1262},"obj":"Sentence"},{"id":"S8","span":{"begin":1263,"end":1360},"obj":"Sentence"},{"id":"S9","span":{"begin":1361,"end":1539},"obj":"Sentence"},{"id":"S10","span":{"begin":1540,"end":1679},"obj":"Sentence"},{"id":"S11","span":{"begin":1680,"end":1906},"obj":"Sentence"},{"id":"S12","span":{"begin":1907,"end":2018},"obj":"Sentence"},{"id":"S13","span":{"begin":2019,"end":2142},"obj":"Sentence"}],"text":"Regulation of human immunodeficiency virus type 1 and cytokine gene expression in myeloid cells by NF-kappa B/Rel transcription factors.\nCD4+ macrophages in tissues such as lung, skin, and lymph nodes, promyelocytic cells in bone marrow, and peripheral blood monocytes serve as important targets and reservoirs for human immunodeficiency virus type 1 (HIV-1) replication. HIV-1-infected myeloid cells are often diminished in their ability to participate in chemotaxis, phagocytosis, and intracellular killing. HIV-1 infection of myeloid cells can lead to the expression of surface receptors associated with cellular activation and/or differentiation that increase the responsiveness of these cells to cytokines secreted by neighboring cells as well as to bacteria or other pathogens. Enhancement of HIV-1 replication is related in part to increased DNA-binding activity of cellular transcription factors such as NF-kappa B. NF-kappa B binds to the HIV-1 enhancer region of the long terminal repeat and contributes to the inducibility of HIV-1 gene expression in response to multiple activating agents. Phosphorylation and degradation of the cytoplasmic inhibitor I kappa B alpha are crucial regulatory events in the activation of NF-kappa B DNA-binding activity. Both N- and C-terminal residues of I kappa B alpha are required for inducer-mediated degradation. Chronic HIV-1 infection of myeloid cells leads to constitutive NF-kappa B DNA-binding activity and provides an intranuclear environment capable of perpetuating HIV-1 replication. Increased intracellular stores of latent NF-kappa B may also result in rapid inducibility of NF-kappa B-dependent cytokine gene expression. In response to secondary pathogenic infections or antigenic challenge, cytokine gene expression is rapidly induced, enhanced, and sustained over prolonged periods in HIV-1-infected myeloid cells compared with uninfected cells. Elevated levels of several inflammatory cytokines have been detected in the sera of HIV-1-infected individuals. Secretion of myeloid cell-derived cytokines may both increase virus production and contribute to AIDS-associated disorders."}

    GENIAcorpus

    {"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":14,"end":49},"obj":"virus"},{"id":"T2","span":{"begin":63,"end":78},"obj":"other_name"},{"id":"T3","span":{"begin":82,"end":95},"obj":"cell_type"},{"id":"T4","span":{"begin":99,"end":109},"obj":"protein_molecule"},{"id":"T5","span":{"begin":114,"end":135},"obj":"protein_family_or_group"},{"id":"T6","span":{"begin":137,"end":153},"obj":"cell_line"},{"id":"T7","span":{"begin":173,"end":177},"obj":"body_part"},{"id":"T8","span":{"begin":179,"end":183},"obj":"body_part"},{"id":"T9","span":{"begin":189,"end":200},"obj":"body_part"},{"id":"T10","span":{"begin":202,"end":221},"obj":"cell_type"},{"id":"T11","span":{"begin":225,"end":236},"obj":"tissue"},{"id":"T12","span":{"begin":242,"end":268},"obj":"cell_type"},{"id":"T13","span":{"begin":315,"end":350},"obj":"virus"},{"id":"T14","span":{"begin":352,"end":357},"obj":"virus"},{"id":"T15","span":{"begin":372,"end":377},"obj":"virus"},{"id":"T16","span":{"begin":387,"end":400},"obj":"cell_type"},{"id":"T17","span":{"begin":457,"end":467},"obj":"other_name"},{"id":"T18","span":{"begin":469,"end":481},"obj":"other_name"},{"id":"T19","span":{"begin":487,"end":508},"obj":"other_name"},{"id":"T20","span":{"begin":510,"end":515},"obj":"virus"},{"id":"T21","span":{"begin":529,"end":542},"obj":"cell_type"},{"id":"T22","span":{"begin":573,"end":590},"obj":"protein_family_or_group"},{"id":"T23","span":{"begin":607,"end":626},"obj":"other_name"},{"id":"T24","span":{"begin":634,"end":649},"obj":"other_name"},{"id":"T25","span":{"begin":701,"end":710},"obj":"protein_family_or_group"},{"id":"T26","span":{"begin":755,"end":763},"obj":"mono_cell"},{"id":"T27","span":{"begin":799,"end":804},"obj":"virus"},{"id":"T28","span":{"begin":849,"end":869},"obj":"other_name"},{"id":"T29","span":{"begin":873,"end":881},"obj":"protein_family_or_group"},{"id":"T30","span":{"begin":882,"end":903},"obj":"protein_family_or_group"},{"id":"T31","span":{"begin":912,"end":922},"obj":"protein_molecule"},{"id":"T32","span":{"begin":924,"end":934},"obj":"protein_molecule"},{"id":"T33","span":{"begin":948,"end":953},"obj":"virus"},{"id":"T34","span":{"begin":977,"end":997},"obj":"DNA_domain_or_region"},{"id":"T35","span":{"begin":1037,"end":1042},"obj":"virus"},{"id":"T36","span":{"begin":1043,"end":1058},"obj":"other_name"},{"id":"T37","span":{"begin":1102,"end":1117},"obj":"other_name"},{"id":"T38","span":{"begin":1122,"end":1133},"obj":"other_name"},{"id":"T39","span":{"begin":1141,"end":1162},"obj":"protein_family_or_group"},{"id":"T40","span":{"begin":1163,"end":1172},"obj":"protein_molecule"},{"id":"T41","span":{"begin":1230,"end":1240},"obj":"protein_molecule"},{"id":"T42","span":{"begin":1241,"end":1261},"obj":"other_name"},{"id":"T43","span":{"begin":1298,"end":1307},"obj":"protein_molecule"},{"id":"T44","span":{"begin":1331,"end":1359},"obj":"other_name"},{"id":"T45","span":{"begin":1369,"end":1374},"obj":"virus"},{"id":"T46","span":{"begin":1388,"end":1401},"obj":"cell_type"},{"id":"T47","span":{"begin":1424,"end":1434},"obj":"protein_molecule"},{"id":"T48","span":{"begin":1435,"end":1455},"obj":"other_name"},{"id":"T49","span":{"begin":1472,"end":1496},"obj":"other_name"},{"id":"T50","span":{"begin":1521,"end":1526},"obj":"virus"},{"id":"T51","span":{"begin":1550,"end":1570},"obj":"other_name"},{"id":"T52","span":{"begin":1574,"end":1580},"obj":"protein_molecule"},{"id":"T53","span":{"begin":1581,"end":1591},"obj":"protein_molecule"},{"id":"T54","span":{"begin":1633,"end":1643},"obj":"protein_molecule"},{"id":"T55","span":{"begin":1654,"end":1662},"obj":"protein_family_or_group"},{"id":"T56","span":{"begin":1663,"end":1678},"obj":"other_name"},{"id":"T57","span":{"begin":1751,"end":1759},"obj":"protein_family_or_group"},{"id":"T58","span":{"begin":1760,"end":1775},"obj":"other_name"},{"id":"T59","span":{"begin":1846,"end":1851},"obj":"virus"},{"id":"T60","span":{"begin":1861,"end":1874},"obj":"cell_type"},{"id":"T61","span":{"begin":1889,"end":1905},"obj":"cell_type"},{"id":"T62","span":{"begin":1934,"end":1956},"obj":"protein_family_or_group"},{"id":"T63","span":{"begin":1991,"end":1996},"obj":"virus"},{"id":"T64","span":{"begin":2032,"end":2052},"obj":"protein_family_or_group"},{"id":"T65","span":{"begin":2053,"end":2062},"obj":"protein_family_or_group"},{"id":"T66","span":{"begin":2081,"end":2097},"obj":"other_name"},{"id":"T67","span":{"begin":2116,"end":2141},"obj":"other_name"}],"text":"Regulation of human immunodeficiency virus type 1 and cytokine gene expression in myeloid cells by NF-kappa B/Rel transcription factors.\nCD4+ macrophages in tissues such as lung, skin, and lymph nodes, promyelocytic cells in bone marrow, and peripheral blood monocytes serve as important targets and reservoirs for human immunodeficiency virus type 1 (HIV-1) replication. HIV-1-infected myeloid cells are often diminished in their ability to participate in chemotaxis, phagocytosis, and intracellular killing. HIV-1 infection of myeloid cells can lead to the expression of surface receptors associated with cellular activation and/or differentiation that increase the responsiveness of these cells to cytokines secreted by neighboring cells as well as to bacteria or other pathogens. Enhancement of HIV-1 replication is related in part to increased DNA-binding activity of cellular transcription factors such as NF-kappa B. NF-kappa B binds to the HIV-1 enhancer region of the long terminal repeat and contributes to the inducibility of HIV-1 gene expression in response to multiple activating agents. Phosphorylation and degradation of the cytoplasmic inhibitor I kappa B alpha are crucial regulatory events in the activation of NF-kappa B DNA-binding activity. Both N- and C-terminal residues of I kappa B alpha are required for inducer-mediated degradation. Chronic HIV-1 infection of myeloid cells leads to constitutive NF-kappa B DNA-binding activity and provides an intranuclear environment capable of perpetuating HIV-1 replication. Increased intracellular stores of latent NF-kappa B may also result in rapid inducibility of NF-kappa B-dependent cytokine gene expression. In response to secondary pathogenic infections or antigenic challenge, cytokine gene expression is rapidly induced, enhanced, and sustained over prolonged periods in HIV-1-infected myeloid cells compared with uninfected cells. Elevated levels of several inflammatory cytokines have been detected in the sera of HIV-1-infected individuals. Secretion of myeloid cell-derived cytokines may both increase virus production and contribute to AIDS-associated disorders."}