PubMed:7559886 JSONTXT

{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":110,"end":129},"obj":"cell_type"},{"id":"T2","span":{"begin":343,"end":369},"obj":"cell_line"},{"id":"T3","span":{"begin":371,"end":375},"obj":"cell_line"},{"id":"T4","span":{"begin":826,"end":839},"obj":"protein"},{"id":"T5","span":{"begin":863,"end":870},"obj":"cell_type"}],"text":"Up-regulation of high-affinity dehydroepiandrosterone binding activity by dehydroepiandrosterone in activated human T lymphocytes.\nAlthough evidence indicates that dehydroepiandrosterone (DHEA) exerts direct physiological effects, its mechanism of action remains unknown. DHEA binding sites were examined using a whole-cell binding assay in a human T lymphoid cell line, PEER, revealing that a single class of high-affinity binding sites for DHEA (dissociation constant = 7.4 +/- 0.53 nmol/L, mean +/- SE, n = 4) was greatly increased when treated with DHEA, phorbol-12-myristate-13-acetate, and the Ca2+ ionophore A23187. Bound [3H]DHEA was displaced sensitively by DHEA and secondarily by dihydrotestosterone, but not effectively by other steroids, including DHEA sulfate. These results not only indicate the existence of a DHEA receptor, but also suggest that T cells become susceptible to regulation by DHEA during the process of signal-induced activation."}

{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":74,"end":96},"obj":"NP"},{"id":"C2","span":{"begin":164,"end":193},"obj":"NP"},{"id":"C3","span":{"begin":231,"end":234},"obj":"NP"},{"id":"C4","span":{"begin":341,"end":369},"obj":"NP"},{"id":"C5","span":{"begin":371,"end":375},"obj":"NP"},{"id":"C6","span":{"begin":442,"end":446},"obj":"NP"},{"id":"C7","span":{"begin":553,"end":557},"obj":"NP"},{"id":"C8","span":{"begin":667,"end":671},"obj":"NP"},{"id":"C9","span":{"begin":907,"end":911},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C2","obj":"C1"},{"id":"R2","pred":"coref-pron","subj":"C3","obj":"C2"},{"id":"R3","pred":"coref-appos","subj":"C5","obj":"C4"},{"id":"R4","pred":"coref-ident","subj":"C6","obj":"C2"},{"id":"R5","pred":"coref-ident","subj":"C7","obj":"C6"},{"id":"R6","pred":"coref-ident","subj":"C8","obj":"C7"},{"id":"R7","pred":"coref-ident","subj":"C9","obj":"C8"}],"text":"Up-regulation of high-affinity dehydroepiandrosterone binding activity by dehydroepiandrosterone in activated human T lymphocytes.\nAlthough evidence indicates that dehydroepiandrosterone (DHEA) exerts direct physiological effects, its mechanism of action remains unknown. DHEA binding sites were examined using a whole-cell binding assay in a human T lymphoid cell line, PEER, revealing that a single class of high-affinity binding sites for DHEA (dissociation constant = 7.4 +/- 0.53 nmol/L, mean +/- SE, n = 4) was greatly increased when treated with DHEA, phorbol-12-myristate-13-acetate, and the Ca2+ ionophore A23187. Bound [3H]DHEA was displaced sensitively by DHEA and secondarily by dihydrotestosterone, but not effectively by other steroids, including DHEA sulfate. These results not only indicate the existence of a DHEA receptor, but also suggest that T cells become susceptible to regulation by DHEA during the process of signal-induced activation."}

{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":130},"obj":"Sentence"},{"id":"S2","span":{"begin":131,"end":271},"obj":"Sentence"},{"id":"S3","span":{"begin":272,"end":622},"obj":"Sentence"},{"id":"S4","span":{"begin":623,"end":774},"obj":"Sentence"},{"id":"S5","span":{"begin":775,"end":960},"obj":"Sentence"}],"text":"Up-regulation of high-affinity dehydroepiandrosterone binding activity by dehydroepiandrosterone in activated human T lymphocytes.\nAlthough evidence indicates that dehydroepiandrosterone (DHEA) exerts direct physiological effects, its mechanism of action remains unknown. DHEA binding sites were examined using a whole-cell binding assay in a human T lymphoid cell line, PEER, revealing that a single class of high-affinity binding sites for DHEA (dissociation constant = 7.4 +/- 0.53 nmol/L, mean +/- SE, n = 4) was greatly increased when treated with DHEA, phorbol-12-myristate-13-acetate, and the Ca2+ ionophore A23187. Bound [3H]DHEA was displaced sensitively by DHEA and secondarily by dihydrotestosterone, but not effectively by other steroids, including DHEA sulfate. These results not only indicate the existence of a DHEA receptor, but also suggest that T cells become susceptible to regulation by DHEA during the process of signal-induced activation."}

{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":17,"end":53},"obj":"lipid"},{"id":"T2","span":{"begin":74,"end":96},"obj":"lipid"},{"id":"T3","span":{"begin":110,"end":129},"obj":"cell_type"},{"id":"T4","span":{"begin":164,"end":186},"obj":"lipid"},{"id":"T5","span":{"begin":188,"end":192},"obj":"lipid"},{"id":"T6","span":{"begin":208,"end":229},"obj":"other_name"},{"id":"T7","span":{"begin":272,"end":276},"obj":"lipid"},{"id":"T8","span":{"begin":313,"end":337},"obj":"other_name"},{"id":"T9","span":{"begin":343,"end":369},"obj":"cell_line"},{"id":"T10","span":{"begin":371,"end":375},"obj":"cell_line"},{"id":"T11","span":{"begin":410,"end":437},"obj":"cell_component"},{"id":"T12","span":{"begin":442,"end":446},"obj":"lipid"},{"id":"T13","span":{"begin":553,"end":557},"obj":"lipid"},{"id":"T14","span":{"begin":559,"end":590},"obj":"other_organic_compound"},{"id":"T15","span":{"begin":600,"end":604},"obj":"atom"},{"id":"T16","span":{"begin":633,"end":637},"obj":"lipid"},{"id":"T17","span":{"begin":667,"end":671},"obj":"lipid"},{"id":"T18","span":{"begin":691,"end":710},"obj":"lipid"},{"id":"T19","span":{"begin":741,"end":749},"obj":"lipid"},{"id":"T20","span":{"begin":761,"end":773},"obj":"lipid"},{"id":"T21","span":{"begin":826,"end":830},"obj":"lipid"},{"id":"T22","span":{"begin":863,"end":870},"obj":"cell_type"},{"id":"T23","span":{"begin":907,"end":911},"obj":"lipid"},{"id":"T24","span":{"begin":934,"end":959},"obj":"other_name"}],"text":"Up-regulation of high-affinity dehydroepiandrosterone binding activity by dehydroepiandrosterone in activated human T lymphocytes.\nAlthough evidence indicates that dehydroepiandrosterone (DHEA) exerts direct physiological effects, its mechanism of action remains unknown. DHEA binding sites were examined using a whole-cell binding assay in a human T lymphoid cell line, PEER, revealing that a single class of high-affinity binding sites for DHEA (dissociation constant = 7.4 +/- 0.53 nmol/L, mean +/- SE, n = 4) was greatly increased when treated with DHEA, phorbol-12-myristate-13-acetate, and the Ca2+ ionophore A23187. Bound [3H]DHEA was displaced sensitively by DHEA and secondarily by dihydrotestosterone, but not effectively by other steroids, including DHEA sulfate. These results not only indicate the existence of a DHEA receptor, but also suggest that T cells become susceptible to regulation by DHEA during the process of signal-induced activation."}