PubMed:7559886 JSON TXT

Annnotations TAB JSON ListView MergeView

Id	Subject	Object	Predicate	Lexical cue
T1	110-129	cell_type	denotes	human T lymphocytes
T2	343-369	cell_line	denotes	human T lymphoid cell line
T3	371-375	cell_line	denotes	PEER
T4	826-839	protein	denotes	DHEA receptor
T5	863-870	cell_type	denotes	T cells

Id	Subject	Object	Predicate	Lexical cue
C1	74-96	NP	denotes	dehydroepiandrosterone
C2	164-193	NP	denotes	dehydroepiandrosterone (DHEA)
C3	231-234	NP	denotes	its
C4	341-369	NP	denotes	a human T lymphoid cell line
C5	371-375	NP	denotes	PEER
C6	442-446	NP	denotes	DHEA
C7	553-557	NP	denotes	DHEA
C8	667-671	NP	denotes	DHEA
C9	907-911	NP	denotes	DHEA
R1	C2	C1	coref-ident	dehydroepiandrosterone (DHEA),dehydroepiandrosterone
R2	C3	C2	coref-pron	its,dehydroepiandrosterone (DHEA)
R3	C5	C4	coref-appos	PEER,a human T lymphoid cell line
R4	C6	C2	coref-ident	DHEA,dehydroepiandrosterone (DHEA)
R5	C7	C6	coref-ident	DHEA,DHEA
R6	C8	C7	coref-ident	DHEA,DHEA
R7	C9	C8	coref-ident	DHEA,DHEA

Id	Subject	Object	Predicate	Lexical cue
S1	0-130	Sentence	denotes	Up-regulation of high-affinity dehydroepiandrosterone binding activity by dehydroepiandrosterone in activated human T lymphocytes.
S2	131-271	Sentence	denotes	Although evidence indicates that dehydroepiandrosterone (DHEA) exerts direct physiological effects, its mechanism of action remains unknown.
S3	272-622	Sentence	denotes	DHEA binding sites were examined using a whole-cell binding assay in a human T lymphoid cell line, PEER, revealing that a single class of high-affinity binding sites for DHEA (dissociation constant = 7.4 +/- 0.53 nmol/L, mean +/- SE, n = 4) was greatly increased when treated with DHEA, phorbol-12-myristate-13-acetate, and the Ca2+ ionophore A23187.
S4	623-774	Sentence	denotes	Bound [3H]DHEA was displaced sensitively by DHEA and secondarily by dihydrotestosterone, but not effectively by other steroids, including DHEA sulfate.
S5	775-960	Sentence	denotes	These results not only indicate the existence of a DHEA receptor, but also suggest that T cells become susceptible to regulation by DHEA during the process of signal-induced activation.

Id	Subject	Object	Predicate	Lexical cue
T1	17-53	lipid	denotes	high-affinity dehydroepiandrosterone
T2	74-96	lipid	denotes	dehydroepiandrosterone
T3	110-129	cell_type	denotes	human T lymphocytes
T4	164-186	lipid	denotes	dehydroepiandrosterone
T5	188-192	lipid	denotes	DHEA
T6	208-229	other_name	denotes	physiological effects
T7	272-276	lipid	denotes	DHEA
T8	313-337	other_name	denotes	whole-cell binding assay
T9	343-369	cell_line	denotes	human T lymphoid cell line
T10	371-375	cell_line	denotes	PEER
T11	410-437	cell_component	denotes	high-affinity binding sites
T12	442-446	lipid	denotes	DHEA
T13	553-557	lipid	denotes	DHEA
T14	559-590	other_organic_compound	denotes	phorbol-12-myristate-13-acetate
T15	600-604	atom	denotes	Ca2+
T16	633-637	lipid	denotes	DHEA
T17	667-671	lipid	denotes	DHEA
T18	691-710	lipid	denotes	dihydrotestosterone
T19	741-749	lipid	denotes	steroids
T20	761-773	lipid	denotes	DHEA sulfate
T21	826-830	lipid	denotes	DHEA
T22	863-870	cell_type	denotes	T cells
T23	907-911	lipid	denotes	DHEA
T24	934-959	other_name	denotes	signal-induced activation