PubMed:7543076 JSONTXT

{"project":"Inflammaging","denotations":[{"id":"T1","span":{"begin":0,"end":150},"obj":"Sentence"},{"id":"T2","span":{"begin":151,"end":290},"obj":"Sentence"},{"id":"T3","span":{"begin":291,"end":593},"obj":"Sentence"},{"id":"T4","span":{"begin":594,"end":699},"obj":"Sentence"},{"id":"T5","span":{"begin":700,"end":880},"obj":"Sentence"},{"id":"T6","span":{"begin":881,"end":1072},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":150},"obj":"Sentence"},{"id":"T2","span":{"begin":151,"end":290},"obj":"Sentence"},{"id":"T3","span":{"begin":291,"end":593},"obj":"Sentence"},{"id":"T4","span":{"begin":594,"end":699},"obj":"Sentence"},{"id":"T5","span":{"begin":700,"end":880},"obj":"Sentence"},{"id":"T6","span":{"begin":881,"end":1072},"obj":"Sentence"}],"text":"Lipopolysaccharide-induced E-selectin expression requires continuous presence of LPS and is inhibited by bactericidal/permeability-increasing protein.\nEndothelial cells stimulated by LPS express E-selectin, which plays an important role in mediating neutrophil adhesion during inflammation. E-selectin is induced within 1-2 h, peaks at 4-6 h, and gradually returns to basal level by 24 h. rBPI21, a recombinant N-terminal fragment of human bactericidal/permeability-increasing protein (BPI), inhibited LPS-induced E-selectin expression when added at the same time as, and up to 6 h after, LPS. Delayed administration of rBPI21 also affected LPS-mediated activation of the nuclear factor, NF-kappa B. Two to 4 h following LPS addition to endothelial cells, when NF-kappa B was already activated, addition of rBPI21 resulted in marked reduction of NF-kappa B detectable at 4 or 6 h. These results indicate that endothelial activation requires continuous presence of LPS, and rBPI21 acts to reverse LPS-mediated endothelial activation by interrupting the on-going LPS signal."}

{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":27,"end":37},"obj":"protein"},{"id":"T2","span":{"begin":105,"end":149},"obj":"protein"},{"id":"T3","span":{"begin":151,"end":168},"obj":"cell_type"},{"id":"T4","span":{"begin":195,"end":205},"obj":"protein"},{"id":"T5","span":{"begin":250,"end":260},"obj":"cell_type"},{"id":"T6","span":{"begin":291,"end":301},"obj":"protein"},{"id":"T7","span":{"begin":389,"end":395},"obj":"protein"},{"id":"T8","span":{"begin":399,"end":430},"obj":"protein"},{"id":"T9","span":{"begin":434,"end":484},"obj":"protein"},{"id":"T10","span":{"begin":486,"end":489},"obj":"protein"},{"id":"T11","span":{"begin":514,"end":524},"obj":"protein"},{"id":"T12","span":{"begin":620,"end":626},"obj":"protein"},{"id":"T13","span":{"begin":672,"end":686},"obj":"protein"},{"id":"T14","span":{"begin":688,"end":698},"obj":"protein"},{"id":"T15","span":{"begin":737,"end":754},"obj":"cell_type"},{"id":"T16","span":{"begin":761,"end":771},"obj":"protein"},{"id":"T17","span":{"begin":807,"end":813},"obj":"protein"},{"id":"T18","span":{"begin":846,"end":856},"obj":"protein"},{"id":"T19","span":{"begin":973,"end":979},"obj":"protein"}],"text":"Lipopolysaccharide-induced E-selectin expression requires continuous presence of LPS and is inhibited by bactericidal/permeability-increasing protein.\nEndothelial cells stimulated by LPS express E-selectin, which plays an important role in mediating neutrophil adhesion during inflammation. E-selectin is induced within 1-2 h, peaks at 4-6 h, and gradually returns to basal level by 24 h. rBPI21, a recombinant N-terminal fragment of human bactericidal/permeability-increasing protein (BPI), inhibited LPS-induced E-selectin expression when added at the same time as, and up to 6 h after, LPS. Delayed administration of rBPI21 also affected LPS-mediated activation of the nuclear factor, NF-kappa B. Two to 4 h following LPS addition to endothelial cells, when NF-kappa B was already activated, addition of rBPI21 resulted in marked reduction of NF-kappa B detectable at 4 or 6 h. These results indicate that endothelial activation requires continuous presence of LPS, and rBPI21 acts to reverse LPS-mediated endothelial activation by interrupting the on-going LPS signal."}

{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":0,"end":48},"obj":"NP"},{"id":"C3","span":{"begin":81,"end":84},"obj":"NP"},{"id":"C2","span":{"begin":58,"end":84},"obj":"NP"},{"id":"C4","span":{"begin":105,"end":149},"obj":"NP"},{"id":"C5","span":{"begin":151,"end":168},"obj":"NP"},{"id":"C6","span":{"begin":183,"end":186},"obj":"NP"},{"id":"C7","span":{"begin":195,"end":205},"obj":"NP"},{"id":"C8","span":{"begin":207,"end":212},"obj":"NP"},{"id":"C9","span":{"begin":291,"end":301},"obj":"NP"},{"id":"C10","span":{"begin":389,"end":395},"obj":"NP"},{"id":"C12","span":{"begin":434,"end":490},"obj":"NP"},{"id":"C11","span":{"begin":397,"end":490},"obj":"NP"},{"id":"C13","span":{"begin":502,"end":535},"obj":"NP"},{"id":"C14","span":{"begin":589,"end":592},"obj":"NP"},{"id":"C15","span":{"begin":620,"end":626},"obj":"NP"},{"id":"C16","span":{"begin":668,"end":686},"obj":"NP"},{"id":"C17","span":{"begin":688,"end":698},"obj":"NP"},{"id":"C18","span":{"begin":737,"end":754},"obj":"NP"},{"id":"C19","span":{"begin":761,"end":771},"obj":"NP"},{"id":"C20","span":{"begin":807,"end":813},"obj":"NP"},{"id":"C21","span":{"begin":846,"end":856},"obj":"NP"},{"id":"C23","span":{"begin":964,"end":967},"obj":"NP"},{"id":"C22","span":{"begin":941,"end":967},"obj":"NP"},{"id":"C24","span":{"begin":973,"end":979},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C6","obj":"C3"},{"id":"R2","pred":"coref-relat","subj":"C8","obj":"C7"},{"id":"R3","pred":"coref-ident","subj":"C9","obj":"C7"},{"id":"R4","pred":"coref-ident","subj":"C12","obj":"C4"},{"id":"R5","pred":"coref-appos","subj":"C11","obj":"C10"},{"id":"R6","pred":"coref-ident","subj":"C13","obj":"C1"},{"id":"R7","pred":"coref-ident","subj":"C14","obj":"C6"},{"id":"R8","pred":"coref-ident","subj":"C15","obj":"C10"},{"id":"R9","pred":"coref-appos","subj":"C17","obj":"C16"},{"id":"R10","pred":"coref-ident","subj":"C18","obj":"C5"},{"id":"R11","pred":"coref-ident","subj":"C19","obj":"C16"},{"id":"R12","pred":"coref-ident","subj":"C20","obj":"C15"},{"id":"R13","pred":"coref-ident","subj":"C21","obj":"C19"},{"id":"R14","pred":"coref-ident","subj":"C23","obj":"C14"},{"id":"R15","pred":"coref-ident","subj":"C22","obj":"C2"},{"id":"R16","pred":"coref-ident","subj":"C24","obj":"C20"}],"text":"Lipopolysaccharide-induced E-selectin expression requires continuous presence of LPS and is inhibited by bactericidal/permeability-increasing protein.\nEndothelial cells stimulated by LPS express E-selectin, which plays an important role in mediating neutrophil adhesion during inflammation. E-selectin is induced within 1-2 h, peaks at 4-6 h, and gradually returns to basal level by 24 h. rBPI21, a recombinant N-terminal fragment of human bactericidal/permeability-increasing protein (BPI), inhibited LPS-induced E-selectin expression when added at the same time as, and up to 6 h after, LPS. Delayed administration of rBPI21 also affected LPS-mediated activation of the nuclear factor, NF-kappa B. Two to 4 h following LPS addition to endothelial cells, when NF-kappa B was already activated, addition of rBPI21 resulted in marked reduction of NF-kappa B detectable at 4 or 6 h. These results indicate that endothelial activation requires continuous presence of LPS, and rBPI21 acts to reverse LPS-mediated endothelial activation by interrupting the on-going LPS signal."}

{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":150},"obj":"Sentence"},{"id":"S2","span":{"begin":151,"end":290},"obj":"Sentence"},{"id":"S3","span":{"begin":291,"end":388},"obj":"Sentence"},{"id":"S4","span":{"begin":389,"end":593},"obj":"Sentence"},{"id":"S5","span":{"begin":594,"end":699},"obj":"Sentence"},{"id":"S6","span":{"begin":700,"end":880},"obj":"Sentence"},{"id":"S7","span":{"begin":881,"end":1072},"obj":"Sentence"}],"text":"Lipopolysaccharide-induced E-selectin expression requires continuous presence of LPS and is inhibited by bactericidal/permeability-increasing protein.\nEndothelial cells stimulated by LPS express E-selectin, which plays an important role in mediating neutrophil adhesion during inflammation. E-selectin is induced within 1-2 h, peaks at 4-6 h, and gradually returns to basal level by 24 h. rBPI21, a recombinant N-terminal fragment of human bactericidal/permeability-increasing protein (BPI), inhibited LPS-induced E-selectin expression when added at the same time as, and up to 6 h after, LPS. Delayed administration of rBPI21 also affected LPS-mediated activation of the nuclear factor, NF-kappa B. Two to 4 h following LPS addition to endothelial cells, when NF-kappa B was already activated, addition of rBPI21 resulted in marked reduction of NF-kappa B detectable at 4 or 6 h. These results indicate that endothelial activation requires continuous presence of LPS, and rBPI21 acts to reverse LPS-mediated endothelial activation by interrupting the on-going LPS signal."}

{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":0,"end":18},"obj":"lipid"},{"id":"T2","span":{"begin":27,"end":37},"obj":"protein_molecule"},{"id":"T3","span":{"begin":81,"end":84},"obj":"lipid"},{"id":"T4","span":{"begin":105,"end":149},"obj":"protein_family_or_group"},{"id":"T5","span":{"begin":151,"end":168},"obj":"cell_type"},{"id":"T6","span":{"begin":183,"end":186},"obj":"lipid"},{"id":"T7","span":{"begin":195,"end":205},"obj":"protein_molecule"},{"id":"T8","span":{"begin":250,"end":260},"obj":"cell_type"},{"id":"T9","span":{"begin":277,"end":289},"obj":"other_name"},{"id":"T10","span":{"begin":291,"end":301},"obj":"protein_molecule"},{"id":"T11","span":{"begin":389,"end":395},"obj":"protein_molecule"},{"id":"T12","span":{"begin":399,"end":430},"obj":"protein_family_or_group"},{"id":"T13","span":{"begin":434,"end":484},"obj":"protein_molecule"},{"id":"T14","span":{"begin":486,"end":489},"obj":"protein_molecule"},{"id":"T15","span":{"begin":502,"end":505},"obj":"lipid"},{"id":"T16","span":{"begin":514,"end":524},"obj":"protein_molecule"},{"id":"T17","span":{"begin":589,"end":592},"obj":"lipid"},{"id":"T18","span":{"begin":620,"end":626},"obj":"protein_molecule"},{"id":"T19","span":{"begin":641,"end":644},"obj":"lipid"},{"id":"T20","span":{"begin":672,"end":686},"obj":"protein_family_or_group"},{"id":"T21","span":{"begin":688,"end":698},"obj":"protein_molecule"},{"id":"T22","span":{"begin":721,"end":724},"obj":"lipid"},{"id":"T23","span":{"begin":737,"end":754},"obj":"cell_type"},{"id":"T24","span":{"begin":761,"end":771},"obj":"protein_molecule"},{"id":"T25","span":{"begin":807,"end":813},"obj":"protein_molecule"},{"id":"T26","span":{"begin":846,"end":856},"obj":"protein_molecule"},{"id":"T27","span":{"begin":909,"end":931},"obj":"other_name"},{"id":"T28","span":{"begin":964,"end":967},"obj":"lipid"},{"id":"T29","span":{"begin":973,"end":979},"obj":"protein_molecule"},{"id":"T30","span":{"begin":996,"end":999},"obj":"lipid"},{"id":"T31","span":{"begin":1052,"end":1060},"obj":"other_name"},{"id":"T32","span":{"begin":1061,"end":1064},"obj":"lipid"}],"text":"Lipopolysaccharide-induced E-selectin expression requires continuous presence of LPS and is inhibited by bactericidal/permeability-increasing protein.\nEndothelial cells stimulated by LPS express E-selectin, which plays an important role in mediating neutrophil adhesion during inflammation. E-selectin is induced within 1-2 h, peaks at 4-6 h, and gradually returns to basal level by 24 h. rBPI21, a recombinant N-terminal fragment of human bactericidal/permeability-increasing protein (BPI), inhibited LPS-induced E-selectin expression when added at the same time as, and up to 6 h after, LPS. Delayed administration of rBPI21 also affected LPS-mediated activation of the nuclear factor, NF-kappa B. Two to 4 h following LPS addition to endothelial cells, when NF-kappa B was already activated, addition of rBPI21 resulted in marked reduction of NF-kappa B detectable at 4 or 6 h. These results indicate that endothelial activation requires continuous presence of LPS, and rBPI21 acts to reverse LPS-mediated endothelial activation by interrupting the on-going LPS signal."}