PubMed:7540942 JSONTXT

{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":17,"end":21},"obj":"protein"},{"id":"T2","span":{"begin":69,"end":76},"obj":"cell_type"},{"id":"T3","span":{"begin":78,"end":82},"obj":"protein"},{"id":"T4","span":{"begin":334,"end":338},"obj":"protein"},{"id":"T5","span":{"begin":352,"end":356},"obj":"protein"},{"id":"T6","span":{"begin":443,"end":454},"obj":"protein"},{"id":"T7","span":{"begin":456,"end":461},"obj":"protein"},{"id":"T8","span":{"begin":491,"end":495},"obj":"protein"},{"id":"T9","span":{"begin":542,"end":553},"obj":"cell_line"},{"id":"T10","span":{"begin":620,"end":634},"obj":"protein"},{"id":"T11","span":{"begin":666,"end":670},"obj":"protein"},{"id":"T12","span":{"begin":680,"end":690},"obj":"protein"},{"id":"T13","span":{"begin":740,"end":744},"obj":"protein"},{"id":"T14","span":{"begin":744,"end":750},"obj":"protein"},{"id":"T15","span":{"begin":858,"end":861},"obj":"protein"},{"id":"T16","span":{"begin":954,"end":966},"obj":"cell_line"}],"text":"Cross-linking of CD30 induces HIV expression in chronically infected T cells.\nCD30, a member of the tumor necrosis factor (TNF) receptor family, is expressed constitutively on the surface of the human T cell line ACH-2, which is chronically infected with human immunodeficiency virus type-1 (HIV)-1. We demonstrate that cross-linking CD30 with an anti-CD30-specific monoclonal antibody, which mimics the described biological activities of the CD30 ligand (CD30L), results in HIV expression. CD30 cross-linking does not alter proliferation of ACH-2 cells and the induction of HIV expression is not mediated by endogenous TNF alpha/beta. Furthermore, cross-linking of CD30 leads to NF-kappa B activation and enhanced HIV transcription. Thus, CD30-CD30L interactions mediate the induction of HIV expression by a kappa B-dependent pathway that is independent of TNF. This mechanism may be important in the activation of HIV expression from latently infected CD4+ T cells, especially in lymphoid organs where cell to cell contact is conducive to receptor-ligand interactions."}

{"project":"genia-medco-coref","denotations":[{"id":"C2","span":{"begin":17,"end":21},"obj":"NP"},{"id":"C1","span":{"begin":0,"end":21},"obj":"NP"},{"id":"C3","span":{"begin":30,"end":44},"obj":"NP"},{"id":"C4","span":{"begin":78,"end":82},"obj":"NP"},{"id":"C5","span":{"begin":84,"end":143},"obj":"NP"},{"id":"C6","span":{"begin":191,"end":218},"obj":"NP"},{"id":"C7","span":{"begin":220,"end":225},"obj":"NP"},{"id":"C8","span":{"begin":334,"end":338},"obj":"NP"},{"id":"C9","span":{"begin":344,"end":385},"obj":"NP"},{"id":"C10","span":{"begin":387,"end":392},"obj":"NP"},{"id":"C11","span":{"begin":475,"end":489},"obj":"NP"},{"id":"C12","span":{"begin":491,"end":509},"obj":"NP"},{"id":"C14","span":{"begin":575,"end":589},"obj":"NP"},{"id":"C13","span":{"begin":558,"end":589},"obj":"NP"},{"id":"C16","span":{"begin":666,"end":670},"obj":"NP"},{"id":"C15","span":{"begin":649,"end":670},"obj":"NP"},{"id":"C18","span":{"begin":789,"end":803},"obj":"NP"},{"id":"C17","span":{"begin":772,"end":803},"obj":"NP"},{"id":"C19","span":{"begin":807,"end":834},"obj":"NP"},{"id":"C20","span":{"begin":835,"end":839},"obj":"NP"},{"id":"C21","span":{"begin":916,"end":930},"obj":"NP"},{"id":"C22","span":{"begin":982,"end":997},"obj":"NP"},{"id":"C23","span":{"begin":998,"end":1003},"obj":"NP"}],"relations":[{"id":"R6","pred":"coref-ident","subj":"C11","obj":"C3"},{"id":"R7","pred":"coref-ident","subj":"C12","obj":"C1"},{"id":"R8","pred":"coref-ident","subj":"C14","obj":"C11"},{"id":"R9","pred":"coref-ident","subj":"C16","obj":"C8"},{"id":"R1","pred":"coref-ident","subj":"C4","obj":"C2"},{"id":"R2","pred":"coref-appos","subj":"C5","obj":"C4"},{"id":"R3","pred":"coref-relat","subj":"C7","obj":"C6"},{"id":"R4","pred":"coref-ident","subj":"C8","obj":"C4"},{"id":"R5","pred":"coref-relat","subj":"C10","obj":"C9"},{"id":"R10","pred":"coref-ident","subj":"C15","obj":"C12"},{"id":"R11","pred":"coref-ident","subj":"C18","obj":"C14"},{"id":"R12","pred":"coref-ident","subj":"C17","obj":"C13"},{"id":"R13","pred":"coref-relat","subj":"C20","obj":"C19"},{"id":"R14","pred":"coref-ident","subj":"C21","obj":"C18"},{"id":"R15","pred":"coref-relat","subj":"C23","obj":"C22"}],"text":"Cross-linking of CD30 induces HIV expression in chronically infected T cells.\nCD30, a member of the tumor necrosis factor (TNF) receptor family, is expressed constitutively on the surface of the human T cell line ACH-2, which is chronically infected with human immunodeficiency virus type-1 (HIV)-1. We demonstrate that cross-linking CD30 with an anti-CD30-specific monoclonal antibody, which mimics the described biological activities of the CD30 ligand (CD30L), results in HIV expression. CD30 cross-linking does not alter proliferation of ACH-2 cells and the induction of HIV expression is not mediated by endogenous TNF alpha/beta. Furthermore, cross-linking of CD30 leads to NF-kappa B activation and enhanced HIV transcription. Thus, CD30-CD30L interactions mediate the induction of HIV expression by a kappa B-dependent pathway that is independent of TNF. This mechanism may be important in the activation of HIV expression from latently infected CD4+ T cells, especially in lymphoid organs where cell to cell contact is conducive to receptor-ligand interactions."}

{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":77},"obj":"Sentence"},{"id":"S2","span":{"begin":78,"end":299},"obj":"Sentence"},{"id":"S3","span":{"begin":300,"end":490},"obj":"Sentence"},{"id":"S4","span":{"begin":491,"end":635},"obj":"Sentence"},{"id":"S5","span":{"begin":636,"end":733},"obj":"Sentence"},{"id":"S6","span":{"begin":734,"end":862},"obj":"Sentence"},{"id":"S7","span":{"begin":863,"end":1070},"obj":"Sentence"}],"text":"Cross-linking of CD30 induces HIV expression in chronically infected T cells.\nCD30, a member of the tumor necrosis factor (TNF) receptor family, is expressed constitutively on the surface of the human T cell line ACH-2, which is chronically infected with human immunodeficiency virus type-1 (HIV)-1. We demonstrate that cross-linking CD30 with an anti-CD30-specific monoclonal antibody, which mimics the described biological activities of the CD30 ligand (CD30L), results in HIV expression. CD30 cross-linking does not alter proliferation of ACH-2 cells and the induction of HIV expression is not mediated by endogenous TNF alpha/beta. Furthermore, cross-linking of CD30 leads to NF-kappa B activation and enhanced HIV transcription. Thus, CD30-CD30L interactions mediate the induction of HIV expression by a kappa B-dependent pathway that is independent of TNF. This mechanism may be important in the activation of HIV expression from latently infected CD4+ T cells, especially in lymphoid organs where cell to cell contact is conducive to receptor-ligand interactions."}

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