
PubMed:7532282
Annnotations
jnlpba-st-training
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 38-53 | protein | denotes | I kappa B alpha |
T2 | 135-161 | RNA | denotes | I kappa B alpha/MAD-3 mRNA |
T3 | 184-205 | protein | denotes | I kappa B alpha/MAD-3 |
T4 | 212-232 | DNA | denotes | immediate-early gene |
T5 | 236-251 | cell_type | denotes | human monocytes |
T6 | 430-453 | protein | denotes | I kappa B alpha protein |
T7 | 591-614 | protein | denotes | I kappa B alpha protein |
T8 | 648-688 | protein | denotes | NF-kappa B-related transcription factors |
T9 | 744-754 | protein | denotes | NF-kappa B |
T10 | 768-794 | DNA | denotes | I kappa B alpha/MAD-3 gene |
T11 | 879-905 | RNA | denotes | I kappa B alpha/MAD-3 mRNA |
T12 | 979-989 | protein | denotes | NF-kappa B |
T13 | 1035-1061 | DNA | denotes | I kappa B alpha/MAD-3 gene |
T14 | 1126-1156 | DNA | denotes | immediate-early cytokine genes |
T15 | 1170-1205 | DNA | denotes | interleukin 1 beta (IL-1 beta) gene |
T16 | 1278-1304 | DNA | denotes | I kappa B alpha/MAD-3 gene |
T17 | 1374-1400 | RNA | denotes | I kappa B alpha/MAD-3 mRNA |
T18 | 1438-1442 | RNA | denotes | mRNA |
T19 | 1579-1597 | cell_type | denotes | adherent monocytes |
T20 | 1621-1635 | RNA | denotes | IL-1 beta mRNA |
T21 | 1680-1706 | RNA | denotes | I kappa B alpha/MAD-3 mRNA |
T22 | 1790-1826 | RNA | denotes | monocytic I kappa B alpha/MAD-3 mRNA |
T23 | 1851-1869 | cell_type | denotes | adherent monocytes |
T24 | 1912-1938 | RNA | denotes | I kappa B alpha/MAD-3 mRNA |
T25 | 1991-2017 | DNA | denotes | I kappa B alpha/MAD-3 gene |
T26 | 2106-2132 | RNA | denotes | I kappa B alpha/MAD-3 mRNA |
T27 | 2153-2179 | DNA | denotes | I kappa B alpha/MAD-3 gene |
T28 | 2237-2263 | RNA | denotes | I kappa B alpha/MAD-3 mRNA |
genia-medco-coref
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
C1 | 61-79 | NP | denotes | monocyte adherence |
C2 | 135-168 | NP | denotes | I kappa B alpha/MAD-3 mRNA levels |
C3 | 184-205 | NP | denotes | I kappa B alpha/MAD-3 |
C4 | 209-251 | NP | denotes | an immediate-early gene in human monocytes |
C5 | 252-256 | NP | denotes | that |
C6 | 394-411 | NP | denotes | monocyte adhesion |
C7 | 426-453 | NP | denotes | the I kappa B alpha protein |
C8 | 587-614 | NP | denotes | the I kappa B alpha protein |
C9 | 692-719 | NP | denotes | nuclei of adhered monocytes |
C10 | 768-808 | NP | denotes | I kappa B alpha/MAD-3 gene transcription |
C11 | 879-912 | NP | denotes | I kappa B alpha/MAD-3 mRNA levels |
C12 | 942-960 | NP | denotes | monocyte adherence |
C13 | 1031-1061 | NP | denotes | the I kappa B alpha/MAD-3 gene |
C14 | 1247-1264 | NP | denotes | monocyte adhesion |
C15 | 1278-1318 | NP | denotes | I kappa B alpha/MAD-3 gene transcription |
C16 | 1374-1407 | NP | denotes | I kappa B alpha/MAD-3 mRNA levels |
C17 | 1569-1597 | NP | denotes | nuclei of adherent monocytes |
C18 | 1599-1617 | NP | denotes | cytoplasmic levels |
C19 | 1671-1676 | NP | denotes | those |
C20 | 1680-1706 | NP | denotes | I kappa B alpha/MAD-3 mRNA |
C21 | 1912-1938 | NP | denotes | I kappa B alpha/MAD-3 mRNA |
C22 | 1991-2031 | NP | denotes | I kappa B alpha/MAD-3 gene transcription |
C23 | 2106-2132 | NP | denotes | I kappa B alpha/MAD-3 mRNA |
C24 | 2153-2193 | NP | denotes | I kappa B alpha/MAD-3 gene transcription |
C25 | 2237-2263 | NP | denotes | I kappa B alpha/MAD-3 mRNA |
R8 | C15 | C10 | coref-ident | I kappa B alpha/MAD-3 gene transcription,I kappa B alpha/MAD-3 gene transcription |
R9 | C16 | C11 | coref-ident | I kappa B alpha/MAD-3 mRNA levels,I kappa B alpha/MAD-3 mRNA levels |
R10 | C17 | C9 | coref-ident | nuclei of adherent monocytes,nuclei of adhered monocytes |
R1 | C5 | C4 | coref-relat | that,an immediate-early gene in human monocytes |
R2 | C6 | C1 | coref-ident | monocyte adhesion,monocyte adherence |
R3 | C8 | C7 | coref-ident | the I kappa B alpha protein,the I kappa B alpha protein |
R4 | C11 | C2 | coref-ident | I kappa B alpha/MAD-3 mRNA levels,I kappa B alpha/MAD-3 mRNA levels |
R5 | C12 | C1 | coref-ident | monocyte adherence,monocyte adherence |
R6 | C13 | C3 | coref-ident | the I kappa B alpha/MAD-3 gene,I kappa B alpha/MAD-3 |
R7 | C14 | C6 | coref-ident | monocyte adhesion,monocyte adhesion |
R11 | C19 | C18 | coref-pron | those,cytoplasmic levels |
R12 | C21 | C20 | coref-ident | I kappa B alpha/MAD-3 mRNA,I kappa B alpha/MAD-3 mRNA |
R13 | C22 | C15 | coref-ident | I kappa B alpha/MAD-3 gene transcription,I kappa B alpha/MAD-3 gene transcription |
R14 | C23 | C21 | coref-ident | I kappa B alpha/MAD-3 mRNA,I kappa B alpha/MAD-3 mRNA |
R15 | C24 | C22 | coref-ident | I kappa B alpha/MAD-3 gene transcription,I kappa B alpha/MAD-3 gene transcription |
R16 | C25 | C23 | coref-ident | I kappa B alpha/MAD-3 mRNA,I kappa B alpha/MAD-3 mRNA |
pubmed-sentences-benchmark
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
S1 | 0-169 | Sentence | denotes | Transcription-independent turnover of I kappa B alpha during monocyte adherence: implications for a translational component regulating I kappa B alpha/MAD-3 mRNA levels. |
S2 | 170-377 | Sentence | denotes | We identified I kappa B alpha/MAD-3 as an immediate-early gene in human monocytes that is expressed in response to a variety of signals, including adhesion, lipopolysaccharide, and phorbol myristate acetate. |
S3 | 378-551 | Sentence | denotes | Within 5 min of monocyte adhesion, the level of the I kappa B alpha protein is markedly diminished but is rapidly replaced in a cycloheximide-sensitive manner within 20 min. |
S4 | 552-720 | Sentence | denotes | Accompanying the rapid turnover of the I kappa B alpha protein is simultaneous translocation of NF-kappa B-related transcription factors to nuclei of adhered monocytes. |
S5 | 721-1062 | Sentence | denotes | The demonstration that NF-kappa B can regulate I kappa B alpha/MAD-3 gene transcription in other cell types suggested that the rapid increase in steady-state I kappa B alpha/MAD-3 mRNA levels we observed within 30 min of monocyte adherence would result from NF-kappa B-dependent transcriptional stimulation of the I kappa B alpha/MAD-3 gene. |
S6 | 1063-1337 | Sentence | denotes | Nuclear run-on analyses indicated that, instead, while several immediate-early cytokine genes, such as the interleukin 1 beta (IL-1 beta) gene, were transcriptionally activated during monocyte adhesion, the rate of I kappa B alpha/MAD-3 gene transcription remained constant. |
S7 | 1338-1464 | Sentence | denotes | The adherence-dependent increase in I kappa B alpha/MAD-3 mRNA levels was also not a consequence of mRNA stabilization events. |
S8 | 1465-1715 | Sentence | denotes | Interestingly, while increases in both IL-1 beta and I kappa B alpha/MAD-3 mRNA levels were detected in nuclei of adherent monocytes, cytoplasmic levels of IL-1 beta mRNA increased during adherence whereas those of I kappa B alpha/MAD-3 mRNA did not. |
S9 | 1716-1834 | Sentence | denotes | Taken together, our data suggest that two interactive mechanisms regulate monocytic I kappa B alpha/MAD-3 mRNA levels. |
S10 | 1835-2032 | Sentence | denotes | We propose that adherent monocytes regulate nuclear processing (or decay) of I kappa B alpha/MAD-3 mRNA, thereby increasing mRNA levels without stimulating I kappa B alpha/MAD-3 gene transcription. |
S11 | 2033-2328 | Sentence | denotes | Moreover, since inhibition of protein synthesis leads to accumulation of I kappa B alpha/MAD-3 mRNA without stimulating I kappa B alpha/MAD-3 gene transcription, we suggest that low cytoplasmic levels of I kappa B alpha/MAD-3 mRNA are maintained by a translation-dependent degradation mechanism. |
GENIAcorpus
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-34 | other_name | denotes | Transcription-independent turnover |
T2 | 38-53 | protein_molecule | denotes | I kappa B alpha |
T3 | 61-79 | other_name | denotes | monocyte adherence |
T4 | 135-150 | protein_molecule | denotes | I kappa B alpha |
T5 | 150-156 | protein_molecule | denotes | /MAD-3 |
T6 | 184-199 | protein_molecule | denotes | I kappa B alpha |
T7 | 212-232 | DNA_domain_or_region | denotes | immediate-early gene |
T8 | 236-251 | cell_type | denotes | human monocytes |
T9 | 317-325 | other_name | denotes | adhesion |
T10 | 327-345 | lipid | denotes | lipopolysaccharide |
T11 | 351-376 | other_organic_compound | denotes | phorbol myristate acetate |
T12 | 394-411 | other_name | denotes | monocyte adhesion |
T13 | 430-445 | protein_molecule | denotes | I kappa B alpha |
T14 | 506-536 | other_name | denotes | cycloheximide-sensitive manner |
T15 | 591-606 | protein_molecule | denotes | I kappa B alpha |
T16 | 648-666 | protein_family_or_group | denotes | NF-kappa B-related |
T17 | 667-688 | protein_family_or_group | denotes | transcription factors |
T18 | 744-754 | protein_molecule | denotes | NF-kappa B |
T19 | 768-783 | protein_molecule | denotes | I kappa B alpha |
T20 | 866-878 | other_name | denotes | steady-state |
T21 | 879-894 | protein_molecule | denotes | I kappa B alpha |
T22 | 942-960 | other_name | denotes | monocyte adherence |
T23 | 979-989 | protein_molecule | denotes | NF-kappa B |
T24 | 1035-1050 | protein_molecule | denotes | I kappa B alpha |
T25 | 1126-1156 | DNA_family_or_group | denotes | immediate-early cytokine genes |
T26 | 1170-1188 | protein_molecule | denotes | interleukin 1 beta |
T27 | 1190-1199 | protein_molecule | denotes | IL-1 beta |
T28 | 1247-1264 | other_name | denotes | monocyte adhesion |
T29 | 1278-1293 | protein_molecule | denotes | I kappa B alpha |
T30 | 1374-1389 | protein_molecule | denotes | I kappa B alpha |
T31 | 1438-1442 | RNA_family_or_group | denotes | mRNA |
T32 | 1569-1575 | cell_component | denotes | nuclei |
T33 | 1579-1597 | cell_type | denotes | adherent monocytes |
T34 | 1599-1617 | other_name | denotes | cytoplasmic levels |
T35 | 1621-1630 | protein_molecule | denotes | IL-1 beta |
T36 | 1680-1695 | protein_molecule | denotes | I kappa B alpha |
T37 | 1790-1799 | RNA_molecule | denotes | monocytic |
T38 | 1800-1815 | protein_molecule | denotes | I kappa B alpha |
T39 | 1851-1869 | cell_type | denotes | adherent monocytes |
T40 | 1912-1927 | protein_molecule | denotes | I kappa B alpha |
T41 | 1991-2006 | protein_molecule | denotes | I kappa B alpha |
T42 | 2106-2121 | protein_molecule | denotes | I kappa B alpha |
T43 | 2153-2168 | protein_molecule | denotes | I kappa B alpha |
T44 | 2215-2233 | other_name | denotes | cytoplasmic levels |
T45 | 2237-2252 | protein_molecule | denotes | I kappa B alpha |
T46 | 2284-2327 | other_name | denotes | translation-dependent degradation mechanism |