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PubMed:7499267 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-217 Sentence denotes Triggering of the human interleukin-6 gene by interferon-gamma and tumor necrosis factor-alpha in monocytic cells involves cooperation between interferon regulatory factor-1, NF kappa B, and Sp1 transcription factors.
T2 218-493 Sentence denotes We investigated the molecular basis of the synergistic induction by interferon-gamma (IFN-gamma)/tumor necrosis factor-alpha (TNF-alpha) of human interleukin-6 (IL-6) gene in THP-1 monocytic cells, and compared it with the basis of this induction by lipopolysaccharide (LPS).
T3 494-698 Sentence denotes Functional studies with IL-6 promoter demonstrated that three regions are the targets of the IFN-gamma and/or TNF-alpha action, whereas only one of these regions seemed to be implicated in LPS activation.
T4 699-731 Sentence denotes The three regions concerned are:
T5 732-1029 Sentence denotes 1) a region between -73 and -36, which is the minimal element inducible by LPS or TNF-alpha; 2) an element located between -181 and -73, which appeared to regulate the response to IFN-gamma and TNF-alpha negatively; and 3) a distal element upstream of -224, which was inducible by IFN-gamma alone.
T6 1030-1115 Sentence denotes LPS signaling was found to involve NF kappa B activation by the p50/p65 heterodimers.
T7 1116-1387 Sentence denotes Synergistic induction of the IL-6 gene by IFN-gamma and TNF-alpha, in monocytic cells, involved cooperation between the IRF-1 and NF kappa B p65 homodimers with concomitant removal of the negative effect of the retinoblastoma control element present in the IL-6 promoter.
T8 1388-1536 Sentence denotes This removal occurred by activation of the constitutive Sp1 factor, whose increased binding activity and phosphorylation were mediated by IFN-gamma.
T1 0-217 Sentence denotes Triggering of the human interleukin-6 gene by interferon-gamma and tumor necrosis factor-alpha in monocytic cells involves cooperation between interferon regulatory factor-1, NF kappa B, and Sp1 transcription factors.
T2 218-493 Sentence denotes We investigated the molecular basis of the synergistic induction by interferon-gamma (IFN-gamma)/tumor necrosis factor-alpha (TNF-alpha) of human interleukin-6 (IL-6) gene in THP-1 monocytic cells, and compared it with the basis of this induction by lipopolysaccharide (LPS).
T3 494-698 Sentence denotes Functional studies with IL-6 promoter demonstrated that three regions are the targets of the IFN-gamma and/or TNF-alpha action, whereas only one of these regions seemed to be implicated in LPS activation.
T4 699-731 Sentence denotes The three regions concerned are:
T5 732-1029 Sentence denotes 1) a region between -73 and -36, which is the minimal element inducible by LPS or TNF-alpha; 2) an element located between -181 and -73, which appeared to regulate the response to IFN-gamma and TNF-alpha negatively; and 3) a distal element upstream of -224, which was inducible by IFN-gamma alone.
T6 1030-1115 Sentence denotes LPS signaling was found to involve NF kappa B activation by the p50/p65 heterodimers.
T7 1116-1387 Sentence denotes Synergistic induction of the IL-6 gene by IFN-gamma and TNF-alpha, in monocytic cells, involved cooperation between the IRF-1 and NF kappa B p65 homodimers with concomitant removal of the negative effect of the retinoblastoma control element present in the IL-6 promoter.
T8 1388-1536 Sentence denotes This removal occurred by activation of the constitutive Sp1 factor, whose increased binding activity and phosphorylation were mediated by IFN-gamma.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 143-173 protein denotes interferon regulatory factor-1
T2 175-185 protein denotes NF kappa B
T3 191-194 protein denotes Sp1
T4 195-216 protein denotes transcription factors
T5 286-302 protein denotes interferon-gamma
T6 304-313 protein denotes IFN-gamma
T7 315-342 protein denotes tumor necrosis factor-alpha
T8 344-353 protein denotes TNF-alpha
T9 358-389 DNA denotes human interleukin-6 (IL-6) gene
T10 393-414 cell_type denotes THP-1 monocytic cells
T11 518-531 DNA denotes IL-6 promoter
T12 587-596 protein denotes IFN-gamma
T13 604-613 protein denotes TNF-alpha
T14 778-793 DNA denotes minimal element
T15 814-823 protein denotes TNF-alpha
T16 912-921 protein denotes IFN-gamma
T17 926-935 protein denotes TNF-alpha
T18 957-980 DNA denotes distal element upstream
T19 1013-1022 protein denotes IFN-gamma
T20 1065-1075 protein denotes NF kappa B
T21 1094-1114 protein denotes p50/p65 heterodimers
T22 1145-1154 DNA denotes IL-6 gene
T23 1158-1167 protein denotes IFN-gamma
T24 1172-1181 protein denotes TNF-alpha
T25 1186-1201 cell_type denotes monocytic cells
T26 1236-1241 protein denotes IRF-1
T27 1246-1271 protein denotes NF kappa B p65 homodimers
T28 1327-1357 DNA denotes retinoblastoma control element
T29 1373-1386 DNA denotes IL-6 promoter
T30 1431-1454 protein denotes constitutive Sp1 factor
T31 1526-1535 protein denotes IFN-gamma

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 14-42 NP denotes the human interleukin-6 gene
C2 46-62 NP denotes interferon-gamma
C3 67-94 NP denotes tumor necrosis factor-alpha
C4 98-113 NP denotes monocytic cells
C7 257-282 NP denotes the synergistic induction
C8 358-389 NP denotes human interleukin-6 (IL-6) gene
C6 257-389 NP denotes the synergistic induction by interferon-gamma (IFN-gamma)/tumor necrosis factor-alpha (TNF-alpha) of human interleukin-6 (IL-6) gene
C5 234-389 NP denotes the molecular basis of the synergistic induction by interferon-gamma (IFN-gamma)/tumor necrosis factor-alpha (TNF-alpha) of human interleukin-6 (IL-6) gene
C9 429-431 NP denotes it
C10 450-464 NP denotes this induction
C11 468-492 NP denotes lipopolysaccharide (LPS)
C12 518-531 NP denotes IL-6 promoter
C13 550-563 NP denotes three regions
C14 642-655 NP denotes these regions
C15 699-726 NP denotes The three regions concerned
C16 735-763 NP denotes a region between -73 and -36
C17 765-770 NP denotes which
C18 807-810 NP denotes LPS
C19 814-823 NP denotes TNF-alpha
C20 828-867 NP denotes an element located between -181 and -73
C21 869-874 NP denotes which
C22 912-921 NP denotes IFN-gamma
C23 926-935 NP denotes TNF-alpha
C24 955-988 NP denotes a distal element upstream of -224
C25 990-995 NP denotes which
C26 1013-1022 NP denotes IFN-gamma
C28 1141-1154 NP denotes the IL-6 gene
C29 1158-1167 NP denotes IFN-gamma
C30 1172-1181 NP denotes TNF-alpha
C27 1116-1181 NP denotes Synergistic induction of the IL-6 gene by IFN-gamma and TNF-alpha
C31 1186-1201 NP denotes monocytic cells
C33 1369-1386 NP denotes the IL-6 promoter
C32 1277-1386 NP denotes concomitant removal of the negative effect of the retinoblastoma control element present in the IL-6 promoter
C34 1388-1400 NP denotes This removal
C35 1427-1454 NP denotes the constitutive Sp1 factor
C36 1456-1461 NP denotes whose
C37 1526-1535 NP denotes IFN-gamma
R13 C26 C22 coref-ident IFN-gamma,IFN-gamma
R14 C28 C8 coref-ident the IL-6 gene,human interleukin-6 (IL-6) gene
R15 C29 C26 coref-ident IFN-gamma,IFN-gamma
R1 C8 C1 coref-ident human interleukin-6 (IL-6) gene,the human interleukin-6 gene
R2 C9 C5 coref-pron it,the molecular basis of the synergistic induction by interferon-gamma (IFN-gamma)/tumor necrosis factor-alpha (TNF-alpha) of human interleukin-6 (IL-6) gene
R3 C10 C7 coref-ident this induction,the synergistic induction
R4 C14 C13 coref-ident these regions,three regions
R5 C15 C14 coref-ident The three regions concerned,these regions
R6 C17 C16 coref-relat which,a region between -73 and -36
R7 C18 C11 coref-ident LPS,lipopolysaccharide (LPS)
R8 C19 C3 coref-ident TNF-alpha,tumor necrosis factor-alpha
R9 C21 C20 coref-relat which,an element located between -181 and -73
R10 C22 C2 coref-ident IFN-gamma,interferon-gamma
R11 C23 C19 coref-ident TNF-alpha,TNF-alpha
R12 C25 C24 coref-relat which,a distal element upstream of -224
R16 C30 C23 coref-ident TNF-alpha,TNF-alpha
R17 C27 C6 coref-ident Synergistic induction of the IL-6 gene by IFN-gamma and TNF-alpha,the synergistic induction by interferon-gamma (IFN-gamma)/tumor necrosis factor-alpha (TNF-alpha) of human interleukin-6 (IL-6) gene
R18 C31 C4 coref-ident monocytic cells,monocytic cells
R19 C33 C12 coref-ident the IL-6 promoter,IL-6 promoter
R20 C34 C32 coref-ident This removal,concomitant removal of the negative effect of the retinoblastoma control element present in the IL-6 promoter
R21 C36 C35 coref-relat whose,the constitutive Sp1 factor
R22 C37 C29 coref-ident IFN-gamma,IFN-gamma

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-217 Sentence denotes Triggering of the human interleukin-6 gene by interferon-gamma and tumor necrosis factor-alpha in monocytic cells involves cooperation between interferon regulatory factor-1, NF kappa B, and Sp1 transcription factors.
S2 218-493 Sentence denotes We investigated the molecular basis of the synergistic induction by interferon-gamma (IFN-gamma)/tumor necrosis factor-alpha (TNF-alpha) of human interleukin-6 (IL-6) gene in THP-1 monocytic cells, and compared it with the basis of this induction by lipopolysaccharide (LPS).
S3 494-698 Sentence denotes Functional studies with IL-6 promoter demonstrated that three regions are the targets of the IFN-gamma and/or TNF-alpha action, whereas only one of these regions seemed to be implicated in LPS activation.
S4 699-1029 Sentence denotes The three regions concerned are: 1) a region between -73 and -36, which is the minimal element inducible by LPS or TNF-alpha; 2) an element located between -181 and -73, which appeared to regulate the response to IFN-gamma and TNF-alpha negatively; and 3) a distal element upstream of -224, which was inducible by IFN-gamma alone.
S5 1030-1115 Sentence denotes LPS signaling was found to involve NF kappa B activation by the p50/p65 heterodimers.
S6 1116-1387 Sentence denotes Synergistic induction of the IL-6 gene by IFN-gamma and TNF-alpha, in monocytic cells, involved cooperation between the IRF-1 and NF kappa B p65 homodimers with concomitant removal of the negative effect of the retinoblastoma control element present in the IL-6 promoter.
S7 1388-1536 Sentence denotes This removal occurred by activation of the constitutive Sp1 factor, whose increased binding activity and phosphorylation were mediated by IFN-gamma.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 143-173 protein_molecule denotes interferon regulatory factor-1
T2 175-185 protein_molecule denotes NF kappa B
T3 191-194 protein_molecule denotes Sp1
T4 195-216 protein_family_or_group denotes transcription factors
T5 261-282 other_name denotes synergistic induction
T6 286-302 protein_molecule denotes interferon-gamma
T7 304-313 protein_molecule denotes IFN-gamma
T8 315-342 protein_molecule denotes tumor necrosis factor-alpha
T9 344-353 protein_molecule denotes TNF-alpha
T10 358-389 DNA_domain_or_region denotes human interleukin-6 (IL-6) gene
T11 393-414 cell_type denotes THP-1 monocytic cells
T12 468-486 lipid denotes lipopolysaccharide
T13 488-491 lipid denotes LPS
T14 518-531 DNA_domain_or_region denotes IL-6 promoter
T15 587-596 protein_molecule denotes IFN-gamma
T16 604-613 protein_molecule denotes TNF-alpha
T17 683-686 lipid denotes LPS
T18 778-793 DNA_domain_or_region denotes minimal element
T19 807-810 lipid denotes LPS
T20 814-823 protein_molecule denotes TNF-alpha
T21 912-921 protein_molecule denotes IFN-gamma
T22 926-935 protein_molecule denotes TNF-alpha
T23 957-980 DNA_domain_or_region denotes distal element upstream
T24 1013-1022 protein_molecule denotes IFN-gamma
T25 1030-1033 lipid denotes LPS
T26 1065-1075 protein_molecule denotes NF kappa B
T27 1094-1114 protein_complex denotes p50/p65 heterodimers
T28 1145-1149 protein_molecule denotes IL-6
T29 1158-1167 protein_molecule denotes IFN-gamma
T30 1172-1181 protein_molecule denotes TNF-alpha
T31 1186-1201 cell_type denotes monocytic cells
T32 1236-1241 protein_molecule denotes IRF-1
T33 1246-1256 protein_molecule denotes NF kappa B
T34 1257-1260 protein_molecule denotes p65
T35 1327-1357 DNA_domain_or_region denotes retinoblastoma control element
T36 1373-1386 DNA_domain_or_region denotes IL-6 promoter
T37 1431-1443 protein_molecule denotes constitutive
T38 1444-1447 protein_molecule denotes Sp1
T39 1472-1488 other_name denotes binding activity
T40 1493-1508 other_name denotes phosphorylation
T41 1526-1535 protein_molecule denotes IFN-gamma

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 67-72 Phenotype denotes tumor HP:0002664
T2 315-320 Phenotype denotes tumor HP:0002664
T3 1327-1341 Phenotype denotes retinoblastoma HP:0009919

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 67-72 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T2 315-320 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T3 1327-1341 Disease denotes retinoblastoma http://purl.obolibrary.org/obo/MONDO_0008380

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 18-23 OrganismTaxon denotes human 9606
T2 358-363 OrganismTaxon denotes human 9606

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 98-107 Cell denotes monocytic http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T3 399-408 Cell denotes monocytic http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T5 1186-1195 Cell denotes monocytic http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054