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PubMed:7481768 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 329-334 gene:3600 denotes IL-15
T1 143-148 disease:C1279481 denotes XSCID
T2 329-334 gene:3600 denotes IL-15
T3 100-141 disease:C1279481 denotes X-linked severe combined immunodeficiency
T4 285-298 gene:3558 denotes interleukin-2
T5 100-141 disease:C1279481 denotes X-linked severe combined immunodeficiency
T6 285-298 gene:3558 denotes interleukin-2
T7 143-148 disease:C1279481 denotes XSCID
T8 300-304 gene:3558 denotes IL-2
T9 100-141 disease:C1279481 denotes X-linked severe combined immunodeficiency
T10 319-323 gene:3578 denotes IL-9
T11 100-141 disease:C1279481 denotes X-linked severe combined immunodeficiency
T12 307-311 gene:3565 denotes IL-4
T13 100-141 disease:C1279481 denotes X-linked severe combined immunodeficiency
T14 313-317 gene:3574 denotes IL-7
T15 100-141 disease:C1279481 denotes X-linked severe combined immunodeficiency
T16 300-304 gene:3558 denotes IL-2
T17 143-148 disease:C1279481 denotes XSCID
T18 481-485 gene:3718 denotes Jak3
T19 501-506 disease:C1279481 denotes XSCID
T20 369-373 gene:3718 denotes Jak3
T21 501-506 disease:C1279481 denotes XSCID
R1 T0 T1 associated_with IL-15,XSCID
R2 T2 T3 associated_with IL-15,X-linked severe combined immunodeficiency
R3 T4 T5 associated_with interleukin-2,X-linked severe combined immunodeficiency
R4 T6 T7 associated_with interleukin-2,XSCID
R5 T8 T9 associated_with IL-2,X-linked severe combined immunodeficiency
R6 T10 T11 associated_with IL-9,X-linked severe combined immunodeficiency
R7 T12 T13 associated_with IL-4,X-linked severe combined immunodeficiency
R8 T14 T15 associated_with IL-7,X-linked severe combined immunodeficiency
R9 T16 T17 associated_with IL-2,XSCID
R10 T18 T19 associated_with Jak3,XSCID
R11 T20 T21 associated_with Jak3,XSCID

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 12-16 protein denotes Jak3
T2 59-63 protein denotes Jak3
T3 177-221 DNA denotes cytokine receptor gamma chain (gamma c) gene
T4 285-298 protein denotes interleukin-2
T5 300-304 protein denotes IL-2
T6 307-311 protein denotes IL-4
T7 313-317 protein denotes IL-7
T8 319-323 protein denotes IL-9
T9 329-334 protein denotes IL-15
T10 340-368 protein denotes Janus family tyrosine kinase
T11 369-373 protein denotes Jak3
T12 433-440 protein denotes gamma c
T13 481-485 protein denotes Jak3
T14 636-682 cell_line denotes Epstein-Barr virus (EBV)-transformed cell line
T15 700-711 cell_type denotes lymphocytes
T16 723-730 protein denotes gamma c
T17 753-765 protein denotes Jak3 protein
T18 793-811 RNA denotes Jak3 messenger RNA
T19 960-975 protein denotes Jak3 JH4 domain
T20 1007-1011 protein denotes Jak3
T21 1036-1040 protein denotes Jak3
T22 1131-1135 protein denotes IL-4
T23 1148-1153 protein denotes Stat6
T24 1161-1186 cell_line denotes EBV-transformed cell line
T25 1255-1262 protein denotes gamma c
T26 1280-1284 protein denotes Jak3
T27 1294-1298 protein denotes Jak3

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
7481768-1#196#209#gene3558 285-298 gene3558 denotes interleukin-2
7481768-1#211#215#gene3558 300-304 gene3558 denotes IL-2
7481768-1#218#222#gene3565 307-311 gene3565 denotes IL-4
7481768-1#224#228#gene3574 313-317 gene3574 denotes IL-7
7481768-1#230#234#gene3578 319-323 gene3578 denotes IL-9
7481768-1#240#245#gene3600 329-334 gene3600 denotes IL-15
7481768-1#11#52#diseaseC1279481 100-141 diseaseC1279481 denotes X-linked severe combined immunodeficiency
7481768-1#54#59#diseaseC1279481 143-148 diseaseC1279481 denotes XSCID
7481768-1#11#52#diseaseC1279481 100-141 diseaseC1279481 denotes X-linked severe combined immunodeficiency
7481768-2#33#37#gene3718 369-373 gene3718 denotes Jak3
7481768-2#145#149#gene3718 481-485 gene3718 denotes Jak3
7481768-2#165#170#diseaseC1279481 501-506 diseaseC1279481 denotes XSCID
196#209#gene355811#52#diseaseC1279481 7481768-1#196#209#gene3558 7481768-1#11#52#diseaseC1279481 associated_with interleukin-2,X-linked severe combined immunodeficiency
196#209#gene355854#59#diseaseC1279481 7481768-1#196#209#gene3558 7481768-1#54#59#diseaseC1279481 associated_with interleukin-2,XSCID
196#209#gene355811#52#diseaseC1279481 7481768-1#196#209#gene3558 7481768-1#11#52#diseaseC1279481 associated_with interleukin-2,X-linked severe combined immunodeficiency
211#215#gene355811#52#diseaseC1279481 7481768-1#211#215#gene3558 7481768-1#11#52#diseaseC1279481 associated_with IL-2,X-linked severe combined immunodeficiency
211#215#gene355854#59#diseaseC1279481 7481768-1#211#215#gene3558 7481768-1#54#59#diseaseC1279481 associated_with IL-2,XSCID
211#215#gene355811#52#diseaseC1279481 7481768-1#211#215#gene3558 7481768-1#11#52#diseaseC1279481 associated_with IL-2,X-linked severe combined immunodeficiency
218#222#gene356511#52#diseaseC1279481 7481768-1#218#222#gene3565 7481768-1#11#52#diseaseC1279481 associated_with IL-4,X-linked severe combined immunodeficiency
218#222#gene356554#59#diseaseC1279481 7481768-1#218#222#gene3565 7481768-1#54#59#diseaseC1279481 associated_with IL-4,XSCID
218#222#gene356511#52#diseaseC1279481 7481768-1#218#222#gene3565 7481768-1#11#52#diseaseC1279481 associated_with IL-4,X-linked severe combined immunodeficiency
224#228#gene357411#52#diseaseC1279481 7481768-1#224#228#gene3574 7481768-1#11#52#diseaseC1279481 associated_with IL-7,X-linked severe combined immunodeficiency
224#228#gene357454#59#diseaseC1279481 7481768-1#224#228#gene3574 7481768-1#54#59#diseaseC1279481 associated_with IL-7,XSCID
224#228#gene357411#52#diseaseC1279481 7481768-1#224#228#gene3574 7481768-1#11#52#diseaseC1279481 associated_with IL-7,X-linked severe combined immunodeficiency
230#234#gene357811#52#diseaseC1279481 7481768-1#230#234#gene3578 7481768-1#11#52#diseaseC1279481 associated_with IL-9,X-linked severe combined immunodeficiency
230#234#gene357854#59#diseaseC1279481 7481768-1#230#234#gene3578 7481768-1#54#59#diseaseC1279481 associated_with IL-9,XSCID
230#234#gene357811#52#diseaseC1279481 7481768-1#230#234#gene3578 7481768-1#11#52#diseaseC1279481 associated_with IL-9,X-linked severe combined immunodeficiency
240#245#gene360011#52#diseaseC1279481 7481768-1#240#245#gene3600 7481768-1#11#52#diseaseC1279481 associated_with IL-15,X-linked severe combined immunodeficiency
240#245#gene360054#59#diseaseC1279481 7481768-1#240#245#gene3600 7481768-1#54#59#diseaseC1279481 associated_with IL-15,XSCID
240#245#gene360011#52#diseaseC1279481 7481768-1#240#245#gene3600 7481768-1#11#52#diseaseC1279481 associated_with IL-15,X-linked severe combined immunodeficiency
33#37#gene3718165#170#diseaseC1279481 7481768-2#33#37#gene3718 7481768-2#165#170#diseaseC1279481 associated_with Jak3,XSCID
145#149#gene3718165#170#diseaseC1279481 7481768-2#145#149#gene3718 7481768-2#165#170#diseaseC1279481 associated_with Jak3,XSCID

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 12-16 NP denotes Jak3
C2 20-39 NP denotes a patient with SCID
C3 59-63 NP denotes Jak3
C4 67-87 NP denotes lymphoid development
C5 100-149 NP denotes X-linked severe combined immunodeficiency (XSCID)
C7 166-221 NP denotes the common cytokine receptor gamma chain (gamma c) gene
C8 222-226 NP denotes that
C9 307-311 NP denotes IL-4
C6 166-334 NP denotes the common cytokine receptor gamma chain (gamma c) gene that encodes a shared, essential component of the receptors of interleukin-2 (IL-2), IL-4, IL-7, IL-9, and IL-15
C10 336-373 NP denotes The Janus family tyrosine kinase Jak3
C11 433-440 NP denotes gamma c
C12 481-485 NP denotes Jak3
C14 535-557 NP denotes immunological features
C15 581-586 NP denotes those
C16 590-595 NP denotes XSCID
C13 523-595 NP denotes A girl with immunological features indistinguishable from those of XSCID
C18 696-699 NP denotes her
C17 633-711 NP denotes An Epstein-Barr virus (EBV)-transformed cell line derived from her lymphocytes
C19 1131-1135 NP denotes IL-4
C20 1157-1186 NP denotes the EBV-transformed cell line
C21 1192-1203 NP denotes the patient
C22 1255-1262 NP denotes gamma c
C23 1280-1284 NP denotes Jak3
C24 1294-1298 NP denotes Jak3
C25 1316-1336 NP denotes lymphoid development
R1 C3 C1 coref-ident Jak3,Jak3
R2 C8 C7 coref-relat that,the common cytokine receptor gamma chain (gamma c) gene
R3 C10 C3 coref-ident The Janus family tyrosine kinase Jak3,Jak3
R4 C11 C6 coref-ident gamma c,"the common cytokine receptor gamma chain (gamma c) gene that encodes a shared, essential component of the receptors of interleukin-2 (IL-2), IL-4, IL-7, IL-9, and IL-15"
R5 C12 C10 coref-ident Jak3,The Janus family tyrosine kinase Jak3
R6 C15 C14 coref-pron those,immunological features
R7 C16 C5 coref-ident XSCID,X-linked severe combined immunodeficiency (XSCID)
R8 C13 C2 coref-ident A girl with immunological features indistinguishable from those of XSCID,a patient with SCID
R9 C18 C13 coref-pron her,A girl with immunological features indistinguishable from those of XSCID
R10 C19 C9 coref-ident IL-4,IL-4
R11 C20 C17 coref-ident the EBV-transformed cell line,An Epstein-Barr virus (EBV)-transformed cell line derived from her lymphocytes
R12 C21 C13 coref-ident the patient,A girl with immunological features indistinguishable from those of XSCID
R13 C22 C11 coref-ident gamma c,gamma c
R14 C23 C12 coref-ident Jak3,Jak3
R15 C24 C23 coref-ident Jak3,Jak3
R16 C25 C4 coref-ident lymphoid development,lymphoid development

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-88 Sentence denotes Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development.
S2 89-335 Sentence denotes Males with X-linked severe combined immunodeficiency (XSCID) have defects in the common cytokine receptor gamma chain (gamma c) gene that encodes a shared, essential component of the receptors of interleukin-2 (IL-2), IL-4, IL-7, IL-9, and IL-15.
S3 336-522 Sentence denotes The Janus family tyrosine kinase Jak3 is the only signaling molecule known to be associated with gamma c, so it was hypothesized that defects in Jak3 might cause an XSCID-like phenotype.
S4 523-632 Sentence denotes A girl with immunological features indistinguishable from those of XSCID was therefore selected for analysis.
S5 633-812 Sentence denotes An Epstein-Barr virus (EBV)-transformed cell line derived from her lymphocytes had normal gamma c expression but lacked Jak3 protein and had greatly diminished Jak3 messenger RNA.
S6 813-1023 Sentence denotes Sequencing revealed a different mutation on each allele: a single nucleotide insertion resulting in a frame shift and premature termination in the Jak3 JH4 domain and a nonsense mutation in the Jak3 JH2 domain.
S7 1024-1204 Sentence denotes The lack of Jak3 expression correlated with impaired B cell signaling, as demonstrated by the inability of IL-4 to activate Stat6 in the EBV-transformed cell line from the patient.
S8 1205-1351 Sentence denotes These observations indicate that the functions of gamma c are dependent on Jak3 and that Jak3 is essential for lymphoid development and signaling.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 12-16 protein_molecule denotes Jak3
T2 22-29 multi_cell denotes patient
T3 35-39 other_name denotes SCID
T4 59-63 protein_molecule denotes Jak3
T5 67-87 other_name denotes lymphoid development
T6 89-94 multi_cell denotes Males
T7 100-141 other_name denotes X-linked severe combined immunodeficiency
T8 143-148 other_name denotes XSCID
T9 177-206 protein_subunit denotes cytokine receptor gamma chain
T10 208-215 protein_subunit denotes gamma c
T11 285-298 protein_molecule denotes interleukin-2
T12 300-304 protein_molecule denotes IL-2
T13 307-311 protein_molecule denotes IL-4
T14 313-317 protein_molecule denotes IL-7
T15 319-323 protein_molecule denotes IL-9
T16 329-334 protein_molecule denotes IL-15
T17 340-368 protein_family_or_group denotes Janus family tyrosine kinase
T18 369-373 protein_molecule denotes Jak3
T19 433-440 protein_subunit denotes gamma c
T20 481-485 protein_molecule denotes Jak3
T21 501-506 other_name denotes XSCID
T22 590-595 other_name denotes XSCID
T23 636-654 virus denotes Epstein-Barr virus
T24 656-659 virus denotes EBV
T25 700-711 cell_type denotes lymphocytes
T26 723-730 protein_subunit denotes gamma c
T27 753-757 protein_molecule denotes Jak3
T28 793-797 protein_molecule denotes Jak3
T29 879-899 other_name denotes nucleotide insertion
T30 915-926 other_name denotes frame shift
T31 931-952 other_name denotes premature termination
T32 960-964 protein_molecule denotes Jak3
T33 982-999 other_name denotes nonsense mutation
T34 1007-1011 protein_molecule denotes Jak3
T35 1036-1040 protein_molecule denotes Jak3
T36 1077-1093 other_name denotes B cell signaling
T37 1131-1135 protein_molecule denotes IL-4
T38 1148-1153 protein_molecule denotes Stat6
T39 1161-1164 virus denotes EBV
T40 1255-1262 protein_subunit denotes gamma c
T41 1280-1284 protein_molecule denotes Jak3
T42 1294-1298 protein_molecule denotes Jak3
T43 1316-1336 other_name denotes lymphoid development

PubCasesHPO

Id Subject Object Predicate Lexical cue
AB1 109-141 HP:0004430 denotes severe combined immunodeficiency