PubMed:38494637
Annnotations
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 44-59 | Glycan | denotes | Keratan Sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G82109MW |
| T2 | 136-151 | Glycan | denotes | Keratan sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G82109MW |
| T3 | 153-155 | Glycan | denotes | KS | https://api.glycosmos.org/wurcs2image/latest/png/binary/G82109MW |
| T4 | 302-304 | Glycan | denotes | KS | https://api.glycosmos.org/wurcs2image/latest/png/binary/G82109MW |
| T5 | 400-402 | Glycan | denotes | KS | https://api.glycosmos.org/wurcs2image/latest/png/binary/G82109MW |
| T6 | 723-729 | Glycan | denotes | LacNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR |
| T7 | 775-777 | Glycan | denotes | KS | https://api.glycosmos.org/wurcs2image/latest/png/binary/G82109MW |
| T8 | 971-977 | Glycan | denotes | LacNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR |
| T9 | 1135-1141 | Glycan | denotes | LacNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR |
| T10 | 1169-1184 | Glycan | denotes | keratan sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G82109MW |
| T11 | 1538-1540 | Glycan | denotes | KS | https://api.glycosmos.org/wurcs2image/latest/png/binary/G82109MW |
| T12 | 1733-1739 | Glycan | denotes | LacNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 44-59 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Keratan Sulfate | http://www.glycoepitope.jp/epitopes/EP0085 |
| T2 | 136-151 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Keratan sulfate | http://www.glycoepitope.jp/epitopes/EP0085 |
| T3 | 153-155 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | KS | http://www.glycoepitope.jp/epitopes/EP0085 |
| T4 | 302-304 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | KS | http://www.glycoepitope.jp/epitopes/EP0085 |
| T5 | 400-402 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | KS | http://www.glycoepitope.jp/epitopes/EP0085 |
| T6 | 775-777 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | KS | http://www.glycoepitope.jp/epitopes/EP0085 |
| T7 | 1169-1184 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | keratan sulfate | http://www.glycoepitope.jp/epitopes/EP0085 |
| T8 | 1538-1540 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | KS | http://www.glycoepitope.jp/epitopes/EP0085 |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 1728-1732 | Cell | denotes | poly | http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 207-227 | Body_part | denotes | extracellular matrix | http://purl.obolibrary.org/obo/GO_0031012 |
| T2 | 239-245 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-135 | Sentence | denotes | A Biomimetic Synthetic Strategy Can Provide Keratan Sulfate I and II Oligosaccharides with Diverse Fucosylation and Sulfation Patterns. |
| T2 | 136-301 | Sentence | denotes | Keratan sulfate (KS) is a proteoglycan that is widely expressed in the extracellular matrix of various tissue types, where it performs multiple biological functions. |
| T3 | 302-568 | Sentence | denotes | KS is the least understood proteoglycan, which in part is due to a lack of panels of well-defined KS oligosaccharides that are needed for structure-binding studies, as analytical standards, to examine substrate specificities of keratinases, and for drug development. |
| T4 | 569-811 | Sentence | denotes | Here, we report a biomimetic approach that makes it possible to install, in a regioselective manner, sulfates and fucosides on oligo-N-acetyllactosamine (LacNAc) chains to provide any structural element of KS by using specific enzyme modules. |
| T5 | 812-985 | Sentence | denotes | It is based on the observation that α1,3-fucosides, α2,6-sialosides and C-6 sulfation of galactose (Gal6S) are mutually exclusive and cannot occur on the same LacNAc moiety. |
| T6 | 986-1222 | Sentence | denotes | As a result, the pattern of sulfation on galactosides can be controlled by installing α1,3-fucosides or α2,6-sialosides to temporarily block certain LacNAc moieties from sulfation by keratan sulfate galactose 6-sulfotransferase (CHST1). |
| T7 | 1223-1412 | Sentence | denotes | The patterns of α1,3-fucosylation and α2,6-sialylation can be controlled by exploiting the mutual exclusivity of these modifications, which in turn controls the sites of sulfation by CHST1. |
| T8 | 1413-1558 | Sentence | denotes | Late-stage treatment with a fucosidase or sialidase to remove blocking fucosides or sialosides provides selectively sulfated KS oligosaccharides. |
| T9 | 1559-1646 | Sentence | denotes | These treatments also unmasked specific galactosides for further modification by CHST1. |
| T10 | 1647-1877 | Sentence | denotes | To showcase the potential of the enzymatic strategy, we have prepared a range of poly-LacNAc derivatives having different patterns of fucosylation and sulfation and several N-glycans decorated by specific arrangements of sulfates. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 44-59 | Glycan | denotes | Keratan Sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G82109MW |
| T2 | 136-151 | Glycan | denotes | Keratan sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G82109MW |
| T3 | 153-155 | Glycan | denotes | KS | https://api.glycosmos.org/wurcs2image/latest/png/binary/G82109MW |
| T4 | 302-304 | Glycan | denotes | KS | https://api.glycosmos.org/wurcs2image/latest/png/binary/G82109MW |
| T5 | 400-402 | Glycan | denotes | KS | https://api.glycosmos.org/wurcs2image/latest/png/binary/G82109MW |
| T6 | 723-729 | Glycan | denotes | LacNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR |
| T7 | 775-777 | Glycan | denotes | KS | https://api.glycosmos.org/wurcs2image/latest/png/binary/G82109MW |
| T8 | 971-977 | Glycan | denotes | LacNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR |
| T9 | 1135-1141 | Glycan | denotes | LacNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR |
| T10 | 1169-1184 | Glycan | denotes | keratan sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G82109MW |
| T11 | 1538-1540 | Glycan | denotes | KS | https://api.glycosmos.org/wurcs2image/latest/png/binary/G82109MW |
| T12 | 1733-1739 | Glycan | denotes | LacNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G66213AR |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 44-59 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Keratan Sulfate | http://www.glycoepitope.jp/epitopes/EP0085 |
| T2 | 136-151 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Keratan sulfate | http://www.glycoepitope.jp/epitopes/EP0085 |
| T3 | 153-155 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | KS | http://www.glycoepitope.jp/epitopes/EP0085 |
| T4 | 302-304 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | KS | http://www.glycoepitope.jp/epitopes/EP0085 |
| T5 | 400-402 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | KS | http://www.glycoepitope.jp/epitopes/EP0085 |
| T6 | 775-777 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | KS | http://www.glycoepitope.jp/epitopes/EP0085 |
| T7 | 1169-1184 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | keratan sulfate | http://www.glycoepitope.jp/epitopes/EP0085 |
| T8 | 1538-1540 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | KS | http://www.glycoepitope.jp/epitopes/EP0085 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 207-227 | Body_part | denotes | extracellular matrix | http://purl.obolibrary.org/obo/GO_0031012 |
| T2 | 239-245 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 1728-1732 | Cell | denotes | poly | http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775 |