PubMed:38100017
Annnotations
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 0-3 | Glycan | denotes | GM1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR |
| T2 | 133-136 | Glycan | denotes | GM1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR |
| T3 | 201-204 | Glycan | denotes | GM1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR |
| T4 | 436-439 | Glycan | denotes | GM1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR |
| T5 | 475-481 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T6 | 491-497 | Glycan | denotes | Neu5Ac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
| T7 | 611-614 | Glycan | denotes | GM1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR |
| T8 | 767-770 | Glycan | denotes | GM1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR |
| T9 | 873-879 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T10 | 889-895 | Glycan | denotes | Neu5Ac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
| T11 | 992-995 | Glycan | denotes | GM1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR |
| T12 | 1048-1052 | Glycan | denotes | GD1a | https://api.glycosmos.org/wurcs2image/latest/png/binary/G46677TE |
| T13 | 1224-1235 | Glycan | denotes | Fucosyl-GM1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91532KA |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 0-3 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T2 | 133-136 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T3 | 201-204 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T4 | 436-439 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T5 | 611-614 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T6 | 767-770 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T7 | 992-995 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T8 | 1048-1052 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GD1a | http://www.glycoepitope.jp/epitopes/EP0056 |
| T9 | 1224-1235 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Fucosyl-GM1 | http://www.glycoepitope.jp/epitopes/EP0049 |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 39-47 | Cell | denotes | neuronal | http://purl.obolibrary.org/obo/CL:0000540 |
| T2 | 140-154 | Cell | denotes | cultured cells | http://purl.obolibrary.org/obo/CL:0000010 |
| T3 | 175-183 | Cell | denotes | neuronal | http://purl.obolibrary.org/obo/CL:0000540 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 291-299 | Body_part | denotes | membrane | http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158 |
| T4 | 404-408 | Body_part | denotes | sole | http://purl.obolibrary.org/obo/UBERON_0008338 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-58 | Sentence | denotes | GM1 structural requirements to mediate neuronal functions. |
| T2 | 59-200 | Sentence | denotes | Since the 1980s, it has been known that the administration of ganglioside GM1 to cultured cells induced or enhanced neuronal differentiation. |
| T3 | 201-371 | Sentence | denotes | GM1 mechanism of action relies on its direct interaction and subsequent activation of the membrane tyrosine kinase receptor, TrkA, which naturally serves as NGF receptor. |
| T4 | 372-672 | Sentence | denotes | This process is mediated by the sole oligosaccharide portion of GM1, the pentasaccharide β-Gal-(1-3)-β-GalNAc-(1-4)-[α-Neu5Ac-(2-3)]-β-Gal-(1-4)-β-Glc. Here we detailed the minimum structural requirements of the oligosaccharide portion of GM1 for mediating the TrkA dependent neuritogenic processing. |
| T5 | 673-1123 | Sentence | denotes | By in vitro and in silico biochemical approaches, we demonstrated that the minimal portion of GM1 required for the TrkA activation is the inner core of the ganglioside's oligosaccharide β-Gal-(1-3)-β-GalNAc-(1-4)-[α-Neu5Ac-(2-3)]-β-Gal. The addition of a sialic acid residue at position 3 of the outer galactose of the GM1 oligosaccharide, which forms the oligosaccharide of GD1a, prevented the interaction with TrkA and the resulting neuritogenesis. |
| T6 | 1124-1302 | Sentence | denotes | On the contrary, the addition of a fucose residue at position 2 of the outer galactose, forming the Fucosyl-GM1 oligosaccharide, did not prevent the TrkA-mediated neuritogenesis. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 0-3 | Glycan | denotes | GM1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR |
| T2 | 133-136 | Glycan | denotes | GM1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR |
| T3 | 201-204 | Glycan | denotes | GM1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR |
| T4 | 436-439 | Glycan | denotes | GM1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR |
| T5 | 475-481 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T6 | 491-497 | Glycan | denotes | Neu5Ac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
| T7 | 611-614 | Glycan | denotes | GM1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR |
| T8 | 767-770 | Glycan | denotes | GM1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR |
| T9 | 873-879 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T10 | 889-895 | Glycan | denotes | Neu5Ac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
| T11 | 992-995 | Glycan | denotes | GM1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR |
| T12 | 1048-1052 | Glycan | denotes | GD1a | https://api.glycosmos.org/wurcs2image/latest/png/binary/G46677TE |
| T13 | 1224-1235 | Glycan | denotes | Fucosyl-GM1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G91532KA |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 0-3 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T2 | 133-136 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T3 | 201-204 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T4 | 436-439 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T5 | 611-614 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T6 | 767-770 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T7 | 992-995 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T8 | 1048-1052 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GD1a | http://www.glycoepitope.jp/epitopes/EP0056 |
| T9 | 1224-1235 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Fucosyl-GM1 | http://www.glycoepitope.jp/epitopes/EP0049 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 291-299 | Body_part | denotes | membrane | http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158 |
| T4 | 404-408 | Body_part | denotes | sole | http://purl.obolibrary.org/obo/UBERON_0008338 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 39-47 | Cell | denotes | neuronal | http://purl.obolibrary.org/obo/CL:0000540 |
| T2 | 140-154 | Cell | denotes | cultured cells | http://purl.obolibrary.org/obo/CL:0000010 |
| T3 | 175-183 | Cell | denotes | neuronal | http://purl.obolibrary.org/obo/CL:0000540 |