PubMed:35351535 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/35351535","sourcedb":"PubMed","sourceid":"35351535","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/35351535","text":"Effect of metformin as an add-on therapy on neuregulin-4 levels and vascular-related complications in adolescents with type 1 diabetes: A randomized controlled trial.\nBACKGROUND: Inflammation is closely associated with atherosclerosis and plays a crucial role in the development of cardiovascular disease. Metformin sensitizes body cells to insulin, which may cause a reduction of atherogenic lipid fractions. Low neuregulin-4 (Nrg-4) levels, an adipokine, are linked to obesity, insulin resistance, impaired glucose tolerance and type 2 diabetes.\nOBJECTIVES: We assessed the effect of oral supplementation with metformin on glycemic control, neuregulin-4 levels and carotid intima media thickness (CIMT) as a marker for subclinical atherosclerosis in adolescents with type 1 diabetes mellitus (T1DM) and microvascular complications.\nMETHODS: This randomized placebo-controlled trial included 80 type 1 diabetic patients with microvascular complications who were randomly divided to receive either 24 weeks of metformin 500 mg/day or matching placebo. Fasting blood glucose (FBG), HbA1c, C-reactive protein (CRP), urinary albumin creatinine ratio (UACR), lipid profile, Nrg-4 and CIMT were assessed at baseline and study end.\nRESULTS: Both groups were well-matched as regards baseline clinical and laboratory data (p greater than 0.05). After 24-weeks, metformin therapy for the intervention group resulted in a significant decrease of HbA1c, CRP, UACR, total cholesterol and CIMT while Nrg-4 levels were increased compared with baseline levels (p \u003c 0.001) and with placebo group(p \u003c 0.001). Baseline Nrg-4 levels were negatively correlated to FBG, HbA1c, total cholesterol, CRP and CIMT. Metformin was well-tolerated.\nCONCLUSIONS: Oral metformin supplementation once daily for 24 weeks as an adjuvant therapy to intensive insulin in pediatric T1DM was safe and effective in improving glycemic control, dyslipidemia and Nrg-4 levels; hence, it decreased inflammation, microvascular complications and subclinical atherosclerosis.","tracks":[{"project":"Inflammaging","denotations":[{"id":"T1","span":{"begin":0,"end":135},"obj":"Sentence"},{"id":"T2","span":{"begin":136,"end":166},"obj":"Sentence"},{"id":"T3","span":{"begin":167,"end":178},"obj":"Sentence"},{"id":"T4","span":{"begin":179,"end":305},"obj":"Sentence"},{"id":"T5","span":{"begin":306,"end":409},"obj":"Sentence"},{"id":"T6","span":{"begin":410,"end":547},"obj":"Sentence"},{"id":"T7","span":{"begin":548,"end":559},"obj":"Sentence"},{"id":"T8","span":{"begin":560,"end":833},"obj":"Sentence"},{"id":"T9","span":{"begin":834,"end":842},"obj":"Sentence"},{"id":"T10","span":{"begin":843,"end":1051},"obj":"Sentence"},{"id":"T11","span":{"begin":1052,"end":1225},"obj":"Sentence"},{"id":"T12","span":{"begin":1226,"end":1234},"obj":"Sentence"},{"id":"T13","span":{"begin":1235,"end":1336},"obj":"Sentence"},{"id":"T14","span":{"begin":1337,"end":1591},"obj":"Sentence"},{"id":"T15","span":{"begin":1592,"end":1688},"obj":"Sentence"},{"id":"T16","span":{"begin":1689,"end":1718},"obj":"Sentence"},{"id":"T17","span":{"begin":1719,"end":1731},"obj":"Sentence"},{"id":"T18","span":{"begin":1732,"end":2028},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":135},"obj":"Sentence"},{"id":"T2","span":{"begin":136,"end":166},"obj":"Sentence"},{"id":"T3","span":{"begin":167,"end":178},"obj":"Sentence"},{"id":"T4","span":{"begin":179,"end":305},"obj":"Sentence"},{"id":"T5","span":{"begin":306,"end":409},"obj":"Sentence"},{"id":"T6","span":{"begin":410,"end":547},"obj":"Sentence"},{"id":"T7","span":{"begin":548,"end":559},"obj":"Sentence"},{"id":"T8","span":{"begin":560,"end":833},"obj":"Sentence"},{"id":"T9","span":{"begin":834,"end":842},"obj":"Sentence"},{"id":"T10","span":{"begin":843,"end":1051},"obj":"Sentence"},{"id":"T11","span":{"begin":1052,"end":1225},"obj":"Sentence"},{"id":"T12","span":{"begin":1226,"end":1234},"obj":"Sentence"},{"id":"T13","span":{"begin":1235,"end":1336},"obj":"Sentence"},{"id":"T14","span":{"begin":1337,"end":1591},"obj":"Sentence"},{"id":"T15","span":{"begin":1592,"end":1688},"obj":"Sentence"},{"id":"T16","span":{"begin":1689,"end":1718},"obj":"Sentence"},{"id":"T17","span":{"begin":1719,"end":1731},"obj":"Sentence"},{"id":"T18","span":{"begin":1732,"end":2028},"obj":"Sentence"}],"attributes":[{"subj":"T1","pred":"source","obj":"Inflammaging"},{"subj":"T2","pred":"source","obj":"Inflammaging"},{"subj":"T3","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"},{"subj":"T5","pred":"source","obj":"Inflammaging"},{"subj":"T6","pred":"source","obj":"Inflammaging"},{"subj":"T7","pred":"source","obj":"Inflammaging"},{"subj":"T8","pred":"source","obj":"Inflammaging"},{"subj":"T9","pred":"source","obj":"Inflammaging"},{"subj":"T10","pred":"source","obj":"Inflammaging"},{"subj":"T11","pred":"source","obj":"Inflammaging"},{"subj":"T12","pred":"source","obj":"Inflammaging"},{"subj":"T13","pred":"source","obj":"Inflammaging"},{"subj":"T14","pred":"source","obj":"Inflammaging"},{"subj":"T15","pred":"source","obj":"Inflammaging"},{"subj":"T16","pred":"source","obj":"Inflammaging"},{"subj":"T17","pred":"source","obj":"Inflammaging"},{"subj":"T18","pred":"source","obj":"Inflammaging"},{"subj":"T1","pred":"source","obj":"Inflammaging"},{"subj":"T2","pred":"source","obj":"Inflammaging"},{"subj":"T3","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"},{"subj":"T5","pred":"source","obj":"Inflammaging"},{"subj":"T6","pred":"source","obj":"Inflammaging"},{"subj":"T7","pred":"source","obj":"Inflammaging"},{"subj":"T8","pred":"source","obj":"Inflammaging"},{"subj":"T9","pred":"source","obj":"Inflammaging"},{"subj":"T10","pred":"source","obj":"Inflammaging"},{"subj":"T11","pred":"source","obj":"Inflammaging"},{"subj":"T12","pred":"source","obj":"Inflammaging"},{"subj":"T13","pred":"source","obj":"Inflammaging"},{"subj":"T14","pred":"source","obj":"Inflammaging"},{"subj":"T15","pred":"source","obj":"Inflammaging"},{"subj":"T16","pred":"source","obj":"Inflammaging"},{"subj":"T17","pred":"source","obj":"Inflammaging"},{"subj":"T18","pred":"source","obj":"Inflammaging"}]},{"project":"maxiaofeng52_800_3","denotations":[{"id":"T1","span":{"begin":119,"end":134},"obj":"DP"},{"id":"T2","span":{"begin":769,"end":793},"obj":"DP"},{"id":"T3","span":{"begin":795,"end":799},"obj":"DP"},{"id":"T4","span":{"begin":1844,"end":1848},"obj":"DP"},{"id":"T5","span":{"begin":10,"end":19},"obj":"CI"},{"id":"T6","span":{"begin":612,"end":621},"obj":"CI"},{"id":"T7","span":{"begin":1010,"end":1019},"obj":"CI"},{"id":"T8","span":{"begin":1353,"end":1362},"obj":"CI"},{"id":"T9","span":{"begin":1737,"end":1746},"obj":"CI"},{"id":"T10","span":{"begin":896,"end":911},"obj":"DP"},{"id":"T11","span":{"begin":306,"end":315},"obj":"CI"},{"id":"T12","span":{"begin":1689,"end":1698},"obj":"CI"},{"id":"T13","span":{"begin":1043,"end":1050},"obj":"CI"},{"id":"T14","span":{"begin":859,"end":866},"obj":"CI"},{"id":"T15","span":{"begin":1566,"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