PubMed:34161143 JSONTXT

{"project":"Inflammaging","denotations":[{"id":"T1","span":{"begin":0,"end":121},"obj":"Sentence"},{"id":"T2","span":{"begin":122,"end":164},"obj":"Sentence"},{"id":"T3","span":{"begin":165,"end":175},"obj":"Sentence"},{"id":"T4","span":{"begin":176,"end":301},"obj":"Sentence"},{"id":"T5","span":{"begin":302,"end":309},"obj":"Sentence"},{"id":"T6","span":{"begin":310,"end":365},"obj":"Sentence"},{"id":"T7","span":{"begin":366,"end":374},"obj":"Sentence"},{"id":"T8","span":{"begin":375,"end":415},"obj":"Sentence"},{"id":"T9","span":{"begin":416,"end":425},"obj":"Sentence"},{"id":"T10","span":{"begin":426,"end":611},"obj":"Sentence"},{"id":"T11","span":{"begin":612,"end":626},"obj":"Sentence"},{"id":"T12","span":{"begin":627,"end":809},"obj":"Sentence"},{"id":"T13","span":{"begin":810,"end":827},"obj":"Sentence"},{"id":"T14","span":{"begin":828,"end":929},"obj":"Sentence"},{"id":"T15","span":{"begin":930,"end":1203},"obj":"Sentence"},{"id":"T16","span":{"begin":1204,"end":1212},"obj":"Sentence"},{"id":"T17","span":{"begin":1213,"end":1310},"obj":"Sentence"},{"id":"T18","span":{"begin":1311,"end":1440},"obj":"Sentence"},{"id":"T19","span":{"begin":1441,"end":1496},"obj":"Sentence"},{"id":"T20","span":{"begin":1497,"end":1682},"obj":"Sentence"},{"id":"T21","span":{"begin":1683,"end":1796},"obj":"Sentence"},{"id":"T22","span":{"begin":1797,"end":1899},"obj":"Sentence"},{"id":"T23","span":{"begin":1900,"end":1912},"obj":"Sentence"},{"id":"T24","span":{"begin":1913,"end":2084},"obj":"Sentence"},{"id":"T25","span":{"begin":2085,"end":2140},"obj":"Sentence"},{"id":"T26","span":{"begin":2141,"end":2183},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":121},"obj":"Sentence"},{"id":"T2","span":{"begin":122,"end":164},"obj":"Sentence"},{"id":"T3","span":{"begin":165,"end":175},"obj":"Sentence"},{"id":"T4","span":{"begin":176,"end":301},"obj":"Sentence"},{"id":"T5","span":{"begin":302,"end":309},"obj":"Sentence"},{"id":"T6","span":{"begin":310,"end":365},"obj":"Sentence"},{"id":"T7","span":{"begin":366,"end":374},"obj":"Sentence"},{"id":"T8","span":{"begin":375,"end":415},"obj":"Sentence"},{"id":"T9","span":{"begin":416,"end":425},"obj":"Sentence"},{"id":"T10","span":{"begin":426,"end":611},"obj":"Sentence"},{"id":"T11","span":{"begin":612,"end":626},"obj":"Sentence"},{"id":"T12","span":{"begin":627,"end":809},"obj":"Sentence"},{"id":"T13","span":{"begin":810,"end":827},"obj":"Sentence"},{"id":"T14","span":{"begin":828,"end":929},"obj":"Sentence"},{"id":"T15","span":{"begin":930,"end":1203},"obj":"Sentence"},{"id":"T16","span":{"begin":1204,"end":1212},"obj":"Sentence"},{"id":"T17","span":{"begin":1213,"end":1310},"obj":"Sentence"},{"id":"T18","span":{"begin":1311,"end":1440},"obj":"Sentence"},{"id":"T19","span":{"begin":1441,"end":1496},"obj":"Sentence"},{"id":"T20","span":{"begin":1497,"end":1682},"obj":"Sentence"},{"id":"T21","span":{"begin":1683,"end":1796},"obj":"Sentence"},{"id":"T22","span":{"begin":1797,"end":1899},"obj":"Sentence"},{"id":"T23","span":{"begin":1900,"end":1912},"obj":"Sentence"},{"id":"T24","span":{"begin":1913,"end":2084},"obj":"Sentence"},{"id":"T25","span":{"begin":2085,"end":2140},"obj":"Sentence"},{"id":"T26","span":{"begin":2141,"end":2183},"obj":"Sentence"}],"text":"Manual Acupuncture Plus Usual Care Versus Usual Care Alone in the Treatment of Endometriosis-Related Chronic Pelvic Pain: A Randomized Controlled Feasibility Study.\nObjective: To determine the acceptability and feasibility of acupuncture for the treatment of endometriosis-related chronic pelvic pain. Design: A prospective, randomized controlled feasibility study. Setting: Outpatient setting in Sydney, Australia. Subjects: Participants who were aged 18-45 years, had a confirmed laparoscopic diagnosis of endometriosis in the past 5 years, and had regular menstrual periods and mean pelvic pain scores ≥4/10. Interventions: Sixteen acupuncture treatments delivered by registered acupuncturists using a standardized point protocol over 8 weeks, twice per week plus usual care compared with usual care alone. Outcome measures: Primary outcome measures were feasibility, safety, and acceptability of the acupuncture intervention. Secondary outcomes were changes in self-reported pelvic pain scores, changes in quality of life as measured by the Endometriosis Health Profile (EHP-30), changes in descending pain modulation, and changes in systemic inflammation (plasma interleukin [IL-6] concentrations). Results: Twenty-nine participants were eligible to participate, with 19 participants completing the trial. There was unequal withdrawals between groups; the acupuncture group had a withdrawal rate of 14% compared with 53% in usual care. Adverse events were uncommon (6.7%) and generally mild. A 1.9 point decrease in median nonmenstrual pain scores and a 2.0 decrease in median menstrual pain scores between baseline and end of trial were observed in the acupuncture group only. Improvements in all domains of the EHP-30 were seen in the acupuncture group, with no changes seen in usual care. There was no difference between baseline and end of treatment in IL-6 concentrations for either group. Conclusions: Acupuncture was an acceptable, well-tolerated treatment and it may reduce pelvic pain and improve quality of life; however, usual care was not an acceptable control group. Trial Registration: anzctr.org.au: ACTRN12617000053325. Prospectively registered January 11, 2017."}