PubMed:33446900 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/33446900","sourcedb":"PubMed","sourceid":"33446900","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/33446900","text":"Symptoms of anxiety/depression is associated with more aggressive inflammatory bowel disease.\nStudies have demonstrated that inflammatory bowel disease (IBD) patients are at an increased risk of developing anxiety and/or depression. IBD patients with depression/anxiety have higher rates of hospitalization and increased disease severity than those without. So far, there is a paucity of data concerning the impact of anxiety/depression on Chinese IBD patients. The aim of this study was to find out the prevalence of symptoms of anxiety/depression in Chinese IBD population and its impact on IBD-related features. This is a cross-sectional study from the southwest China IBD referral center. Eligible participants were divided into those with symptoms of anxiety/depression and those without based on the Hospital Anxiety and Depression Scale (HADS). Demographic data and disease duration, IBD-related surgery, tobacco use, extra-intestinal manifestations, disease activity scores, endoscopic evaluation, laboratory data and current medication use were compared between two groups. A total of 341 IBD patients [221 Crohn's disease (CD) and 120 ulcerative colitis (UC)] were included. The prevalence of symptoms of anxiety/depression in IBD was 33.1%. CD patients with symptoms of anxiety/depression tended to have higher scores of simple endoscopic scores for Crohn's disease (SES-CD) (p = 0.0005). UC patients with symptoms of anxiety/depression had a significantly higher Mayo score (p = 0.0017) and ulcerative colitis endoscopic index of severity (UCEIS) (p \u003c 0.0001) than their non-anxiety/depression counterparts. CD-related surgery (p = 0.012) and Crohn's disease activity index (CDAI) (p \u003c 0.0001) were identified as independent risk factors for symptoms of anxiety/depression in CD, while corticosteroid use (p = 0.036) as an independent risk factor for symptoms of anxiety/depression in UC. This study helps our understanding of the prevalence of symptoms of anxiety/depression in IBD patients and its impact on IBD course and reminds us to pay more attention on IBD management with anxiety/depression.","tracks":[{"project":"Inflammaging","denotations":[{"id":"T1","span":{"begin":0,"end":93},"obj":"Sentence"},{"id":"T2","span":{"begin":94,"end":232},"obj":"Sentence"},{"id":"T3","span":{"begin":233,"end":357},"obj":"Sentence"},{"id":"T4","span":{"begin":358,"end":461},"obj":"Sentence"},{"id":"T5","span":{"begin":462,"end":614},"obj":"Sentence"},{"id":"T6","span":{"begin":615,"end":692},"obj":"Sentence"},{"id":"T7","span":{"begin":693,"end":851},"obj":"Sentence"},{"id":"T8","span":{"begin":852,"end":1082},"obj":"Sentence"},{"id":"T9","span":{"begin":1083,"end":1184},"obj":"Sentence"},{"id":"T10","span":{"begin":1185,"end":1251},"obj":"Sentence"},{"id":"T11","span":{"begin":1252,"end":1399},"obj":"Sentence"},{"id":"T12","span":{"begin":1400,"end":1619},"obj":"Sentence"},{"id":"T13","span":{"begin":1620,"end":1900},"obj":"Sentence"},{"id":"T14","span":{"begin":1901,"end":2112},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":93},"obj":"Sentence"},{"id":"T2","span":{"begin":94,"end":232},"obj":"Sentence"},{"id":"T3","span":{"begin":233,"end":357},"obj":"Sentence"},{"id":"T4","span":{"begin":358,"end":461},"obj":"Sentence"},{"id":"T5","span":{"begin":462,"end":614},"obj":"Sentence"},{"id":"T6","span":{"begin":615,"end":692},"obj":"Sentence"},{"id":"T7","span":{"begin":693,"end":851},"obj":"Sentence"},{"id":"T8","span":{"begin":852,"end":1082},"obj":"Sentence"},{"id":"T9","span":{"begin":1083,"end":1184},"obj":"Sentence"},{"id":"T10","span":{"begin":1185,"end":1251},"obj":"Sentence"},{"id":"T11","span":{"begin":1252,"end":1399},"obj":"Sentence"},{"id":"T12","span":{"begin":1400,"end":1619},"obj":"Sentence"},{"id":"T13","span":{"begin":1620,"end":1900},"obj":"Sentence"},{"id":"T14","span":{"begin":1901,"end":2112},"obj":"Sentence"}],"attributes":[{"subj":"T1","pred":"source","obj":"Inflammaging"},{"subj":"T2","pred":"source","obj":"Inflammaging"},{"subj":"T3","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"},{"subj":"T5","pred":"source","obj":"Inflammaging"},{"subj":"T6","pred":"source","obj":"Inflammaging"},{"subj":"T7","pred":"source","obj":"Inflammaging"},{"subj":"T8","pred":"source","obj":"Inflammaging"},{"subj":"T9","pred":"source","obj":"Inflammaging"},{"subj":"T10","pred":"source","obj":"Inflammaging"},{"subj":"T11","pred":"source","obj":"Inflammaging"},{"subj":"T12","pred":"source","obj":"Inflammaging"},{"subj":"T13","pred":"source","obj":"Inflammaging"},{"subj":"T14","pred":"source","obj":"Inflammaging"},{"subj":"T1","pred":"source","obj":"Inflammaging"},{"subj":"T2","pred":"source","obj":"Inflammaging"},{"subj":"T3","pred":"source","obj":"Inflammaging"},{"subj":"T4","pred":"source","obj":"Inflammaging"},{"subj":"T5","pred":"source","obj":"Inflammaging"},{"subj":"T6","pred":"source","obj":"Inflammaging"},{"subj":"T7","pred":"source","obj":"Inflammaging"},{"subj":"T8","pred":"source","obj":"Inflammaging"},{"subj":"T9","pred":"source","obj":"Inflammaging"},{"subj":"T10","pred":"source","obj":"Inflammaging"},{"subj":"T11","pred":"source","obj":"Inflammaging"},{"subj":"T12","pred":"source","obj":"Inflammaging"},{"subj":"T13","pred":"source","obj":"Inflammaging"},{"subj":"T14","pred":"source","obj":"Inflammaging"}]},{"project":"Anatomy-MAT","denotations":[{"id":"T1","span":{"begin":931,"end":941},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"mat_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MAT_0000043"},{"subj":"T1","pred":"source","obj":"Anatomy-MAT"}]},{"project":"mondo_disease","denotations":[{"id":"T1","span":{"begin":12,"end":30},"obj":"Disease"},{"id":"T2","span":{"begin":66,"end":92},"obj":"Disease"},{"id":"T3","span":{"begin":125,"end":151},"obj":"Disease"},{"id":"T4","span":{"begin":153,"end":156},"obj":"Disease"},{"id":"T6","span":{"begin":206,"end":231},"obj":"Disease"},{"id":"T7","span":{"begin":233,"end":236},"obj":"Disease"},{"id":"T9","span":{"begin":251,"end":261},"obj":"Disease"},{"id":"T10","span":{"begin":262,"end":269},"obj":"Disease"},{"id":"T12","span":{"begin":418,"end":436},"obj":"Disease"},{"id":"T13","span":{"begin":448,"end":451},"obj":"Disease"},{"id":"T15","span":{"begin":530,"end":548},"obj":"Disease"},{"id":"T16","span":{"begin":560,"end":563},"obj":"Disease"},{"id":"T18","span":{"begin":593,"end":596},"obj":"Disease"},{"id":"T20","span":{"begin":672,"end":675},"obj":"Disease"},{"id":"T22","span":{"begin":756,"end":774},"obj":"Disease"},{"id":"T23","span":{"begin":815,"end":837},"obj":"Disease"},{"id":"T24","span":{"begin":891,"end":894},"obj":"Disease"},{"id":"T26","span":{"begin":1098,"end":1101},"obj":"Disease"},{"id":"T28","span":{"begin":1116,"end":1131},"obj":"Disease"},{"id":"T29","span":{"begin":1133,"end":1135},"obj":"Disease"},{"id":"T30","span":{"begin":1145,"end":1163},"obj":"Disease"},{"id":"T32","span":{"begin":1165,"end":1167},"obj":"Disease"},{"id":"T33","span":{"begin":1215,"end":1233},"obj":"Disease"},{"id":"T34","span":{"begin":1237,"end":1240},"obj":"Disease"},{"id":"T36","span":{"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