PubMed:33174592
Annnotations
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T1 | 19-35 | Body_part | denotes | immunoglobulin G | http://purl.org/sig/ont/fma/fma62872 |
T2 | 456-469 | Body_part | denotes | immune system | http://purl.org/sig/ont/fma/fma9825 |
T3 | 521-524 | Body_part | denotes | IgG | http://purl.org/sig/ont/fma/fma62872 |
T4 | 674-677 | Body_part | denotes | IgG | http://purl.org/sig/ont/fma/fma62872 |
T5 | 894-897 | Body_part | denotes | IgG | http://purl.org/sig/ont/fma/fma62872 |
T6 | 967-986 | Body_part | denotes | N-acetylglucosamine | http://purl.org/sig/ont/fma/fma82787 |
T7 | 1039-1042 | Body_part | denotes | IgG | http://purl.org/sig/ont/fma/fma62872 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 456-469 | Body_part | denotes | immune system | http://purl.obolibrary.org/obo/UBERON_0002405 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 76-84 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T2 | 176-184 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T3 | 254-262 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T4 | 504-512 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T5 | 721-729 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 86-87 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
T2 | 215-216 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T3 | 456-469 | http://purl.obolibrary.org/obo/UBERON_0002405 | denotes | immune system |
T4 | 487-488 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T5 | 1208-1215 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | testing |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T1 | 967-986 | Chemical | denotes | N-acetylglucosamine | http://purl.obolibrary.org/obo/CHEBI_28009|http://purl.obolibrary.org/obo/CHEBI_59640 |
T3 | 988-994 | Chemical | denotes | GlcNAc | http://purl.obolibrary.org/obo/CHEBI_506227|http://purl.obolibrary.org/obo/CHEBI_73685 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 525-538 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
T2 | 570-580 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-85 | Sentence | denotes | Composition of the immunoglobulin G glycome associates with the severity of COVID-19. |
T2 | 86-195 | Sentence | denotes | A large variation in the severity of disease symptoms is one of the key open questions in COVID-19 pandemics. |
T3 | 196-427 | Sentence | denotes | The fact that only a small subset of people infected with SARS-CoV-2 develop severe disease suggests that there have to be some predisposing factors, but biomarkers that reliably predict disease severity have not been found so far. |
T4 | 428-730 | Sentence | denotes | Since overactivation of the immune system is implicated in a severe form of COVID-19 and the IgG glycosylation is known to be involved in the regulation of different immune processes, we evaluated the association of inter-individual variation in IgG N-glycome composition with the severity of COVID-19. |
T5 | 731-908 | Sentence | denotes | The analysis of 166 severe and 167 mild cases from hospitals in Spain, Italy and Portugal revealed statistically significant differences in the composition of the IgG N-glycome. |
T6 | 909-1038 | Sentence | denotes | The most notable difference was the decrease in bisecting N-acetylglucosamine (GlcNAc) in severe patients from all three cohorts. |
T7 | 1039-1216 | Sentence | denotes | IgG galactosylation was also lower in severe cases in all cohorts, but the difference in galactosylation was not statistically significant after correction for multiple testing. |
GlyCosmos6-Glycan-Motif-Image
Id | Subject | Object | Predicate | Lexical cue | image |
---|---|---|---|---|---|
T1 | 967-986 | Glycan_Motif | denotes | N-acetylglucosamine | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G64581RP |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-85 | Sentence | denotes | Composition of the immunoglobulin G glycome associates with the severity of COVID-19. |
T2 | 86-195 | Sentence | denotes | A large variation in the severity of disease symptoms is one of the key open questions in COVID-19 pandemics. |
T3 | 196-427 | Sentence | denotes | The fact that only a small subset of people infected with SARS-CoV-2 develop severe disease suggests that there have to be some predisposing factors, but biomarkers that reliably predict disease severity have not been found so far. |
T4 | 428-730 | Sentence | denotes | Since overactivation of the immune system is implicated in a severe form of COVID-19 and the IgG glycosylation is known to be involved in the regulation of different immune processes, we evaluated the association of inter-individual variation in IgG N-glycome composition with the severity of COVID-19. |
T5 | 731-908 | Sentence | denotes | The analysis of 166 severe and 167 mild cases from hospitals in Spain, Italy and Portugal revealed statistically significant differences in the composition of the IgG N-glycome. |
T6 | 909-1038 | Sentence | denotes | The most notable difference was the decrease in bisecting N-acetylglucosamine (GlcNAc) in severe patients from all three cohorts. |
T7 | 1039-1216 | Sentence | denotes | IgG galactosylation was also lower in severe cases in all cohorts, but the difference in galactosylation was not statistically significant after correction for multiple testing. |
T1 | 0-85 | Sentence | denotes | Composition of the immunoglobulin G glycome associates with the severity of COVID-19. |
T2 | 86-195 | Sentence | denotes | A large variation in the severity of disease symptoms is one of the key open questions in COVID-19 pandemics. |
T3 | 196-427 | Sentence | denotes | The fact that only a small subset of people infected with SARS-CoV-2 develop severe disease suggests that there have to be some predisposing factors, but biomarkers that reliably predict disease severity have not been found so far. |
T4 | 428-730 | Sentence | denotes | Since overactivation of the immune system is implicated in a severe form of COVID-19 and the IgG glycosylation is known to be involved in the regulation of different immune processes, we evaluated the association of inter-individual variation in IgG N-glycome composition with the severity of COVID-19. |
T5 | 731-908 | Sentence | denotes | The analysis of 166 severe and 167 mild cases from hospitals in Spain, Italy and Portugal revealed statistically significant differences in the composition of the IgG N-glycome. |
T6 | 909-1038 | Sentence | denotes | The most notable difference was the decrease in bisecting N-acetylglucosamine (GlcNAc) in severe patients from all three cohorts. |
T7 | 1039-1216 | Sentence | denotes | IgG galactosylation was also lower in severe cases in all cohorts, but the difference in galactosylation was not statistically significant after correction for multiple testing. |
GlyCosmos6-Glycan-Motif-Structure
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 967-986 | https://glytoucan.org/Structures/Glycans/G64581RP | denotes | N-acetylglucosamine |
mondo_disease
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 76-84 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T2 | 176-184 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T3 | 254-264 | Disease | denotes | SARS-CoV-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T4 | 504-512 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T5 | 721-729 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
NCBITAXON
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 254-262 | OrganismTaxon | denotes | SARS-CoV | 694009 |
Anatomy-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 456-469 | Body_part | denotes | immune system | http://purl.obolibrary.org/obo/UBERON_0002405 |