PubMed:33162738 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PubMed/sourceid/33162738","sourcedb":"PubMed","sourceid":"33162738","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/33162738","text":"Gastrointestinal predictors of severe COVID-19: systematic review and meta-analysis.\nBackground: COVID-19 pandemic has created a need to identify potential predictors of severe disease. We performed a systematic review and meta-analysis of gastrointestinal predictors of severe COVID-19.\nMethods: An extensive literature search was performed using PubMed, Embase, Web of Science and Cochrane. Odds ratio (OR) and mean difference (MD) were calculated for proportional and continuous outcomes using a random-effect model. For each outcome, a 95% confidence interval (CI) and P-value were generated.\nResults: A total of 83 studies (26912 patients, mean age 43.5±16.4 years, 48.2% female) were included. Gastrointestinal predictors of severe COVID-19 included the presence of diarrhea (OR 1.50, 95%CI 1.10-2.03; P=0.01), elevated serum aspartate aminotransferase (AST) (OR 4.00, 95%CI 3.02-5.28; P\u003c0.001), and elevated serum alanine aminotransferase (ALT) (OR 2.54, 95%CI 1.91-3.37; P\u003c0.001). Significantly higher levels of mean AST (MD 14.78 U/L, 95%CI 11.70-17.86 U/L; P\u003c0.001), ALT (MD 11.87 U/L, 95%CI 9.23-14.52 U/L; P\u003c0.001), and total bilirubin (MD 2.08 mmol/L, 95%CI 1.36-2.80 mmol/L; P\u003c0.001) were observed in the severe COVID-19 group compared to non-severe COVID-19 group.\nConclusion: Gastrointestinal symptoms and biomarkers should be assessed early to recognize severe COVID-19.","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T1","span":{"begin":826,"end":831},"obj":"Body_part"},{"id":"T2","span":{"begin":915,"end":920},"obj":"Body_part"},{"id":"T3","span":{"begin":921,"end":928},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma82749"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T1","span":{"begin":826,"end":831},"obj":"Body_part"},{"id":"T2","span":{"begin":915,"end":920},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T1","span":{"begin":38,"end":46},"obj":"Disease"},{"id":"T2","span":{"begin":97,"end":105},"obj":"Disease"},{"id":"T3","span":{"begin":278,"end":286},"obj":"Disease"},{"id":"T4","span":{"begin":738,"end":746},"obj":"Disease"},{"id":"T5","span":{"begin":772,"end":780},"obj":"Disease"},{"id":"T6","span":{"begin":1226,"end":1234},"obj":"Disease"},{"id":"T7","span":{"begin":1264,"end":1272},"obj":"Disease"},{"id":"T8","span":{"begin":1378,"end":1386},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0001673"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1","span":{"begin":115,"end":118},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T2","span":{"begin":127,"end":128},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T3","span":{"begin":199,"end":200},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T4","span":{"begin":430,"end":432},"obj":"http://purl.obolibrary.org/obo/CLO_0007622"},{"id":"T5","span":{"begin":497,"end":498},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T6","span":{"begin":538,"end":542},"obj":"http://purl.obolibrary.org/obo/CLO_0001625"},{"id":"T7","span":{"begin":606,"end":607},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T8","span":{"begin":677,"end":683},"obj":"http://purl.obolibrary.org/obo/UBERON_0003100"},{"id":"T9","span":{"begin":1030,"end":1032},"obj":"http://purl.obolibrary.org/obo/CLO_0007622"},{"id":"T10","span":{"begin":1082,"end":1084},"obj":"http://purl.obolibrary.org/obo/CLO_0007622"},{"id":"T11","span":{"begin":1149,"end":1151},"obj":"http://purl.obolibrary.org/obo/CLO_0007622"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T2","span":{"begin":832,"end":841},"obj":"Chemical"},{"id":"T5","span":{"begin":860,"end":863},"obj":"Chemical"},{"id":"T6","span":{"begin":921,"end":928},"obj":"Chemical"},{"id":"T7","span":{"begin":1025,"end":1028},"obj":"Chemical"},{"id":"T8","span":{"begin":1030,"end":1032},"obj":"Chemical"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