PubMed:33023821 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/33023821","sourcedb":"PubMed","sourceid":"33023821","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/33023821","text":"COVID-19 outbreak in Italy: Clinical-radiological presentation and outcome in three oncologic patients.\nWe present three patients affected by pulmonary squamous cell carcinoma, metastatic esophageal cancer and advanced non-Hodgkin lymphoma, who incurred in coronavirus 2019 (COVID-19) infection during the early phase of epidemic wave in Italy. All patients presented with fever. Social contact with subject positive for COVID-19 was declared in only one of the three cases. In all cases, laboratory findings showed lymphopenia and elevated C-reactive protein (CRP). Chest x-ray and computed tomography showed bilateral ground-glass opacities, shadowing, interstitial abnormalities, and \"crazy paving\" pattern which evolved with superimposition of consolidations in one patient. All patients received antiviral therapy based on ritonavir and lopinavir, associated with hydroxychloroquine. Despite treatment, two patients with advanced cancers died after 39 and 17 days of hospitalization, while the patient with lung cancer was dismissed at home, in good conditions.","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T1","span":{"begin":161,"end":165},"obj":"Body_part"},{"id":"T2","span":{"begin":552,"end":559},"obj":"Body_part"},{"id":"T3","span":{"begin":567,"end":572},"obj":"Body_part"},{"id":"T4","span":{"begin":1012,"end":1016},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma9576"},{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma7195"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T1","span":{"begin":567,"end":572},"obj":"Body_part"},{"id":"T2","span":{"begin":1012,"end":1016},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0001443"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T1","span":{"begin":152,"end":175},"obj":"Phenotype"},{"id":"T2","span":{"begin":199,"end":205},"obj":"Phenotype"},{"id":"T3","span":{"begin":219,"end":239},"obj":"Phenotype"},{"id":"T4","span":{"begin":373,"end":378},"obj":"Phenotype"},{"id":"T5","span":{"begin":516,"end":527},"obj":"Phenotype"},{"id":"T6","span":{"begin":1012,"end":1023},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/HP_0002860"},{"id":"A2","pred":"hp_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"A3","pred":"hp_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/HP_0012539"},{"id":"A4","pred":"hp_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/HP_0001945"},{"id":"A5","pred":"hp_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/HP_0001888"},{"id":"A6","pred":"hp_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/HP_0100526"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T1","span":{"begin":0,"end":8},"obj":"Disease"},{"id":"T2","span":{"begin":152,"end":175},"obj":"Disease"},{"id":"T3","span":{"begin":166,"end":175},"obj":"Disease"},{"id":"T4","span":{"begin":188,"end":205},"obj":"Disease"},{"id":"T6","span":{"begin":199,"end":205},"obj":"Disease"},{"id":"T7","span":{"begin":219,"end":239},"obj":"Disease"},{"id":"T9","span":{"begin":223,"end":239},"obj":"Disease"},{"id":"T10","span":{"begin":231,"end":239},"obj":"Disease"},{"id":"T11","span":{"begin":275,"end":283},"obj":"Disease"},{"id":"T12","span":{"begin":285,"end":294},"obj":"Disease"},{"id":"T13","span":{"begin":421,"end":429},"obj":"Disease"},{"id":"T14","span":{"begin":516,"end":527},"obj":"Disease"},{"id":"T15","span":{"begin":1012,"end":1023},"obj":"Disease"},{"id":"T16","span":{"begin":1017,"end":1023},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0005096"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0004993"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0007576"},{"id":"A5","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0019086"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0011508"},{"id":"A8","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0018908"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0004952"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MONDO_0005062"},{"id":"A11","pred":"mondo_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A12","pred":"mondo_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A13","pred":"mondo_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A14","pred":"mondo_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/MONDO_0003783"},{"id":"A15","pred":"mondo_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/MONDO_0008903"},{"id":"A16","pred":"mondo_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1","span":{"begin":161,"end":165},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T2","span":{"begin":567,"end":572},"obj":"http://www.ebi.ac.uk/efo/EFO_0000965"},{"id":"T3","span":{"begin":1012,"end":1016},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T4","span":{"begin":1012,"end":1016},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1","span":{"begin":552,"end":559},"obj":"Chemical"},{"id":"T2","span":{"begin":801,"end":810},"obj":"Chemical"},{"id":"T3","span":{"begin":828,"end":837},"obj":"Chemical"},{"id":"T4","span":{"begin":842,"end":851},"obj":"Chemical"},{"id":"T5","span":{"begin":869,"end":887},"obj":"Chemical"}],"attributes":[{"id":"A1","pred":"chebi_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A2","pred":"chebi_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A3","pred":"chebi_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_45409"},{"id":"A4","pred":"chebi_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_31781"},{"id":"A5","pred":"chebi_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_5801"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":27},"obj":"Sentence"},{"id":"T2","span":{"begin":28,"end":103},"obj":"Sentence"},{"id":"T3","span":{"begin":104,"end":344},"obj":"Sentence"},{"id":"T4","span":{"begin":345,"end":379},"obj":"Sentence"},{"id":"T5","span":{"begin":380,"end":474},"obj":"Sentence"},{"id":"T6","span":{"begin":475,"end":566},"obj":"Sentence"},{"id":"T7","span":{"begin":567,"end":778},"obj":"Sentence"},{"id":"T8","span":{"begin":779,"end":888},"obj":"Sentence"},{"id":"T9","span":{"begin":889,"end":1066},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-sentences"},{"subj":"T2","pred":"source","obj":"LitCovid-sentences"},{"subj":"T3","pred":"source","obj":"LitCovid-sentences"},{"subj":"T4","pred":"source","obj":"LitCovid-sentences"},{"subj":"T5","pred":"source","obj":"LitCovid-sentences"},{"subj":"T6","pred":"source","obj":"LitCovid-sentences"},{"subj":"T7","pred":"source","obj":"LitCovid-sentences"},{"subj":"T8","pred":"source","obj":"LitCovid-sentences"},{"subj":"T9","pred":"source","obj":"LitCovid-sentences"}]},{"project":"hydroxychloroquine","denotations":[{"id":"T1","span":{"begin":152,"end":175},"obj":"Phenotype"},{"id":"T2","span":{"begin":199,"end":205},"obj":"Phenotype"},{"id":"T3","span":{"begin":219,"end":239},"obj":"Phenotype"},{"id":"T4","span":{"begin":373,"end":378},"obj":"Phenotype"},{"id":"T5","span":{"begin":516,"end":527},"obj":"Phenotype"},{"id":"T6","span":{"begin":1012,"end":1023},"obj":"Phenotype"}],"attributes":[{"id":"A6","pred":"hp_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/HP_0100526"},{"id":"A5","pred":"hp_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/HP_0001888"},{"id":"A3","pred":"hp_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/HP_0012539"},{"id":"A4","pred":"hp_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/HP_0001945"},{"id":"A1","pred":"hp_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/HP_0002860"},{"id":"A2","pred":"hp_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"subj":"T1","pred":"source","obj":"hydroxychloroquine"},{"subj":"T2","pred":"source","obj":"hydroxychloroquine"},{"subj":"T3","pred":"source","obj":"hydroxychloroquine"},{"subj":"T4","pred":"source","obj":"hydroxychloroquine"},{"subj":"T5","pred":"source","obj":"hydroxychloroquine"},{"subj":"T6","pred":"source","obj":"hydroxychloroquine"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"2","span":{"begin":0,"end":8},"obj":"Disease"},{"id":"3","span":{"begin":94,"end":102},"obj":"Species"},{"id":"27","span":{"begin":121,"end":129},"obj":"Species"},{"id":"28","span":{"begin":142,"end":175},"obj":"Disease"},{"id":"29","span":{"begin":199,"end":205},"obj":"Disease"},{"id":"30","span":{"begin":219,"end":239},"obj":"Disease"},{"id":"31","span":{"begin":257,"end":273},"obj":"Species"},{"id":"32","span":{"begin":275,"end":283},"obj":"Disease"},{"id":"33","span":{"begin":285,"end":294},"obj":"Disease"},{"id":"34","span":{"begin":349,"end":357},"obj":"Species"},{"id":"35","span":{"begin":373,"end":378},"obj":"Disease"},{"id":"36","span":{"begin":421,"end":429},"obj":"Disease"},{"id":"37","span":{"begin":516,"end":527},"obj":"Disease"},{"id":"38","span":{"begin":541,"end":559},"obj":"Gene"},{"id":"39","span":{"begin":561,"end":564},"obj":"Gene"},{"id":"40","span":{"begin":655,"end":681},"obj":"Disease"},{"id":"41","span":{"begin":770,"end":777},"obj":"Species"},{"id":"42","span":{"begin":783,"end":791},"obj":"Species"},{"id":"43","span":{"begin":828,"end":837},"obj":"Chemical"},{"id":"44","span":{"begin":842,"end":851},"obj":"Chemical"},{"id":"45","span":{"begin":869,"end":887},"obj":"Chemical"},{"id":"46","span":{"begin":912,"end":920},"obj":"Species"},{"id":"47","span":{"begin":935,"end":947},"obj":"Disease"},{"id":"48","span":{"begin":999,"end":1006},"obj":"Species"},{"id":"49","span":{"begin":1012,"end":1023},"obj":"Disease"}],"attributes":[{"id":"A2","pred":"tao:has_database_id","subj":"2","obj":"MESH:C000657245"},{"id":"A3","pred":"tao:has_database_id","subj":"3","obj":"Tax:9606"},{"id":"A27","pred":"tao:has_database_id","subj":"27","obj":"Tax:9606"},{"id":"A28","pred":"tao:has_database_id","subj":"28","obj":"MESH:D002294"},{"id":"A29","pred":"tao:has_database_id","subj":"29","obj":"MESH:D009369"},{"id":"A30","pred":"tao:has_database_id","subj":"30","obj":"MESH:D008228"},{"id":"A31","pred":"tao:has_database_id","subj":"31","obj":"Tax:2697049"},{"id":"A32","pred":"tao:has_database_id","subj":"32","obj":"MESH:C000657245"},{"id":"A33","pred":"tao:has_database_id","subj":"33","obj":"MESH:D007239"},{"id":"A34","pred":"tao:has_database_id","subj":"34","obj":"Tax:9606"},{"id":"A35","pred":"tao:has_database_id","subj":"35","obj":"MESH:D005334"},{"id":"A36","pred":"tao:has_database_id","subj":"36","obj":"MESH:C000657245"},{"id":"A37","pred":"tao:has_database_id","subj":"37","obj":"MESH:D008231"},{"id":"A38","pred":"tao:has_database_id","subj":"38","obj":"Gene:1401"},{"id":"A39","pred":"tao:has_database_id","subj":"39","obj":"Gene:1401"},{"id":"A40","pred":"tao:has_database_id","subj":"40","obj":"MESH:D009395"},{"id":"A41","pred":"tao:has_database_id","subj":"41","obj":"Tax:9606"},{"id":"A42","pred":"tao:has_database_id","subj":"42","obj":"Tax:9606"},{"id":"A43","pred":"tao:has_database_id","subj":"43","obj":"MESH:D019438"},{"id":"A44","pred":"tao:has_database_id","subj":"44","obj":"MESH:D061466"},{"id":"A45","pred":"tao:has_database_id","subj":"45","obj":"MESH:D006886"},{"id":"A46","pred":"tao:has_database_id","subj":"46","obj":"Tax:9606"},{"id":"A47","pred":"tao:has_database_id","subj":"47","obj":"MESH:D003643"},{"id":"A48","pred":"tao:has_database_id","subj":"48","obj":"Tax:9606"},{"id":"A49","pred":"tao:has_database_id","subj":"49","obj":"MESH:D008175"},{"subj":"2","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3","pred":"source","obj":"LitCovid-PubTator"},{"subj":"27","pred":"source","obj":"LitCovid-PubTator"},{"subj":"28","pred":"source","obj":"LitCovid-PubTator"},{"subj":"29","pred":"source","obj":"LitCovid-PubTator"},{"subj":"30","pred":"source","obj":"LitCovid-PubTator"},{"subj":"31","pred":"source","obj":"LitCovid-PubTator"},{"subj":"32","pred":"source","obj":"LitCovid-PubTator"},{"subj":"33","pred":"source","obj":"LitCovid-PubTator"},{"subj":"34","pred":"source","obj":"LitCovid-PubTator"},{"subj":"35","pred":"source","obj":"LitCovid-PubTator"},{"subj":"36","pred":"source","obj":"LitCovid-PubTator"},{"subj":"37","pred":"source","obj":"LitCovid-PubTator"},{"subj":"38","pred":"source","obj":"LitCovid-PubTator"},{"subj":"39","pred":"source","obj":"LitCovid-PubTator"},{"subj":"40","pred":"source","obj":"LitCovid-PubTator"},{"subj":"41","pred":"source","obj":"LitCovid-PubTator"},{"subj":"42","pred":"source","obj":"LitCovid-PubTator"},{"subj":"43","pred":"source","obj":"LitCovid-PubTator"},{"subj":"44","pred":"source","obj":"LitCovid-PubTator"},{"subj":"45","pred":"source","obj":"LitCovid-PubTator"},{"subj":"46","pred":"source","obj":"LitCovid-PubTator"},{"subj":"47","pred":"source","obj":"LitCovid-PubTator"},{"subj":"48","pred":"source","obj":"LitCovid-PubTator"},{"subj":"49","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#93bcec","default":true},{"id":"LitCovid-PD-UBERON","color":"#d6ec93"},{"id":"LitCovid-PD-HP","color":"#e793ec"},{"id":"LitCovid-PD-MONDO","color":"#93eccd"},{"id":"LitCovid-PD-CLO","color":"#ecb393"},{"id":"LitCovid-PD-CHEBI","color":"#9993ec"},{"id":"LitCovid-sentences","color":"#a6ec93"},{"id":"hydroxychloroquine","color":"#ec93c0"},{"id":"LitCovid-PubTator","color":"#93daec"}]}]}}