PubMed:32936438 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/32936438","sourcedb":"PubMed","sourceid":"32936438","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/32936438","text":"Steroids and COVID-19: We Need a Precision Approach, Not One Size Fits All.\nCOVID-19 is a new infectious disease causing severe respiratory failure and death for which optimal treatment is currently unclear. Many therapies have been proven to be ineffective; however, promising findings related to corticosteroid therapy have been published. Analysis of published data including in this issue suggests that therapy with corticosteroids in the range of 6 mg of dexamethasone (or equivalent) per day likely has a positive effect in patients requiring mechanical ventilation but there remains considerable doubt in patients over the age of 70, in patients with diabetes and patients with milder disease. Clinicians must consider the individual potential risks and benefits of corticosteroid in patients with COVID-19 rather than routinely using them until more data is available.","tracks":[{"project":"LitCovid-PD-HP","denotations":[{"id":"T1","span":{"begin":128,"end":147},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/HP_0002878"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T1","span":{"begin":13,"end":21},"obj":"Disease"},{"id":"T2","span":{"begin":76,"end":84},"obj":"Disease"},{"id":"T3","span":{"begin":94,"end":112},"obj":"Disease"},{"id":"T4","span":{"begin":128,"end":147},"obj":"Disease"},{"id":"T5","span":{"begin":658,"end":666},"obj":"Disease"},{"id":"T6","span":{"begin":805,"end":813},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0021113"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0005015"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1","span":{"begin":31,"end":32},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T2","span":{"begin":88,"end":89},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T3","span":{"begin":505,"end":508},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T4","span":{"begin":509,"end":510},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1","span":{"begin":298,"end":312},"obj":"Chemical"},{"id":"T2","span":{"begin":420,"end":435},"obj":"Chemical"},{"id":"T3","span":{"begin":460,"end":473},"obj":"Chemical"},{"id":"T4","span":{"begin":773,"end":787},"obj":"Chemical"}],"attributes":[{"id":"A1","pred":"chebi_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_50858"},{"id":"A2","pred":"chebi_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_50858"},{"id":"A3","pred":"chebi_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_41879"},{"id":"A4","pred":"chebi_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_50858"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"3","span":{"begin":0,"end":8},"obj":"Chemical"},{"id":"4","span":{"begin":13,"end":21},"obj":"Disease"},{"id":"5","span":{"begin":66,"end":70},"obj":"Disease"},{"id":"18","span":{"begin":76,"end":84},"obj":"Disease"},{"id":"19","span":{"begin":94,"end":112},"obj":"Disease"},{"id":"20","span":{"begin":121,"end":147},"obj":"Disease"},{"id":"21","span":{"begin":152,"end":157},"obj":"Disease"},{"id":"22","span":{"begin":460,"end":473},"obj":"Chemical"},{"id":"23","span":{"begin":530,"end":538},"obj":"Species"},{"id":"24","span":{"begin":612,"end":620},"obj":"Species"},{"id":"25","span":{"begin":644,"end":652},"obj":"Species"},{"id":"26","span":{"begin":658,"end":666},"obj":"Disease"},{"id":"27","span":{"begin":671,"end":679},"obj":"Species"},{"id":"28","span":{"begin":791,"end":799},"obj":"Species"},{"id":"29","span":{"begin":805,"end":813},"obj":"Disease"}],"attributes":[{"id":"A3","pred":"tao:has_database_id","subj":"3","obj":"MESH:D013256"},{"id":"A4","pred":"tao:has_database_id","subj":"4","obj":"MESH:C000657245"},{"id":"A5","pred":"tao:has_database_id","subj":"5","obj":"MESH:D012640"},{"id":"A18","pred":"tao:has_database_id","subj":"18","obj":"MESH:C000657245"},{"id":"A19","pred":"tao:has_database_id","subj":"19","obj":"MESH:D003141"},{"id":"A20","pred":"tao:has_database_id","subj":"20","obj":"MESH:D012131"},{"id":"A21","pred":"tao:has_database_id","subj":"21","obj":"MESH:D003643"},{"id":"A22","pred":"tao:has_database_id","subj":"22","obj":"MESH:D003907"},{"id":"A23","pred":"tao:has_database_id","subj":"23","obj":"Tax:9606"},{"id":"A24","pred":"tao:has_database_id","subj":"24","obj":"Tax:9606"},{"id":"A25","pred":"tao:has_database_id","subj":"25","obj":"Tax:9606"},{"id":"A26","pred":"tao:has_database_id","subj":"26","obj":"MESH:D003920"},{"id":"A27","pred":"tao:has_database_id","subj":"27","obj":"Tax:9606"},{"id":"A28","pred":"tao:has_database_id","subj":"28","obj":"Tax:9606"},{"id":"A29","pred":"tao:has_database_id","subj":"29","obj":"MESH:C000657245"},{"subj":"3","pred":"source","obj":"LitCovid-PubTator"},{"subj":"4","pred":"source","obj":"LitCovid-PubTator"},{"subj":"5","pred":"source","obj":"LitCovid-PubTator"},{"subj":"18","pred":"source","obj":"LitCovid-PubTator"},{"subj":"19","pred":"source","obj":"LitCovid-PubTator"},{"subj":"20","pred":"source","obj":"LitCovid-PubTator"},{"subj":"21","pred":"source","obj":"LitCovid-PubTator"},{"subj":"22","pred":"source","obj":"LitCovid-PubTator"},{"subj":"23","pred":"source","obj":"LitCovid-PubTator"},{"subj":"24","pred":"source","obj":"LitCovid-PubTator"},{"subj":"25","pred":"source","obj":"LitCovid-PubTator"},{"subj":"26","pred":"source","obj":"LitCovid-PubTator"},{"subj":"27","pred":"source","obj":"LitCovid-PubTator"},{"subj":"28","pred":"source","obj":"LitCovid-PubTator"},{"subj":"29","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":22},"obj":"Sentence"},{"id":"T2","span":{"begin":23,"end":75},"obj":"Sentence"},{"id":"T3","span":{"begin":76,"end":207},"obj":"Sentence"},{"id":"T4","span":{"begin":208,"end":341},"obj":"Sentence"},{"id":"T5","span":{"begin":342,"end":700},"obj":"Sentence"},{"id":"T6","span":{"begin":701,"end":876},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-sentences"},{"subj":"T2","pred":"source","obj":"LitCovid-sentences"},{"subj":"T3","pred":"source","obj":"LitCovid-sentences"},{"subj":"T4","pred":"source","obj":"LitCovid-sentences"},{"subj":"T5","pred":"source","obj":"LitCovid-sentences"},{"subj":"T6","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-HP","color":"#93abec","default":true},{"id":"LitCovid-PD-MONDO","color":"#c5ec93"},{"id":"LitCovid-PD-CLO","color":"#ec93df"},{"id":"LitCovid-PD-CHEBI","color":"#93ecde"},{"id":"LitCovid-PubTator","color":"#ecc493"},{"id":"LitCovid-sentences","color":"#aa93ec"}]}]}}