PubMed:32926596 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/32926596","sourcedb":"PubMed","sourceid":"32926596","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/32926596","text":"Progression to Fibrosing Diffuse Alveolar Damage in a Series of 30 Minimally Invasive Autopsies with COVID-19 Pneumonia in Wuhan, China.\nAIMS: Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus -2 (SARS-CoV-2) infection has been deemed as a global pandemic by World Health Organization. While diffuse alveolar damage (DAD) is recognized to be the primary manifestation COVID-19 pneumonia, there has been little emphasis on the progression to the fibrosing phase of DAD. This topic is of great interest due to growing concerns regarding the potential long-term complications in prolonged survivors.\nMETHODS: Here we report a detailed histopathologic study of thirty autopsy cases with COVID-19 virus infection, based on minimally invasive autopsies performed between February to March, 2020.\nRESULTS: The mean age was 69 years, with twenty (67%) males and 10 (33%) females and frequent (70.0%) underlying comorbidities. The duration of illness ranged from 16 to 82 (median=42) days. Histologically, the most common manifestation was diffuse alveolar damage (DAD) in 28 (93.3%) cases which showed predominantly acute (32%), organizing (25%), and/or fibrosing (43%) patterns. Patients with fibrosing DAD were one decade younger (p=0.034) and they had a longer duration of illness (p=0.033), hospitalization (p=0.037) and mechanical ventilation (p=0.014) compared to those with acute DAD. Patients with organizing DAD had a longer duration of illness (p=0.032) and hospitalization (p=0.023) compared to those with acute DAD.\nCONCLUSIONS: COVID-19 pneumonia patients who develop DAD can progress to the fibrosing pattern. While we observed fibrosing DAD in fatal cases, whether surviving patients are at risk for developing pulmonary fibrosis and the frequency of this complication will require further clinical and radiologic follow-up studies.","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T1","span":{"begin":33,"end":41},"obj":"Body_part"},{"id":"T2","span":{"begin":342,"end":350},"obj":"Body_part"},{"id":"T3","span":{"begin":1081,"end":1089},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma264783"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma264783"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma264783"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T1","span":{"begin":25,"end":48},"obj":"Phenotype"},{"id":"T2","span":{"begin":110,"end":119},"obj":"Phenotype"},{"id":"T3","span":{"begin":334,"end":357},"obj":"Phenotype"},{"id":"T4","span":{"begin":359,"end":362},"obj":"Phenotype"},{"id":"T5","span":{"begin":419,"end":428},"obj":"Phenotype"},{"id":"T6","span":{"begin":506,"end":509},"obj":"Phenotype"},{"id":"T7","span":{"begin":1073,"end":1096},"obj":"Phenotype"},{"id":"T8","span":{"begin":1098,"end":1101},"obj":"Phenotype"},{"id":"T9","span":{"begin":1238,"end":1241},"obj":"Phenotype"},{"id":"T10","span":{"begin":1421,"end":1424},"obj":"Phenotype"},{"id":"T11","span":{"begin":1451,"end":1454},"obj":"Phenotype"},{"id":"T12","span":{"begin":1557,"end":1560},"obj":"Phenotype"},{"id":"T13","span":{"begin":1584,"end":1593},"obj":"Phenotype"},{"id":"T14","span":{"begin":1615,"end":1618},"obj":"Phenotype"},{"id":"T15","span":{"begin":1686,"end":1689},"obj":"Phenotype"},{"id":"T16","span":{"begin":1760,"end":1778},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/HP_0033006"},{"id":"A2","pred":"hp_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/HP_0002090"},{"id":"A3","pred":"hp_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/HP_0033006"},{"id":"A4","pred":"hp_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/HP_0033006"},{"id":"A5","pred":"hp_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/HP_0002090"},{"id":"A6","pred":"hp_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/HP_0033006"},{"id":"A7","pred":"hp_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/HP_0033006"},{"id":"A8","pred":"hp_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/HP_0033006"},{"id":"A9","pred":"hp_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/HP_0033006"},{"id":"A10","pred":"hp_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/HP_0033006"},{"id":"A11","pred":"hp_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/HP_0033006"},{"id":"A12","pred":"hp_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/HP_0033006"},{"id":"A13","pred":"hp_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/HP_0002090"},{"id":"A14","pred":"hp_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/HP_0033006"},{"id":"A15","pred":"hp_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/HP_0033006"},{"id":"A16","pred":"hp_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/HP_0002206"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T1","span":{"begin":101,"end":109},"obj":"Disease"},{"id":"T2","span":{"begin":110,"end":119},"obj":"Disease"},{"id":"T3","span":{"begin":143,"end":167},"obj":"Disease"},{"id":"T4","span":{"begin":169,"end":177},"obj":"Disease"},{"id":"T5","span":{"begin":189,"end":237},"obj":"Disease"},{"id":"T6","span":{"begin":239,"end":247},"obj":"Disease"},{"id":"T7","span":{"begin":251,"end":260},"obj":"Disease"},{"id":"T8","span":{"begin":410,"end":418},"obj":"Disease"},{"id":"T9","span":{"begin":419,"end":428},"obj":"Disease"},{"id":"T10","span":{"begin":725,"end":733},"obj":"Disease"},{"id":"T11","span":{"begin":734,"end":749},"obj":"Disease"},{"id":"T12","span":{"begin":740,"end":749},"obj":"Disease"},{"id":"T13","span":{"begin":1575,"end":1583},"obj":"Disease"},{"id":"T14","span":{"begin":1584,"end":1593},"obj":"Disease"},{"id":"T15","span":{"begin":1760,"end":1778},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A11","pred":"mondo_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A12","pred":"mondo_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A13","pred":"mondo_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A14","pred":"mondo_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"},{"id":"A15","pred":"mondo_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/MONDO_0002771"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1","span":{"begin":52,"end":53},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T2","span":{"begin":137,"end":141},"obj":"http://purl.obolibrary.org/obo/PR_000001343"},{"id":"T3","span":{"begin":261,"end":264},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T4","span":{"begin":280,"end":281},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T5","span":{"begin":314,"end":326},"obj":"http://purl.obolibrary.org/obo/OBI_0000245"},{"id":"T6","span":{"begin":436,"end":439},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T7","span":{"begin":663,"end":664},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T8","span":{"begin":734,"end":739},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T9","span":{"begin":886,"end":891},"obj":"http://purl.obolibrary.org/obo/UBERON_0003101"},{"id":"T10","span":{"begin":886,"end":891},"obj":"http://www.ebi.ac.uk/efo/EFO_0000970"},{"id":"T11","span":{"begin":905,"end":912},"obj":"http://purl.obolibrary.org/obo/UBERON_0003100"},{"id":"T12","span":{"begin":1163,"end":1173},"obj":"http://purl.obolibrary.org/obo/OBI_0000245"},{"id":"T13","span":{"begin":1289,"end":1290},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T14","span":{"begin":1440,"end":1450},"obj":"http://purl.obolibrary.org/obo/OBI_0000245"},{"id":"T15","span":{"begin":1459,"end":1460},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":136},"obj":"Sentence"},{"id":"T2","span":{"begin":137,"end":142},"obj":"Sentence"},{"id":"T3","span":{"begin":143,"end":327},"obj":"Sentence"},{"id":"T4","span":{"begin":328,"end":510},"obj":"Sentence"},{"id":"T5","span":{"begin":511,"end":638},"obj":"Sentence"},{"id":"T6","span":{"begin":639,"end":647},"obj":"Sentence"},{"id":"T7","span":{"begin":648,"end":831},"obj":"Sentence"},{"id":"T8","span":{"begin":832,"end":840},"obj":"Sentence"},{"id":"T9","span":{"begin":841,"end":959},"obj":"Sentence"},{"id":"T10","span":{"begin":960,"end":1022},"obj":"Sentence"},{"id":"T11","span":{"begin":1023,"end":1213},"obj":"Sentence"},{"id":"T12","span":{"begin":1214,"end":1425},"obj":"Sentence"},{"id":"T13","span":{"begin":1426,"end":1561},"obj":"Sentence"},{"id":"T14","span":{"begin":1562,"end":1657},"obj":"Sentence"},{"id":"T15","span":{"begin":1658,"end":1881},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-sentences"},{"subj":"T2","pred":"source","obj":"LitCovid-sentences"},{"subj":"T3","pred":"source","obj":"LitCovid-sentences"},{"subj":"T4","pred":"source","obj":"LitCovid-sentences"},{"subj":"T5","pred":"source","obj":"LitCovid-sentences"},{"subj":"T6","pred":"source","obj":"LitCovid-sentences"},{"subj":"T7","pred":"source","obj":"LitCovid-sentences"},{"subj":"T8","pred":"source","obj":"LitCovid-sentences"},{"subj":"T9","pred":"source","obj":"LitCovid-sentences"},{"subj":"T10","pred":"source","obj":"LitCovid-sentences"},{"subj":"T11","pred":"source","obj":"LitCovid-sentences"},{"subj":"T12","pred":"source","obj":"LitCovid-sentences"},{"subj":"T13","pred":"source","obj":"LitCovid-sentences"},{"subj":"T14","pred":"source","obj":"LitCovid-sentences"},{"subj":"T15","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"1","span":{"begin":101,"end":119},"obj":"Disease"},{"id":"15","span":{"begin":143,"end":167},"obj":"Disease"},{"id":"16","span":{"begin":169,"end":177},"obj":"Disease"},{"id":"17","span":{"begin":189,"end":237},"obj":"Species"},{"id":"18","span":{"begin":239,"end":249},"obj":"Species"},{"id":"19","span":{"begin":251,"end":260},"obj":"Disease"},{"id":"20","span":{"begin":410,"end":428},"obj":"Disease"},{"id":"21","span":{"begin":734,"end":749},"obj":"Disease"},{"id":"22","span":{"begin":1214,"end":1222},"obj":"Species"},{"id":"23","span":{"begin":1426,"end":1434},"obj":"Species"},{"id":"24","span":{"begin":1575,"end":1593},"obj":"Disease"},{"id":"25","span":{"begin":1594,"end":1602},"obj":"Species"},{"id":"26","span":{"begin":1724,"end":1732},"obj":"Species"},{"id":"27","span":{"begin":1760,"end":1778},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"tao:has_database_id","subj":"1","obj":"MESH:C000657245"},{"id":"A15","pred":"tao:has_database_id","subj":"15","obj":"MESH:C000657245"},{"id":"A16","pred":"tao:has_database_id","subj":"16","obj":"MESH:C000657245"},{"id":"A17","pred":"tao:has_database_id","subj":"17","obj":"Tax:2697049"},{"id":"A18","pred":"tao:has_database_id","subj":"18","obj":"Tax:2697049"},{"id":"A19","pred":"tao:has_database_id","subj":"19","obj":"MESH:D007239"},{"id":"A20","pred":"tao:has_database_id","subj":"20","obj":"MESH:C000657245"},{"id":"A21","pred":"tao:has_database_id","subj":"21","obj":"MESH:D001102"},{"id":"A22","pred":"tao:has_database_id","subj":"22","obj":"Tax:9606"},{"id":"A23","pred":"tao:has_database_id","subj":"23","obj":"Tax:9606"},{"id":"A24","pred":"tao:has_database_id","subj":"24","obj":"MESH:C000657245"},{"id":"A25","pred":"tao:has_database_id","subj":"25","obj":"Tax:9606"},{"id":"A26","pred":"tao:has_database_id","subj":"26","obj":"Tax:9606"},{"id":"A27","pred":"tao:has_database_id","subj":"27","obj":"MESH:D011658"},{"subj":"1","pred":"source","obj":"LitCovid-PubTator"},{"subj":"15","pred":"source","obj":"LitCovid-PubTator"},{"subj":"16","pred":"source","obj":"LitCovid-PubTator"},{"subj":"17","pred":"source","obj":"LitCovid-PubTator"},{"subj":"18","pred":"source","obj":"LitCovid-PubTator"},{"subj":"19","pred":"source","obj":"LitCovid-PubTator"},{"subj":"20","pred":"source","obj":"LitCovid-PubTator"},{"subj":"21","pred":"source","obj":"LitCovid-PubTator"},{"subj":"22","pred":"source","obj":"LitCovid-PubTator"},{"subj":"23","pred":"source","obj":"LitCovid-PubTator"},{"subj":"24","pred":"source","obj":"LitCovid-PubTator"},{"subj":"25","pred":"source","obj":"LitCovid-PubTator"},{"subj":"26","pred":"source","obj":"LitCovid-PubTator"},{"subj":"27","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid_AGAC_only","denotations":[{"id":"p171106s8","span":{"begin":179,"end":188},"obj":"Reg"}],"attributes":[{"subj":"p171106s8","pred":"source","obj":"LitCovid_AGAC_only"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#93ec9c","default":true},{"id":"LitCovid-PD-HP","color":"#ec93a3"},{"id":"LitCovid-PD-MONDO","color":"#93bdec"},{"id":"LitCovid-PD-CLO","color":"#d7ec93"},{"id":"LitCovid-sentences","color":"#e793ec"},{"id":"LitCovid-PubTator","color":"#93eccd"},{"id":"LitCovid_AGAC_only","color":"#ecb393"}]}]}}