PubMed:32921678 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T1","span":{"begin":177,"end":183},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma7203"}],"text":"Suspected Hydroxychloroquine-Induced Sinus Bradycardia and QTc Prolongation in a Patient with COVID-19.\nAn 84-year-old woman with hypertension, Alzheimer's disease, and chronic kidney disease presented with fever and was diagnosed with corona virus disease 2019 (COVID-19). During the hospitalization, she experienced unexpected sinus bradycardia with prolonged QTc, which was thought to be closely related to the short-term use of hydroxychloroquine (HCQ), an old drug used to treat malaria and autoimmune diseases, but now used against COVID-19. The cardiac side effects of HCQ were rare, seen with short-term and low-dose use. With the COVID-19 pandemic, this case alerts clinicians to be aware of the arrhythmogenic effects of HCQ when it is used as an antiviral drug, especially in patients with preexisting cardiovascular diseases."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T1","span":{"begin":177,"end":183},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0002113"}],"text":"Suspected Hydroxychloroquine-Induced Sinus Bradycardia and QTc Prolongation in a Patient with COVID-19.\nAn 84-year-old woman with hypertension, Alzheimer's disease, and chronic kidney disease presented with fever and was diagnosed with corona virus disease 2019 (COVID-19). During the hospitalization, she experienced unexpected sinus bradycardia with prolonged QTc, which was thought to be closely related to the short-term use of hydroxychloroquine (HCQ), an old drug used to treat malaria and autoimmune diseases, but now used against COVID-19. The cardiac side effects of HCQ were rare, seen with short-term and low-dose use. With the COVID-19 pandemic, this case alerts clinicians to be aware of the arrhythmogenic effects of HCQ when it is used as an antiviral drug, especially in patients with preexisting cardiovascular diseases."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T1","span":{"begin":94,"end":102},"obj":"Disease"},{"id":"T2","span":{"begin":130,"end":142},"obj":"Disease"},{"id":"T3","span":{"begin":144,"end":163},"obj":"Disease"},{"id":"T4","span":{"begin":169,"end":191},"obj":"Disease"},{"id":"T5","span":{"begin":177,"end":191},"obj":"Disease"},{"id":"T7","span":{"begin":236,"end":261},"obj":"Disease"},{"id":"T8","span":{"begin":263,"end":271},"obj":"Disease"},{"id":"T9","span":{"begin":484,"end":491},"obj":"Disease"},{"id":"T10","span":{"begin":496,"end":515},"obj":"Disease"},{"id":"T11","span":{"begin":538,"end":546},"obj":"Disease"},{"id":"T12","span":{"begin":639,"end":647},"obj":"Disease"},{"id":"T13","span":{"begin":813,"end":836},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0005044"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0004975"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0005300"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0001343"},{"id":"A6","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0005240"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0005136"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MONDO_0007179"},{"id":"A11","pred":"mondo_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A12","pred":"mondo_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A13","pred":"mondo_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/MONDO_0004995"}],"text":"Suspected Hydroxychloroquine-Induced Sinus Bradycardia and QTc Prolongation in a Patient with COVID-19.\nAn 84-year-old woman with hypertension, Alzheimer's disease, and chronic kidney disease presented with fever and was diagnosed with corona virus disease 2019 (COVID-19). During the hospitalization, she experienced unexpected sinus bradycardia with prolonged QTc, which was thought to be closely related to the short-term use of hydroxychloroquine (HCQ), an old drug used to treat malaria and autoimmune diseases, but now used against COVID-19. The cardiac side effects of HCQ were rare, seen with short-term and low-dose use. With the COVID-19 pandemic, this case alerts clinicians to be aware of the arrhythmogenic effects of HCQ when it is used as an antiviral drug, especially in patients with preexisting cardiovascular diseases."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1","span":{"begin":79,"end":80},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T2","span":{"begin":177,"end":183},"obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"T3","span":{"begin":177,"end":183},"obj":"http://www.ebi.ac.uk/efo/EFO_0000927"},{"id":"T4","span":{"begin":177,"end":183},"obj":"http://www.ebi.ac.uk/efo/EFO_0000929"},{"id":"T5","span":{"begin":243,"end":248},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"}],"text":"Suspected Hydroxychloroquine-Induced Sinus Bradycardia and QTc Prolongation in a Patient with COVID-19.\nAn 84-year-old woman with hypertension, Alzheimer's disease, and chronic kidney disease presented with fever and was diagnosed with corona virus disease 2019 (COVID-19). During the hospitalization, she experienced unexpected sinus bradycardia with prolonged QTc, which was thought to be closely related to the short-term use of hydroxychloroquine (HCQ), an old drug used to treat malaria and autoimmune diseases, but now used against COVID-19. The cardiac side effects of HCQ were rare, seen with short-term and low-dose use. With the COVID-19 pandemic, this case alerts clinicians to be aware of the arrhythmogenic effects of HCQ when it is used as an antiviral drug, especially in patients with preexisting cardiovascular diseases."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1","span":{"begin":236,"end":242},"obj":"Chemical"},{"id":"T2","span":{"begin":432,"end":450},"obj":"Chemical"},{"id":"T3","span":{"begin":465,"end":469},"obj":"Chemical"},{"id":"T4","span":{"begin":757,"end":771},"obj":"Chemical"},{"id":"T5","span":{"begin":757,"end":766},"obj":"Chemical"},{"id":"T6","span":{"begin":767,"end":771},"obj":"Chemical"}],"attributes":[{"id":"A1","pred":"chebi_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_37409"},{"id":"A2","pred":"chebi_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_5801"},{"id":"A3","pred":"chebi_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A4","pred":"chebi_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_36044"},{"id":"A5","pred":"chebi_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A6","pred":"chebi_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"}],"text":"Suspected Hydroxychloroquine-Induced Sinus Bradycardia and QTc Prolongation in a Patient with COVID-19.\nAn 84-year-old woman with hypertension, Alzheimer's disease, and chronic kidney disease presented with fever and was diagnosed with corona virus disease 2019 (COVID-19). During the hospitalization, she experienced unexpected sinus bradycardia with prolonged QTc, which was thought to be closely related to the short-term use of hydroxychloroquine (HCQ), an old drug used to treat malaria and autoimmune diseases, but now used against COVID-19. The cardiac side effects of HCQ were rare, seen with short-term and low-dose use. With the COVID-19 pandemic, this case alerts clinicians to be aware of the arrhythmogenic effects of HCQ when it is used as an antiviral drug, especially in patients with preexisting cardiovascular diseases."}

{"project":"LitCovid-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":103},"obj":"Sentence"},{"id":"T2","span":{"begin":104,"end":273},"obj":"Sentence"},{"id":"T3","span":{"begin":274,"end":547},"obj":"Sentence"},{"id":"T4","span":{"begin":548,"end":629},"obj":"Sentence"},{"id":"T5","span":{"begin":630,"end":837},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Suspected Hydroxychloroquine-Induced Sinus Bradycardia and QTc Prolongation in a Patient with COVID-19.\nAn 84-year-old woman with hypertension, Alzheimer's disease, and chronic kidney disease presented with fever and was diagnosed with corona virus disease 2019 (COVID-19). During the hospitalization, she experienced unexpected sinus bradycardia with prolonged QTc, which was thought to be closely related to the short-term use of hydroxychloroquine (HCQ), an old drug used to treat malaria and autoimmune diseases, but now used against COVID-19. The cardiac side effects of HCQ were rare, seen with short-term and low-dose use. With the COVID-19 pandemic, this case alerts clinicians to be aware of the arrhythmogenic effects of HCQ when it is used as an antiviral drug, especially in patients with preexisting cardiovascular diseases."}

{"project":"LitCovid-PubTator","denotations":[{"id":"4","span":{"begin":10,"end":28},"obj":"Chemical"},{"id":"5","span":{"begin":37,"end":75},"obj":"Disease"},{"id":"6","span":{"begin":81,"end":88},"obj":"Species"},{"id":"7","span":{"begin":94,"end":102},"obj":"Disease"},{"id":"26","span":{"begin":119,"end":124},"obj":"Species"},{"id":"27","span":{"begin":130,"end":142},"obj":"Disease"},{"id":"28","span":{"begin":144,"end":163},"obj":"Disease"},{"id":"29","span":{"begin":169,"end":191},"obj":"Disease"},{"id":"30","span":{"begin":207,"end":212},"obj":"Disease"},{"id":"31","span":{"begin":236,"end":261},"obj":"Disease"},{"id":"32","span":{"begin":263,"end":271},"obj":"Disease"},{"id":"33","span":{"begin":329,"end":346},"obj":"Disease"},{"id":"34","span":{"begin":432,"end":450},"obj":"Chemical"},{"id":"35","span":{"begin":452,"end":455},"obj":"Chemical"},{"id":"36","span":{"begin":484,"end":491},"obj":"Disease"},{"id":"37","span":{"begin":496,"end":515},"obj":"Disease"},{"id":"38","span":{"begin":538,"end":546},"obj":"Disease"},{"id":"39","span":{"begin":576,"end":579},"obj":"Chemical"},{"id":"40","span":{"begin":639,"end":647},"obj":"Disease"},{"id":"41","span":{"begin":731,"end":734},"obj":"Chemical"},{"id":"42","span":{"begin":787,"end":795},"obj":"Species"},{"id":"43","span":{"begin":813,"end":836},"obj":"Disease"}],"attributes":[{"id":"A4","pred":"tao:has_database_id","subj":"4","obj":"MESH:D006886"},{"id":"A5","pred":"tao:has_database_id","subj":"5","obj":"MESH:D012804"},{"id":"A6","pred":"tao:has_database_id","subj":"6","obj":"Tax:9606"},{"id":"A7","pred":"tao:has_database_id","subj":"7","obj":"MESH:C000657245"},{"id":"A26","pred":"tao:has_database_id","subj":"26","obj":"Tax:9606"},{"id":"A27","pred":"tao:has_database_id","subj":"27","obj":"MESH:D006973"},{"id":"A28","pred":"tao:has_database_id","subj":"28","obj":"MESH:D000544"},{"id":"A29","pred":"tao:has_database_id","subj":"29","obj":"MESH:D051436"},{"id":"A30","pred":"tao:has_database_id","subj":"30","obj":"MESH:D005334"},{"id":"A31","pred":"tao:has_database_id","subj":"31","obj":"MESH:C000657245"},{"id":"A32","pred":"tao:has_database_id","subj":"32","obj":"MESH:C000657245"},{"id":"A33","pred":"tao:has_database_id","subj":"33","obj":"MESH:D012804"},{"id":"A34","pred":"tao:has_database_id","subj":"34","obj":"MESH:D006886"},{"id":"A35","pred":"tao:has_database_id","subj":"35","obj":"MESH:D006886"},{"id":"A36","pred":"tao:has_database_id","subj":"36","obj":"MESH:D008288"},{"id":"A37","pred":"tao:has_database_id","subj":"37","obj":"MESH:D001327"},{"id":"A38","pred":"tao:has_database_id","subj":"38","obj":"MESH:C000657245"},{"id":"A39","pred":"tao:has_database_id","subj":"39","obj":"MESH:D006886"},{"id":"A40","pred":"tao:has_database_id","subj":"40","obj":"MESH:C000657245"},{"id":"A41","pred":"tao:has_database_id","subj":"41","obj":"MESH:D006886"},{"id":"A42","pred":"tao:has_database_id","subj":"42","obj":"Tax:9606"},{"id":"A43","pred":"tao:has_database_id","subj":"43","obj":"MESH:D002318"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Suspected Hydroxychloroquine-Induced Sinus Bradycardia and QTc Prolongation in a Patient with COVID-19.\nAn 84-year-old woman with hypertension, Alzheimer's disease, and chronic kidney disease presented with fever and was diagnosed with corona virus disease 2019 (COVID-19). During the hospitalization, she experienced unexpected sinus bradycardia with prolonged QTc, which was thought to be closely related to the short-term use of hydroxychloroquine (HCQ), an old drug used to treat malaria and autoimmune diseases, but now used against COVID-19. The cardiac side effects of HCQ were rare, seen with short-term and low-dose use. With the COVID-19 pandemic, this case alerts clinicians to be aware of the arrhythmogenic effects of HCQ when it is used as an antiviral drug, especially in patients with preexisting cardiovascular diseases."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T1","span":{"begin":37,"end":54},"obj":"Phenotype"},{"id":"T2","span":{"begin":130,"end":142},"obj":"Phenotype"},{"id":"T3","span":{"begin":144,"end":163},"obj":"Phenotype"},{"id":"T4","span":{"begin":169,"end":191},"obj":"Phenotype"},{"id":"T5","span":{"begin":207,"end":212},"obj":"Phenotype"},{"id":"T6","span":{"begin":329,"end":346},"obj":"Phenotype"},{"id":"T7","span":{"begin":496,"end":515},"obj":"Phenotype"},{"id":"T8","span":{"begin":813,"end":836},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/HP_0001688"},{"id":"A2","pred":"hp_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/HP_0000822"},{"id":"A3","pred":"hp_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/HP_0002511"},{"id":"A4","pred":"hp_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/HP_0012622"},{"id":"A5","pred":"hp_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/HP_0001945"},{"id":"A6","pred":"hp_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/HP_0001688"},{"id":"A7","pred":"hp_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/HP_0002960"},{"id":"A8","pred":"hp_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/HP_0001626"}],"text":"Suspected Hydroxychloroquine-Induced Sinus Bradycardia and QTc Prolongation in a Patient with COVID-19.\nAn 84-year-old woman with hypertension, Alzheimer's disease, and chronic kidney disease presented with fever and was diagnosed with corona virus disease 2019 (COVID-19). During the hospitalization, she experienced unexpected sinus bradycardia with prolonged QTc, which was thought to be closely related to the short-term use of hydroxychloroquine (HCQ), an old drug used to treat malaria and autoimmune diseases, but now used against COVID-19. The cardiac side effects of HCQ were rare, seen with short-term and low-dose use. With the COVID-19 pandemic, this case alerts clinicians to be aware of the arrhythmogenic effects of HCQ when it is used as an antiviral drug, especially in patients with preexisting cardiovascular diseases."}

{"project":"hydroxychloroquine","denotations":[{"id":"T1","span":{"begin":37,"end":54},"obj":"Phenotype"},{"id":"T2","span":{"begin":130,"end":142},"obj":"Phenotype"},{"id":"T3","span":{"begin":144,"end":163},"obj":"Phenotype"},{"id":"T4","span":{"begin":169,"end":191},"obj":"Phenotype"},{"id":"T5","span":{"begin":207,"end":212},"obj":"Phenotype"},{"id":"T6","span":{"begin":329,"end":346},"obj":"Phenotype"},{"id":"T7","span":{"begin":496,"end":515},"obj":"Phenotype"},{"id":"T8","span":{"begin":813,"end":836},"obj":"Phenotype"}],"attributes":[{"id":"A8","pred":"hp_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/HP_0001626"},{"id":"A6","pred":"hp_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/HP_0001688"},{"id":"A5","pred":"hp_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/HP_0001945"},{"id":"A3","pred":"hp_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/HP_0002511"},{"id":"A7","pred":"hp_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/HP_0002960"},{"id":"A2","pred":"hp_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/HP_0000822"},{"id":"A4","pred":"hp_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/HP_0012622"},{"id":"A1","pred":"hp_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/HP_0001688"}],"text":"Suspected Hydroxychloroquine-Induced Sinus Bradycardia and QTc Prolongation in a Patient with COVID-19.\nAn 84-year-old woman with hypertension, Alzheimer's disease, and chronic kidney disease presented with fever and was diagnosed with corona virus disease 2019 (COVID-19). During the hospitalization, she experienced unexpected sinus bradycardia with prolonged QTc, which was thought to be closely related to the short-term use of hydroxychloroquine (HCQ), an old drug used to treat malaria and autoimmune diseases, but now used against COVID-19. The cardiac side effects of HCQ were rare, seen with short-term and low-dose use. With the COVID-19 pandemic, this case alerts clinicians to be aware of the arrhythmogenic effects of HCQ when it is used as an antiviral drug, especially in patients with preexisting cardiovascular diseases."}

{"project":"LitCovid_AGAC_only","denotations":[{"id":"p168744s10","span":{"begin":144,"end":163},"obj":"Disease"}],"text":"Suspected Hydroxychloroquine-Induced Sinus Bradycardia and QTc Prolongation in a Patient with COVID-19.\nAn 84-year-old woman with hypertension, Alzheimer's disease, and chronic kidney disease presented with fever and was diagnosed with corona virus disease 2019 (COVID-19). During the hospitalization, she experienced unexpected sinus bradycardia with prolonged QTc, which was thought to be closely related to the short-term use of hydroxychloroquine (HCQ), an old drug used to treat malaria and autoimmune diseases, but now used against COVID-19. The cardiac side effects of HCQ were rare, seen with short-term and low-dose use. With the COVID-19 pandemic, this case alerts clinicians to be aware of the arrhythmogenic effects of HCQ when it is used as an antiviral drug, especially in patients with preexisting cardiovascular diseases."}