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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 160-177 Body_part denotes respiratory tract http://purl.org/sig/ont/fma/fma265130
T2 394-410 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T3 405-410 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T4 718-734 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T5 729-734 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T6 767-783 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T7 778-783 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T8 1069-1076 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 160-177 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 32-40 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T2 132-152 Disease denotes bacterial infections http://purl.obolibrary.org/obo/MONDO_0005113
T3 249-265 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T4 338-347 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T5 449-457 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T6 474-482 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T7 536-544 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T8 547-556 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T9 651-660 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T10 669-677 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T11 849-858 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T12 871-879 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T13 978-986 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T14 1148-1164 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 92-95 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T2 270-274 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T3 394-404 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T4 405-410 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5 507-508 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T6 713-717 http://purl.obolibrary.org/obo/CLO_0009524 denotes Vero
T7 713-717 http://purl.obolibrary.org/obo/CLO_0050515 denotes Vero
T8 718-728 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T9 729-734 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10 755-760 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T11 767-777 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T12 778-783 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13 1208-1213 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T14 1362-1363 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 0-11 Chemical denotes Sphingosine http://purl.obolibrary.org/obo/CHEBI_16393
T2 80-91 Chemical denotes Sphingosine http://purl.obolibrary.org/obo/CHEBI_16393
T3 205-216 Chemical denotes sphingosine http://purl.obolibrary.org/obo/CHEBI_16393
T4 312-323 Chemical denotes sphingosine http://purl.obolibrary.org/obo/CHEBI_16393
T5 598-609 Chemical denotes sphingosine http://purl.obolibrary.org/obo/CHEBI_16393
T6 628-632 Chemical denotes NaCl http://purl.obolibrary.org/obo/CHEBI_26710
T7 811-822 Chemical denotes sphingosine http://purl.obolibrary.org/obo/CHEBI_16393
T8 926-937 Chemical denotes sphingosine http://purl.obolibrary.org/obo/CHEBI_16393
T9 1069-1076 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T10 1113-1124 Chemical denotes sphingosine http://purl.obolibrary.org/obo/CHEBI_16393
T11 1316-1327 Chemical denotes sphingosine http://purl.obolibrary.org/obo/CHEBI_16393

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 249-265 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T2 1148-1164 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-79 Sentence denotes Sphingosine prevents binding of SARS-CoV-2 spike to its cellular receptor ACE2.
T2 80-266 Sentence denotes Sphingosine has been shown to prevent and eliminate bacterial infections of the respiratory tract, but it is unknown whether sphingosine can be also employed to prevent viral infections.
T3 267-557 Sentence denotes To test this hypothesis, we analyzed whether sphingosine regulates the infection of cultured and freshly isolated ex vivohuman epithelial cells with pseudoviral particles expressing SARS-CoV-2 spike (pp-VSV-SARS-CoV-2 spike) that served as a bona fide system mimicking SARS-CoV-2 infection.
T4 558-686 Sentence denotes We demonstrate that exogenously applied sphingosine suspended in 0.9% NaCl prevents cellular infection with pp-SARS-CoV-2 spike.
T5 687-888 Sentence denotes Pre-treatment of cultured Vero epithelial cells or freshly isolated human nasal epithelial cells with low concentrations of sphingosine prevented adhesion of and infection with pp-VSV-SARS-CoV-2 spike.
T6 889-1087 Sentence denotes Mechanistically, we demonstrate that sphingosine binds to ACE2, the cellular receptor of SARS-CoV-2, and prevents the interaction of the receptor binding domain of the viral spike protein with ACE2.
T7 1088-1232 Sentence denotes These data indicate that sphingosine prevents at least some viral infections by interfering with the interaction of the virus with its receptor.
T8 1233-1423 Sentence denotes Our data also suggest that further preclinical and finally clinical examination of sphingosine is warranted for potential use as a prophylactic or early treatment for coronavirus disease-19.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
4 0-11 Chemical denotes Sphingosine MESH:D013110
5 32-42 Species denotes SARS-CoV-2 Tax:2697049
6 43-48 Gene denotes spike Gene:43740568
7 74-78 Gene denotes ACE2 Gene:59272
38 80-91 Chemical denotes Sphingosine MESH:D013110
39 132-152 Disease denotes bacterial infections MESH:D001424
40 205-216 Chemical denotes sphingosine MESH:D013110
41 249-265 Disease denotes viral infections MESH:D001102
42 312-323 Chemical denotes sphingosine MESH:D013110
43 338-347 Disease denotes infection MESH:D007239
44 449-459 Species denotes SARS-CoV-2 Tax:2697049
45 460-465 Gene denotes spike Gene:43740568
46 474-484 Species denotes SARS-CoV-2 Tax:2697049
47 485-490 Gene denotes spike Gene:43740568
48 536-556 Disease denotes SARS-CoV-2 infection MESH:C000657245
49 598-609 Chemical denotes sphingosine MESH:D013110
50 628-632 Chemical denotes NaCl MESH:D012965
51 651-660 Disease denotes infection MESH:D007239
52 669-679 Species denotes SARS-CoV-2 Tax:2697049
53 680-685 Gene denotes spike Gene:43740568
54 755-760 Species denotes human Tax:9606
55 811-822 Chemical denotes sphingosine MESH:D013110
56 849-858 Disease denotes infection MESH:D007239
57 871-881 Species denotes SARS-CoV-2 Tax:2697049
58 882-887 Gene denotes spike Gene:43740568
59 926-937 Chemical denotes sphingosine MESH:D013110
60 947-951 Gene denotes ACE2 Gene:59272
61 978-988 Species denotes SARS-CoV-2 Tax:2697049
62 1063-1068 Gene denotes spike Gene:43740568
63 1082-1086 Gene denotes ACE2 Gene:59272
64 1113-1124 Chemical denotes sphingosine MESH:D013110
65 1148-1164 Disease denotes viral infections MESH:D001102
66 1316-1327 Chemical denotes sphingosine MESH:D013110
67 1400-1422 Disease denotes coronavirus disease-19 MESH:C000657245

sentences

Id Subject Object Predicate Lexical cue
T1 0-79 Sentence denotes Sphingosine prevents binding of SARS-CoV-2 spike to its cellular receptor ACE2.
T2 80-266 Sentence denotes Sphingosine has been shown to prevent and eliminate bacterial infections of the respiratory tract, but it is unknown whether sphingosine can be also employed to prevent viral infections.
T3 267-557 Sentence denotes To test this hypothesis, we analyzed whether sphingosine regulates the infection of cultured and freshly isolated ex vivohuman epithelial cells with pseudoviral particles expressing SARS-CoV-2 spike (pp-VSV-SARS-CoV-2 spike) that served as a bona fide system mimicking SARS-CoV-2 infection.
T4 558-686 Sentence denotes We demonstrate that exogenously applied sphingosine suspended in 0.9% NaCl prevents cellular infection with pp-SARS-CoV-2 spike.
T5 687-888 Sentence denotes Pre-treatment of cultured Vero epithelial cells or freshly isolated human nasal epithelial cells with low concentrations of sphingosine prevented adhesion of and infection with pp-VSV-SARS-CoV-2 spike.
T6 889-1087 Sentence denotes Mechanistically, we demonstrate that sphingosine binds to ACE2, the cellular receptor of SARS-CoV-2, and prevents the interaction of the receptor binding domain of the viral spike protein with ACE2.
T7 1088-1232 Sentence denotes These data indicate that sphingosine prevents at least some viral infections by interfering with the interaction of the virus with its receptor.
T8 1233-1423 Sentence denotes Our data also suggest that further preclinical and finally clinical examination of sphingosine is warranted for potential use as a prophylactic or early treatment for coronavirus disease-19.

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 32-42 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T2 132-152 Disease denotes bacterial infections http://purl.obolibrary.org/obo/MONDO_0005113
T3 249-265 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T4 338-347 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T5 449-459 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T6 474-484 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T7 536-546 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T8 547-556 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T9 651-660 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T10 669-679 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T11 849-858 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T12 871-881 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T13 978-988 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T14 1148-1164 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T15 1400-1422 Disease denotes coronavirus disease-19 http://purl.obolibrary.org/obo/MONDO_0100096

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 32-40 OrganismTaxon denotes SARS-CoV 694009
T2 449-457 OrganismTaxon denotes SARS-CoV 694009
T3 474-482 OrganismTaxon denotes SARS-CoV 694009
T4 536-544 OrganismTaxon denotes SARS-CoV 694009
T5 669-677 OrganismTaxon denotes SARS-CoV 694009
T6 755-760 OrganismTaxon denotes human 9606
T7 871-879 OrganismTaxon denotes SARS-CoV 694009
T8 978-986 OrganismTaxon denotes SARS-CoV 694009

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 160-177 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065|http://purl.obolibrary.org/obo/UBERON_0000072
T3 394-410 Body_part denotes epithelial cells http://purl.obolibrary.org/obo/CL_0000066
T4 718-734 Body_part denotes epithelial cells http://purl.obolibrary.org/obo/CL_0000066
T5 767-783 Body_part denotes epithelial cells http://purl.obolibrary.org/obo/CL_0000066

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 394-410 Cell denotes epithelial cells http://purl.obolibrary.org/obo/CL:0000066
T2 718-734 Cell denotes epithelial cells http://purl.obolibrary.org/obo/CL:0000066
T3 767-783 Cell denotes epithelial cells http://purl.obolibrary.org/obo/CL:0000066