PubMed:32876196
Annnotations
LitCovid-PD-FMA-UBERON
{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T1","span":{"begin":257,"end":260},"obj":"Body_part"},{"id":"T2","span":{"begin":1285,"end":1295},"obj":"Body_part"},{"id":"T3","span":{"begin":1285,"end":1293},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma62340"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma62338"}],"text":"Myocardial Injury Biomarkers and Cardiac Complications Associated with Mortality in Patients with COVID-19.\nBiomarcadores de Lesão Miocárdica e Complicações Cardíacas Associadas à Mortalidade em Pacientes com COVID-19.\nBACKGROUND: SARS-CoV-2 is an emerging RNA virus associated with a severe acute respiratory disease known as COVID-19. Although COVID-19 is predominantly a pulmonary disease, some patients have severe cardiovascular damage. We performed a quantitative evidence synthesis of clinical data, myocardial injury biomarkers, and cardiac complications associated with in-hospital death in patients with COVID-19.\nMETHODS: We searched the databases PubMed, Embase, and Google Scholar to identify studies comparing clinical data, myocardial injury biomarkers, and cardiac complications between non-survivors and survivors of COVID-19. Effect sizes were reported as mean difference or standardized mean difference for continuous variables and risk ratio for dichotomous variables with 95% confidence intervals. A random effects model was used to pool the results.\nRESULTS: Six retrospective studies reporting data from 1,141 patients (832 survivors and 309 non-survivors) were included. We found that underlying cardiovascular conditions; elevation of high-sensitivity cardiac troponin I, N-terminal pro-B-type natriuretic peptide, and creatine kinase-MB; and cardiac complications were associated with increased risk of death for patients with SARS-CoV-2 infection.\nCONCLUSIONS: The confirmation that underlying cardiovascular conditions, elevation of myocardial injury biomarkers during COVID-19 infection, and acute cardiovascular decompensation are predictors for mortality in SARS-CoV-2 infection must encourage new research to clarify potential mechanisms and test appropriate treatments. (Arq Bras Cardiol. 2020; 115(2):273-277)."}
LitCovid-PD-MONDO
{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T1","span":{"begin":11,"end":17},"obj":"Disease"},{"id":"T2","span":{"begin":98,"end":106},"obj":"Disease"},{"id":"T3","span":{"begin":209,"end":217},"obj":"Disease"},{"id":"T4","span":{"begin":231,"end":239},"obj":"Disease"},{"id":"T5","span":{"begin":298,"end":317},"obj":"Disease"},{"id":"T6","span":{"begin":327,"end":335},"obj":"Disease"},{"id":"T7","span":{"begin":346,"end":354},"obj":"Disease"},{"id":"T8","span":{"begin":374,"end":391},"obj":"Disease"},{"id":"T9","span":{"begin":518,"end":524},"obj":"Disease"},{"id":"T10","span":{"begin":614,"end":622},"obj":"Disease"},{"id":"T11","span":{"begin":750,"end":756},"obj":"Disease"},{"id":"T12","span":{"begin":834,"end":842},"obj":"Disease"},{"id":"T13","span":{"begin":1453,"end":1461},"obj":"Disease"},{"id":"T14","span":{"begin":1464,"end":1473},"obj":"Disease"},{"id":"T15","span":{"begin":1572,"end":1578},"obj":"Disease"},{"id":"T16","span":{"begin":1597,"end":1605},"obj":"Disease"},{"id":"T17","span":{"begin":1606,"end":1615},"obj":"Disease"},{"id":"T18","span":{"begin":1689,"end":1697},"obj":"Disease"},{"id":"T19","span":{"begin":1700,"end":1709},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0005087"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0005275"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A11","pred":"mondo_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"},{"id":"A12","pred":"mondo_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A13","pred":"mondo_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A14","pred":"mondo_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A15","pred":"mondo_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"},{"id":"A16","pred":"mondo_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A17","pred":"mondo_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A18","pred":"mondo_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A19","pred":"mondo_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"Myocardial Injury Biomarkers and Cardiac Complications Associated with Mortality in Patients with COVID-19.\nBiomarcadores de Lesão Miocárdica e Complicações Cardíacas Associadas à Mortalidade em Pacientes com COVID-19.\nBACKGROUND: SARS-CoV-2 is an emerging RNA virus associated with a severe acute respiratory disease known as COVID-19. Although COVID-19 is predominantly a pulmonary disease, some patients have severe cardiovascular damage. We performed a quantitative evidence synthesis of clinical data, myocardial injury biomarkers, and cardiac complications associated with in-hospital death in patients with COVID-19.\nMETHODS: We searched the databases PubMed, Embase, and Google Scholar to identify studies comparing clinical data, myocardial injury biomarkers, and cardiac complications between non-survivors and survivors of COVID-19. Effect sizes were reported as mean difference or standardized mean difference for continuous variables and risk ratio for dichotomous variables with 95% confidence intervals. A random effects model was used to pool the results.\nRESULTS: Six retrospective studies reporting data from 1,141 patients (832 survivors and 309 non-survivors) were included. We found that underlying cardiovascular conditions; elevation of high-sensitivity cardiac troponin I, N-terminal pro-B-type natriuretic peptide, and creatine kinase-MB; and cardiac complications were associated with increased risk of death for patients with SARS-CoV-2 infection.\nCONCLUSIONS: The confirmation that underlying cardiovascular conditions, elevation of myocardial injury biomarkers during COVID-19 infection, and acute cardiovascular decompensation are predictors for mortality in SARS-CoV-2 infection must encourage new research to clarify potential mechanisms and test appropriate treatments. (Arq Bras Cardiol. 2020; 115(2):273-277)."}
LitCovid-PD-CLO
{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1","span":{"begin":178,"end":179},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T2","span":{"begin":261,"end":266},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T3","span":{"begin":283,"end":284},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T4","span":{"begin":372,"end":373},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T5","span":{"begin":455,"end":456},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T6","span":{"begin":1019,"end":1020},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T7","span":{"begin":1312,"end":1313},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T8","span":{"begin":1331,"end":1338},"obj":"http://purl.obolibrary.org/obo/PR_000018263"},{"id":"T9","span":{"begin":1360,"end":1362},"obj":"http://purl.obolibrary.org/obo/PR_000010213"},{"id":"T10","span":{"begin":1774,"end":1778},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"}],"text":"Myocardial Injury Biomarkers and Cardiac Complications Associated with Mortality in Patients with COVID-19.\nBiomarcadores de Lesão Miocárdica e Complicações Cardíacas Associadas à Mortalidade em Pacientes com COVID-19.\nBACKGROUND: SARS-CoV-2 is an emerging RNA virus associated with a severe acute respiratory disease known as COVID-19. Although COVID-19 is predominantly a pulmonary disease, some patients have severe cardiovascular damage. We performed a quantitative evidence synthesis of clinical data, myocardial injury biomarkers, and cardiac complications associated with in-hospital death in patients with COVID-19.\nMETHODS: We searched the databases PubMed, Embase, and Google Scholar to identify studies comparing clinical data, myocardial injury biomarkers, and cardiac complications between non-survivors and survivors of COVID-19. Effect sizes were reported as mean difference or standardized mean difference for continuous variables and risk ratio for dichotomous variables with 95% confidence intervals. A random effects model was used to pool the results.\nRESULTS: Six retrospective studies reporting data from 1,141 patients (832 survivors and 309 non-survivors) were included. We found that underlying cardiovascular conditions; elevation of high-sensitivity cardiac troponin I, N-terminal pro-B-type natriuretic peptide, and creatine kinase-MB; and cardiac complications were associated with increased risk of death for patients with SARS-CoV-2 infection.\nCONCLUSIONS: The confirmation that underlying cardiovascular conditions, elevation of myocardial injury biomarkers during COVID-19 infection, and acute cardiovascular decompensation are predictors for mortality in SARS-CoV-2 infection must encourage new research to clarify potential mechanisms and test appropriate treatments. (Arq Bras Cardiol. 2020; 115(2):273-277)."}
LitCovid-PD-CHEBI
{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1","span":{"begin":1331,"end":1338},"obj":"Chemical"},{"id":"T2","span":{"begin":1344,"end":1352},"obj":"Chemical"}],"attributes":[{"id":"A1","pred":"chebi_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"},{"id":"A2","pred":"chebi_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_16919"},{"id":"A3","pred":"chebi_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_57947"}],"text":"Myocardial Injury Biomarkers and Cardiac Complications Associated with Mortality in Patients with COVID-19.\nBiomarcadores de Lesão Miocárdica e Complicações Cardíacas Associadas à Mortalidade em Pacientes com COVID-19.\nBACKGROUND: SARS-CoV-2 is an emerging RNA virus associated with a severe acute respiratory disease known as COVID-19. Although COVID-19 is predominantly a pulmonary disease, some patients have severe cardiovascular damage. We performed a quantitative evidence synthesis of clinical data, myocardial injury biomarkers, and cardiac complications associated with in-hospital death in patients with COVID-19.\nMETHODS: We searched the databases PubMed, Embase, and Google Scholar to identify studies comparing clinical data, myocardial injury biomarkers, and cardiac complications between non-survivors and survivors of COVID-19. Effect sizes were reported as mean difference or standardized mean difference for continuous variables and risk ratio for dichotomous variables with 95% confidence intervals. A random effects model was used to pool the results.\nRESULTS: Six retrospective studies reporting data from 1,141 patients (832 survivors and 309 non-survivors) were included. We found that underlying cardiovascular conditions; elevation of high-sensitivity cardiac troponin I, N-terminal pro-B-type natriuretic peptide, and creatine kinase-MB; and cardiac complications were associated with increased risk of death for patients with SARS-CoV-2 infection.\nCONCLUSIONS: The confirmation that underlying cardiovascular conditions, elevation of myocardial injury biomarkers during COVID-19 infection, and acute cardiovascular decompensation are predictors for mortality in SARS-CoV-2 infection must encourage new research to clarify potential mechanisms and test appropriate treatments. (Arq Bras Cardiol. 2020; 115(2):273-277)."}
LitCovid-PD-GO-BP
{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T1","span":{"begin":479,"end":488},"obj":"http://purl.obolibrary.org/obo/GO_0009058"}],"text":"Myocardial Injury Biomarkers and Cardiac Complications Associated with Mortality in Patients with COVID-19.\nBiomarcadores de Lesão Miocárdica e Complicações Cardíacas Associadas à Mortalidade em Pacientes com COVID-19.\nBACKGROUND: SARS-CoV-2 is an emerging RNA virus associated with a severe acute respiratory disease known as COVID-19. Although COVID-19 is predominantly a pulmonary disease, some patients have severe cardiovascular damage. We performed a quantitative evidence synthesis of clinical data, myocardial injury biomarkers, and cardiac complications associated with in-hospital death in patients with COVID-19.\nMETHODS: We searched the databases PubMed, Embase, and Google Scholar to identify studies comparing clinical data, myocardial injury biomarkers, and cardiac complications between non-survivors and survivors of COVID-19. Effect sizes were reported as mean difference or standardized mean difference for continuous variables and risk ratio for dichotomous variables with 95% confidence intervals. A random effects model was used to pool the results.\nRESULTS: Six retrospective studies reporting data from 1,141 patients (832 survivors and 309 non-survivors) were included. We found that underlying cardiovascular conditions; elevation of high-sensitivity cardiac troponin I, N-terminal pro-B-type natriuretic peptide, and creatine kinase-MB; and cardiac complications were associated with increased risk of death for patients with SARS-CoV-2 infection.\nCONCLUSIONS: The confirmation that underlying cardiovascular conditions, elevation of myocardial injury biomarkers during COVID-19 infection, and acute cardiovascular decompensation are predictors for mortality in SARS-CoV-2 infection must encourage new research to clarify potential mechanisms and test appropriate treatments. (Arq Bras Cardiol. 2020; 115(2):273-277)."}
LitCovid-PubTator
{"project":"LitCovid-PubTator","denotations":[{"id":"4","span":{"begin":0,"end":17},"obj":"Disease"},{"id":"5","span":{"begin":71,"end":80},"obj":"Disease"},{"id":"6","span":{"begin":84,"end":92},"obj":"Species"},{"id":"7","span":{"begin":98,"end":106},"obj":"Disease"},{"id":"33","span":{"begin":231,"end":241},"obj":"Species"},{"id":"34","span":{"begin":292,"end":317},"obj":"Disease"},{"id":"35","span":{"begin":327,"end":335},"obj":"Disease"},{"id":"36","span":{"begin":346,"end":354},"obj":"Disease"},{"id":"37","span":{"begin":374,"end":391},"obj":"Disease"},{"id":"38","span":{"begin":398,"end":406},"obj":"Species"},{"id":"39","span":{"begin":419,"end":440},"obj":"Disease"},{"id":"40","span":{"begin":507,"end":524},"obj":"Disease"},{"id":"41","span":{"begin":541,"end":562},"obj":"Disease"},{"id":"42","span":{"begin":591,"end":596},"obj":"Disease"},{"id":"43","span":{"begin":600,"end":608},"obj":"Species"},{"id":"44","span":{"begin":614,"end":622},"obj":"Disease"},{"id":"45","span":{"begin":739,"end":756},"obj":"Disease"},{"id":"46","span":{"begin":773,"end":794},"obj":"Disease"},{"id":"47","span":{"begin":834,"end":842},"obj":"Disease"},{"id":"48","span":{"begin":1133,"end":1141},"obj":"Species"},{"id":"49","span":{"begin":1368,"end":1389},"obj":"Disease"},{"id":"50","span":{"begin":1429,"end":1434},"obj":"Disease"},{"id":"51","span":{"begin":1439,"end":1447},"obj":"Species"},{"id":"52","span":{"begin":1453,"end":1473},"obj":"Disease"},{"id":"53","span":{"begin":1561,"end":1578},"obj":"Disease"},{"id":"54","span":{"begin":1597,"end":1605},"obj":"Disease"},{"id":"55","span":{"begin":1606,"end":1615},"obj":"Disease"},{"id":"56","span":{"begin":1676,"end":1685},"obj":"Disease"},{"id":"57","span":{"begin":1689,"end":1709},"obj":"Disease"}],"attributes":[{"id":"A4","pred":"tao:has_database_id","subj":"4","obj":"MESH:D009202"},{"id":"A5","pred":"tao:has_database_id","subj":"5","obj":"MESH:D003643"},{"id":"A6","pred":"tao:has_database_id","subj":"6","obj":"Tax:9606"},{"id":"A7","pred":"tao:has_database_id","subj":"7","obj":"MESH:C000657245"},{"id":"A33","pred":"tao:has_database_id","subj":"33","obj":"Tax:2697049"},{"id":"A34","pred":"tao:has_database_id","subj":"34","obj":"MESH:D012120"},{"id":"A35","pred":"tao:has_database_id","subj":"35","obj":"MESH:C000657245"},{"id":"A36","pred":"tao:has_database_id","subj":"36","obj":"MESH:C000657245"},{"id":"A37","pred":"tao:has_database_id","subj":"37","obj":"MESH:D008171"},{"id":"A38","pred":"tao:has_database_id","subj":"38","obj":"Tax:9606"},{"id":"A39","pred":"tao:has_database_id","subj":"39","obj":"MESH:D002318"},{"id":"A40","pred":"tao:has_database_id","subj":"40","obj":"MESH:D009202"},{"id":"A41","pred":"tao:has_database_id","subj":"41","obj":"MESH:D005117"},{"id":"A42","pred":"tao:has_database_id","subj":"42","obj":"MESH:D003643"},{"id":"A43","pred":"tao:has_database_id","subj":"43","obj":"Tax:9606"},{"id":"A44","pred":"tao:has_database_id","subj":"44","obj":"MESH:C000657245"},{"id":"A45","pred":"tao:has_database_id","subj":"45","obj":"MESH:D009202"},{"id":"A46","pred":"tao:has_database_id","subj":"46","obj":"MESH:D005117"},{"id":"A47","pred":"tao:has_database_id","subj":"47","obj":"MESH:C000657245"},{"id":"A48","pred":"tao:has_database_id","subj":"48","obj":"Tax:9606"},{"id":"A49","pred":"tao:has_database_id","subj":"49","obj":"MESH:D005117"},{"id":"A50","pred":"tao:has_database_id","subj":"50","obj":"MESH:D003643"},{"id":"A51","pred":"tao:has_database_id","subj":"51","obj":"Tax:9606"},{"id":"A52","pred":"tao:has_database_id","subj":"52","obj":"MESH:C000657245"},{"id":"A53","pred":"tao:has_database_id","subj":"53","obj":"MESH:D009202"},{"id":"A54","pred":"tao:has_database_id","subj":"54","obj":"MESH:C000657245"},{"id":"A55","pred":"tao:has_database_id","subj":"55","obj":"MESH:D007239"},{"id":"A56","pred":"tao:has_database_id","subj":"56","obj":"MESH:D003643"},{"id":"A57","pred":"tao:has_database_id","subj":"57","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Myocardial Injury Biomarkers and Cardiac Complications Associated with Mortality in Patients with COVID-19.\nBiomarcadores de Lesão Miocárdica e Complicações Cardíacas Associadas à Mortalidade em Pacientes com COVID-19.\nBACKGROUND: SARS-CoV-2 is an emerging RNA virus associated with a severe acute respiratory disease known as COVID-19. Although COVID-19 is predominantly a pulmonary disease, some patients have severe cardiovascular damage. We performed a quantitative evidence synthesis of clinical data, myocardial injury biomarkers, and cardiac complications associated with in-hospital death in patients with COVID-19.\nMETHODS: We searched the databases PubMed, Embase, and Google Scholar to identify studies comparing clinical data, myocardial injury biomarkers, and cardiac complications between non-survivors and survivors of COVID-19. Effect sizes were reported as mean difference or standardized mean difference for continuous variables and risk ratio for dichotomous variables with 95% confidence intervals. A random effects model was used to pool the results.\nRESULTS: Six retrospective studies reporting data from 1,141 patients (832 survivors and 309 non-survivors) were included. We found that underlying cardiovascular conditions; elevation of high-sensitivity cardiac troponin I, N-terminal pro-B-type natriuretic peptide, and creatine kinase-MB; and cardiac complications were associated with increased risk of death for patients with SARS-CoV-2 infection.\nCONCLUSIONS: The confirmation that underlying cardiovascular conditions, elevation of myocardial injury biomarkers during COVID-19 infection, and acute cardiovascular decompensation are predictors for mortality in SARS-CoV-2 infection must encourage new research to clarify potential mechanisms and test appropriate treatments. (Arq Bras Cardiol. 2020; 115(2):273-277)."}
LitCovid-sentences
{"project":"LitCovid-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":107},"obj":"Sentence"},{"id":"T2","span":{"begin":108,"end":218},"obj":"Sentence"},{"id":"T3","span":{"begin":219,"end":336},"obj":"Sentence"},{"id":"T4","span":{"begin":337,"end":441},"obj":"Sentence"},{"id":"T5","span":{"begin":442,"end":623},"obj":"Sentence"},{"id":"T6","span":{"begin":624,"end":632},"obj":"Sentence"},{"id":"T7","span":{"begin":633,"end":843},"obj":"Sentence"},{"id":"T8","span":{"begin":844,"end":1018},"obj":"Sentence"},{"id":"T9","span":{"begin":1019,"end":1071},"obj":"Sentence"},{"id":"T10","span":{"begin":1072,"end":1080},"obj":"Sentence"},{"id":"T11","span":{"begin":1081,"end":1194},"obj":"Sentence"},{"id":"T12","span":{"begin":1195,"end":1474},"obj":"Sentence"},{"id":"T13","span":{"begin":1475,"end":1487},"obj":"Sentence"},{"id":"T14","span":{"begin":1488,"end":1821},"obj":"Sentence"},{"id":"T15","span":{"begin":1822,"end":1844},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Myocardial Injury Biomarkers and Cardiac Complications Associated with Mortality in Patients with COVID-19.\nBiomarcadores de Lesão Miocárdica e Complicações Cardíacas Associadas à Mortalidade em Pacientes com COVID-19.\nBACKGROUND: SARS-CoV-2 is an emerging RNA virus associated with a severe acute respiratory disease known as COVID-19. Although COVID-19 is predominantly a pulmonary disease, some patients have severe cardiovascular damage. We performed a quantitative evidence synthesis of clinical data, myocardial injury biomarkers, and cardiac complications associated with in-hospital death in patients with COVID-19.\nMETHODS: We searched the databases PubMed, Embase, and Google Scholar to identify studies comparing clinical data, myocardial injury biomarkers, and cardiac complications between non-survivors and survivors of COVID-19. Effect sizes were reported as mean difference or standardized mean difference for continuous variables and risk ratio for dichotomous variables with 95% confidence intervals. A random effects model was used to pool the results.\nRESULTS: Six retrospective studies reporting data from 1,141 patients (832 survivors and 309 non-survivors) were included. We found that underlying cardiovascular conditions; elevation of high-sensitivity cardiac troponin I, N-terminal pro-B-type natriuretic peptide, and creatine kinase-MB; and cardiac complications were associated with increased risk of death for patients with SARS-CoV-2 infection.\nCONCLUSIONS: The confirmation that underlying cardiovascular conditions, elevation of myocardial injury biomarkers during COVID-19 infection, and acute cardiovascular decompensation are predictors for mortality in SARS-CoV-2 infection must encourage new research to clarify potential mechanisms and test appropriate treatments. (Arq Bras Cardiol. 2020; 115(2):273-277)."}
ENG_RE_CONSENSUS
{"project":"ENG_RE_CONSENSUS","denotations":[{"id":"T0","span":{"begin":257,"end":260},"obj":"CHEBI_33697"},{"id":"T1","span":{"begin":285,"end":291},"obj":"HP_0012828"},{"id":"T2","span":{"begin":292,"end":297},"obj":"HP_0011009"},{"id":"T17","span":{"begin":298,"end":317},"obj":"HP_0002795"},{"id":"T16","span":{"begin":298,"end":317},"obj":"DOID_1579"},{"id":"T18","span":{"begin":327,"end":335},"obj":"HP_0033141"},{"id":"T4","span":{"begin":327,"end":335},"obj":"DOID_0080600"},{"id":"T19","span":{"begin":346,"end":354},"obj":"HP_0033141"},{"id":"T5","span":{"begin":346,"end":354},"obj":"DOID_0080600"},{"id":"T21","span":{"begin":374,"end":391},"obj":"HP_0002795"},{"id":"T20","span":{"begin":374,"end":391},"obj":"DOID_850"},{"id":"T7","span":{"begin":412,"end":418},"obj":"HP_0012828"},{"id":"T22","span":{"begin":419,"end":440},"obj":"HP_0001626"},{"id":"T23","span":{"begin":507,"end":524},"obj":"HP_0001637"},{"id":"T24","span":{"begin":614,"end":622},"obj":"HP_0033141"},{"id":"T9","span":{"begin":614,"end":622},"obj":"DOID_0080600"},{"id":"T27","span":{"begin":834,"end":842},"obj":"HP_0033141"},{"id":"T10","span":{"begin":834,"end":842},"obj":"DOID_0080600"},{"id":"T25","span":{"begin":1319,"end":1338},"obj":"CHEBI_80233"},{"id":"T11","span":{"begin":1344,"end":1352},"obj":"CHEBI_16919"},{"id":"T26","span":{"begin":1453,"end":1473},"obj":"HP_0033141"},{"id":"T12","span":{"begin":1453,"end":1473},"obj":"DOID_0080600"},{"id":"T28","span":{"begin":1597,"end":1605},"obj":"HP_0033141"},{"id":"T13","span":{"begin":1597,"end":1605},"obj":"DOID_0080600"},{"id":"T14","span":{"begin":1621,"end":1626},"obj":"HP_0011009"},{"id":"T30","span":{"begin":1627,"end":1656},"obj":"HP_0030872"},{"id":"T29","span":{"begin":1689,"end":1709},"obj":"HP_0033141"},{"id":"T15","span":{"begin":1689,"end":1709},"obj":"DOID_0080600"}],"relations":[{"id":"R11","pred":"effect","subj":"T9","obj":"T0"},{"id":"R14","pred":"effect","subj":"T12","obj":"T11"},{"id":"R16","pred":"no_relation","subj":"T13","obj":"T11"},{"id":"R18","pred":"effect","subj":"T15","obj":"T11"},{"id":"R7","pred":"no_relation","subj":"T5","obj":"T0"},{"id":"R5","pred":"no_relation","subj":"T4","obj":"T0"},{"id":"R19","pred":"effect","subj":"T2","obj":"T17"},{"id":"R20","pred":"effect","subj":"T1","obj":"T17"},{"id":"R21","pred":"effect","subj":"T1","obj":"T16"},{"id":"R22","pred":"effect","subj":"T2","obj":"T16"},{"id":"R23","pred":"effect","subj":"T7","obj":"T22"},{"id":"R24","pred":"effect","subj":"T19","obj":"T22"},{"id":"R25","pred":"effect","subj":"T5","obj":"T22"},{"id":"R26","pred":"effect","subj":"T18","obj":"T22"},{"id":"R27","pred":"effect","subj":"T4","obj":"T22"},{"id":"R28","pred":"effect","subj":"T24","obj":"T23"},{"id":"R29","pred":"effect","subj":"T9","obj":"T23"},{"id":"R30","pred":"effect","subj":"T26","obj":"T11"},{"id":"R31","pred":"effect","subj":"T29","obj":"T11"},{"id":"R32","pred":"effect","subj":"T28","obj":"T11"},{"id":"R33","pred":"effect","subj":"T13","obj":"T25"},{"id":"R34","pred":"effect","subj":"T28","obj":"T25"},{"id":"R35","pred":"effect","subj":"T12","obj":"T25"},{"id":"R36","pred":"effect","subj":"T26","obj":"T15"},{"id":"R37","pred":"effect","subj":"T29","obj":"T25"},{"id":"R38","pred":"effect","subj":"T28","obj":"T30"},{"id":"R39","pred":"effect","subj":"T13","obj":"T30"},{"id":"R40","pred":"effect","subj":"T14","obj":"T30"}],"text":"Myocardial Injury Biomarkers and Cardiac Complications Associated with Mortality in Patients with COVID-19.\nBiomarcadores de Lesão Miocárdica e Complicações Cardíacas Associadas à Mortalidade em Pacientes com COVID-19.\nBACKGROUND: SARS-CoV-2 is an emerging RNA virus associated with a severe acute respiratory disease known as COVID-19. Although COVID-19 is predominantly a pulmonary disease, some patients have severe cardiovascular damage. We performed a quantitative evidence synthesis of clinical data, myocardial injury biomarkers, and cardiac complications associated with in-hospital death in patients with COVID-19.\nMETHODS: We searched the databases PubMed, Embase, and Google Scholar to identify studies comparing clinical data, myocardial injury biomarkers, and cardiac complications between non-survivors and survivors of COVID-19. Effect sizes were reported as mean difference or standardized mean difference for continuous variables and risk ratio for dichotomous variables with 95% confidence intervals. A random effects model was used to pool the results.\nRESULTS: Six retrospective studies reporting data from 1,141 patients (832 survivors and 309 non-survivors) were included. We found that underlying cardiovascular conditions; elevation of high-sensitivity cardiac troponin I, N-terminal pro-B-type natriuretic peptide, and creatine kinase-MB; and cardiac complications were associated with increased risk of death for patients with SARS-CoV-2 infection.\nCONCLUSIONS: The confirmation that underlying cardiovascular conditions, elevation of myocardial injury biomarkers during COVID-19 infection, and acute cardiovascular decompensation are predictors for mortality in SARS-CoV-2 infection must encourage new research to clarify potential mechanisms and test appropriate treatments. (Arq Bras Cardiol. 2020; 115(2):273-277)."}
ENG_NER_NEL_CONSENSUS
{"project":"ENG_NER_NEL_CONSENSUS","denotations":[{"id":"T70","span":{"begin":1285,"end":1295},"obj":"MESH:D019210"},{"id":"T72","span":{"begin":1319,"end":1338},"obj":"CHEBI:80233"},{"id":"T73","span":{"begin":1453,"end":1473},"obj":"HP:0033141"},{"id":"T74","span":{"begin":327,"end":335},"obj":"MESH:D000086382"},{"id":"T75","span":{"begin":614,"end":622},"obj":"MESH:D000086382"},{"id":"T76","span":{"begin":834,"end":842},"obj":"MESH:D000086382"},{"id":"T77","span":{"begin":834,"end":842},"obj":"HP:0033141"},{"id":"T78","span":{"begin":1453,"end":1473},"obj":"MESH:D000086382"},{"id":"T79","span":{"begin":1597,"end":1605},"obj":"MESH:D000086382"},{"id":"T80","span":{"begin":1597,"end":1605},"obj":"HP:0033141"},{"id":"T81","span":{"begin":1368,"end":1389},"obj":"MESH:D018376"},{"id":"T82","span":{"begin":1521,"end":1546},"obj":"MESH:D018376"},{"id":"T83","span":{"begin":1689,"end":1709},"obj":"HP:0033141"},{"id":"T84","span":{"begin":1689,"end":1709},"obj":"MESH:D000086382"},{"id":"T85","span":{"begin":1627,"end":1656},"obj":"HP:0030872"},{"id":"T86","span":{"begin":285,"end":317},"obj":"MESH:D045169"},{"id":"T87","span":{"begin":346,"end":354},"obj":"MESH:D000086382"},{"id":"T88","span":{"begin":997,"end":1018},"obj":"MESH:D016001"},{"id":"T89","span":{"begin":951,"end":955},"obj":"MESH:D012306"},{"id":"T10","span":{"begin":346,"end":354},"obj":"DOID:0080600"},{"id":"T14","span":{"begin":398,"end":406},"obj":"MESH:D010361"},{"id":"T15","span":{"begin":412,"end":418},"obj":"HP:0012828"},{"id":"T17","span":{"begin":525,"end":535},"obj":"MESH:D015415"},{"id":"T19","span":{"begin":591,"end":596},"obj":"MESH:D003643"},{"id":"T20","span":{"begin":600,"end":608},"obj":"MESH:D010361"},{"id":"T21","span":{"begin":614,"end":622},"obj":"DOID:0080600"},{"id":"T23","span":{"begin":757,"end":767},"obj":"MESH:D015415"},{"id":"T24","span":{"begin":821,"end":830},"obj":"MESH:D017741"},{"id":"T25","span":{"begin":834,"end":842},"obj":"DOID:0080600"},{"id":"T3","span":{"begin":257,"end":266},"obj":"MESH:D012328"},{"id":"T30","span":{"begin":1085,"end":1106},"obj":"MESH:D012189"},{"id":"T31","span":{"begin":1133,"end":1141},"obj":"MESH:D010361"},{"id":"T32","span":{"begin":1147,"end":1156},"obj":"MESH:D017741"},{"id":"T34","span":{"begin":1344,"end":1352},"obj":"CHEBI:16919"},{"id":"T35","span":{"begin":1344,"end":1352},"obj":"MESH:D003401"},{"id":"T37","span":{"begin":1421,"end":1425},"obj":"MESH:D012306"},{"id":"T39","span":{"begin":1429,"end":1434},"obj":"MESH:D003643"},{"id":"T4","span":{"begin":285,"end":291},"obj":"HP:0012828"},{"id":"T40","span":{"begin":1439,"end":1447},"obj":"MESH:D010361"},{"id":"T42","span":{"begin":1453,"end":1473},"obj":"DOID:0080600"},{"id":"T44","span":{"begin":1579,"end":1589},"obj":"MESH:D015415"},{"id":"T45","span":{"begin":1597,"end":1605},"obj":"DOID:0080600"},{"id":"T48","span":{"begin":1621,"end":1626},"obj":"HP:0011009"},{"id":"T49","span":{"begin":1676,"end":1685},"obj":"MESH:D009026"},{"id":"T5","span":{"begin":292,"end":297},"obj":"HP:0011009"},{"id":"T51","span":{"begin":1689,"end":1709},"obj":"DOID:0080600"},{"id":"T53","span":{"begin":1729,"end":1737},"obj":"MESH:D012106"},{"id":"T54","span":{"begin":257,"end":260},"obj":"CHEBI:33697"},{"id":"T55","span":{"begin":231,"end":241},"obj":"MESH:D000086402"},{"id":"T58","span":{"begin":298,"end":317},"obj":"DOID:1579"},{"id":"T59","span":{"begin":327,"end":335},"obj":"DOID:0080600"},{"id":"T61","span":{"begin":298,"end":317},"obj":"HP:0002795"},{"id":"T62","span":{"begin":327,"end":335},"obj":"HP:0033141"},{"id":"T63","span":{"begin":346,"end":354},"obj":"HP:0033141"},{"id":"T64","span":{"begin":374,"end":391},"obj":"DOID:850"},{"id":"T65","span":{"begin":374,"end":391},"obj":"HP:0002795"},{"id":"T66","span":{"begin":374,"end":391},"obj":"MESH:D008171"},{"id":"T67","span":{"begin":419,"end":440},"obj":"HP:0001626"},{"id":"T68","span":{"begin":507,"end":524},"obj":"HP:0001637"},{"id":"T69","span":{"begin":614,"end":622},"obj":"HP:0033141"}],"text":"Myocardial Injury Biomarkers and Cardiac Complications Associated with Mortality in Patients with COVID-19.\nBiomarcadores de Lesão Miocárdica e Complicações Cardíacas Associadas à Mortalidade em Pacientes com COVID-19.\nBACKGROUND: SARS-CoV-2 is an emerging RNA virus associated with a severe acute respiratory disease known as COVID-19. Although COVID-19 is predominantly a pulmonary disease, some patients have severe cardiovascular damage. We performed a quantitative evidence synthesis of clinical data, myocardial injury biomarkers, and cardiac complications associated with in-hospital death in patients with COVID-19.\nMETHODS: We searched the databases PubMed, Embase, and Google Scholar to identify studies comparing clinical data, myocardial injury biomarkers, and cardiac complications between non-survivors and survivors of COVID-19. Effect sizes were reported as mean difference or standardized mean difference for continuous variables and risk ratio for dichotomous variables with 95% confidence intervals. A random effects model was used to pool the results.\nRESULTS: Six retrospective studies reporting data from 1,141 patients (832 survivors and 309 non-survivors) were included. We found that underlying cardiovascular conditions; elevation of high-sensitivity cardiac troponin I, N-terminal pro-B-type natriuretic peptide, and creatine kinase-MB; and cardiac complications were associated with increased risk of death for patients with SARS-CoV-2 infection.\nCONCLUSIONS: The confirmation that underlying cardiovascular conditions, elevation of myocardial injury biomarkers during COVID-19 infection, and acute cardiovascular decompensation are predictors for mortality in SARS-CoV-2 infection must encourage new research to clarify potential mechanisms and test appropriate treatments. (Arq Bras Cardiol. 2020; 115(2):273-277)."}