PubMed:32756549 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/32756549","sourcedb":"PubMed","sourceid":"32756549","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/32756549","text":"SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness.\nA vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is needed to control the global coronavirus infectious disease (COVID-19) public health crisis. Atomic-level structures directed the application of prefusion-stabilizing mutations that improved the expression and immunogenicity of betacoronavirus spike proteins1. Using this established immunogen design, the release of SARS-CoV-2 sequences triggered immediate rapid manufacturing of an mRNA vaccine expressing the prefusion-stabilized SARS-CoV-2 spike trimer (mRNA-1273). Here we show that mRNA-1273 induces both potent neutralizing antibody responses to wild-type (D614) and D614G mutant2 SARS-CoV-2 and CD8 T cell responses, and protects against SARS-CoV-2 infection in the lungs and noses of mice without evidence of immunopathology. mRNA-1273 is currently in Phase 3 efficacy 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