PubMed:32735992 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/32735992","sourcedb":"PubMed","sourceid":"32735992","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/32735992","text":"Design of an engineered ACE2 as a novel therapeutics against COVID-19.\nThe interaction between the angiotensin-converting enzyme 2 (ACE2) and the receptor binding domain (RBD) of the spike protein from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) plays a pivotal role in virus entry into the host cells. Since recombinant ACE2 protein has been suggested as an anti-SARS-CoV-2 therapeutic agent, this study was conducted to design an ACE2 protein with more desirable properties. In this regard, the amino acids with central roles in enzymatic activity of the ACE2 were substituted. Moreover, saturation mutagenesis at the interaction interface between the ACE2 and RBD was performed to increase their interaction affinity. The best mutations to increase the structural and thermal stability of the ACE2 were also selected based on B factors and mutation effects. The obtained resulted revealed that the Arg273Gln and Thr445Gly mutation have drastically reduced the binding affinity of the angiotensin-II into the active site of ACE2. The Thr27Arg mutation was determined to be the most potent mutation to increase the binding affinity. The Asp427Arg mutation was done to decrease the flexibility of the region with high B factor. The Pro451Met mutation along with the Gly448Trp mutation was predicted to increase the thermodynamic stability and thermostability of the ACE2. The designed therapeutic ACE2 would have no enzymatic activity while it could bear stronger interaction with Spike glycoprotein of the SARS-CoV-2. Moreover, decreased in vivo enzymatic degradation would be anticipated due to increased thermostability. This engineered ACE2 could be exploited as a novel therapeutic agent against COVID-19 after necessary evaluations.","tracks":[{"project":"LitCovid-OGER-BB","denotations":[{"id":"T1","span":{"begin":24,"end":28},"obj":"G_3"},{"id":"T2","span":{"begin":24,"end":28},"obj":"PG_10"},{"id":"T3","span":{"begin":24,"end":28},"obj":"PR:000003622"},{"id":"T4","span":{"begin":61,"end":69},"obj":"SP_7"},{"id":"T5","span":{"begin":99,"end":130},"obj":"PG_10"},{"id":"T6","span":{"begin":99,"end":130},"obj":"PR:000003622"},{"id":"T7","span":{"begin":132,"end":136},"obj":"G_3"},{"id":"T8","span":{"begin":132,"end":136},"obj":"PG_10"},{"id":"T9","span":{"begin":132,"end":136},"obj":"PR:000003622"},{"id":"T10","span":{"begin":163,"end":169},"obj":"SO:0000417"},{"id":"T11","span":{"begin":202,"end":249},"obj":"SP_7"},{"id":"T12","span":{"begin":215,"end":226},"obj":"UBERON:0001004"},{"id":"T13","span":{"begin":215,"end":226},"obj":"GO:0045333"},{"id":"T14","span":{"begin":251,"end":261},"obj":"SP_7"},{"id":"T15","span":{"begin":287,"end":292},"obj":"NCBITaxon:10239"},{"id":"T16","span":{"begin":287,"end":303},"obj":"GO:0035376"},{"id":"T17","span":{"begin":338,"end":342},"obj":"G_3"},{"id":"T18","span":{"begin":338,"end":342},"obj":"PG_10"},{"id":"T19","span":{"begin":338,"end":342},"obj":"PR:000003622"},{"id":"T20","span":{"begin":381,"end":391},"obj":"SP_7"},{"id":"T21","span":{"begin":449,"end":453},"obj":"G_3"},{"id":"T22","span":{"begin":449,"end":453},"obj":"PG_10"},{"id":"T23","span":{"begin":449,"end":453},"obj":"PR:000003622"},{"id":"T24","span":{"begin":574,"end":578},"obj":"G_3"},{"id":"T25","span":{"begin":574,"end":578},"obj":"PG_10"},{"id":"T26","span":{"begin":574,"end":578},"obj":"PR:000003622"},{"id":"T27","span":{"begin":671,"end":675},"obj":"G_3"},{"id":"T28","span":{"begin":671,"end":675},"obj":"PG_10"},{"id":"T29","span":{"begin":671,"end":675},"obj":"PR:000003622"},{"id":"T30","span":{"begin":813,"end":817},"obj":"G_3"},{"id":"T31","span":{"begin":813,"end":817},"obj":"PG_10"},{"id":"T32","span":{"begin":813,"end":817},"obj":"PR:000003622"},{"id":"T33","span":{"begin":1004,"end":1018},"obj":"DG_37"},{"id":"T34","span":{"begin":1004,"end":1018},"obj":"PR:000036009"},{"id":"T35","span":{"begin":1028,"end":1039},"obj":"SO:0100019"},{"id":"T36","span":{"begin":1043,"end":1047},"obj":"PR:000003622"},{"id":"T37","span":{"begin":1043,"end":1047},"obj":"G_3"},{"id":"T38","span":{"begin":1043,"end":1047},"obj":"PG_10"},{"id":"T39","span":{"begin":1383,"end":1387},"obj":"G_3"},{"id":"T40","span":{"begin":1383,"end":1387},"obj":"PG_10"},{"id":"T41","span":{"begin":1383,"end":1387},"obj":"PR:000003622"},{"id":"T42","span":{"begin":1414,"end":1418},"obj":"G_3"},{"id":"T43","span":{"begin":1414,"end":1418},"obj":"PG_10"},{"id":"T44","span":{"begin":1414,"end":1418},"obj":"PR:000003622"},{"id":"T45","span":{"begin":1498,"end":1516},"obj":"PG_18"},{"id":"T46","span":{"begin":1498,"end":1516},"obj":"PG_1"},{"id":"T47","span":{"begin":1504,"end":1516},"obj":"CHEBI:17089"},{"id":"T48","span":{"begin":1504,"end":1516},"obj":"BV_11"},{"id":"T49","span":{"begin":1504,"end":1516},"obj":"CHEBI:17089"},{"id":"T50","span":{"begin":1524,"end":1534},"obj":"SP_7"},{"id":"T51","span":{"begin":1574,"end":1585},"obj":"GO:0009056"},{"id":"T52","span":{"begin":1657,"end":1661},"obj":"G_3"},{"id":"T53","span":{"begin":1657,"end":1661},"obj":"PG_10"},{"id":"T54","span":{"begin":1657,"end":1661},"obj":"PR:000003622"},{"id":"T55","span":{"begin":1718,"end":1726},"obj":"SP_7"}],"namespaces":[{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T2","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T3","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T4","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T5","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T6","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T7","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T8","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T9","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T10","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T11","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T12","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T13","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T14","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T15","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T16","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T17","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T18","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T19","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T20","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T21","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T22","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T23","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T24","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T25","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T26","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T27","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T28","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T29","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T30","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T31","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T32","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T33","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T34","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T35","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T36","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T37","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T38","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T39","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T40","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T41","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T42","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T43","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T44","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T45","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T46","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T47","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T48","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T49","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T50","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T51","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T52","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T53","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T54","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T55","pred":"source","obj":"LitCovid-OGER-BB"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T1","span":{"begin":189,"end":196},"obj":"Body_part"},{"id":"T2","span":{"begin":313,"end":318},"obj":"Body_part"},{"id":"T3","span":{"begin":343,"end":350},"obj":"Body_part"},{"id":"T4","span":{"begin":454,"end":461},"obj":"Body_part"},{"id":"T5","span":{"begin":514,"end":525},"obj":"Body_part"},{"id":"T6","span":{"begin":1504,"end":1516},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A5","pred":"fma_id","subj":"T5","obj":"http://purl.org/sig/ont/fma/fma82739"},{"id":"A6","pred":"fma_id","subj":"T6","obj":"http://purl.org/sig/ont/fma/fma62925"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T1","span":{"begin":61,"end":69},"obj":"Disease"},{"id":"T2","span":{"begin":202,"end":249},"obj":"Disease"},{"id":"T3","span":{"begin":202,"end":235},"obj":"Disease"},{"id":"T4","span":{"begin":251,"end":259},"obj":"Disease"},{"id":"T5","span":{"begin":381,"end":389},"obj":"Disease"},{"id":"T6","span":{"begin":1524,"end":1532},"obj":"Disease"},{"id":"T7","span":{"begin":1718,"end":1726},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1","span":{"begin":32,"end":33},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T2","span":{"begin":269,"end":270},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T3","span":{"begin":287,"end":292},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T4","span":{"begin":313,"end":318},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T5","span":{"begin":351,"end":354},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T6","span":{"begin":558,"end":566},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T7","span":{"begin":846,"end":847},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T8","span":{"begin":1028,"end":1034},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T9","span":{"begin":1235,"end":1236},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T10","span":{"begin":1443,"end":1451},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T11","span":{"begin":1684,"end":1685},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T6","span":{"begin":514,"end":519},"obj":"Chemical"},{"id":"T1","span":{"begin":99,"end":110},"obj":"Chemical"},{"id":"T2","span":{"begin":189,"end":196},"obj":"Chemical"},{"id":"T3","span":{"begin":343,"end":350},"obj":"Chemical"},{"id":"T4","span":{"begin":454,"end":461},"obj":"Chemical"},{"id":"T5","span":{"begin":514,"end":525},"obj":"Chemical"},{"id":"T7","span":{"begin":520,"end":525},"obj":"Chemical"},{"id":"T8","span":{"begin":1004,"end":1015},"obj":"Chemical"},{"id":"T9","span":{"begin":1016,"end":1018},"obj":"Chemical"},{"id":"T10","span":{"begin":1504,"end":1516},"obj":"Chemical"}],"attributes":[{"id":"A1","pred":"chebi_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A2","pred":"chebi_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A3","pred":"chebi_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A4","pred":"chebi_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A5","pred":"chebi_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_33709"},{"id":"A6","pred":"chebi_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A7","pred":"chebi_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A8","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A9","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A10","pred":"chebi_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_17089"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T1","span":{"begin":287,"end":318},"obj":"http://purl.obolibrary.org/obo/GO_0046718"},{"id":"T2","span":{"begin":293,"end":312},"obj":"http://purl.obolibrary.org/obo/GO_0044409"},{"id":"T3","span":{"begin":1574,"end":1585},"obj":"http://purl.obolibrary.org/obo/GO_0009056"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"2","span":{"begin":24,"end":28},"obj":"Gene"},{"id":"3","span":{"begin":61,"end":69},"obj":"Disease"},{"id":"21","span":{"begin":99,"end":130},"obj":"Gene"},{"id":"22","span":{"begin":132,"end":136},"obj":"Gene"},{"id":"23","span":{"begin":202,"end":249},"obj":"Species"},{"id":"24","span":{"begin":251,"end":261},"obj":"Species"},{"id":"25","span":{"begin":338,"end":342},"obj":"Gene"},{"id":"26","span":{"begin":381,"end":391},"obj":"Species"},{"id":"27","span":{"begin":449,"end":453},"obj":"Gene"},{"id":"28","span":{"begin":574,"end":578},"obj":"Gene"},{"id":"29","span":{"begin":671,"end":675},"obj":"Gene"},{"id":"30","span":{"begin":813,"end":817},"obj":"Gene"},{"id":"31","span":{"begin":1004,"end":1018},"obj":"Gene"},{"id":"32","span":{"begin":1043,"end":1047},"obj":"Gene"},{"id":"33","span":{"begin":1383,"end":1387},"obj":"Gene"},{"id":"34","span":{"begin":1414,"end":1418},"obj":"Gene"},{"id":"35","span":{"begin":1524,"end":1534},"obj":"Species"},{"id":"36","span":{"begin":1657,"end":1661},"obj":"Gene"},{"id":"37","span":{"begin":1718,"end":1726},"obj":"Disease"}],"attributes":[{"id":"A2","pred":"tao:has_database_id","subj":"2","obj":"Gene:59272"},{"id":"A3","pred":"tao:has_database_id","subj":"3","obj":"MESH:C000657245"},{"id":"A21","pred":"tao:has_database_id","subj":"21","obj":"Gene:59272"},{"id":"A22","pred":"tao:has_database_id","subj":"22","obj":"Gene:59272"},{"id":"A23","pred":"tao:has_database_id","subj":"23","obj":"Tax:2697049"},{"id":"A24","pred":"tao:has_database_id","subj":"24","obj":"Tax:2697049"},{"id":"A25","pred":"tao:has_database_id","subj":"25","obj":"Gene:59272"},{"id":"A26","pred":"tao:has_database_id","subj":"26","obj":"Tax:2697049"},{"id":"A27","pred":"tao:has_database_id","subj":"27","obj":"Gene:59272"},{"id":"A28","pred":"tao:has_database_id","subj":"28","obj":"Gene:59272"},{"id":"A29","pred":"tao:has_database_id","subj":"29","obj":"Gene:59272"},{"id":"A30","pred":"tao:has_database_id","subj":"30","obj":"Gene:59272"},{"id":"A31","pred":"tao:has_database_id","subj":"31","obj":"Gene:183"},{"id":"A32","pred":"tao:has_database_id","subj":"32","obj":"Gene:59272"},{"id":"A33","pred":"tao:has_database_id","subj":"33","obj":"Gene:59272"},{"id":"A34","pred":"tao:has_database_id","subj":"34","obj":"Gene:59272"},{"id":"A35","pred":"tao:has_database_id","subj":"35","obj":"Tax:2697049"},{"id":"A36","pred":"tao:has_database_id","subj":"36","obj":"Gene:59272"},{"id":"A37","pred":"tao:has_database_id","subj":"37","obj":"MESH:C000657245"},{"subj":"2","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3","pred":"source","obj":"LitCovid-PubTator"},{"subj":"21","pred":"source","obj":"LitCovid-PubTator"},{"subj":"22","pred":"source","obj":"LitCovid-PubTator"},{"subj":"23","pred":"source","obj":"LitCovid-PubTator"},{"subj":"24","pred":"source","obj":"LitCovid-PubTator"},{"subj":"25","pred":"source","obj":"LitCovid-PubTator"},{"subj":"26","pred":"source","obj":"LitCovid-PubTator"},{"subj":"27","pred":"source","obj":"LitCovid-PubTator"},{"subj":"28","pred":"source","obj":"LitCovid-PubTator"},{"subj":"29","pred":"source","obj":"LitCovid-PubTator"},{"subj":"30","pred":"source","obj":"LitCovid-PubTator"},{"subj":"31","pred":"source","obj":"LitCovid-PubTator"},{"subj":"32","pred":"source","obj":"LitCovid-PubTator"},{"subj":"33","pred":"source","obj":"LitCovid-PubTator"},{"subj":"34","pred":"source","obj":"LitCovid-PubTator"},{"subj":"35","pred":"source","obj":"LitCovid-PubTator"},{"subj":"36","pred":"source","obj":"LitCovid-PubTator"},{"subj":"37","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":70},"obj":"Sentence"},{"id":"T2","span":{"begin":71,"end":319},"obj":"Sentence"},{"id":"T3","span":{"begin":320,"end":493},"obj":"Sentence"},{"id":"T4","span":{"begin":494,"end":596},"obj":"Sentence"},{"id":"T5","span":{"begin":597,"end":737},"obj":"Sentence"},{"id":"T6","span":{"begin":738,"end":877},"obj":"Sentence"},{"id":"T7","span":{"begin":878,"end":1048},"obj":"Sentence"},{"id":"T8","span":{"begin":1049,"end":1150},"obj":"Sentence"},{"id":"T9","span":{"begin":1151,"end":1244},"obj":"Sentence"},{"id":"T10","span":{"begin":1245,"end":1388},"obj":"Sentence"},{"id":"T11","span":{"begin":1389,"end":1535},"obj":"Sentence"},{"id":"T12","span":{"begin":1536,"end":1640},"obj":"Sentence"},{"id":"T13","span":{"begin":1641,"end":1755},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-sentences"},{"subj":"T2","pred":"source","obj":"LitCovid-sentences"},{"subj":"T3","pred":"source","obj":"LitCovid-sentences"},{"subj":"T4","pred":"source","obj":"LitCovid-sentences"},{"subj":"T5","pred":"source","obj":"LitCovid-sentences"},{"subj":"T6","pred":"source","obj":"LitCovid-sentences"},{"subj":"T7","pred":"source","obj":"LitCovid-sentences"},{"subj":"T8","pred":"source","obj":"LitCovid-sentences"},{"subj":"T9","pred":"source","obj":"LitCovid-sentences"},{"subj":"T10","pred":"source","obj":"LitCovid-sentences"},{"subj":"T11","pred":"source","obj":"LitCovid-sentences"},{"subj":"T12","pred":"source","obj":"LitCovid-sentences"},{"subj":"T13","pred":"source","obj":"LitCovid-sentences"}]},{"project":"Covid19_manual_annotation_v2","denotations":[{"id":"T1","span":{"begin":251,"end":261},"obj":"Species"},{"id":"T10","span":{"begin":671,"end":675},"obj":"Gene"},{"id":"T11","span":{"begin":813,"end":817},"obj":"Gene"},{"id":"T12","span":{"begin":1043,"end":1047},"obj":"Gene"},{"id":"T13","span":{"begin":1383,"end":1387},"obj":"Gene"},{"id":"T14","span":{"begin":1414,"end":1418},"obj":"Gene"},{"id":"T15","span":{"begin":1657,"end":1661},"obj":"Gene"},{"id":"T16","span":{"begin":99,"end":130},"obj":"Gene"},{"id":"T17","span":{"begin":61,"end":69},"obj":"Disease"},{"id":"T18","span":{"begin":1718,"end":1726},"obj":"Disease"},{"id":"T19","span":{"begin":146,"end":169},"obj":"Phenomena"},{"id":"T2","span":{"begin":381,"end":391},"obj":"Species"},{"id":"T20","span":{"begin":171,"end":174},"obj":"Phenomena"},{"id":"T21","span":{"begin":680,"end":683},"obj":"Phenomena"},{"id":"T22","span":{"begin":183,"end":196},"obj":"Gene"},{"id":"T23","span":{"begin":326,"end":337},"obj":"Type"},{"id":"T24","span":{"begin":13,"end":23},"obj":"Type"},{"id":"T25","span":{"begin":1646,"end":1656},"obj":"Type"},{"id":"T26","span":{"begin":75,"end":86},"obj":"Phenomena"},{"id":"T27","span":{"begin":637,"end":648},"obj":"Phenomena"},{"id":"T28","span":{"begin":716,"end":736},"obj":"Phenomena"},{"id":"T29","span":{"begin":1481,"end":1492},"obj":"Phenomena"},{"id":"T3","span":{"begin":1524,"end":1534},"obj":"Species"},{"id":"T30","span":{"begin":796,"end":805},"obj":"Phenomena"},{"id":"T34","span":{"begin":788,"end":805},"obj":"Phenomena"},{"id":"T35","span":{"begin":773,"end":783},"obj":"Phenomena"},{"id":"T36","span":{"begin":846,"end":855},"obj":"Index"},{"id":"T37","span":{"begin":760,"end":768},"obj":"PositiveRegulation"},{"id":"T39","span":{"begin":1120,"end":1128},"obj":"PositiveRegulation"},{"id":"T4","span":{"begin":202,"end":249},"obj":"Species"},{"id":"T40","span":{"begin":1319,"end":1327},"obj":"PositiveRegulation"},{"id":"T41","span":{"begin":1614,"end":1623},"obj":"PositiveRegulation"},{"id":"T42","span":{"begin":747,"end":756},"obj":"Variation"},{"id":"T43","span":{"begin":918,"end":927},"obj":"Variation"},{"id":"T44","span":{"begin":932,"end":950},"obj":"Variation"},{"id":"T45","span":{"begin":1053,"end":1070},"obj":"Variation"},{"id":"T46","span":{"begin":1155,"end":1173},"obj":"Variation"},{"id":"T47","span":{"begin":1235,"end":1243},"obj":"Index"},{"id":"T48","span":{"begin":1249,"end":1267},"obj":"Variation"},{"id":"T49","span":{"begin":1283,"end":1301},"obj":"Variation"},{"id":"T5","span":{"begin":338,"end":342},"obj":"Gene"},{"id":"T50","span":{"begin":1498,"end":1516},"obj":"Gene"},{"id":"T51","span":{"begin":1028,"end":1039},"obj":"Phenomena"},{"id":"T52","span":{"begin":1004,"end":1018},"obj":"Gene"},{"id":"T53","span":{"begin":980,"end":996},"obj":"Phenomena"},{"id":"T54","span":{"begin":1133,"end":1149},"obj":"Phenomena"},{"id":"T55","span":{"begin":968,"end":975},"obj":"NegativeRegulation"},{"id":"T56","span":{"begin":956,"end":967},"obj":"High"},{"id":"T57","span":{"begin":1186,"end":1194},"obj":"NegativeRegulation"},{"id":"T58","span":{"begin":1546,"end":1555},"obj":"NegativeRegulation"},{"id":"T59","span":{"begin":1199,"end":1210},"obj":"Phenomena"},{"id":"T6","span":{"begin":24,"end":28},"obj":"Gene"},{"id":"T60","span":{"begin":1230,"end":1234},"obj":"High"},{"id":"T61","span":{"begin":1346,"end":1355},"obj":"Phenomena"},{"id":"T62","span":{"begin":1360,"end":1375},"obj":"Phenomena"},{"id":"T63","span":{"begin":1624,"end":1639},"obj":"Phenomena"},{"id":"T64","span":{"begin":1393,"end":1401},"obj":"Type"},{"id":"T65","span":{"begin":1433,"end":1451},"obj":"Phenomena"},{"id":"T66","span":{"begin":548,"end":566},"obj":"Phenomena"},{"id":"T67","span":{"begin":1430,"end":1432},"obj":"Without"},{"id":"T68","span":{"begin":1556,"end":1563},"obj":"Condition"},{"id":"T69","span":{"begin":1564,"end":1585},"obj":"Phenomena"},{"id":"T7","span":{"begin":132,"end":136},"obj":"Gene"},{"id":"T70","span":{"begin":1472,"end":1480},"obj":"PositiveRegulation"},{"id":"T71","span":{"begin":1393,"end":1401},"obj":"Type"},{"id":"T72","span":{"begin":1414,"end":1418},"obj":"Gene"},{"id":"T73","span":{"begin":1692,"end":1709},"obj":"Chemical"},{"id":"T74","span":{"begin":942,"end":950},"obj":"Variation"},{"id":"T75","span":{"begin":1043,"end":1047},"obj":"Gene"},{"id":"T76","span":{"begin":1043,"end":1047},"obj":"Gene"},{"id":"T77","span":{"begin":1393,"end":1401},"obj":"Type"},{"id":"T78","span":{"begin":1414,"end":1418},"obj":"Gene"},{"id":"T79","span":{"begin":1332,"end":1345},"obj":"Phenomena"},{"id":"T8","span":{"begin":449,"end":453},"obj":"Gene"},{"id":"T9","span":{"begin":574,"end":578},"obj":"Gene"}],"relations":[{"id":"R2","pred":"abbreviation","subj":"T20","obj":"T19"},{"id":"R20","pred":"is_a","subj":"T43","obj":"T55"},{"id":"R21","pred":"is_a","subj":"T55","obj":"T53"},{"id":"R22","pred":"is_a","subj":"T44","obj":"T55"},{"id":"R23","pred":"is_a","subj":"T55","obj":"T53"},{"id":"R24","pred":"of_a","subj":"T56","obj":"T55"},{"id":"R25","pred":"of_a","subj":"T51","obj":"T12"},{"id":"R27","pred":"is_a","subj":"T39","obj":"T54"},{"id":"R28","pred":"of_a","subj":"T60","obj":"T47"},{"id":"R3","pred":"abbreviation","subj":"T1","obj":"T4"},{"id":"R30","pred":"is_a","subj":"T57","obj":"T59"},{"id":"R33","pred":"is_a","subj":"T40","obj":"T61"},{"id":"R34","pred":"is_a","subj":"T40","obj":"T62"},{"id":"R37","pred":"of_a","subj":"T64","obj":"T14"},{"id":"R39","pred":"is_a","subj":"T67","obj":"T65"},{"id":"R62","pred":"is_a","subj":"T13","obj":"T40"},{"id":"R65","pred":"has_a","subj":"T14","obj":"T65"},{"id":"R66","pred":"has_role","subj":"T64","obj":"T67"},{"id":"R67","pred":"of_a","subj":"T77","obj":"T78"},{"id":"R68","pred":"to","subj":"T29","obj":"T78"},{"id":"R69","pred":"is_a","subj":"T77","obj":"T70"},{"id":"R7","pred":"of_a","subj":"T24","obj":"T6"},{"id":"R70","pred":"of_a","subj":"T22","obj":"T19"},{"id":"R71","pred":"to","subj":"T26","obj":"T16"},{"id":"R72","pred":"of_a","subj":"T79","obj":"T61"},{"id":"R8","pred":"is_a","subj":"T22","obj":"T26"},{"id":"R14","pred":"is_a","subj":"T37","obj":"T34"},{"id":"R15","pred":"of_a","subj":"T11","obj":"T34"},{"id":"R16","pred":"of_a","subj":"T11","obj":"T35"},{"id":"R59","pred":"of_a","subj":"T49","obj":"T13"},{"id":"R6","pred":"of_a","subj":"T25","obj":"T15"},{"id":"R60","pred":"is_a","subj":"T75","obj":"T39"},{"id":"R61","pred":"is_a","subj":"T76","obj":"T57"},{"id":"R1","pred":"abbreviation","subj":"T7","obj":"T16"},{"id":"R11","pred":"-","subj":"T35","obj":"T30"},{"id":"R12","pred":"is_a","subj":"T42","obj":"T37"},{"id":"R13","pred":"is_a","subj":"T37","obj":"T35"},{"id":"R17","pred":"has_a","subj":"T12","obj":"T53"},{"id":"R18","pred":"to","subj":"T52","obj":"T53"},{"id":"R4","pred":"of_a","subj":"T4","obj":"T22"},{"id":"R40","pred":"of_a","subj":"T3","obj":"T50"},{"id":"R42","pred":"is_a","subj":"T70","obj":"T29"},{"id":"R43","pred":"is_a","subj":"T50","obj":"T29"},{"id":"R44","pred":"of_a","subj":"T71","obj":"T72"},{"id":"R45","pred":"is_a","subj":"T72","obj":"T41"},{"id":"R46","pred":"is_a","subj":"T41","obj":"T63"},{"id":"R47","pred":"is_a","subj":"T72","obj":"T58"},{"id":"R48","pred":"is_a","subj":"T58","obj":"T69"},{"id":"R49","pred":"has_status","subj":"T72","obj":"T68"},{"id":"R5","pred":"of_a","subj":"T23","obj":"T5"},{"id":"R50","pred":"cause_of","subj":"T41","obj":"T58"},{"id":"R51","pred":"is_a","subj":"T15","obj":"T73"},{"id":"R52","pred":"against","subj":"T18","obj":"T73"},{"id":"R53","pred":"-","subj":"T43","obj":"T74"},{"id":"R54","pred":"of_a","subj":"T43","obj":"T12"},{"id":"R55","pred":"of_a","subj":"T44","obj":"T12"},{"id":"R56","pred":"of_a","subj":"T45","obj":"T75"},{"id":"R57","pred":"of_a","subj":"T46","obj":"T76"},{"id":"R58","pred":"of_a","subj":"T48","obj":"T13"}],"attributes":[{"id":"A57","pred":"Memo","subj":"T27","obj":"MESH:D053585"},{"id":"A45","pred":"tao:has_database_id","subj":"T75","obj":"Gene:59272"},{"id":"A25","pred":"tao:has_standard_notation","subj":"T46","obj":"p.D427R"},{"id":"A4","pred":"tao:has_database_id","subj":"T4","obj":"Tax:2697049"},{"id":"A27","pred":"tao:has_standard_notation","subj":"T49","obj":"p.G448W"},{"id":"A41","pred":"Memo","subj":"T74","obj":"MESH:D009154"},{"id":"A42","pred":"tao:has_standard_notation","subj":"T74","obj":"p.R273Q"},{"id":"A43","pred":"Memo","subj":"T49","obj":"MESH:D009154"},{"id":"A49","pred":"Memo","subj":"T65","obj":"MESH:D004789"},{"id":"A14","pred":"tao:has_database_id","subj":"T14","obj":"Gene:59272"},{"id":"A31","pred":"ForCovid19","subj":"T73","obj":"drug"},{"id":"A19","pred":"tao:has_database_id","subj":"T22","obj":"Gene:43740568"},{"id":"A9","pred":"tao:has_database_id","subj":"T9","obj":"Gene:59272"},{"id":"A30","pred":"tao:has_database_id","subj":"T72","obj":"Gene:59272"},{"id":"A12","pred":"tao:has_database_id","subj":"T12","obj":"Gene:59272"},{"id":"A15","pred":"tao:has_database_id","subj":"T15","obj":"Gene:59272"},{"id":"A33","pred":"tao:has_database_id","subj":"T23","obj":"MESH:D011994"},{"id":"A1","pred":"tao:has_database_id","subj":"T1","obj":"Tax:2697049"},{"id":"A10","pred":"tao:has_database_id","subj":"T10","obj":"Gene:59272"},{"id":"A52","pred":"tao:has_database_id","subj":"T78","obj":"Gene:59272"},{"id":"A53","pred":"Memo","subj":"T19","obj":"MESH:D000072417"},{"id":"A64","pred":"Memo","subj":"T34","obj":"MESH:D000071436"},{"id":"A5","pred":"tao:has_database_id","subj":"T5","obj":"Gene:59272"},{"id":"A13","pred":"tao:has_database_id","subj":"T13","obj":"Gene:59272"},{"id":"A18","pred":"tao:has_database_id","subj":"T18","obj":"MESH:D000086382"},{"id":"A29","pred":"tao:has_database_id","subj":"T52","obj":"MESH:D000804"},{"id":"A56","pred":"Memo","subj":"T26","obj":"MESH:D053585"},{"id":"A68","pred":"tao:has_database_id","subj":"T52","obj":"Gene:183"},{"id":"A69","pred":"ForCovid19","subj":"T52","obj":"peptide"},{"id":"A20","pred":"tao:has_database_id","subj":"T35","obj":"MESH:D055550"},{"id":"A7","pred":"tao:has_database_id","subj":"T7","obj":"Gene:59272"},{"id":"A32","pred":"Memo","subj":"T24","obj":"MESH:D011994"},{"id":"A23","pred":"tao:has_standard_notation","subj":"T44","obj":"p.T445G"},{"id":"A40","pred":"Memo","subj":"T44","obj":"MESH:D009154"},{"id":"A24","pred":"tao:has_standard_notation","subj":"T45","obj":"p.T27R"},{"id":"A39","pred":"Memo","subj":"T45","obj":"MESH:D009154"},{"id":"A59","pred":"Memo","subj":"T66","obj":"MESH:D004789"},{"id":"A61","pred":"Memo","subj":"T63","obj":"MESH:D000071436"},{"id":"A67","pred":"Memo","subj":"T69","obj":"MESH:D059748"},{"id":"A2","pred":"tao:has_database_id","subj":"T2","obj":"Tax:2697049"},{"id":"A62","pred":"tao:has_database_id","subj":"T61","obj":"MESH:D055550"},{"id":"A34","pred":"Memo","subj":"T64","obj":"MESH:D011994"},{"id":"A51","pred":"Memo","subj":"T77","obj":"MESH:D011994"},{"id":"A63","pred":"tao:has_database_id","subj":"T79","obj":"MESH:D013816"},{"id":"A3","pred":"tao:has_database_id","subj":"T3","obj":"Tax:2697049"},{"id":"A22","pred":"tao:has_standard_notation","subj":"T43","obj":"p.R273Q"},{"id":"A38","pred":"Memo","subj":"T43","obj":"MESH:D009154"},{"id":"A26","pred":"tao:has_standard_notation","subj":"T48","obj":"p.P451M"},{"id":"A44","pred":"Memo","subj":"T48","obj":"MESH:D009154"},{"id":"A46","pred":"tao:has_database_id","subj":"T76","obj":"Gene:59272"},{"id":"A58","pred":"Memo","subj":"T29","obj":"MESH:D053585"},{"id":"A6","pred":"tao:has_database_id","subj":"T6","obj":"Gene:59272"},{"id":"A28","pred":"tao:has_database_id","subj":"T50","obj":"Gene:43740568"},{"id":"A11","pred":"tao:has_database_id","subj":"T11","obj":"Gene:59272"},{"id":"A37","pred":"tao:has_database_id","subj":"T42","obj":"MESH:D009154"},{"id":"A16","pred":"tao:has_database_id","subj":"T16","obj":"Gene:59272"},{"id":"A21","pred":"tao:has_database_id","subj":"T30","obj":"MESH:D055550"},{"id":"A35","pred":"Memo","subj":"T71","obj":"MESH:D011994"},{"id":"A60","pred":"Memo","subj":"T62","obj":"MESH:D000071436"},{"id":"A36","pred":"Memo","subj":"T25","obj":"MESH:D011994"},{"id":"A55","pred":"Memo","subj":"T21","obj":"MESH:D000072417"},{"id":"A66","pred":"tao:has_database_id","subj":"T46","obj":"MESH:D009154"},{"id":"A17","pred":"tao:has_database_id","subj":"T17","obj":"MESH:D000086382"},{"id":"A54","pred":"Memo","subj":"T20","obj":"MESH:D000072417"},{"id":"A65","pred":"tao:has_database_id","subj":"T51","obj":"MESH:D020134"},{"id":"A8","pred":"tao:has_database_id","subj":"T8","obj":"Gene:59272"},{"subj":"T1","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T10","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T11","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T12","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T13","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T14","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T15","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T16","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T17","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T18","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T19","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T2","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T20","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T21","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T22","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T23","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T24","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T25","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T26","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T27","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T28","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T29","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T3","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T30","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T34","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T35","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T36","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T37","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T39","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T4","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T40","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T41","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T42","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T43","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T44","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T45","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T46","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T47","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T48","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T49","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T5","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T50","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T51","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T52","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T53","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T54","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T55","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T56","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T57","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T58","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T59","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T6","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T60","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T61","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T62","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T63","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T64","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T65","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T66","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T67","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T68","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T69","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T7","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T70","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T71","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T72","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T73","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T74","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T75","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T76","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T77","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T78","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T79","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T8","pred":"source","obj":"Covid19_manual_annotation_v2"},{"subj":"T9","pred":"source","obj":"Covid19_manual_annotation_v2"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"BioProject","uri":"https://www.ncbi.nlm.nih.gov/bioproject/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"},{"prefix":"HP","uri":"https://hpo.jax.org/app/browse/term/HP:"},{"prefix":"BioSample","uri":"https://www.ncbi.nlm.nih.gov/biosample/"}]},{"project":"Zoonoses","denotations":[{"id":"T1","span":{"begin":251,"end":261},"obj":"Species"},{"id":"T10","span":{"begin":671,"end":675},"obj":"Gene"},{"id":"T11","span":{"begin":813,"end":817},"obj":"Gene"},{"id":"T12","span":{"begin":1043,"end":1047},"obj":"Gene"},{"id":"T13","span":{"begin":1383,"end":1387},"obj":"Gene"},{"id":"T14","span":{"begin":1414,"end":1418},"obj":"Gene"},{"id":"T15","span":{"begin":1657,"end":1661},"obj":"Gene"},{"id":"T16","span":{"begin":99,"end":130},"obj":"Gene"},{"id":"T17","span":{"begin":61,"end":69},"obj":"Disease"},{"id":"T18","span":{"begin":1718,"end":1726},"obj":"Disease"},{"id":"T19","span":{"begin":146,"end":169},"obj":"Phenomena"},{"id":"T2","span":{"begin":381,"end":391},"obj":"Species"},{"id":"T20","span":{"begin":171,"end":174},"obj":"Phenomena"},{"id":"T21","span":{"begin":680,"end":683},"obj":"Phenomena"},{"id":"T22","span":{"begin":183,"end":196},"obj":"Gene"},{"id":"T23","span":{"begin":326,"end":337},"obj":"Type"},{"id":"T24","span":{"begin":13,"end":23},"obj":"Type"},{"id":"T25","span":{"begin":1646,"end":1656},"obj":"Type"},{"id":"T26","span":{"begin":75,"end":86},"obj":"Phenomena"},{"id":"T27","span":{"begin":637,"end":648},"obj":"Phenomena"},{"id":"T28","span":{"begin":716,"end":736},"obj":"Phenomena"},{"id":"T29","span":{"begin":1481,"end":1492},"obj":"Phenomena"},{"id":"T3","span":{"begin":1524,"end":1534},"obj":"Species"},{"id":"T30","span":{"begin":796,"end":805},"obj":"Phenomena"},{"id":"T34","span":{"begin":788,"end":805},"obj":"Phenomena"},{"id":"T35","span":{"begin":773,"end":783},"obj":"Phenomena"},{"id":"T36","span":{"begin":846,"end":855},"obj":"Index"},{"id":"T37","span":{"begin":760,"end":768},"obj":"PositiveRegulation"},{"id":"T39","span":{"begin":1120,"end":1128},"obj":"PositiveRegulation"},{"id":"T4","span":{"begin":202,"end":249},"obj":"Species"},{"id":"T40","span":{"begin":1319,"end":1327},"obj":"PositiveRegulation"},{"id":"T41","span":{"begin":1614,"end":1623},"obj":"PositiveRegulation"},{"id":"T42","span":{"begin":747,"end":756},"obj":"Variation"},{"id":"T43","span":{"begin":918,"end":927},"obj":"Variation"},{"id":"T44","span":{"begin":932,"end":950},"obj":"Variation"},{"id":"T45","span":{"begin":1053,"end":1070},"obj":"Variation"},{"id":"T46","span":{"begin":1155,"end":1173},"obj":"Variation"},{"id":"T47","span":{"begin":1235,"end":1243},"obj":"Index"},{"id":"T48","span":{"begin":1249,"end":1267},"obj":"Variation"},{"id":"T49","span":{"begin":1283,"end":1301},"obj":"Variation"},{"id":"T5","span":{"begin":338,"end":342},"obj":"Gene"},{"id":"T50","span":{"begin":1498,"end":1516},"obj":"Gene"},{"id":"T51","span":{"begin":1028,"end":1039},"obj":"Phenomena"},{"id":"T52","span":{"begin":1004,"end":1018},"obj":"Gene"},{"id":"T53","span":{"begin":980,"end":996},"obj":"Phenomena"},{"id":"T54","span":{"begin":1133,"end":1149},"obj":"Phenomena"},{"id":"T55","span":{"begin":968,"end":975},"obj":"NegativeRegulation"},{"id":"T56","span":{"begin":956,"end":967},"obj":"High"},{"id":"T57","span":{"begin":1186,"end":1194},"obj":"NegativeRegulation"},{"id":"T58","span":{"begin":1546,"end":1555},"obj":"NegativeRegulation"},{"id":"T59","span":{"begin":1199,"end":1210},"obj":"Phenomena"},{"id":"T6","span":{"begin":24,"end":28},"obj":"Gene"},{"id":"T60","span":{"begin":1230,"end":1234},"obj":"High"},{"id":"T61","span":{"begin":1346,"end":1355},"obj":"Phenomena"},{"id":"T62","span":{"begin":1360,"end":1375},"obj":"Phenomena"},{"id":"T63","span":{"begin":1624,"end":1639},"obj":"Phenomena"},{"id":"T64","span":{"begin":1393,"end":1401},"obj":"Type"},{"id":"T65","span":{"begin":1433,"end":1451},"obj":"Phenomena"},{"id":"T66","span":{"begin":548,"end":566},"obj":"Phenomena"},{"id":"T67","span":{"begin":1430,"end":1432},"obj":"Without"},{"id":"T68","span":{"begin":1556,"end":1563},"obj":"Condition"},{"id":"T69","span":{"begin":1564,"end":1585},"obj":"Phenomena"},{"id":"T7","span":{"begin":132,"end":136},"obj":"Gene"},{"id":"T70","span":{"begin":1472,"end":1480},"obj":"PositiveRegulation"},{"id":"T71","span":{"begin":1393,"end":1401},"obj":"Type"},{"id":"T72","span":{"begin":1414,"end":1418},"obj":"Gene"},{"id":"T73","span":{"begin":1692,"end":1709},"obj":"Chemical"},{"id":"T74","span":{"begin":942,"end":950},"obj":"Variation"},{"id":"T75","span":{"begin":1043,"end":1047},"obj":"Gene"},{"id":"T76","span":{"begin":1043,"end":1047},"obj":"Gene"},{"id":"T77","span":{"begin":1393,"end":1401},"obj":"Type"},{"id":"T78","span":{"begin":1414,"end":1418},"obj":"Gene"},{"id":"T79","span":{"begin":1332,"end":1345},"obj":"Phenomena"},{"id":"T8","span":{"begin":449,"end":453},"obj":"Gene"},{"id":"T9","span":{"begin":574,"end":578},"obj":"Gene"}],"relations":[{"id":"R1","pred":"abbreviation","subj":"T7","obj":"T16"},{"id":"R11","pred":"-","subj":"T35","obj":"T30"},{"id":"R12","pred":"is_a","subj":"T42","obj":"T37"},{"id":"R13","pred":"is_a","subj":"T37","obj":"T35"},{"id":"R14","pred":"is_a","subj":"T37","obj":"T34"},{"id":"R15","pred":"of_a","subj":"T11","obj":"T34"},{"id":"R16","pred":"of_a","subj":"T11","obj":"T35"},{"id":"R17","pred":"has_a","subj":"T12","obj":"T53"},{"id":"R18","pred":"to","subj":"T52","obj":"T53"},{"id":"R2","pred":"abbreviation","subj":"T20","obj":"T19"},{"id":"R20","pred":"is_a","subj":"T43","obj":"T55"},{"id":"R21","pred":"is_a","subj":"T55","obj":"T53"},{"id":"R22","pred":"is_a","subj":"T44","obj":"T55"},{"id":"R23","pred":"is_a","subj":"T55","obj":"T53"},{"id":"R24","pred":"is_a","subj":"T56","obj":"T55"},{"id":"R27","pred":"is_a","subj":"T39","obj":"T54"},{"id":"R28","pred":"is_a","subj":"T60","obj":"T47"},{"id":"R3","pred":"abbreviation","subj":"T1","obj":"T4"},{"id":"R30","pred":"is_a","subj":"T57","obj":"T59"},{"id":"R33","pred":"is_a","subj":"T40","obj":"T61"},{"id":"R34","pred":"is_a","subj":"T40","obj":"T62"},{"id":"R37","pred":"of_a","subj":"T64","obj":"T14"},{"id":"R39","pred":"is_a","subj":"T67","obj":"T65"},{"id":"R4","pred":"of_a","subj":"T4","obj":"T22"},{"id":"R40","pred":"of_a","subj":"T3","obj":"T50"},{"id":"R42","pred":"is_a","subj":"T70","obj":"T29"},{"id":"R43","pred":"is_a","subj":"T50","obj":"T29"},{"id":"R44","pred":"of_a","subj":"T71","obj":"T72"},{"id":"R45","pred":"is_a","subj":"T72","obj":"T41"},{"id":"R46","pred":"is_a","subj":"T41","obj":"T63"},{"id":"R47","pred":"is_a","subj":"T72","obj":"T58"},{"id":"R48","pred":"is_a","subj":"T58","obj":"T69"},{"id":"R49","pred":"has_status","subj":"T72","obj":"T68"},{"id":"R5","pred":"of_a","subj":"T23","obj":"T5"},{"id":"R50","pred":"cause_of","subj":"T41","obj":"T58"},{"id":"R51","pred":"is_a","subj":"T15","obj":"T73"},{"id":"R52","pred":"against","subj":"T18","obj":"T73"},{"id":"R53","pred":"-","subj":"T43","obj":"T74"},{"id":"R6","pred":"of_a","subj":"T25","obj":"T15"},{"id":"R60","pred":"is_a","subj":"T75","obj":"T39"},{"id":"R61","pred":"is_a","subj":"T76","obj":"T57"},{"id":"R62","pred":"is_a","subj":"T13","obj":"T40"},{"id":"R65","pred":"has_a","subj":"T14","obj":"T65"},{"id":"R66","pred":"has_role","subj":"T64","obj":"T67"},{"id":"R67","pred":"of_a","subj":"T77","obj":"T78"},{"id":"R68","pred":"to","subj":"T29","obj":"T78"},{"id":"R69","pred":"is_a","subj":"T77","obj":"T70"},{"id":"R7","pred":"of_a","subj":"T24","obj":"T6"},{"id":"R70","pred":"of_a","subj":"T22","obj":"T19"},{"id":"R71","pred":"to","subj":"T26","obj":"T16"},{"id":"R72","pred":"of_a","subj":"T79","obj":"T61"},{"id":"R8","pred":"is_a","subj":"T22","obj":"T26"},{"id":"R73","pred":"of_a","subj":"T11","obj":"T42"},{"id":"R74","pred":"of_a","subj":"T12","obj":"T51"},{"id":"R75","pred":"of_a","subj":"T12","obj":"T44"},{"id":"R76","pred":"of_a","subj":"T12","obj":"T43"},{"id":"R77","pred":"of_a","subj":"T75","obj":"T45"},{"id":"R78","pred":"of_a","subj":"T76","obj":"T46"},{"id":"R79","pred":"of_a","subj":"T13","obj":"T49"},{"id":"R80","pred":"of_a","subj":"T13","obj":"T48"}],"attributes":[{"id":"A57","pred":"Memo","subj":"T27","obj":"MESH:D053585"},{"id":"A68","pred":"tao:has_database_id","subj":"T52","obj":"Gene:183"},{"id":"A41","pred":"Memo","subj":"T74","obj":"MESH:D009154"},{"id":"A42","pred":"tao:has_standard_notation","subj":"T74","obj":"p.R273Q"},{"id":"A67","pred":"Memo","subj":"T69","obj":"MESH:D059748"},{"id":"A45","pred":"tao:has_database_id","subj":"T75","obj":"Gene:59272"},{"id":"A38","pred":"Memo","subj":"T43","obj":"MESH:D009154"},{"id":"A43","pred":"Memo","subj":"T49","obj":"MESH:D009154"},{"id":"A36","pred":"Memo","subj":"T25","obj":"MESH:D011994"},{"id":"A66","pred":"tao:has_database_id","subj":"T46","obj":"MESH:D009154"},{"id":"A49","pred":"Memo","subj":"T65","obj":"MESH:D004789"},{"id":"A52","pred":"tao:has_database_id","subj":"T78","obj":"Gene:59272"},{"id":"A69","pred":"ForZoonoses","subj":"T73","obj":"drug"},{"id":"A37","pred":"tao:has_database_id","subj":"T42","obj":"MESH:D009154"},{"id":"A7","pred":"tao:has_database_id","subj":"T7","obj":"Gene:59272"},{"id":"A65","pred":"tao:has_database_id","subj":"T51","obj":"MESH:D020134"},{"id":"A34","pred":"Memo","subj":"T64","obj":"MESH:D011994"},{"id":"A56","pred":"Memo","subj":"T26","obj":"MESH:D053585"},{"id":"A5","pred":"tao:has_database_id","subj":"T5","obj":"Gene:59272"},{"id":"A54","pred":"Memo","subj":"T20","obj":"MESH:D000072417"},{"id":"A40","pred":"Memo","subj":"T44","obj":"MESH:D009154"},{"id":"A53","pred":"Memo","subj":"T19","obj":"MESH:D000072417"},{"id":"A9","pred":"tao:has_database_id","subj":"T9","obj":"Gene:59272"},{"id":"A4","pred":"tao:has_database_id","subj":"T4","obj":"Tax:2697049"},{"id":"A30","pred":"tao:has_database_id","subj":"T72","obj":"Gene:59272"},{"id":"A8","pred":"tao:has_database_id","subj":"T8","obj":"Gene:59272"},{"id":"A33","pred":"tao:has_database_id","subj":"T23","obj":"MESH:D011994"},{"id":"A62","pred":"tao:has_database_id","subj":"T61","obj":"MESH:D055550"},{"id":"A60","pred":"Memo","subj":"T62","obj":"MESH:D000071436"},{"id":"A58","pred":"Memo","subj":"T29","obj":"MESH:D053585"},{"id":"A6","pred":"tao:has_database_id","subj":"T6","obj":"Gene:59272"},{"id":"A35","pred":"Memo","subj":"T71","obj":"MESH:D011994"},{"id":"A63","pred":"tao:has_database_id","subj":"T79","obj":"MESH:D013816"},{"id":"A61","pred":"Memo","subj":"T63","obj":"MESH:D000071436"},{"id":"A64","pred":"Memo","subj":"T34","obj":"MESH:D000071436"},{"id":"A46","pred":"tao:has_database_id","subj":"T76","obj":"Gene:59272"},{"id":"A55","pred":"Memo","subj":"T21","obj":"MESH:D000072417"},{"id":"A3","pred":"tao:has_database_id","subj":"T3","obj":"Tax:2697049"},{"id":"A44","pred":"Memo","subj":"T48","obj":"MESH:D009154"},{"id":"A51","pred":"Memo","subj":"T77","obj":"MESH:D011994"},{"id":"A29","pred":"tao:has_database_id","subj":"T52","obj":"MESH:D000804"},{"id":"A10","pred":"tao:has_database_id","subj":"T10","obj":"Gene:59272"},{"id":"A22","pred":"tao:has_standard_notation","subj":"T43","obj":"p.R273Q"},{"id":"A27","pred":"tao:has_standard_notation","subj":"T49","obj":"p.G448W"},{"id":"A28","pred":"tao:has_database_id","subj":"T50","obj":"Gene:43740568"},{"id":"A25","pred":"tao:has_standard_notation","subj":"T46","obj":"p.D427R"},{"id":"A13","pred":"tao:has_database_id","subj":"T13","obj":"Gene:59272"},{"id":"A18","pred":"tao:has_database_id","subj":"T18","obj":"MESH:D000086382"},{"id":"A16","pred":"tao:has_database_id","subj":"T16","obj":"Gene:59272"},{"id":"A21","pred":"tao:has_database_id","subj":"T30","obj":"MESH:D055550"},{"id":"A23","pred":"tao:has_standard_notation","subj":"T44","obj":"p.T445G"},{"id":"A17","pred":"tao:has_database_id","subj":"T17","obj":"MESH:D000086382"},{"id":"A1","pred":"tao:has_database_id","subj":"T1","obj":"Tax:2697049"},{"id":"A15","pred":"tao:has_database_id","subj":"T15","obj":"Gene:59272"},{"id":"A19","pred":"tao:has_database_id","subj":"T22","obj":"Gene:43740568"},{"id":"A14","pred":"tao:has_database_id","subj":"T14","obj":"Gene:59272"},{"id":"A12","pred":"tao:has_database_id","subj":"T12","obj":"Gene:59272"},{"id":"A11","pred":"tao:has_database_id","subj":"T11","obj":"Gene:59272"},{"id":"A20","pred":"tao:has_database_id","subj":"T35","obj":"MESH:D055550"},{"id":"A26","pred":"tao:has_standard_notation","subj":"T48","obj":"p.P451M"},{"id":"A2","pred":"tao:has_database_id","subj":"T2","obj":"Tax:2697049"},{"id":"A24","pred":"tao:has_standard_notation","subj":"T45","obj":"p.T27R"},{"id":"A39","pred":"Memo","subj":"T45","obj":"MESH:D009154"},{"id":"A32","pred":"Memo","subj":"T24","obj":"MESH:D011994"},{"id":"A59","pred":"Memo","subj":"T66","obj":"MESH:D004789"},{"subj":"T1","pred":"source","obj":"Zoonoses"},{"subj":"T10","pred":"source","obj":"Zoonoses"},{"subj":"T11","pred":"source","obj":"Zoonoses"},{"subj":"T12","pred":"source","obj":"Zoonoses"},{"subj":"T13","pred":"source","obj":"Zoonoses"},{"subj":"T14","pred":"source","obj":"Zoonoses"},{"subj":"T15","pred":"source","obj":"Zoonoses"},{"subj":"T16","pred":"source","obj":"Zoonoses"},{"subj":"T17","pred":"source","obj":"Zoonoses"},{"subj":"T18","pred":"source","obj":"Zoonoses"},{"subj":"T19","pred":"source","obj":"Zoonoses"},{"subj":"T2","pred":"source","obj":"Zoonoses"},{"subj":"T20","pred":"source","obj":"Zoonoses"},{"subj":"T21","pred":"source","obj":"Zoonoses"},{"subj":"T22","pred":"source","obj":"Zoonoses"},{"subj":"T23","pred":"source","obj":"Zoonoses"},{"subj":"T24","pred":"source","obj":"Zoonoses"},{"subj":"T25","pred":"source","obj":"Zoonoses"},{"subj":"T26","pred":"source","obj":"Zoonoses"},{"subj":"T27","pred":"source","obj":"Zoonoses"},{"subj":"T28","pred":"source","obj":"Zoonoses"},{"subj":"T29","pred":"source","obj":"Zoonoses"},{"subj":"T3","pred":"source","obj":"Zoonoses"},{"subj":"T30","pred":"source","obj":"Zoonoses"},{"subj":"T34","pred":"source","obj":"Zoonoses"},{"subj":"T35","pred":"source","obj":"Zoonoses"},{"subj":"T36","pred":"source","obj":"Zoonoses"},{"subj":"T37","pred":"source","obj":"Zoonoses"},{"subj":"T39","pred":"source","obj":"Zoonoses"},{"subj":"T4","pred":"source","obj":"Zoonoses"},{"subj":"T40","pred":"source","obj":"Zoonoses"},{"subj":"T41","pred":"source","obj":"Zoonoses"},{"subj":"T42","pred":"source","obj":"Zoonoses"},{"subj":"T43","pred":"source","obj":"Zoonoses"},{"subj":"T44","pred":"source","obj":"Zoonoses"},{"subj":"T45","pred":"source","obj":"Zoonoses"},{"subj":"T46","pred":"source","obj":"Zoonoses"},{"subj":"T47","pred":"source","obj":"Zoonoses"},{"subj":"T48","pred":"source","obj":"Zoonoses"},{"subj":"T49","pred":"source","obj":"Zoonoses"},{"subj":"T5","pred":"source","obj":"Zoonoses"},{"subj":"T50","pred":"source","obj":"Zoonoses"},{"subj":"T51","pred":"source","obj":"Zoonoses"},{"subj":"T52","pred":"source","obj":"Zoonoses"},{"subj":"T53","pred":"source","obj":"Zoonoses"},{"subj":"T54","pred":"source","obj":"Zoonoses"},{"subj":"T55","pred":"source","obj":"Zoonoses"},{"subj":"T56","pred":"source","obj":"Zoonoses"},{"subj":"T57","pred":"source","obj":"Zoonoses"},{"subj":"T58","pred":"source","obj":"Zoonoses"},{"subj":"T59","pred":"source","obj":"Zoonoses"},{"subj":"T6","pred":"source","obj":"Zoonoses"},{"subj":"T60","pred":"source","obj":"Zoonoses"},{"subj":"T61","pred":"source","obj":"Zoonoses"},{"subj":"T62","pred":"source","obj":"Zoonoses"},{"subj":"T63","pred":"source","obj":"Zoonoses"},{"subj":"T64","pred":"source","obj":"Zoonoses"},{"subj":"T65","pred":"source","obj":"Zoonoses"},{"subj":"T66","pred":"source","obj":"Zoonoses"},{"subj":"T67","pred":"source","obj":"Zoonoses"},{"subj":"T68","pred":"source","obj":"Zoonoses"},{"subj":"T69","pred":"source","obj":"Zoonoses"},{"subj":"T7","pred":"source","obj":"Zoonoses"},{"subj":"T70","pred":"source","obj":"Zoonoses"},{"subj":"T71","pred":"source","obj":"Zoonoses"},{"subj":"T72","pred":"source","obj":"Zoonoses"},{"subj":"T73","pred":"source","obj":"Zoonoses"},{"subj":"T74","pred":"source","obj":"Zoonoses"},{"subj":"T75","pred":"source","obj":"Zoonoses"},{"subj":"T76","pred":"source","obj":"Zoonoses"},{"subj":"T77","pred":"source","obj":"Zoonoses"},{"subj":"T78","pred":"source","obj":"Zoonoses"},{"subj":"T79","pred":"source","obj":"Zoonoses"},{"subj":"T8","pred":"source","obj":"Zoonoses"},{"subj":"T9","pred":"source","obj":"Zoonoses"}]},{"project":"LitCovid_AGAC_only","denotations":[{"id":"p75930s6","span":{"begin":918,"end":927},"obj":"Var"},{"id":"p75930s8","span":{"begin":932,"end":941},"obj":"Var"},{"id":"p75930s12","span":{"begin":968,"end":975},"obj":"NegReg"},{"id":"p75930s14","span":{"begin":980,"end":987},"obj":"MPA"},{"id":"p75930s15","span":{"begin":988,"end":996},"obj":"MPA"},{"id":"p75930s26","span":{"begin":1043,"end":1047},"obj":"Gene"},{"id":"p75931s1","span":{"begin":1053,"end":1061},"obj":"Var"},{"id":"p75932s1","span":{"begin":1155,"end":1164},"obj":"Var"},{"id":"p75932s8","span":{"begin":1199,"end":1210},"obj":"MPA"},{"id":"p75933s1","span":{"begin":1249,"end":1258},"obj":"Var"},{"id":"p75933s6","span":{"begin":1283,"end":1292},"obj":"Var"},{"id":"p75933s11","span":{"begin":1319,"end":1327},"obj":"PosReg"},{"id":"p75933s13","span":{"begin":1332,"end":1355},"obj":"MPA"},{"id":"p75933s16","span":{"begin":1360,"end":1375},"obj":"MPA"},{"id":"p75933s19","span":{"begin":1383,"end":1387},"obj":"Protein"},{"id":"p75935s5","span":{"begin":1564,"end":1585},"obj":"MPA"}],"attributes":[{"subj":"p75930s6","pred":"source","obj":"LitCovid_AGAC_only"},{"subj":"p75930s8","pred":"source","obj":"LitCovid_AGAC_only"},{"subj":"p75930s12","pred":"source","obj":"LitCovid_AGAC_only"},{"subj":"p75930s14","pred":"source","obj":"LitCovid_AGAC_only"},{"subj":"p75930s15","pred":"source","obj":"LitCovid_AGAC_only"},{"subj":"p75930s26","pred":"source","obj":"LitCovid_AGAC_only"},{"subj":"p75931s1","pred":"source","obj":"LitCovid_AGAC_only"},{"subj":"p75932s1","pred":"source","obj":"LitCovid_AGAC_only"},{"subj":"p75932s8","pred":"source","obj":"LitCovid_AGAC_only"},{"subj":"p75933s1","pred":"source","obj":"LitCovid_AGAC_only"},{"subj":"p75933s6","pred":"source","obj":"LitCovid_AGAC_only"},{"subj":"p75933s11","pred":"source","obj":"LitCovid_AGAC_only"},{"subj":"p75933s13","pred":"source","obj":"LitCovid_AGAC_only"},{"subj":"p75933s16","pred":"source","obj":"LitCovid_AGAC_only"},{"subj":"p75933s19","pred":"source","obj":"LitCovid_AGAC_only"},{"subj":"p75935s5","pred":"source","obj":"LitCovid_AGAC_only"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-OGER-BB","color":"#ecd493","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#ba93ec"},{"id":"LitCovid-PD-MONDO","color":"#93eca0"},{"id":"LitCovid-PD-CLO","color":"#ec93a0"},{"id":"LitCovid-PD-CHEBI","color":"#93baec"},{"id":"LitCovid-PD-GO-BP","color":"#d4ec93"},{"id":"LitCovid-PubTator","color":"#ea93ec"},{"id":"LitCovid-sentences","color":"#93ecd0"},{"id":"Covid19_manual_annotation_v2","color":"#ecb693"},{"id":"Zoonoses","color":"#9c93ec"},{"id":"LitCovid_AGAC_only","color":"#a4ec93"}]}]}}