PubMed:32727845 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/32727845","sourcedb":"PubMed","sourceid":"32727845","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/32727845","text":"Identification of an anti-SARS-CoV-2 receptor binding domain directed human monoclonal antibody from a naïve semi-synthetic library.\nThere is a desperate need for safe and effective vaccines, therapies and diagnostics for SARS-CoV-2, the development of which will be aided by the discovery of potent and selective antibodies against relevant viral epitopes. Human phage display technology has revolutionized the process of identifying and optimizing antibodies, providing facile entry points for further applications. Here in, we use this technology to search for antibodies targeting the receptor binding domain (RBD) of CoV-2. Specifically, we screened a naïve human semi-synthetic phage library against RBD, leading to the identification of a high-affinity single chain fragment variable region (scFv). The scFv was further engineered into two other antibody formats (scFv-Fc and IgG1). All the three antibody formats showed high binding specificity to CoV-2 RBD and the spike antigens in different assay systems. Flow cytometry analysis demonstrated specific binding of the IgG1 format to cells expressing membrane bound CoV-2 spike protein. Docking studies revealed that the scFv recognizes an epitope that partially overlaps with angiotensin converting enzyme 2 (ACE2)-interacting sites on the CoV-2 RBD. Given its high specificity and affinity, we anticipate that these anti-CoV-2 antibodies will be useful as valuable reagents for accessing the antigenicity of vaccine candidates, as well as developing antibody-based therapeutics and diagnostics for CoV-2.","tracks":[{"project":"LitCovid-OGER-BB","denotations":[{"id":"T1","span":{"begin":26,"end":36},"obj":"SP_7"},{"id":"T2","span":{"begin":54,"end":60},"obj":"SO:0000417"},{"id":"T3","span":{"begin":70,"end":75},"obj":"SP_6"},{"id":"T4","span":{"begin":70,"end":75},"obj":"NCBITaxon:9606"},{"id":"T5","span":{"begin":87,"end":95},"obj":"GO:0042571"},{"id":"T6","span":{"begin":222,"end":232},"obj":"SP_7"},{"id":"T7","span":{"begin":314,"end":324},"obj":"GO:0042571"},{"id":"T8","span":{"begin":342,"end":347},"obj":"NCBITaxon:10239"},{"id":"T9","span":{"begin":348,"end":356},"obj":"BV_9"},{"id":"T10","span":{"begin":358,"end":363},"obj":"SP_6"},{"id":"T11","span":{"begin":358,"end":363},"obj":"NCBITaxon:9606"},{"id":"T12","span":{"begin":450,"end":460},"obj":"GO:0042571"},{"id":"T13","span":{"begin":564,"end":574},"obj":"GO:0042571"},{"id":"T14","span":{"begin":606,"end":612},"obj":"SO:0000417"},{"id":"T15","span":{"begin":663,"end":668},"obj":"SP_6"},{"id":"T16","span":{"begin":663,"end":668},"obj":"NCBITaxon:9606"},{"id":"T17","span":{"begin":760,"end":772},"obj":"SO:0000984"},{"id":"T18","span":{"begin":853,"end":861},"obj":"GO:0042571"},{"id":"T19","span":{"begin":904,"end":912},"obj":"GO:0042571"},{"id":"T20","span":{"begin":980,"end":988},"obj":"CHEBI:59132"},{"id":"T21","span":{"begin":980,"end":988},"obj":"CHEBI:59132"},{"id":"T22","span":{"begin":1099,"end":1109},"obj":"GO:0010467"},{"id":"T23","span":{"begin":1110,"end":1118},"obj":"GO:0016020"},{"id":"T24","span":{"begin":1199,"end":1206},"obj":"BV_9"},{"id":"T25","span":{"begin":1236,"end":1267},"obj":"PG_10"},{"id":"T26","span":{"begin":1236,"end":1267},"obj":"PR:000003622"},{"id":"T27","span":{"begin":1269,"end":1273},"obj":"G_3"},{"id":"T28","span":{"begin":1269,"end":1273},"obj":"PG_10"},{"id":"T29","span":{"begin":1269,"end":1273},"obj":"PR:000003622"},{"id":"T30","span":{"begin":1388,"end":1398},"obj":"GO:0042571"},{"id":"T31","span":{"begin":1426,"end":1434},"obj":"CHEBI:33893"},{"id":"T32","span":{"begin":1426,"end":1434},"obj":"CHEBI:33893"},{"id":"T33","span":{"begin":1511,"end":1519},"obj":"GO:0042571"}],"namespaces":[{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T2","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T3","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T4","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T5","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T6","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T7","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T8","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T9","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T10","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T11","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T12","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T13","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T14","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T15","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T16","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T17","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T18","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T19","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T20","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T21","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T22","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T23","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T24","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T25","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T26","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T27","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T28","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T29","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T30","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T31","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T32","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T33","pred":"source","obj":"LitCovid-OGER-BB"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T1","span":{"begin":87,"end":95},"obj":"Body_part"},{"id":"T2","span":{"begin":853,"end":861},"obj":"Body_part"},{"id":"T3","span":{"begin":904,"end":912},"obj":"Body_part"},{"id":"T4","span":{"begin":1093,"end":1098},"obj":"Body_part"},{"id":"T5","span":{"begin":1137,"end":1144},"obj":"Body_part"},{"id":"T6","span":{"begin":1511,"end":1519},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A5","pred":"fma_id","subj":"T5","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A6","pred":"fma_id","subj":"T6","obj":"http://purl.org/sig/ont/fma/fma62871"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T1","span":{"begin":26,"end":34},"obj":"Disease"},{"id":"T2","span":{"begin":222,"end":230},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1","span":{"begin":70,"end":75},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T2","span":{"begin":101,"end":102},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T3","span":{"begin":142,"end":143},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T4","span":{"begin":358,"end":363},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T5","span":{"begin":389,"end":392},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T6","span":{"begin":655,"end":656},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T7","span":{"begin":663,"end":668},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T8","span":{"begin":744,"end":745},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T9","span":{"begin":876,"end":878},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T10","span":{"begin":1093,"end":1098},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T11","span":{"begin":1110,"end":1118},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1","span":{"begin":980,"end":988},"obj":"Chemical"},{"id":"T2","span":{"begin":1137,"end":1144},"obj":"Chemical"},{"id":"T3","span":{"begin":1199,"end":1206},"obj":"Chemical"},{"id":"T4","span":{"begin":1236,"end":1247},"obj":"Chemical"},{"id":"T5","span":{"begin":1426,"end":1434},"obj":"Chemical"}],"attributes":[{"id":"A1","pred":"chebi_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A2","pred":"chebi_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A3","pred":"chebi_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_53000"},{"id":"A4","pred":"chebi_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A5","pred":"chebi_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_33893"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"2","span":{"begin":31,"end":36},"obj":"Species"},{"id":"3","span":{"begin":70,"end":75},"obj":"Species"},{"id":"18","span":{"begin":227,"end":232},"obj":"Species"},{"id":"19","span":{"begin":358,"end":363},"obj":"Species"},{"id":"20","span":{"begin":622,"end":627},"obj":"Species"},{"id":"21","span":{"begin":663,"end":668},"obj":"Species"},{"id":"22","span":{"begin":799,"end":803},"obj":"Gene"},{"id":"23","span":{"begin":810,"end":814},"obj":"Gene"},{"id":"24","span":{"begin":871,"end":875},"obj":"Gene"},{"id":"25","span":{"begin":1180,"end":1184},"obj":"Gene"},{"id":"26","span":{"begin":1236,"end":1267},"obj":"Gene"},{"id":"27","span":{"begin":1269,"end":1273},"obj":"Gene"},{"id":"28","span":{"begin":1382,"end":1387},"obj":"Species"},{"id":"29","span":{"begin":1559,"end":1564},"obj":"Species"}],"attributes":[{"id":"A2","pred":"tao:has_database_id","subj":"2","obj":"Tax:2697049"},{"id":"A3","pred":"tao:has_database_id","subj":"3","obj":"Tax:9606"},{"id":"A18","pred":"tao:has_database_id","subj":"18","obj":"Tax:2697049"},{"id":"A19","pred":"tao:has_database_id","subj":"19","obj":"Tax:9606"},{"id":"A20","pred":"tao:has_database_id","subj":"20","obj":"Tax:2697049"},{"id":"A21","pred":"tao:has_database_id","subj":"21","obj":"Tax:9606"},{"id":"A22","pred":"tao:has_database_id","subj":"22","obj":"Gene:652070"},{"id":"A23","pred":"tao:has_database_id","subj":"23","obj":"Gene:652070"},{"id":"A24","pred":"tao:has_database_id","subj":"24","obj":"Gene:652070"},{"id":"A25","pred":"tao:has_database_id","subj":"25","obj":"Gene:652070"},{"id":"A26","pred":"tao:has_database_id","subj":"26","obj":"Gene:59272"},{"id":"A27","pred":"tao:has_database_id","subj":"27","obj":"Gene:59272"},{"id":"A28","pred":"tao:has_database_id","subj":"28","obj":"Tax:2697049"},{"id":"A29","pred":"tao:has_database_id","subj":"29","obj":"Tax:2697049"},{"subj":"2","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3","pred":"source","obj":"LitCovid-PubTator"},{"subj":"18","pred":"source","obj":"LitCovid-PubTator"},{"subj":"19","pred":"source","obj":"LitCovid-PubTator"},{"subj":"20","pred":"source","obj":"LitCovid-PubTator"},{"subj":"21","pred":"source","obj":"LitCovid-PubTator"},{"subj":"22","pred":"source","obj":"LitCovid-PubTator"},{"subj":"23","pred":"source","obj":"LitCovid-PubTator"},{"subj":"24","pred":"source","obj":"LitCovid-PubTator"},{"subj":"25","pred":"source","obj":"LitCovid-PubTator"},{"subj":"26","pred":"source","obj":"LitCovid-PubTator"},{"subj":"27","pred":"source","obj":"LitCovid-PubTator"},{"subj":"28","pred":"source","obj":"LitCovid-PubTator"},{"subj":"29","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":132},"obj":"Sentence"},{"id":"T2","span":{"begin":133,"end":357},"obj":"Sentence"},{"id":"T3","span":{"begin":358,"end":517},"obj":"Sentence"},{"id":"T4","span":{"begin":518,"end":628},"obj":"Sentence"},{"id":"T5","span":{"begin":629,"end":805},"obj":"Sentence"},{"id":"T6","span":{"begin":806,"end":889},"obj":"Sentence"},{"id":"T7","span":{"begin":890,"end":1016},"obj":"Sentence"},{"id":"T8","span":{"begin":1017,"end":1145},"obj":"Sentence"},{"id":"T9","span":{"begin":1146,"end":1310},"obj":"Sentence"},{"id":"T10","span":{"begin":1311,"end":1565},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-sentences"},{"subj":"T2","pred":"source","obj":"LitCovid-sentences"},{"subj":"T3","pred":"source","obj":"LitCovid-sentences"},{"subj":"T4","pred":"source","obj":"LitCovid-sentences"},{"subj":"T5","pred":"source","obj":"LitCovid-sentences"},{"subj":"T6","pred":"source","obj":"LitCovid-sentences"},{"subj":"T7","pred":"source","obj":"LitCovid-sentences"},{"subj":"T8","pred":"source","obj":"LitCovid-sentences"},{"subj":"T9","pred":"source","obj":"LitCovid-sentences"},{"subj":"T10","pred":"source","obj":"LitCovid-sentences"}]},{"project":"sentences","denotations":[{"id":"T1","span":{"begin":0,"end":132},"obj":"Sentence"},{"id":"T2","span":{"begin":133,"end":357},"obj":"Sentence"},{"id":"T3","span":{"begin":358,"end":517},"obj":"Sentence"},{"id":"T4","span":{"begin":518,"end":628},"obj":"Sentence"},{"id":"T5","span":{"begin":629,"end":805},"obj":"Sentence"},{"id":"T6","span":{"begin":806,"end":889},"obj":"Sentence"},{"id":"T7","span":{"begin":890,"end":1016},"obj":"Sentence"},{"id":"T8","span":{"begin":1017,"end":1145},"obj":"Sentence"},{"id":"T9","span":{"begin":1146,"end":1310},"obj":"Sentence"},{"id":"T10","span":{"begin":1311,"end":1565},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"},{"subj":"T9","pred":"source","obj":"sentences"},{"subj":"T10","pred":"source","obj":"sentences"}]},{"project":"HP-phenotype","denotations":[{"id":"T1","span":{"begin":614,"end":617},"obj":"Phenotype"},{"id":"T2","span":{"begin":706,"end":709},"obj":"Phenotype"},{"id":"T3","span":{"begin":962,"end":965},"obj":"Phenotype"},{"id":"T4","span":{"begin":1306,"end":1309},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"HP:5200291"},{"id":"A2","pred":"hp_id","subj":"T2","obj":"HP:5200291"},{"id":"A3","pred":"hp_id","subj":"T3","obj":"HP:5200291"},{"id":"A4","pred":"hp_id","subj":"T4","obj":"HP:5200291"},{"subj":"T1","pred":"source","obj":"HP-phenotype"},{"subj":"T2","pred":"source","obj":"HP-phenotype"},{"subj":"T3","pred":"source","obj":"HP-phenotype"},{"subj":"T4","pred":"source","obj":"HP-phenotype"}],"namespaces":[{"prefix":"HP","uri":"http://purl.obolibrary.org/obo/HP_"}]},{"project":"mondo_disease","denotations":[{"id":"T1","span":{"begin":26,"end":36},"obj":"Disease"},{"id":"T2","span":{"begin":222,"end":232},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T1","pred":"source","obj":"mondo_disease"},{"subj":"T2","pred":"source","obj":"mondo_disease"}]},{"project":"NCBITAXON","denotations":[{"id":"T1","span":{"begin":26,"end":34},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":70,"end":75},"obj":"OrganismTaxon"},{"id":"T3","span":{"begin":222,"end":230},"obj":"OrganismTaxon"},{"id":"T4","span":{"begin":358,"end":363},"obj":"OrganismTaxon"},{"id":"T5","span":{"begin":663,"end":668},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"694009"},{"id":"A2","pred":"db_id","subj":"T2","obj":"9606"},{"id":"A3","pred":"db_id","subj":"T3","obj":"694009"},{"id":"A4","pred":"db_id","subj":"T4","obj":"9606"},{"id":"A5","pred":"db_id","subj":"T5","obj":"9606"},{"subj":"T1","pred":"source","obj":"NCBITAXON"},{"subj":"T2","pred":"source","obj":"NCBITAXON"},{"subj":"T3","pred":"source","obj":"NCBITAXON"},{"subj":"T4","pred":"source","obj":"NCBITAXON"},{"subj":"T5","pred":"source","obj":"NCBITAXON"}]},{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":1110,"end":1118},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/GO_0016020"},{"id":"A2","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0000094"},{"id":"A3","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"subj":"T1","pred":"source","obj":"Anatomy-UBERON"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-OGER-BB","color":"#ebec93","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#d393ec"},{"id":"LitCovid-PD-MONDO","color":"#93ecb9"},{"id":"LitCovid-PD-CLO","color":"#ec9e93"},{"id":"LitCovid-PD-CHEBI","color":"#93a1ec"},{"id":"LitCovid-PubTator","color":"#bbec93"},{"id":"LitCovid-sentences","color":"#ec93d5"},{"id":"sentences","color":"#93ece9"},{"id":"HP-phenotype","color":"#eccf93"},{"id":"mondo_disease","color":"#b593ec"},{"id":"NCBITAXON","color":"#93ec9b"},{"id":"Anatomy-UBERON","color":"#ec93a5"}]}]}}