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LitCovid-OGER-BB

Id Subject Object Predicate Lexical cue
T1 26-36 SP_7 denotes SARS-CoV-2
T2 54-60 SO:0000417 denotes domain
T3 70-75 SP_6 denotes human
T4 70-75 NCBITaxon:9606 denotes human
T5 87-95 GO:0042571 denotes antibody
T6 222-232 SP_7 denotes SARS-CoV-2
T7 314-324 GO:0042571 denotes antibodies
T8 342-347 NCBITaxon:10239 denotes viral
T9 348-356 BV_9 denotes epitopes
T10 358-363 SP_6 denotes Human
T11 358-363 NCBITaxon:9606 denotes Human
T12 450-460 GO:0042571 denotes antibodies
T13 564-574 GO:0042571 denotes antibodies
T14 606-612 SO:0000417 denotes domain
T15 663-668 SP_6 denotes human
T16 663-668 NCBITaxon:9606 denotes human
T17 760-772 SO:0000984 denotes single chain
T18 853-861 GO:0042571 denotes antibody
T19 904-912 GO:0042571 denotes antibody
T20 980-988 CHEBI:59132 denotes antigens
T21 980-988 CHEBI:59132 denotes antigens
T22 1099-1109 GO:0010467 denotes expressing
T23 1110-1118 GO:0016020 denotes membrane
T24 1199-1206 BV_9 denotes epitope
T25 1236-1267 PG_10 denotes angiotensin converting enzyme 2
T26 1236-1267 PR:000003622 denotes angiotensin converting enzyme 2
T27 1269-1273 G_3 denotes ACE2
T28 1269-1273 PG_10 denotes ACE2
T29 1269-1273 PR:000003622 denotes ACE2
T30 1388-1398 GO:0042571 denotes antibodies
T31 1426-1434 CHEBI:33893 denotes reagents
T32 1426-1434 CHEBI:33893 denotes reagents
T33 1511-1519 GO:0042571 denotes antibody

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 87-95 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T2 853-861 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T3 904-912 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T4 1093-1098 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T5 1137-1144 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T6 1511-1519 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 26-34 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T2 222-230 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 70-75 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T2 101-102 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T3 142-143 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T4 358-363 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T5 389-392 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T6 655-656 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T7 663-668 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T8 744-745 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T9 876-878 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T10 1093-1098 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11 1110-1118 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 980-988 Chemical denotes antigens http://purl.obolibrary.org/obo/CHEBI_59132
T2 1137-1144 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T3 1199-1206 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T4 1236-1247 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T5 1426-1434 Chemical denotes reagents http://purl.obolibrary.org/obo/CHEBI_33893

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2 31-36 Species denotes CoV-2 Tax:2697049
3 70-75 Species denotes human Tax:9606
18 227-232 Species denotes CoV-2 Tax:2697049
19 358-363 Species denotes Human Tax:9606
20 622-627 Species denotes CoV-2 Tax:2697049
21 663-668 Species denotes human Tax:9606
22 799-803 Gene denotes scFv Gene:652070
23 810-814 Gene denotes scFv Gene:652070
24 871-875 Gene denotes scFv Gene:652070
25 1180-1184 Gene denotes scFv Gene:652070
26 1236-1267 Gene denotes angiotensin converting enzyme 2 Gene:59272
27 1269-1273 Gene denotes ACE2 Gene:59272
28 1382-1387 Species denotes CoV-2 Tax:2697049
29 1559-1564 Species denotes CoV-2 Tax:2697049

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-132 Sentence denotes Identification of an anti-SARS-CoV-2 receptor binding domain directed human monoclonal antibody from a naïve semi-synthetic library.
T2 133-357 Sentence denotes There is a desperate need for safe and effective vaccines, therapies and diagnostics for SARS-CoV-2, the development of which will be aided by the discovery of potent and selective antibodies against relevant viral epitopes.
T3 358-517 Sentence denotes Human phage display technology has revolutionized the process of identifying and optimizing antibodies, providing facile entry points for further applications.
T4 518-628 Sentence denotes Here in, we use this technology to search for antibodies targeting the receptor binding domain (RBD) of CoV-2.
T5 629-805 Sentence denotes Specifically, we screened a naïve human semi-synthetic phage library against RBD, leading to the identification of a high-affinity single chain fragment variable region (scFv).
T6 806-889 Sentence denotes The scFv was further engineered into two other antibody formats (scFv-Fc and IgG1).
T7 890-1016 Sentence denotes All the three antibody formats showed high binding specificity to CoV-2 RBD and the spike antigens in different assay systems.
T8 1017-1145 Sentence denotes Flow cytometry analysis demonstrated specific binding of the IgG1 format to cells expressing membrane bound CoV-2 spike protein.
T9 1146-1310 Sentence denotes Docking studies revealed that the scFv recognizes an epitope that partially overlaps with angiotensin converting enzyme 2 (ACE2)-interacting sites on the CoV-2 RBD.
T10 1311-1565 Sentence denotes Given its high specificity and affinity, we anticipate that these anti-CoV-2 antibodies will be useful as valuable reagents for accessing the antigenicity of vaccine candidates, as well as developing antibody-based therapeutics and diagnostics for CoV-2.

sentences

Id Subject Object Predicate Lexical cue
T1 0-132 Sentence denotes Identification of an anti-SARS-CoV-2 receptor binding domain directed human monoclonal antibody from a naïve semi-synthetic library.
T2 133-357 Sentence denotes There is a desperate need for safe and effective vaccines, therapies and diagnostics for SARS-CoV-2, the development of which will be aided by the discovery of potent and selective antibodies against relevant viral epitopes.
T3 358-517 Sentence denotes Human phage display technology has revolutionized the process of identifying and optimizing antibodies, providing facile entry points for further applications.
T4 518-628 Sentence denotes Here in, we use this technology to search for antibodies targeting the receptor binding domain (RBD) of CoV-2.
T5 629-805 Sentence denotes Specifically, we screened a naïve human semi-synthetic phage library against RBD, leading to the identification of a high-affinity single chain fragment variable region (scFv).
T6 806-889 Sentence denotes The scFv was further engineered into two other antibody formats (scFv-Fc and IgG1).
T7 890-1016 Sentence denotes All the three antibody formats showed high binding specificity to CoV-2 RBD and the spike antigens in different assay systems.
T8 1017-1145 Sentence denotes Flow cytometry analysis demonstrated specific binding of the IgG1 format to cells expressing membrane bound CoV-2 spike protein.
T9 1146-1310 Sentence denotes Docking studies revealed that the scFv recognizes an epitope that partially overlaps with angiotensin converting enzyme 2 (ACE2)-interacting sites on the CoV-2 RBD.
T10 1311-1565 Sentence denotes Given its high specificity and affinity, we anticipate that these anti-CoV-2 antibodies will be useful as valuable reagents for accessing the antigenicity of vaccine candidates, as well as developing antibody-based therapeutics and diagnostics for CoV-2.

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 614-617 Phenotype denotes RBD HP:5200291
T2 706-709 Phenotype denotes RBD HP:5200291
T3 962-965 Phenotype denotes RBD HP:5200291
T4 1306-1309 Phenotype denotes RBD HP:5200291

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 26-36 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T2 222-232 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 26-34 OrganismTaxon denotes SARS-CoV 694009
T2 70-75 OrganismTaxon denotes human 9606
T3 222-230 OrganismTaxon denotes SARS-CoV 694009
T4 358-363 OrganismTaxon denotes Human 9606
T5 663-668 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1110-1118 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158