PubMed:32703420
Annnotations
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T1 | 53-60 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T2 | 299-306 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T3 | 310-317 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T4 | 405-413 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T5 | 453-458 | Body_part | denotes | serum | http://purl.org/sig/ont/fma/fma63083 |
T6 | 515-523 | Body_part | denotes | fat body | http://purl.org/sig/ont/fma/fma58616 |
T7 | 538-543 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T8 | 565-572 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T9 | 668-675 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T10 | 694-701 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T11 | 778-783 | Body_part | denotes | serum | http://purl.org/sig/ont/fma/fma63083 |
T12 | 868-876 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T13 | 1000-1007 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T14 | 1024-1029 | Body_part | denotes | serum | http://purl.org/sig/ont/fma/fma63083 |
T15 | 1074-1081 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T16 | 1178-1192 | Body_part | denotes | immunoglobulin | http://purl.org/sig/ont/fma/fma62871 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 453-458 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
T2 | 778-783 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
T3 | 1024-1029 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 36-44 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T2 | 121-134 | Disease | denotes | viral disease | http://purl.obolibrary.org/obo/MONDO_0005108 |
T3 | 224-232 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T4 | 282-290 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T5 | 854-862 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T6 | 987-995 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 83-91 | http://purl.obolibrary.org/obo/NCBITaxon_7091 | denotes | silkworm |
T2 | 115-116 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T3 | 173-178 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T4 | 249-250 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T5 | 344-352 | http://purl.obolibrary.org/obo/NCBITaxon_7091 | denotes | silkworm |
T6 | 444-452 | http://purl.obolibrary.org/obo/NCBITaxon_7091 | denotes | silkworm |
T7 | 515-518 | http://purl.obolibrary.org/obo/UBERON_0001013 | denotes | fat |
T8 | 538-543 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T9 | 769-777 | http://purl.obolibrary.org/obo/NCBITaxon_7091 | denotes | silkworm |
T10 | 865-867 | http://purl.obolibrary.org/obo/CLO_0008922 | denotes | S2 |
T11 | 865-867 | http://purl.obolibrary.org/obo/CLO_0050052 | denotes | S2 |
T12 | 936-945 | http://purl.obolibrary.org/obo/NCBITaxon_7091 | denotes | silkworms |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T2 | 299-306 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T1 | 53-60 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T3 | 310-317 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T4 | 405-413 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T5 | 565-572 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T6 | 668-675 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T7 | 694-701 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T8 | 804-813 | Chemical | denotes | oligomers | http://purl.obolibrary.org/obo/CHEBI_132554 |
T9 | 865-867 | Chemical | denotes | S2 | http://purl.obolibrary.org/obo/CHEBI_29387 |
T10 | 1000-1007 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T11 | 1074-1081 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T12 | 1149-1156 | Chemical | denotes | antigen | http://purl.obolibrary.org/obo/CHEBI_59132 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 1178-1203 | http://purl.obolibrary.org/obo/GO_0002377 | denotes | immunoglobulin production |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
2 | 36-46 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
3 | 83-91 | Species | denotes | silkworm | Tax:7091 |
19 | 121-134 | Disease | denotes | viral disease | MESH:D001102 |
20 | 224-232 | Disease | denotes | COVID-19 | MESH:C000657245 |
21 | 282-292 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
22 | 293-298 | Gene | denotes | spike | Gene:43740568 |
23 | 308-317 | Gene | denotes | S protein | Gene:43740568 |
24 | 344-352 | Species | denotes | silkworm | Tax:7091 |
25 | 444-452 | Species | denotes | silkworm | Tax:7091 |
26 | 563-572 | Gene | denotes | S protein | Gene:43740568 |
27 | 692-701 | Gene | denotes | S protein | Gene:43740568 |
28 | 769-777 | Species | denotes | silkworm | Tax:7091 |
29 | 854-864 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
30 | 936-945 | Species | denotes | silkworms | Tax:7091 |
31 | 987-997 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
32 | 998-1007 | Gene | denotes | S protein | Gene:43740568 |
33 | 1072-1081 | Gene | denotes | S protein | Gene:43740568 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-99 | Sentence | denotes | Efficient production of recombinant SARS-CoV-2 spike protein using the baculovirus-silkworm system. |
T2 | 100-219 | Sentence | denotes | In the case of a new viral disease outbreak, an immediate development of virus detection kits and vaccines is required. |
T3 | 220-371 | Sentence | denotes | For COVID-19, we established a rapid production procedure for SARS-CoV-2 spike protein (S protein) by using the baculovirus-silkworm expression system. |
T4 | 372-544 | Sentence | denotes | The baculovirus vector-derived S proteins were successfully secreted to silkworm serum, whereas those formed insoluble structure in the larval fat body and the pupal cells. |
T5 | 545-687 | Sentence | denotes | The ectodomain of S protein with the native sequence was cleaved by the host furin-protease, resulting in less recombinant protein production. |
T6 | 688-877 | Sentence | denotes | The S protein modified in furin protease-target site was efficiently secreted to silkworm serum and was purified as oligomers, which showed immunoreactivity for anti-SARS-CoV-2 S2 antibody. |
T7 | 878-1048 | Sentence | denotes | By using the direct transfection of recombinant bacmid to silkworms, we achieved the efficient production of SARS-CoV-2 S protein as fetal bovine serum (FBS)-free system. |
T8 | 1049-1218 | Sentence | denotes | The resultant purified S protein would be useful tools for the development of immunodetection kits, antigen for immunization for immunoglobulin production, and vaccines. |
silkwormbase
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 36-46 | Species:2697049 | denotes | SARS-CoV-2 |
T10 | 563-572 | Gene:7448 | denotes | S protein |
T11 | 692-701 | Gene:7448 | denotes | S protein |
T12 | 769-777 | Species:7091 | denotes | silkworm |
T13 | 854-864 | Species:2697049 | denotes | SARS-CoV-2 |
T14 | 936-945 | Species:7091 | denotes | silkworms |
T15 | 987-997 | Species:2697049 | denotes | SARS-CoV-2 |
T16 | 998-1007 | Gene:7448 | denotes | S protein |
T17 | 1072-1081 | Gene:7448 | denotes | S protein |
T2 | 83-91 | Species:7091 | denotes | silkworm |
T3 | 121-134 | Disease:MESH:D001102 | denotes | viral disease |
T4 | 224-232 | Disease:MESH:C000657245 | denotes | COVID-19 |
T5 | 282-292 | Species:2697049 | denotes | SARS-CoV-2 |
T6 | 293-298 | Gene:43740568 | denotes | spike |
T7 | 308-317 | Gene:7448 | denotes | S protein |
T8 | 344-352 | Species:7091 | denotes | silkworm |
T9 | 444-452 | Species:7091 | denotes | silkworm |
LitCovid_AGAC_only
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
p64037s3 | 563-564 | Protein | denotes | S |
p64037s4 | 565-572 | Protein | denotes | protein |
p64037s20 | 651-655 | NegReg | denotes | less |
p64037s21 | 656-686 | MPA | denotes | recombinant protein production |
silkworm
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 36-46 | Species:2697049 | denotes | SARS-CoV-2 |
T2 | 83-91 | Species:7091 | denotes | silkworm |
T3 | 121-134 | Disease:MESH:D001102 | denotes | viral disease |
T4 | 224-232 | Disease:MESH:C000657245 | denotes | COVID-19 |
T5 | 282-292 | Species:2697049 | denotes | SARS-CoV-2 |
T6 | 293-298 | Gene:43740568 | denotes | spike |
T7 | 308-317 | Gene:7448 | denotes | S protein |
T8 | 344-352 | Species:7091 | denotes | silkworm |
T9 | 444-452 | Species:7091 | denotes | silkworm |
T10 | 563-572 | Gene:7448 | denotes | S protein |
T11 | 692-701 | Gene:7448 | denotes | S protein |
T12 | 769-777 | Species:7091 | denotes | silkworm |
T13 | 854-864 | Species:2697049 | denotes | SARS-CoV-2 |
T14 | 936-945 | Species:7091 | denotes | silkworms |
T15 | 987-997 | Species:2697049 | denotes | SARS-CoV-2 |
T16 | 998-1007 | Gene:7448 | denotes | S protein |
T17 | 1072-1081 | Gene:7448 | denotes | S protein |