PubMed:32691370 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/32691370","sourcedb":"PubMed","sourceid":"32691370","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/32691370","text":"SARS-CoV-2 Entry Receptor ACE2 Is Expressed on Very Small CD45- Precursors of Hematopoietic and Endothelial Cells and in Response to Virus Spike Protein Activates the Nlrp3 Inflammasome.\nAngiotensin-converting enzyme 2 (ACE2) plays an important role as a member of the renin-angiotensin-aldosterone system (RAAS) in regulating the conversion of angiotensin II (Ang II) into angiotensin (1-7) (Ang [1-7]). But at the same time, while expressed on the surface of human cells, ACE2 is the entry receptor for SARS-CoV-2. Expression of this receptor has been described in several types of cells, including hematopoietic stem cells (HSCs) and endothelial progenitor cells (EPCs), which raises a concern that the virus may infect and damage the stem cell compartment. We demonstrate for the first time that ACE2 and the entry-facilitating transmembrane protease TMPRSS2 are expressed on very small CD133+CD34+Lin-CD45- cells in human umbilical cord blood (UCB), which can be specified into functional HSCs and EPCs. The existence of these cells known as very small embryonic-like stem cells (VSELs) has been confirmed by several laboratories, and some of them may correspond to putative postnatal hemangioblasts. Moreover, we demonstrate for the first time that, in human VSELs and HSCs, the interaction of the ACE2 receptor with the SARS-CoV-2 spike protein activates the Nlrp3 inflammasome, which if hyperactivated may lead to cell death by pyroptosis. Based on this finding, there is a possibility that human VSELs residing in adult tissues could be damaged by SARS-CoV-2, with remote effects on tissue/organ regeneration. We also report that ACE2 is expressed on the surface of murine bone marrow-derived VSELs and HSCs, although it is known that murine cells are not infected by SARS-CoV-2. Finally, human and murine VSELs express several RAAS genes, which sheds new light on the role of these genes in the specification of early-development stem cells. Graphical Abstract •Human VSELs and HSCs express ACE2 receptor for SARS-CoV2 entry. •Interaction of viral spike protein with ACE2 receptor may hyperactivate Nlrp3 inflammasome which induces cell death by pyroptosis. •SARS-CoV2 may also enter cells and eliminate them by cell lysis. •What is not shown since these cells express also Ang II receptor they may hyperactivate Nlrp3 inflammasome in response to Ang II which may induce pyroptosis. Our data indicates that Ang 1-7 may have a protective effect.","tracks":[{"project":"LitCovid-OGER-BB","denotations":[{"id":"T1","span":{"begin":0,"end":10},"obj":"SP_7"},{"id":"T2","span":{"begin":26,"end":30},"obj":"G_3"},{"id":"T3","span":{"begin":26,"end":30},"obj":"PG_10"},{"id":"T4","span":{"begin":26,"end":30},"obj":"PR:000003622"},{"id":"T5","span":{"begin":34,"end":43},"obj":"GO:0010467"},{"id":"T6","span":{"begin":58,"end":62},"obj":"PR:000001006"},{"id":"T7","span":{"begin":78,"end":91},"obj":"GO:0030097"},{"id":"T8","span":{"begin":78,"end":91},"obj":"CL:0000988"},{"id":"T9","span":{"begin":96,"end":107},"obj":"UBERON:0001986"},{"id":"T10","span":{"begin":96,"end":113},"obj":"CL:0000115"},{"id":"T11","span":{"begin":167,"end":172},"obj":"PR:000011271"},{"id":"T12","span":{"begin":187,"end":218},"obj":"PG_10"},{"id":"T13","span":{"begin":187,"end":218},"obj":"PR:000003622"},{"id":"T14","span":{"begin":220,"end":224},"obj":"G_3"},{"id":"T15","span":{"begin":220,"end":224},"obj":"PG_10"},{"id":"T16","span":{"begin":220,"end":224},"obj":"PR:000003622"},{"id":"T17","span":{"begin":269,"end":274},"obj":"PR:000013883"},{"id":"T18","span":{"begin":316,"end":326},"obj":"GO:0065007"},{"id":"T19","span":{"begin":345,"end":359},"obj":"PR:000036009"},{"id":"T20","span":{"begin":345,"end":359},"obj":"DG_37"},{"id":"T21","span":{"begin":361,"end":367},"obj":"PR:000036009"},{"id":"T22","span":{"begin":433,"end":442},"obj":"GO:0010467"},{"id":"T23","span":{"begin":450,"end":460},"obj":"GO:0009986"},{"id":"T24","span":{"begin":461,"end":466},"obj":"SP_6"},{"id":"T25","span":{"begin":461,"end":466},"obj":"NCBITaxon:9606"},{"id":"T26","span":{"begin":474,"end":478},"obj":"G_3"},{"id":"T27","span":{"begin":474,"end":478},"obj":"PG_10"},{"id":"T28","span":{"begin":474,"end":478},"obj":"PR:000003622"},{"id":"T29","span":{"begin":505,"end":509},"obj":"PR:000014459"},{"id":"T30","span":{"begin":505,"end":515},"obj":"SP_7"},{"id":"T31","span":{"begin":517,"end":527},"obj":"GO:0010467"},{"id":"T32","span":{"begin":601,"end":614},"obj":"GO:0030097"},{"id":"T33","span":{"begin":601,"end":625},"obj":"CL:0000037"},{"id":"T34","span":{"begin":627,"end":631},"obj":"CL:0000037"},{"id":"T35","span":{"begin":637,"end":648},"obj":"CL:0000115"},{"id":"T36","span":{"begin":637,"end":648},"obj":"UBERON:0001986"},{"id":"T37","span":{"begin":649,"end":659},"obj":"CL:0008001"},{"id":"T38","span":{"begin":667,"end":671},"obj":"CL:0002619"},{"id":"T39","span":{"begin":706,"end":711},"obj":"NCBITaxon:10239"},{"id":"T40","span":{"begin":738,"end":747},"obj":"CL:0000034"},{"id":"T41","span":{"begin":800,"end":804},"obj":"G_3"},{"id":"T42","span":{"begin":800,"end":804},"obj":"PG_10"},{"id":"T43","span":{"begin":800,"end":804},"obj":"PR:000003622"},{"id":"T44","span":{"begin":832,"end":845},"obj":"GO:0016020"},{"id":"T45","span":{"begin":855,"end":862},"obj":"G_2"},{"id":"T46","span":{"begin":855,"end":862},"obj":"PR:000016456"},{"id":"T47","span":{"begin":867,"end":876},"obj":"GO:0010467"},{"id":"T48","span":{"begin":891,"end":896},"obj":"PR:000001786"},{"id":"T49","span":{"begin":897,"end":901},"obj":"PR:000001003"},{"id":"T50","span":{"begin":906,"end":910},"obj":"PR:000001006"},{"id":"T51","span":{"begin":921,"end":926},"obj":"SP_6"},{"id":"T52","span":{"begin":921,"end":926},"obj":"NCBITaxon:9606"},{"id":"T53","span":{"begin":927,"end":941},"obj":"UBERON:0012168"},{"id":"T54","span":{"begin":942,"end":947},"obj":"UBERON:0012168"},{"id":"T55","span":{"begin":1058,"end":1067},"obj":"CL:0002322"},{"id":"T56","span":{"begin":1058,"end":1067},"obj":"UBERON:0000922"},{"id":"T57","span":{"begin":1073,"end":1083},"obj":"CL:0000034"},{"id":"T58","span":{"begin":1180,"end":1189},"obj":"GO:0007567"},{"id":"T59","span":{"begin":1259,"end":1264},"obj":"SP_6"},{"id":"T60","span":{"begin":1259,"end":1264},"obj":"NCBITaxon:9606"},{"id":"T61","span":{"begin":1304,"end":1308},"obj":"G_3"},{"id":"T62","span":{"begin":1304,"end":1308},"obj":"PG_10"},{"id":"T63","span":{"begin":1304,"end":1308},"obj":"PR:000003622"},{"id":"T64","span":{"begin":1327,"end":1331},"obj":"PR:000014459"},{"id":"T65","span":{"begin":1327,"end":1337},"obj":"SP_7"},{"id":"T66","span":{"begin":1366,"end":1371},"obj":"PR:000011271"},{"id":"T67","span":{"begin":1422,"end":1432},"obj":"GO:0008219"},{"id":"T68","span":{"begin":1436,"end":1446},"obj":"GO:0070269"},{"id":"T69","span":{"begin":1499,"end":1504},"obj":"SP_6"},{"id":"T70","span":{"begin":1499,"end":1504},"obj":"NCBITaxon:9606"},{"id":"T71","span":{"begin":1523,"end":1528},"obj":"UBERON:0007023"},{"id":"T72","span":{"begin":1529,"end":1536},"obj":"UBERON:0000479"},{"id":"T73","span":{"begin":1557,"end":1567},"obj":"SP_7"},{"id":"T74","span":{"begin":1592,"end":1598},"obj":"UBERON:0000479"},{"id":"T75","span":{"begin":1592,"end":1598},"obj":"GO:0048771"},{"id":"T76","span":{"begin":1599,"end":1604},"obj":"UBERON:0000062"},{"id":"T77","span":{"begin":1599,"end":1617},"obj":"GO:0031100"},{"id":"T78","span":{"begin":1639,"end":1643},"obj":"G_3"},{"id":"T79","span":{"begin":1639,"end":1643},"obj":"PG_10"},{"id":"T80","span":{"begin":1639,"end":1643},"obj":"PR:000003622"},{"id":"T81","span":{"begin":1647,"end":1656},"obj":"GO:0010467"},{"id":"T82","span":{"begin":1675,"end":1681},"obj":"NCBITaxon:39107"},{"id":"T83","span":{"begin":1682,"end":1693},"obj":"UBERON:0002371"},{"id":"T84","span":{"begin":1744,"end":1750},"obj":"NCBITaxon:39107"},{"id":"T85","span":{"begin":1777,"end":1787},"obj":"SP_7"},{"id":"T86","span":{"begin":1798,"end":1803},"obj":"SP_6"},{"id":"T87","span":{"begin":1798,"end":1803},"obj":"NCBITaxon:9606"},{"id":"T88","span":{"begin":1808,"end":1814},"obj":"NCBITaxon:39107"},{"id":"T89","span":{"begin":1821,"end":1828},"obj":"GO:0010467"},{"id":"T90","span":{"begin":1842,"end":1847},"obj":"SO:0000704"},{"id":"T91","span":{"begin":1892,"end":1897},"obj":"SO:0000704"},{"id":"T92","span":{"begin":1905,"end":1921},"obj":"GO:0048866"},{"id":"T93","span":{"begin":1940,"end":1950},"obj":"CL:0000034"},{"id":"T94","span":{"begin":1972,"end":1977},"obj":"SP_6"},{"id":"T95","span":{"begin":1972,"end":1977},"obj":"NCBITaxon:9606"},{"id":"T96","span":{"begin":1993,"end":2000},"obj":"GO:0010467"},{"id":"T97","span":{"begin":2001,"end":2005},"obj":"G_3"},{"id":"T98","span":{"begin":2001,"end":2005},"obj":"PG_10"},{"id":"T99","span":{"begin":2001,"end":2005},"obj":"PR:000003622"},{"id":"T100","span":{"begin":2019,"end":2028},"obj":"SP_7"},{"id":"T101","span":{"begin":2052,"end":2057},"obj":"NCBITaxon:10239"},{"id":"T102","span":{"begin":2077,"end":2081},"obj":"G_3"},{"id":"T103","span":{"begin":2077,"end":2081},"obj":"PG_10"},{"id":"T104","span":{"begin":2077,"end":2081},"obj":"PR:000003622"},{"id":"T105","span":{"begin":2109,"end":2114},"obj":"PR:000011271"},{"id":"T106","span":{"begin":2142,"end":2152},"obj":"GO:0008219"},{"id":"T107","span":{"begin":2156,"end":2166},"obj":"GO:0070269"},{"id":"T108","span":{"begin":2169,"end":2178},"obj":"SP_7"},{"id":"T109","span":{"begin":2222,"end":2232},"obj":"GO:0019835"},{"id":"T110","span":{"begin":2271,"end":2278},"obj":"GO:0010467"},{"id":"T111","span":{"begin":2284,"end":2287},"obj":"CHEBI:37886"},{"id":"T112","span":{"begin":2284,"end":2287},"obj":"CHEBI:37886"},{"id":"T113","span":{"begin":2284,"end":2290},"obj":"PR:000036009"},{"id":"T114","span":{"begin":2323,"end":2328},"obj":"PR:000011271"},{"id":"T115","span":{"begin":2357,"end":2360},"obj":"CHEBI:37886"},{"id":"T116","span":{"begin":2357,"end":2360},"obj":"CHEBI:37886"},{"id":"T117","span":{"begin":2357,"end":2363},"obj":"PR:000036009"},{"id":"T118","span":{"begin":2381,"end":2391},"obj":"GO:0070269"},{"id":"T119","span":{"begin":2417,"end":2422},"obj":"PR:000036013"}],"namespaces":[{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T2","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T3","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T4","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T5","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T6","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T7","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T8","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T9","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T10","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T11","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T12","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T13","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T14","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T15","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T16","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T17","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T18","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T19","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T20","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T21","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T22","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T23","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T24","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T25","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T26","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T27","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T28","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T29","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T30","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T31","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T32","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T33","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T34","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T35","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T36","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T37","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T38","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T39","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T40","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T41","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T42","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T43","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T44","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T45","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T46","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T47","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T48","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T49","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T50","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T51","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T52","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T53","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T54","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T55","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T56","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T57","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T58","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T59","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T60","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T61","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T62","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T63","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T64","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T65","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T66","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T67","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T68","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T69","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T70","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T71","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T72","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T73","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T74","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T75","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T76","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T77","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T78","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T79","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T80","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T81","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T82","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T83","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T84","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T85","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T86","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T87","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T88","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T89","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T90","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T91","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T92","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T93","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T94","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T95","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T96","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T97","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T98","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T99","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T100","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T101","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T102","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T103","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T104","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T105","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T106","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T107","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T108","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T109","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T110","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T111","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T112","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T113","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T114","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T115","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T116","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T117","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T118","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T119","pred":"source","obj":"LitCovid-OGER-BB"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T1","span":{"begin":96,"end":113},"obj":"Body_part"},{"id":"T2","span":{"begin":108,"end":113},"obj":"Body_part"},{"id":"T3","span":{"begin":145,"end":152},"obj":"Body_part"},{"id":"T4","span":{"begin":467,"end":472},"obj":"Body_part"},{"id":"T5","span":{"begin":584,"end":589},"obj":"Body_part"},{"id":"T6","span":{"begin":601,"end":625},"obj":"Body_part"},{"id":"T7","span":{"begin":620,"end":625},"obj":"Body_part"},{"id":"T8","span":{"begin":660,"end":665},"obj":"Body_part"},{"id":"T9","span":{"begin":743,"end":759},"obj":"Body_part"},{"id":"T10","span":{"begin":743,"end":747},"obj":"Body_part"},{"id":"T11","span":{"begin":912,"end":917},"obj":"Body_part"},{"id":"T12","span":{"begin":927,"end":941},"obj":"Body_part"},{"id":"T13","span":{"begin":942,"end":947},"obj":"Body_part"},{"id":"T14","span":{"begin":1032,"end":1037},"obj":"Body_part"},{"id":"T15","span":{"begin":1073,"end":1083},"obj":"Body_part"},{"id":"T16","span":{"begin":1078,"end":1083},"obj":"Body_part"},{"id":"T17","span":{"begin":1344,"end":1351},"obj":"Body_part"},{"id":"T18","span":{"begin":1422,"end":1426},"obj":"Body_part"},{"id":"T19","span":{"begin":1529,"end":1536},"obj":"Body_part"},{"id":"T20","span":{"begin":1592,"end":1598},"obj":"Body_part"},{"id":"T21","span":{"begin":1599,"end":1604},"obj":"Body_part"},{"id":"T22","span":{"begin":1682,"end":1693},"obj":"Body_part"},{"id":"T23","span":{"begin":1751,"end":1756},"obj":"Body_part"},{"id":"T24","span":{"begin":1940,"end":1950},"obj":"Body_part"},{"id":"T25","span":{"begin":1945,"end":1950},"obj":"Body_part"},{"id":"T26","span":{"begin":2064,"end":2071},"obj":"Body_part"},{"id":"T27","span":{"begin":2142,"end":2146},"obj":"Body_part"},{"id":"T28","span":{"begin":2194,"end":2199},"obj":"Body_part"},{"id":"T29","span":{"begin":2222,"end":2226},"obj":"Body_part"},{"id":"T30","span":{"begin":2265,"end":2270},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma66772"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A5","pred":"fma_id","subj":"T5","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A6","pred":"fma_id","subj":"T6","obj":"http://purl.org/sig/ont/fma/fma86475"},{"id":"A7","pred":"fma_id","subj":"T7","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A8","pred":"fma_id","subj":"T8","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A9","pred":"fma_id","subj":"T9","obj":"http://purl.org/sig/ont/fma/fma223408"},{"id":"A10","pred":"fma_id","subj":"T10","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A11","pred":"fma_id","subj":"T11","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A12","pred":"fma_id","subj":"T12","obj":"http://purl.org/sig/ont/fma/fma85541"},{"id":"A13","pred":"fma_id","subj":"T13","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A14","pred":"fma_id","subj":"T14","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A15","pred":"fma_id","subj":"T15","obj":"http://purl.org/sig/ont/fma/fma63368"},{"id":"A16","pred":"fma_id","subj":"T16","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A17","pred":"fma_id","subj":"T17","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A18","pred":"fma_id","subj":"T18","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A19","pred":"fma_id","subj":"T19","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A20","pred":"fma_id","subj":"T20","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A21","pred":"fma_id","subj":"T21","obj":"http://purl.org/sig/ont/fma/fma67498"},{"id":"A22","pred":"fma_id","subj":"T22","obj":"http://purl.org/sig/ont/fma/fma9608"},{"id":"A23","pred":"fma_id","subj":"T23","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A24","pred":"fma_id","subj":"T24","obj":"http://purl.org/sig/ont/fma/fma63368"},{"id":"A25","pred":"fma_id","subj":"T25","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A26","pred":"fma_id","subj":"T26","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A27","pred":"fma_id","subj":"T27","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A28","pred":"fma_id","subj":"T28","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A29","pred":"fma_id","subj":"T29","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A30","pred":"fma_id","subj":"T30","obj":"http://purl.org/sig/ont/fma/fma68646"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T17","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T18","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T23","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T24","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T25","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T26","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T27","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T28","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T29","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T30","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T1","span":{"begin":927,"end":947},"obj":"Body_part"},{"id":"T2","span":{"begin":927,"end":941},"obj":"Body_part"},{"id":"T3","span":{"begin":942,"end":947},"obj":"Body_part"},{"id":"T4","span":{"begin":949,"end":952},"obj":"Body_part"},{"id":"T5","span":{"begin":1592,"end":1598},"obj":"Body_part"},{"id":"T6","span":{"begin":1599,"end":1604},"obj":"Body_part"},{"id":"T7","span":{"begin":1682,"end":1693},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0012168"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0002331"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/UBERON_0012168"},{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/UBERON_0000062"},{"id":"A7","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/UBERON_0002371"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T1","span":{"begin":0,"end":8},"obj":"Disease"},{"id":"T2","span":{"begin":505,"end":513},"obj":"Disease"},{"id":"T3","span":{"begin":1327,"end":1335},"obj":"Disease"},{"id":"T4","span":{"begin":1557,"end":1565},"obj":"Disease"},{"id":"T5","span":{"begin":1777,"end":1785},"obj":"Disease"},{"id":"T6","span":{"begin":2019,"end":2023},"obj":"Disease"},{"id":"T7","span":{"begin":2169,"end":2173},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1","span":{"begin":96,"end":113},"obj":"http://purl.obolibrary.org/obo/CL_0000115"},{"id":"T2","span":{"begin":133,"end":138},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T3","span":{"begin":153,"end":162},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T4","span":{"begin":253,"end":254},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T5","span":{"begin":461,"end":472},"obj":"http://purl.obolibrary.org/obo/CLO_0053065"},{"id":"T6","span":{"begin":545,"end":548},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T7","span":{"begin":584,"end":589},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T8","span":{"begin":615,"end":625},"obj":"http://purl.obolibrary.org/obo/CL_0000034"},{"id":"T9","span":{"begin":660,"end":665},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T10","span":{"begin":667,"end":671},"obj":"http://purl.obolibrary.org/obo/CLO_0002940"},{"id":"T11","span":{"begin":687,"end":688},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T12","span":{"begin":706,"end":711},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T13","span":{"begin":738,"end":747},"obj":"http://purl.obolibrary.org/obo/CL_0000034"},{"id":"T14","span":{"begin":912,"end":917},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T15","span":{"begin":921,"end":926},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T16","span":{"begin":927,"end":941},"obj":"http://purl.obolibrary.org/obo/UBERON_0002331"},{"id":"T17","span":{"begin":927,"end":941},"obj":"http://www.ebi.ac.uk/efo/EFO_0001415"},{"id":"T18","span":{"begin":942,"end":947},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T19","span":{"begin":942,"end":947},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T20","span":{"begin":1003,"end":1007},"obj":"http://purl.obolibrary.org/obo/CLO_0002940"},{"id":"T21","span":{"begin":1032,"end":1037},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T22","span":{"begin":1073,"end":1083},"obj":"http://purl.obolibrary.org/obo/CL_0000034"},{"id":"T23","span":{"begin":1092,"end":1095},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T24","span":{"begin":1259,"end":1264},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T25","span":{"begin":1352,"end":1361},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T26","span":{"begin":1422,"end":1426},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T27","span":{"begin":1480,"end":1481},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T28","span":{"begin":1499,"end":1504},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T29","span":{"begin":1599,"end":1604},"obj":"http://purl.obolibrary.org/obo/UBERON_0003103"},{"id":"T30","span":{"begin":1682,"end":1686},"obj":"http://purl.obolibrary.org/obo/UBERON_0002481"},{"id":"T31","span":{"begin":1751,"end":1756},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T32","span":{"begin":1798,"end":1803},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T33","span":{"begin":1842,"end":1847},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T34","span":{"begin":1892,"end":1897},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T35","span":{"begin":1940,"end":1950},"obj":"http://purl.obolibrary.org/obo/CL_0000034"},{"id":"T36","span":{"begin":1972,"end":1977},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T37","span":{"begin":2142,"end":2146},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T38","span":{"begin":2194,"end":2199},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T39","span":{"begin":2222,"end":2226},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T40","span":{"begin":2265,"end":2270},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T41","span":{"begin":2434,"end":2435},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T17","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T18","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T23","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T24","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T25","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T26","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T27","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T28","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T29","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T30","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T31","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T32","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T33","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T34","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T35","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T36","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T37","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T38","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T39","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T40","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T41","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1","span":{"begin":145,"end":152},"obj":"Chemical"},{"id":"T2","span":{"begin":187,"end":198},"obj":"Chemical"},{"id":"T3","span":{"begin":275,"end":286},"obj":"Chemical"},{"id":"T4","span":{"begin":287,"end":298},"obj":"Chemical"},{"id":"T6","span":{"begin":345,"end":359},"obj":"Chemical"},{"id":"T9","span":{"begin":345,"end":356},"obj":"Chemical"},{"id":"T10","span":{"begin":357,"end":359},"obj":"Chemical"},{"id":"T11","span":{"begin":365,"end":367},"obj":"Chemical"},{"id":"T12","span":{"begin":374,"end":385},"obj":"Chemical"},{"id":"T13","span":{"begin":902,"end":905},"obj":"Chemical"},{"id":"T14","span":{"begin":1344,"end":1351},"obj":"Chemical"},{"id":"T15","span":{"begin":2064,"end":2071},"obj":"Chemical"},{"id":"T16","span":{"begin":2288,"end":2290},"obj":"Chemical"},{"id":"T17","span":{"begin":2361,"end":2363},"obj":"Chemical"}],"attributes":[{"id":"A1","pred":"chebi_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_16541"},{"id":"A2","pred":"chebi_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_2719"},{"id":"A3","pred":"chebi_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A4","pred":"chebi_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_27584"},{"id":"A5","pred":"chebi_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_30834"},{"id":"A6","pred":"chebi_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_2719"},{"id":"A7","pred":"chebi_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_48432"},{"id":"A8","pred":"chebi_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_58506"},{"id":"A9","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A10","pred":"chebi_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A11","pred":"chebi_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A12","pred":"chebi_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A13","pred":"chebi_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_32386"},{"id":"A14","pred":"chebi_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A15","pred":"chebi_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A16","pred":"chebi_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A17","pred":"chebi_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T17","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T1","span":{"begin":121,"end":138},"obj":"http://purl.obolibrary.org/obo/GO_0009615"},{"id":"T2","span":{"begin":1422,"end":1432},"obj":"http://purl.obolibrary.org/obo/GO_0008219"},{"id":"T3","span":{"begin":1436,"end":1446},"obj":"http://purl.obolibrary.org/obo/GO_0070269"},{"id":"T4","span":{"begin":1605,"end":1617},"obj":"http://purl.obolibrary.org/obo/GO_0031099"},{"id":"T5","span":{"begin":2142,"end":2152},"obj":"http://purl.obolibrary.org/obo/GO_0008219"},{"id":"T6","span":{"begin":2156,"end":2166},"obj":"http://purl.obolibrary.org/obo/GO_0070269"},{"id":"T7","span":{"begin":2227,"end":2232},"obj":"http://purl.obolibrary.org/obo/GO_0019835"},{"id":"T8","span":{"begin":2381,"end":2391},"obj":"http://purl.obolibrary.org/obo/GO_0070269"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":186},"obj":"Sentence"},{"id":"T2","span":{"begin":187,"end":404},"obj":"Sentence"},{"id":"T3","span":{"begin":405,"end":516},"obj":"Sentence"},{"id":"T4","span":{"begin":517,"end":760},"obj":"Sentence"},{"id":"T5","span":{"begin":761,"end":1008},"obj":"Sentence"},{"id":"T6","span":{"begin":1009,"end":1205},"obj":"Sentence"},{"id":"T7","span":{"begin":1206,"end":1447},"obj":"Sentence"},{"id":"T8","span":{"begin":1448,"end":1618},"obj":"Sentence"},{"id":"T9","span":{"begin":1619,"end":1788},"obj":"Sentence"},{"id":"T10","span":{"begin":1789,"end":1951},"obj":"Sentence"},{"id":"T11","span":{"begin":1952,"end":2392},"obj":"Sentence"},{"id":"T12","span":{"begin":2393,"end":2454},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-sentences"},{"subj":"T2","pred":"source","obj":"LitCovid-sentences"},{"subj":"T3","pred":"source","obj":"LitCovid-sentences"},{"subj":"T4","pred":"source","obj":"LitCovid-sentences"},{"subj":"T5","pred":"source","obj":"LitCovid-sentences"},{"subj":"T6","pred":"source","obj":"LitCovid-sentences"},{"subj":"T7","pred":"source","obj":"LitCovid-sentences"},{"subj":"T8","pred":"source","obj":"LitCovid-sentences"},{"subj":"T9","pred":"source","obj":"LitCovid-sentences"},{"subj":"T10","pred":"source","obj":"LitCovid-sentences"},{"subj":"T11","pred":"source","obj":"LitCovid-sentences"},{"subj":"T12","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-OGER-BB","color":"#93b7ec","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#d1ec93"},{"id":"LitCovid-PD-UBERON","color":"#ec93eb"},{"id":"LitCovid-PD-MONDO","color":"#93ecd3"},{"id":"LitCovid-PD-CLO","color":"#ecb993"},{"id":"LitCovid-PD-CHEBI","color":"#9f93ec"},{"id":"LitCovid-PD-GO-BP","color":"#a1ec93"},{"id":"LitCovid-sentences","color":"#ec93bb"}]}]}}