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LitCovid-OGER-BB

Id Subject Object Predicate Lexical cue
T1 0-10 SP_7 denotes SARS-CoV-2
T2 26-30 G_3 denotes ACE2
T3 26-30 PG_10 denotes ACE2
T4 26-30 PR:000003622 denotes ACE2
T5 34-43 GO:0010467 denotes Expressed
T6 58-62 PR:000001006 denotes CD45
T7 78-91 GO:0030097 denotes Hematopoietic
T8 78-91 CL:0000988 denotes Hematopoietic
T9 96-107 UBERON:0001986 denotes Endothelial
T10 96-113 CL:0000115 denotes Endothelial Cells
T11 167-172 PR:000011271 denotes Nlrp3
T12 187-218 PG_10 denotes Angiotensin-converting enzyme 2
T13 187-218 PR:000003622 denotes Angiotensin-converting enzyme 2
T14 220-224 G_3 denotes ACE2
T15 220-224 PG_10 denotes ACE2
T16 220-224 PR:000003622 denotes ACE2
T17 269-274 PR:000013883 denotes renin
T18 316-326 GO:0065007 denotes regulating
T19 345-359 PR:000036009 denotes angiotensin II
T20 345-359 DG_37 denotes angiotensin II
T21 361-367 PR:000036009 denotes Ang II
T22 433-442 GO:0010467 denotes expressed
T23 450-460 GO:0009986 denotes surface of
T24 461-466 SP_6 denotes human
T25 461-466 NCBITaxon:9606 denotes human
T26 474-478 G_3 denotes ACE2
T27 474-478 PG_10 denotes ACE2
T28 474-478 PR:000003622 denotes ACE2
T29 505-509 PR:000014459 denotes SARS
T30 505-515 SP_7 denotes SARS-CoV-2
T31 517-527 GO:0010467 denotes Expression
T32 601-614 GO:0030097 denotes hematopoietic
T33 601-625 CL:0000037 denotes hematopoietic stem cells
T34 627-631 CL:0000037 denotes HSCs
T35 637-648 CL:0000115 denotes endothelial
T36 637-648 UBERON:0001986 denotes endothelial
T37 649-659 CL:0008001 denotes progenitor
T38 667-671 CL:0002619 denotes EPCs
T39 706-711 NCBITaxon:10239 denotes virus
T40 738-747 CL:0000034 denotes stem cell
T41 800-804 G_3 denotes ACE2
T42 800-804 PG_10 denotes ACE2
T43 800-804 PR:000003622 denotes ACE2
T44 832-845 GO:0016020 denotes transmembrane
T45 855-862 G_2 denotes TMPRSS2
T46 855-862 PR:000016456 denotes TMPRSS2
T47 867-876 GO:0010467 denotes expressed
T48 891-896 PR:000001786 denotes CD133
T49 897-901 PR:000001003 denotes CD34
T50 906-910 PR:000001006 denotes CD45
T51 921-926 SP_6 denotes human
T52 921-926 NCBITaxon:9606 denotes human
T53 927-941 UBERON:0012168 denotes umbilical cord
T54 942-947 UBERON:0012168 denotes blood
T55 1058-1067 CL:0002322 denotes embryonic
T56 1058-1067 UBERON:0000922 denotes embryonic
T57 1073-1083 CL:0000034 denotes stem cells
T58 1180-1189 GO:0007567 denotes postnatal
T59 1259-1264 SP_6 denotes human
T60 1259-1264 NCBITaxon:9606 denotes human
T61 1304-1308 G_3 denotes ACE2
T62 1304-1308 PG_10 denotes ACE2
T63 1304-1308 PR:000003622 denotes ACE2
T64 1327-1331 PR:000014459 denotes SARS
T65 1327-1337 SP_7 denotes SARS-CoV-2
T66 1366-1371 PR:000011271 denotes Nlrp3
T67 1422-1432 GO:0008219 denotes cell death
T68 1436-1446 GO:0070269 denotes pyroptosis
T69 1499-1504 SP_6 denotes human
T70 1499-1504 NCBITaxon:9606 denotes human
T71 1523-1528 UBERON:0007023 denotes adult
T72 1529-1536 UBERON:0000479 denotes tissues
T73 1557-1567 SP_7 denotes SARS-CoV-2
T74 1592-1598 UBERON:0000479 denotes tissue
T75 1592-1598 GO:0048771 denotes tissue
T76 1599-1604 UBERON:0000062 denotes organ
T77 1599-1617 GO:0031100 denotes organ regeneration
T78 1639-1643 G_3 denotes ACE2
T79 1639-1643 PG_10 denotes ACE2
T80 1639-1643 PR:000003622 denotes ACE2
T81 1647-1656 GO:0010467 denotes expressed
T82 1675-1681 NCBITaxon:39107 denotes murine
T83 1682-1693 UBERON:0002371 denotes bone marrow
T84 1744-1750 NCBITaxon:39107 denotes murine
T85 1777-1787 SP_7 denotes SARS-CoV-2
T86 1798-1803 SP_6 denotes human
T87 1798-1803 NCBITaxon:9606 denotes human
T88 1808-1814 NCBITaxon:39107 denotes murine
T89 1821-1828 GO:0010467 denotes express
T90 1842-1847 SO:0000704 denotes genes
T91 1892-1897 SO:0000704 denotes genes
T92 1905-1921 GO:0048866 denotes specification of
T93 1940-1950 CL:0000034 denotes stem cells
T94 1972-1977 SP_6 denotes Human
T95 1972-1977 NCBITaxon:9606 denotes Human
T96 1993-2000 GO:0010467 denotes express
T97 2001-2005 G_3 denotes ACE2
T98 2001-2005 PG_10 denotes ACE2
T99 2001-2005 PR:000003622 denotes ACE2
T100 2019-2028 SP_7 denotes SARS-CoV2
T101 2052-2057 NCBITaxon:10239 denotes viral
T102 2077-2081 G_3 denotes ACE2
T103 2077-2081 PG_10 denotes ACE2
T104 2077-2081 PR:000003622 denotes ACE2
T105 2109-2114 PR:000011271 denotes Nlrp3
T106 2142-2152 GO:0008219 denotes cell death
T107 2156-2166 GO:0070269 denotes pyroptosis
T108 2169-2178 SP_7 denotes SARS-CoV2
T109 2222-2232 GO:0019835 denotes cell lysis
T110 2271-2278 GO:0010467 denotes express
T111 2284-2287 CHEBI:37886 denotes Ang
T112 2284-2287 CHEBI:37886 denotes Ang
T113 2284-2290 PR:000036009 denotes Ang II
T114 2323-2328 PR:000011271 denotes Nlrp3
T115 2357-2360 CHEBI:37886 denotes Ang
T116 2357-2360 CHEBI:37886 denotes Ang
T117 2357-2363 PR:000036009 denotes Ang II
T118 2381-2391 GO:0070269 denotes pyroptosis
T119 2417-2422 PR:000036013 denotes Ang 1

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 96-113 Body_part denotes Endothelial Cells http://purl.org/sig/ont/fma/fma66772
T2 108-113 Body_part denotes Cells http://purl.org/sig/ont/fma/fma68646
T3 145-152 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T4 467-472 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T5 584-589 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T6 601-625 Body_part denotes hematopoietic stem cells http://purl.org/sig/ont/fma/fma86475
T7 620-625 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T8 660-665 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T9 743-759 Body_part denotes cell compartment http://purl.org/sig/ont/fma/fma223408
T10 743-747 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T11 912-917 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T12 927-941 Body_part denotes umbilical cord http://purl.org/sig/ont/fma/fma85541
T13 942-947 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T14 1032-1037 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T15 1073-1083 Body_part denotes stem cells http://purl.org/sig/ont/fma/fma63368
T16 1078-1083 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T17 1344-1351 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T18 1422-1426 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T19 1529-1536 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T20 1592-1598 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T21 1599-1604 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T22 1682-1693 Body_part denotes bone marrow http://purl.org/sig/ont/fma/fma9608
T23 1751-1756 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T24 1940-1950 Body_part denotes stem cells http://purl.org/sig/ont/fma/fma63368
T25 1945-1950 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T26 2064-2071 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T27 2142-2146 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T28 2194-2199 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T29 2222-2226 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T30 2265-2270 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 927-947 Body_part denotes umbilical cord blood http://purl.obolibrary.org/obo/UBERON_0012168
T2 927-941 Body_part denotes umbilical cord http://purl.obolibrary.org/obo/UBERON_0002331
T3 942-947 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T4 949-952 Body_part denotes UCB http://purl.obolibrary.org/obo/UBERON_0012168
T5 1592-1598 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T6 1599-1604 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T7 1682-1693 Body_part denotes bone marrow http://purl.obolibrary.org/obo/UBERON_0002371

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 0-8 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T2 505-513 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T3 1327-1335 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T4 1557-1565 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T5 1777-1785 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T6 2019-2023 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T7 2169-2173 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 96-113 http://purl.obolibrary.org/obo/CL_0000115 denotes Endothelial Cells
T2 133-138 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes Virus
T3 153-162 http://purl.obolibrary.org/obo/CLO_0001658 denotes Activates
T4 253-254 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T5 461-472 http://purl.obolibrary.org/obo/CLO_0053065 denotes human cells
T6 545-548 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T7 584-589 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8 615-625 http://purl.obolibrary.org/obo/CL_0000034 denotes stem cells
T9 660-665 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10 667-671 http://purl.obolibrary.org/obo/CLO_0002940 denotes EPCs
T11 687-688 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T12 706-711 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T13 738-747 http://purl.obolibrary.org/obo/CL_0000034 denotes stem cell
T14 912-917 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15 921-926 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T16 927-941 http://purl.obolibrary.org/obo/UBERON_0002331 denotes umbilical cord
T17 927-941 http://www.ebi.ac.uk/efo/EFO_0001415 denotes umbilical cord
T18 942-947 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T19 942-947 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T20 1003-1007 http://purl.obolibrary.org/obo/CLO_0002940 denotes EPCs
T21 1032-1037 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T22 1073-1083 http://purl.obolibrary.org/obo/CL_0000034 denotes stem cells
T23 1092-1095 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T24 1259-1264 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T25 1352-1361 http://purl.obolibrary.org/obo/CLO_0001658 denotes activates
T26 1422-1426 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T27 1480-1481 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T28 1499-1504 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T29 1599-1604 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T30 1682-1686 http://purl.obolibrary.org/obo/UBERON_0002481 denotes bone
T31 1751-1756 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T32 1798-1803 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T33 1842-1847 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T34 1892-1897 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T35 1940-1950 http://purl.obolibrary.org/obo/CL_0000034 denotes stem cells
T36 1972-1977 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T37 2142-2146 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T38 2194-2199 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T39 2222-2226 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T40 2265-2270 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T41 2434-2435 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 145-152 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T2 187-198 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T3 275-286 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T4 287-298 Chemical denotes aldosterone http://purl.obolibrary.org/obo/CHEBI_27584|http://purl.obolibrary.org/obo/CHEBI_30834
T6 345-359 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T9 345-356 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T10 357-359 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T11 365-367 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T12 374-385 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T13 902-905 Chemical denotes Lin http://purl.obolibrary.org/obo/CHEBI_32386
T14 1344-1351 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T15 2064-2071 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T16 2288-2290 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T17 2361-2363 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 121-138 http://purl.obolibrary.org/obo/GO_0009615 denotes Response to Virus
T2 1422-1432 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T3 1436-1446 http://purl.obolibrary.org/obo/GO_0070269 denotes pyroptosis
T4 1605-1617 http://purl.obolibrary.org/obo/GO_0031099 denotes regeneration
T5 2142-2152 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T6 2156-2166 http://purl.obolibrary.org/obo/GO_0070269 denotes pyroptosis
T7 2227-2232 http://purl.obolibrary.org/obo/GO_0019835 denotes lysis
T8 2381-2391 http://purl.obolibrary.org/obo/GO_0070269 denotes pyroptosis

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-186 Sentence denotes SARS-CoV-2 Entry Receptor ACE2 Is Expressed on Very Small CD45- Precursors of Hematopoietic and Endothelial Cells and in Response to Virus Spike Protein Activates the Nlrp3 Inflammasome.
T2 187-404 Sentence denotes Angiotensin-converting enzyme 2 (ACE2) plays an important role as a member of the renin-angiotensin-aldosterone system (RAAS) in regulating the conversion of angiotensin II (Ang II) into angiotensin (1-7) (Ang [1-7]).
T3 405-516 Sentence denotes But at the same time, while expressed on the surface of human cells, ACE2 is the entry receptor for SARS-CoV-2.
T4 517-760 Sentence denotes Expression of this receptor has been described in several types of cells, including hematopoietic stem cells (HSCs) and endothelial progenitor cells (EPCs), which raises a concern that the virus may infect and damage the stem cell compartment.
T5 761-1008 Sentence denotes We demonstrate for the first time that ACE2 and the entry-facilitating transmembrane protease TMPRSS2 are expressed on very small CD133+CD34+Lin-CD45- cells in human umbilical cord blood (UCB), which can be specified into functional HSCs and EPCs.
T6 1009-1205 Sentence denotes The existence of these cells known as very small embryonic-like stem cells (VSELs) has been confirmed by several laboratories, and some of them may correspond to putative postnatal hemangioblasts.
T7 1206-1447 Sentence denotes Moreover, we demonstrate for the first time that, in human VSELs and HSCs, the interaction of the ACE2 receptor with the SARS-CoV-2 spike protein activates the Nlrp3 inflammasome, which if hyperactivated may lead to cell death by pyroptosis.
T8 1448-1618 Sentence denotes Based on this finding, there is a possibility that human VSELs residing in adult tissues could be damaged by SARS-CoV-2, with remote effects on tissue/organ regeneration.
T9 1619-1788 Sentence denotes We also report that ACE2 is expressed on the surface of murine bone marrow-derived VSELs and HSCs, although it is known that murine cells are not infected by SARS-CoV-2.
T10 1789-1951 Sentence denotes Finally, human and murine VSELs express several RAAS genes, which sheds new light on the role of these genes in the specification of early-development stem cells.
T11 1952-2392 Sentence denotes Graphical Abstract •Human VSELs and HSCs express ACE2 receptor for SARS-CoV2 entry. •Interaction of viral spike protein with ACE2 receptor may hyperactivate Nlrp3 inflammasome which induces cell death by pyroptosis. •SARS-CoV2 may also enter cells and eliminate them by cell lysis. •What is not shown since these cells express also Ang II receptor they may hyperactivate Nlrp3 inflammasome in response to Ang II which may induce pyroptosis.
T12 2393-2454 Sentence denotes Our data indicates that Ang 1-7 may have a protective effect.