PubMed:32676976 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/32676976","sourcedb":"PubMed","sourceid":"32676976","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/32676976","text":"Exploring an Integrative Therapy for Treating COVID-19: A Randomized Controlled Trial.\nOBJECTIVES: To develop a new Chinese medicine (CM)-based drug and to evaluate its safety and effect for suppressing acute respiratory distress syndrome (ARDS) in COVID-19 patients.\nMETHODS: A putative ARDS-suppressing drug Keguan-1 was first developed and then evaluated by a randomized, controlled two-arm trial. The two arms of the trial consist of a control therapy (alpha interferon inhalation, 50 µg twice daily; and lopinavir/ritonavir, 400 and 100 mg twice daily, respectively) and a testing therapy (control therapy plus Keguan-1 19.4 g twice daily) by random number table at 1:1 ratio with 24 cases each group. After 2-week treatment, adverse events, time to fever resolution, ARDS development, and lung injury on newly diagnosed COVID-19 patients were assessed.\nRESULTS: An analysis of the data from the first 30 participants showed that the control arm and the testing arm did not exhibit any significant differences in terms of adverse events. Based on this result, the study was expanded to include a total of 48 participants (24 cases each arm). The results show that compared with the control arm, the testing arm exhibited a significant improvement in time to fever resolution (P=0.035), and a significant reduction in the development of ARDS (P=0.048).\nCONCLUSIONS: Keguan-1-based integrative therapy was safe and superior to the standard therapy in suppressing the development of ARDS in COVID-19 patients. (Trial registration No. NCT04251871 at www.clinicaltrials.gov ).","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T1","span":{"begin":390,"end":393},"obj":"Body_part"},{"id":"T2","span":{"begin":795,"end":799},"obj":"Body_part"},{"id":"T3","span":{"begin":947,"end":950},"obj":"Body_part"},{"id":"T4","span":{"begin":967,"end":970},"obj":"Body_part"},{"id":"T5","span":{"begin":1141,"end":1144},"obj":"Body_part"},{"id":"T6","span":{"begin":1195,"end":1198},"obj":"Body_part"},{"id":"T7","span":{"begin":1212,"end":1215},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma24890"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma24890"},{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma24890"},{"id":"A5","pred":"fma_id","subj":"T5","obj":"http://purl.org/sig/ont/fma/fma24890"},{"id":"A6","pred":"fma_id","subj":"T6","obj":"http://purl.org/sig/ont/fma/fma24890"},{"id":"A7","pred":"fma_id","subj":"T7","obj":"http://purl.org/sig/ont/fma/fma24890"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T1","span":{"begin":390,"end":393},"obj":"Body_part"},{"id":"T2","span":{"begin":795,"end":799},"obj":"Body_part"},{"id":"T3","span":{"begin":947,"end":950},"obj":"Body_part"},{"id":"T4","span":{"begin":967,"end":970},"obj":"Body_part"},{"id":"T5","span":{"begin":1141,"end":1144},"obj":"Body_part"},{"id":"T6","span":{"begin":1195,"end":1198},"obj":"Body_part"},{"id":"T7","span":{"begin":1212,"end":1215},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0001460"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/UBERON_0001460"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/UBERON_0001460"},{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/UBERON_0001460"},{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/UBERON_0001460"},{"id":"A7","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/UBERON_0001460"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T1","span":{"begin":209,"end":229},"obj":"Phenotype"},{"id":"T2","span":{"begin":755,"end":760},"obj":"Phenotype"},{"id":"T3","span":{"begin":1263,"end":1268},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/HP_0002098"},{"id":"A2","pred":"hp_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/HP_0001945"},{"id":"A3","pred":"hp_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/HP_0001945"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T1","span":{"begin":46,"end":54},"obj":"Disease"},{"id":"T2","span":{"begin":203,"end":238},"obj":"Disease"},{"id":"T3","span":{"begin":209,"end":238},"obj":"Disease"},{"id":"T4","span":{"begin":240,"end":244},"obj":"Disease"},{"id":"T5","span":{"begin":249,"end":257},"obj":"Disease"},{"id":"T6","span":{"begin":288,"end":292},"obj":"Disease"},{"id":"T7","span":{"begin":773,"end":777},"obj":"Disease"},{"id":"T8","span":{"begin":800,"end":806},"obj":"Disease"},{"id":"T9","span":{"begin":826,"end":834},"obj":"Disease"},{"id":"T10","span":{"begin":1341,"end":1345},"obj":"Disease"},{"id":"T11","span":{"begin":1485,"end":1489},"obj":"Disease"},{"id":"T12","span":{"begin":1493,"end":1501},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0009971"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A11","pred":"mondo_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A12","pred":"mondo_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1","span":{"begin":56,"end":57},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T2","span":{"begin":87,"end":97},"obj":"http://purl.obolibrary.org/obo/BFO_0000030"},{"id":"T3","span":{"begin":110,"end":111},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T4","span":{"begin":277,"end":278},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T5","span":{"begin":361,"end":362},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T6","span":{"begin":390,"end":393},"obj":"http://www.ebi.ac.uk/efo/EFO_0001410"},{"id":"T7","span":{"begin":409,"end":413},"obj":"http://www.ebi.ac.uk/efo/EFO_0001410"},{"id":"T8","span":{"begin":438,"end":439},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T9","span":{"begin":576,"end":577},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T10","span":{"begin":578,"end":585},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T11","span":{"begin":668,"end":672},"obj":"http://purl.obolibrary.org/obo/CLO_0001757"},{"id":"T12","span":{"begin":795,"end":799},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T13","span":{"begin":795,"end":799},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T14","span":{"begin":947,"end":950},"obj":"http://www.ebi.ac.uk/efo/EFO_0001410"},{"id":"T15","span":{"begin":959,"end":966},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T16","span":{"begin":967,"end":970},"obj":"http://www.ebi.ac.uk/efo/EFO_0001410"},{"id":"T17","span":{"begin":1099,"end":1100},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T18","span":{"begin":1110,"end":1112},"obj":"http://purl.obolibrary.org/obo/CLO_0001382"},{"id":"T19","span":{"begin":1141,"end":1144},"obj":"http://www.ebi.ac.uk/efo/EFO_0001410"},{"id":"T20","span":{"begin":1195,"end":1198},"obj":"http://www.ebi.ac.uk/efo/EFO_0001410"},{"id":"T21","span":{"begin":1204,"end":1211},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T22","span":{"begin":1212,"end":1215},"obj":"http://www.ebi.ac.uk/efo/EFO_0001410"},{"id":"T23","span":{"begin":1226,"end":1227},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T24","span":{"begin":1295,"end":1296},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T17","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T18","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T23","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T24","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1","span":{"begin":124,"end":132},"obj":"Chemical"},{"id":"T2","span":{"begin":144,"end":148},"obj":"Chemical"},{"id":"T3","span":{"begin":305,"end":309},"obj":"Chemical"},{"id":"T4","span":{"begin":457,"end":462},"obj":"Chemical"},{"id":"T5","span":{"begin":463,"end":473},"obj":"Chemical"},{"id":"T6","span":{"begin":509,"end":528},"obj":"Chemical"},{"id":"T7","span":{"begin":509,"end":518},"obj":"Chemical"},{"id":"T8","span":{"begin":519,"end":528},"obj":"Chemical"},{"id":"T9","span":{"begin":700,"end":705},"obj":"Chemical"}],"attributes":[{"id":"A1","pred":"chebi_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A2","pred":"chebi_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A3","pred":"chebi_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A4","pred":"chebi_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_30216"},{"id":"A5","pred":"chebi_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_52999"},{"id":"A6","pred":"chebi_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_145924"},{"id":"A7","pred":"chebi_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_31781"},{"id":"A8","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_45409"},{"id":"A9","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":55},"obj":"Sentence"},{"id":"T2","span":{"begin":56,"end":86},"obj":"Sentence"},{"id":"T3","span":{"begin":87,"end":98},"obj":"Sentence"},{"id":"T4","span":{"begin":99,"end":267},"obj":"Sentence"},{"id":"T5","span":{"begin":268,"end":276},"obj":"Sentence"},{"id":"T6","span":{"begin":277,"end":400},"obj":"Sentence"},{"id":"T7","span":{"begin":401,"end":706},"obj":"Sentence"},{"id":"T8","span":{"begin":707,"end":858},"obj":"Sentence"},{"id":"T9","span":{"begin":859,"end":867},"obj":"Sentence"},{"id":"T10","span":{"begin":868,"end":1042},"obj":"Sentence"},{"id":"T11","span":{"begin":1043,"end":1146},"obj":"Sentence"},{"id":"T12","span":{"begin":1147,"end":1356},"obj":"Sentence"},{"id":"T13","span":{"begin":1357,"end":1369},"obj":"Sentence"},{"id":"T14","span":{"begin":1370,"end":1535},"obj":"Sentence"},{"id":"T15","span":{"begin":1536,"end":1576},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-sentences"},{"subj":"T2","pred":"source","obj":"LitCovid-sentences"},{"subj":"T3","pred":"source","obj":"LitCovid-sentences"},{"subj":"T4","pred":"source","obj":"LitCovid-sentences"},{"subj":"T5","pred":"source","obj":"LitCovid-sentences"},{"subj":"T6","pred":"source","obj":"LitCovid-sentences"},{"subj":"T7","pred":"source","obj":"LitCovid-sentences"},{"subj":"T8","pred":"source","obj":"LitCovid-sentences"},{"subj":"T9","pred":"source","obj":"LitCovid-sentences"},{"subj":"T10","pred":"source","obj":"LitCovid-sentences"},{"subj":"T11","pred":"source","obj":"LitCovid-sentences"},{"subj":"T12","pred":"source","obj":"LitCovid-sentences"},{"subj":"T13","pred":"source","obj":"LitCovid-sentences"},{"subj":"T14","pred":"source","obj":"LitCovid-sentences"},{"subj":"T15","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#c5ec93","default":true},{"id":"LitCovid-PD-UBERON","color":"#ec93df"},{"id":"LitCovid-PD-HP","color":"#93ecdf"},{"id":"LitCovid-PD-MONDO","color":"#ecc593"},{"id":"LitCovid-PD-CLO","color":"#ab93ec"},{"id":"LitCovid-PD-CHEBI","color":"#95ec93"},{"id":"LitCovid-sentences","color":"#ec93af"}]}]}}