PubMed:32676976
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T1 | 390-393 | Body_part | denotes | arm | http://purl.org/sig/ont/fma/fma24890 |
| T2 | 795-799 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T3 | 947-950 | Body_part | denotes | arm | http://purl.org/sig/ont/fma/fma24890 |
| T4 | 967-970 | Body_part | denotes | arm | http://purl.org/sig/ont/fma/fma24890 |
| T5 | 1141-1144 | Body_part | denotes | arm | http://purl.org/sig/ont/fma/fma24890 |
| T6 | 1195-1198 | Body_part | denotes | arm | http://purl.org/sig/ont/fma/fma24890 |
| T7 | 1212-1215 | Body_part | denotes | arm | http://purl.org/sig/ont/fma/fma24890 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 390-393 | Body_part | denotes | arm | http://purl.obolibrary.org/obo/UBERON_0001460 |
| T2 | 795-799 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T3 | 947-950 | Body_part | denotes | arm | http://purl.obolibrary.org/obo/UBERON_0001460 |
| T4 | 967-970 | Body_part | denotes | arm | http://purl.obolibrary.org/obo/UBERON_0001460 |
| T5 | 1141-1144 | Body_part | denotes | arm | http://purl.obolibrary.org/obo/UBERON_0001460 |
| T6 | 1195-1198 | Body_part | denotes | arm | http://purl.obolibrary.org/obo/UBERON_0001460 |
| T7 | 1212-1215 | Body_part | denotes | arm | http://purl.obolibrary.org/obo/UBERON_0001460 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 46-54 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T2 | 203-238 | Disease | denotes | acute respiratory distress syndrome | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T3 | 209-238 | Disease | denotes | respiratory distress syndrome | http://purl.obolibrary.org/obo/MONDO_0009971 |
| T4 | 240-244 | Disease | denotes | ARDS | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T5 | 249-257 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T6 | 288-292 | Disease | denotes | ARDS | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T7 | 773-777 | Disease | denotes | ARDS | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T8 | 800-806 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T9 | 826-834 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T10 | 1341-1345 | Disease | denotes | ARDS | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T11 | 1485-1489 | Disease | denotes | ARDS | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T12 | 1493-1501 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 56-57 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T2 | 87-97 | http://purl.obolibrary.org/obo/BFO_0000030 | denotes | OBJECTIVES |
| T3 | 110-111 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T4 | 277-278 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T5 | 361-362 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T6 | 390-393 | http://www.ebi.ac.uk/efo/EFO_0001410 | denotes | arm |
| T7 | 409-413 | http://www.ebi.ac.uk/efo/EFO_0001410 | denotes | arms |
| T8 | 438-439 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T9 | 576-577 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T10 | 578-585 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | testing |
| T11 | 668-672 | http://purl.obolibrary.org/obo/CLO_0001757 | denotes | at 1 |
| T12 | 795-799 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T13 | 795-799 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T14 | 947-950 | http://www.ebi.ac.uk/efo/EFO_0001410 | denotes | arm |
| T15 | 959-966 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | testing |
| T16 | 967-970 | http://www.ebi.ac.uk/efo/EFO_0001410 | denotes | arm |
| T17 | 1099-1100 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T18 | 1110-1112 | http://purl.obolibrary.org/obo/CLO_0001382 | denotes | 48 |
| T19 | 1141-1144 | http://www.ebi.ac.uk/efo/EFO_0001410 | denotes | arm |
| T20 | 1195-1198 | http://www.ebi.ac.uk/efo/EFO_0001410 | denotes | arm |
| T21 | 1204-1211 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | testing |
| T22 | 1212-1215 | http://www.ebi.ac.uk/efo/EFO_0001410 | denotes | arm |
| T23 | 1226-1227 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T24 | 1295-1296 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T1 | 124-132 | Chemical | denotes | medicine | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T2 | 144-148 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T3 | 305-309 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T4 | 457-462 | Chemical | denotes | alpha | http://purl.obolibrary.org/obo/CHEBI_30216 |
| T5 | 463-473 | Chemical | denotes | interferon | http://purl.obolibrary.org/obo/CHEBI_52999 |
| T6 | 509-528 | Chemical | denotes | lopinavir/ritonavir | http://purl.obolibrary.org/obo/CHEBI_145924 |
| T7 | 509-518 | Chemical | denotes | lopinavir | http://purl.obolibrary.org/obo/CHEBI_31781 |
| T8 | 519-528 | Chemical | denotes | ritonavir | http://purl.obolibrary.org/obo/CHEBI_45409 |
| T9 | 700-705 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-55 | Sentence | denotes | Exploring an Integrative Therapy for Treating COVID-19: |
| T2 | 56-86 | Sentence | denotes | A Randomized Controlled Trial. |
| T3 | 87-98 | Sentence | denotes | OBJECTIVES: |
| T4 | 99-267 | Sentence | denotes | To develop a new Chinese medicine (CM)-based drug and to evaluate its safety and effect for suppressing acute respiratory distress syndrome (ARDS) in COVID-19 patients. |
| T5 | 268-276 | Sentence | denotes | METHODS: |
| T6 | 277-400 | Sentence | denotes | A putative ARDS-suppressing drug Keguan-1 was first developed and then evaluated by a randomized, controlled two-arm trial. |
| T7 | 401-706 | Sentence | denotes | The two arms of the trial consist of a control therapy (alpha interferon inhalation, 50 µg twice daily; and lopinavir/ritonavir, 400 and 100 mg twice daily, respectively) and a testing therapy (control therapy plus Keguan-1 19.4 g twice daily) by random number table at 1:1 ratio with 24 cases each group. |
| T8 | 707-858 | Sentence | denotes | After 2-week treatment, adverse events, time to fever resolution, ARDS development, and lung injury on newly diagnosed COVID-19 patients were assessed. |
| T9 | 859-867 | Sentence | denotes | RESULTS: |
| T10 | 868-1042 | Sentence | denotes | An analysis of the data from the first 30 participants showed that the control arm and the testing arm did not exhibit any significant differences in terms of adverse events. |
| T11 | 1043-1146 | Sentence | denotes | Based on this result, the study was expanded to include a total of 48 participants (24 cases each arm). |
| T12 | 1147-1356 | Sentence | denotes | The results show that compared with the control arm, the testing arm exhibited a significant improvement in time to fever resolution (P=0.035), and a significant reduction in the development of ARDS (P=0.048). |
| T13 | 1357-1369 | Sentence | denotes | CONCLUSIONS: |
| T14 | 1370-1535 | Sentence | denotes | Keguan-1-based integrative therapy was safe and superior to the standard therapy in suppressing the development of ARDS in COVID-19 patients. (Trial registration No. |
| T15 | 1536-1576 | Sentence | denotes | NCT04251871 at www.clinicaltrials.gov ). |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 209-229 | Phenotype | denotes | respiratory distress | http://purl.obolibrary.org/obo/HP_0002098 |
| T2 | 755-760 | Phenotype | denotes | fever | http://purl.obolibrary.org/obo/HP_0001945 |
| T3 | 1263-1268 | Phenotype | denotes | fever | http://purl.obolibrary.org/obo/HP_0001945 |