PubMed:32408070 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/32408070","sourcedb":"PubMed","sourceid":"32408070","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/32408070","text":"Does zinc supplementation enhance the clinical efficacy of chloroquine/hydroxychloroquine to win today's battle against COVID-19?\nCurrently, drug repurposing is an alternative to novel drug development for the treatment of COVID-19 patients. The antimalarial drug chloroquine (CQ) and its metabolite hydroxychloroquine (HCQ) are currently being tested in several clinical studies as potential candidates to limit SARS-CoV-2-mediated morbidity and mortality. CQ and HCQ (CQ/HCQ) inhibit pH-dependent steps of SARS-CoV-2 replication by increasing pH in intracellular vesicles and interfere with virus particle delivery into host cells. Besides direct antiviral effects, CQ/HCQ specifically target extracellular zinc to intracellular lysosomes where it interferes with RNA-dependent RNA polymerase activity and coronavirus replication. As zinc deficiency frequently occurs in elderly patients and in those with cardiovascular disease, chronic pulmonary disease, or diabetes, we hypothesize that CQ/HCQ plus zinc supplementation may be more effective in reducing COVID-19 morbidity and mortality than CQ or HCQ in monotherapy. Therefore, CQ/HCQ in combination with zinc should be considered as additional study arm for COVID-19 clinical trials.","tracks":[{"project":"PubMed_ArguminSci","denotations":[{"id":"T1","span":{"begin":130,"end":241},"obj":"DRI_Background"},{"id":"T2","span":{"begin":242,"end":457},"obj":"DRI_Background"},{"id":"T3","span":{"begin":458,"end":633},"obj":"DRI_Background"},{"id":"T4","span":{"begin":634,"end":832},"obj":"DRI_Background"},{"id":"T5","span":{"begin":833,"end":1122},"obj":"DRI_Challenge"},{"id":"T6","span":{"begin":1123,"end":1240},"obj":"DRI_Challenge"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T2","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T3","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T4","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T5","pred":"source","obj":"PubMed_ArguminSci"},{"subj":"T6","pred":"source","obj":"PubMed_ArguminSci"}]},{"project":"LitCovid-OGER-BB","denotations":[{"id":"T1","span":{"begin":59,"end":70},"obj":"CHEBI:3638;DG_10;CHEBI:3638"},{"id":"T2","span":{"begin":71,"end":89},"obj":"CHEBI:5801;DG_20;CHEBI:5801"},{"id":"T3","span":{"begin":120,"end":128},"obj":"SP_7"},{"id":"T4","span":{"begin":141,"end":145},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T5","span":{"begin":185,"end":189},"obj":"CHEBI:23888;CHEBI:23888;GO:0017144"},{"id":"T6","span":{"begin":223,"end":231},"obj":"SP_7"},{"id":"T7","span":{"begin":246,"end":258},"obj":"CHEBI:35718;CHEBI:35718"},{"id":"T8","span":{"begin":259,"end":263},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T9","span":{"begin":264,"end":275},"obj":"CHEBI:3638;CHEBI:3638;DG_10"},{"id":"T10","span":{"begin":289,"end":299},"obj":"CHEBI:25212;CHEBI:25212"},{"id":"T11","span":{"begin":300,"end":318},"obj":"CHEBI:5801;CHEBI:5801;DG_20"},{"id":"T12","span":{"begin":413,"end":423},"obj":"SP_7"},{"id":"T13","span":{"begin":508,"end":518},"obj":"SP_7"},{"id":"T14","span":{"begin":519,"end":530},"obj":"GO:0006260"},{"id":"T15","span":{"begin":551,"end":564},"obj":"GO:0005622"},{"id":"T16","span":{"begin":565,"end":573},"obj":"GO:0031982"},{"id":"T17","span":{"begin":593,"end":598},"obj":"NCBITaxon:10239"},{"id":"T18","span":{"begin":695,"end":708},"obj":"GO:0005576"},{"id":"T19","span":{"begin":717,"end":730},"obj":"GO:0005622"},{"id":"T20","span":{"begin":731,"end":740},"obj":"GO:0005764"},{"id":"T21","span":{"begin":808,"end":819},"obj":"NCBITaxon:11118"},{"id":"T22","span":{"begin":820,"end":831},"obj":"GO:0006260"},{"id":"T23","span":{"begin":908,"end":922},"obj":"UBERON:0004535"},{"id":"T24","span":{"begin":940,"end":949},"obj":"UBERON:0002048"},{"id":"T25","span":{"begin":1059,"end":1067},"obj":"SP_7"},{"id":"T26","span":{"begin":1215,"end":1223},"obj":"SP_7"}],"namespaces":[{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T2","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T3","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T4","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T5","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T6","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T7","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T8","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T9","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T10","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T11","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T12","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T13","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T14","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T15","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T16","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T17","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T18","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T19","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T20","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T21","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T22","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T23","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T24","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T25","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T26","pred":"source","obj":"LitCovid-OGER-BB"}]},{"project":"hydroxychloroquine","denotations":[{"id":"T1","span":{"begin":908,"end":930},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/HP_0001626"},{"subj":"T1","pred":"source","obj":"hydroxychloroquine"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"PubMed_ArguminSci","color":"#9398ec","default":true},{"id":"LitCovid-OGER-BB","color":"#b2ec93"},{"id":"hydroxychloroquine","color":"#ec93cc"}]}]}}