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PubMed:32408070 JSONTXT

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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 130-241 DRI_Background denotes Currently, drug repurposing is an alternative to novel drug development for the treatment of COVID-19 patients.
T2 242-457 DRI_Background denotes The antimalarial drug chloroquine (CQ) and its metabolite hydroxychloroquine (HCQ) are currently being tested in several clinical studies as potential candidates to limit SARS-CoV-2-mediated morbidity and mortality.
T3 458-633 DRI_Background denotes CQ and HCQ (CQ/HCQ) inhibit pH-dependent steps of SARS-CoV-2 replication by increasing pH in intracellular vesicles and interfere with virus particle delivery into host cells.
T4 634-832 DRI_Background denotes Besides direct antiviral effects, CQ/HCQ specifically target extracellular zinc to intracellular lysosomes where it interferes with RNA-dependent RNA polymerase activity and coronavirus replication.
T5 833-1122 DRI_Challenge denotes As zinc deficiency frequently occurs in elderly patients and in those with cardiovascular disease, chronic pulmonary disease, or diabetes, we hypothesize that CQ/HCQ plus zinc supplementation may be more effective in reducing COVID-19 morbidity and mortality than CQ or HCQ in monotherapy.
T6 1123-1240 DRI_Challenge denotes Therefore, CQ/HCQ in combination with zinc should be considered as additional study arm for COVID-19 clinical trials.

LitCovid-OGER-BB

Id Subject Object Predicate Lexical cue
T1 59-70 CHEBI:3638;DG_10;CHEBI:3638 denotes chloroquine
T2 71-89 CHEBI:5801;DG_20;CHEBI:5801 denotes hydroxychloroquine
T3 120-128 SP_7 denotes COVID-19
T4 141-145 CHEBI:23888;CHEBI:23888 denotes drug
T5 185-189 CHEBI:23888;CHEBI:23888;GO:0017144 denotes drug
T6 223-231 SP_7 denotes COVID-19
T7 246-258 CHEBI:35718;CHEBI:35718 denotes antimalarial
T8 259-263 CHEBI:23888;CHEBI:23888 denotes drug
T9 264-275 CHEBI:3638;CHEBI:3638;DG_10 denotes chloroquine
T10 289-299 CHEBI:25212;CHEBI:25212 denotes metabolite
T11 300-318 CHEBI:5801;CHEBI:5801;DG_20 denotes hydroxychloroquine
T12 413-423 SP_7 denotes SARS-CoV-2
T13 508-518 SP_7 denotes SARS-CoV-2
T14 519-530 GO:0006260 denotes replication
T15 551-564 GO:0005622 denotes intracellular
T16 565-573 GO:0031982 denotes vesicles
T17 593-598 NCBITaxon:10239 denotes virus
T18 695-708 GO:0005576 denotes extracellular
T19 717-730 GO:0005622 denotes intracellular
T20 731-740 GO:0005764 denotes lysosomes
T21 808-819 NCBITaxon:11118 denotes coronavirus
T22 820-831 GO:0006260 denotes replication
T23 908-922 UBERON:0004535 denotes cardiovascular
T24 940-949 UBERON:0002048 denotes pulmonary
T25 1059-1067 SP_7 denotes COVID-19
T26 1215-1223 SP_7 denotes COVID-19

hydroxychloroquine

Id Subject Object Predicate Lexical cue hp_id
T1 908-930 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626