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Coagulation results and clinical features of consecutive patients with severe pneumonia induced by SARS-CoV2 (COVID group) and non-SARS-CoV2 (non-COVID group) in Tongji hospital were retrospectively analyzed and compared. Whether patients with elevated D-dimer could benefit from anticoagulant treatment was evaluated. There were 449 COVID patients and 104 non-COVID patients enrolled into the study. The 28-day mortality in COVID group was approximately twofold of mortality in non-COVID group (29.8% vs. 15.4%, P = 0.003), COVID group were older (65.1 ± 12.0 vs. 58.4 ± 18.0, years, P \u003c 0.001) and with higher platelet count (215 ± 100 vs. 188 ± 98, ×109/L, P = 0.015), comparing to non-COVID group. The 28-day mortality of heparin users were lower than nonusers In COVID group with D-dimer \u003e 3.0 μg/mL (32.8% vs. 52.4%, P = 0.017). Patients with severe pneumonia induced by SARS-CoV2 had higher platelet count than those induced by non-SARS-CoV2, and only the former with markedly elevated D-dimer may benefit from anticoagulant treatment."}

{"project":"LitCovid-PD-MONDO-v1","denotations":[{"id":"T1","span":{"begin":50,"end":59},"obj":"Disease"},{"id":"T2","span":{"begin":71,"end":75},"obj":"Disease"},{"id":"T3","span":{"begin":89,"end":93},"obj":"Disease"},{"id":"T4","span":{"begin":107,"end":131},"obj":"Disease"},{"id":"T5","span":{"begin":133,"end":141},"obj":"Disease"},{"id":"T6","span":{"begin":172,"end":184},"obj":"Disease"},{"id":"T7","span":{"begin":240,"end":249},"obj":"Disease"},{"id":"T8","span":{"begin":261,"end":265},"obj":"Disease"},{"id":"T9","span":{"begin":279,"end":283},"obj":"Disease"},{"id":"T10","span":{"begin":390,"end":399},"obj":"Disease"},{"id":"T11","span":{"begin":411,"end":415},"obj":"Disease"},{"id":"T12","span":{"begin":443,"end":447},"obj":"Disease"},{"id":"T13","span":{"begin":1168,"end":1177},"obj":"Disease"},{"id":"T14","span":{"begin":1189,"end":1193},"obj":"Disease"},{"id":"T15","span":{"begin":1251,"end":1255},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0001531"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"},{"id":"A11","pred":"mondo_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A12","pred":"mondo_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A13","pred":"mondo_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"},{"id":"A14","pred":"mondo_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A15","pred":"mondo_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Difference of coagulation features between severe pneumonia induced by SARS-CoV2 and non-SARS-CoV2.\nSevere coronavirus disease 2019 (COVID-19) is commonly complicated with coagulopathy, the difference of coagulation features between severe pneumonia induced by SARS-CoV2 and non-SARS-CoV2 has not been analyzed. Coagulation results and clinical features of consecutive patients with severe pneumonia induced by SARS-CoV2 (COVID group) and non-SARS-CoV2 (non-COVID group) in Tongji hospital were retrospectively analyzed and compared. Whether patients with elevated D-dimer could benefit from anticoagulant treatment was evaluated. There were 449 COVID patients and 104 non-COVID patients enrolled into the study. The 28-day mortality in COVID group was approximately twofold of mortality in non-COVID group (29.8% vs. 15.4%, P = 0.003), COVID group were older (65.1 ± 12.0 vs. 58.4 ± 18.0, years, P \u003c 0.001) and with higher platelet count (215 ± 100 vs. 188 ± 98, ×109/L, P = 0.015), comparing to non-COVID group. The 28-day mortality of heparin users were lower than nonusers In COVID group with D-dimer \u003e 3.0 μg/mL (32.8% vs. 52.4%, P = 0.017). Patients with severe pneumonia induced by SARS-CoV2 had higher platelet count than those induced by non-SARS-CoV2, and only the former with markedly elevated D-dimer may benefit from anticoagulant treatment."}

{"project":"LitCovid-PD-HP-v1","denotations":[{"id":"T1","span":{"begin":50,"end":59},"obj":"Phenotype"},{"id":"T2","span":{"begin":172,"end":184},"obj":"Phenotype"},{"id":"T3","span":{"begin":240,"end":249},"obj":"Phenotype"},{"id":"T4","span":{"begin":390,"end":399},"obj":"Phenotype"},{"id":"T5","span":{"begin":1168,"end":1177},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/HP_0002090"},{"id":"A2","pred":"hp_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/HP_0003256"},{"id":"A3","pred":"hp_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/HP_0002090"},{"id":"A4","pred":"hp_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/HP_0002090"},{"id":"A5","pred":"hp_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/HP_0002090"}],"text":"Difference of coagulation features between severe pneumonia induced by SARS-CoV2 and non-SARS-CoV2.\nSevere coronavirus disease 2019 (COVID-19) is commonly complicated with coagulopathy, the difference of coagulation features between severe pneumonia induced by SARS-CoV2 and non-SARS-CoV2 has not been analyzed. Coagulation results and clinical features of consecutive patients with severe pneumonia induced by SARS-CoV2 (COVID group) and non-SARS-CoV2 (non-COVID group) in Tongji hospital were retrospectively analyzed and compared. Whether patients with elevated D-dimer could benefit from anticoagulant treatment was evaluated. There were 449 COVID patients and 104 non-COVID patients enrolled into the study. The 28-day mortality in COVID group was approximately twofold of mortality in non-COVID group (29.8% vs. 15.4%, P = 0.003), COVID group were older (65.1 ± 12.0 vs. 58.4 ± 18.0, years, P \u003c 0.001) and with higher platelet count (215 ± 100 vs. 188 ± 98, ×109/L, P = 0.015), comparing to non-COVID group. The 28-day mortality of heparin users were lower than nonusers In COVID group with D-dimer \u003e 3.0 μg/mL (32.8% vs. 52.4%, P = 0.017). Patients with severe pneumonia induced by SARS-CoV2 had higher platelet count than those induced by non-SARS-CoV2, and only the former with markedly elevated D-dimer may benefit from anticoagulant treatment."}

{"project":"LitCovid-PD-FMA-UBERON-v1","denotations":[{"id":"T1","span":{"begin":924,"end":932},"obj":"Body_part"},{"id":"T2","span":{"begin":1038,"end":1045},"obj":"Body_part"},{"id":"T3","span":{"begin":1210,"end":1218},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma82839"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma62851"}],"text":"Difference of coagulation features between severe pneumonia induced by SARS-CoV2 and non-SARS-CoV2.\nSevere coronavirus disease 2019 (COVID-19) is commonly complicated with coagulopathy, the difference of coagulation features between severe pneumonia induced by SARS-CoV2 and non-SARS-CoV2 has not been analyzed. Coagulation results and clinical features of consecutive patients with severe pneumonia induced by SARS-CoV2 (COVID group) and non-SARS-CoV2 (non-COVID group) in Tongji hospital were retrospectively analyzed and compared. Whether patients with elevated D-dimer could benefit from anticoagulant treatment was evaluated. There were 449 COVID patients and 104 non-COVID patients enrolled into the study. The 28-day mortality in COVID group was approximately twofold of mortality in non-COVID group (29.8% vs. 15.4%, P = 0.003), COVID group were older (65.1 ± 12.0 vs. 58.4 ± 18.0, years, P \u003c 0.001) and with higher platelet count (215 ± 100 vs. 188 ± 98, ×109/L, P = 0.015), comparing to non-COVID group. The 28-day mortality of heparin users were lower than nonusers In COVID group with D-dimer \u003e 3.0 μg/mL (32.8% vs. 52.4%, P = 0.017). Patients with severe pneumonia induced by SARS-CoV2 had higher platelet count than those induced by non-SARS-CoV2, and only the former with markedly elevated D-dimer may benefit from anticoagulant treatment."}

{"project":"LitCovid-OGER-BB","denotations":[{"id":"T1","span":{"begin":14,"end":25},"obj":"GO:0050817"},{"id":"T2","span":{"begin":71,"end":80},"obj":"SP_7"},{"id":"T3","span":{"begin":89,"end":98},"obj":"SP_7"},{"id":"T4","span":{"begin":107,"end":118},"obj":"NCBITaxon:11118"},{"id":"T5","span":{"begin":133,"end":141},"obj":"SP_7"},{"id":"T6","span":{"begin":172,"end":184},"obj":"GO:0050817"},{"id":"T7","span":{"begin":204,"end":215},"obj":"GO:0050817"},{"id":"T8","span":{"begin":261,"end":270},"obj":"SP_7"},{"id":"T9","span":{"begin":279,"end":288},"obj":"SP_7"},{"id":"T10","span":{"begin":312,"end":323},"obj":"GO:0050817"},{"id":"T11","span":{"begin":411,"end":420},"obj":"SP_7"},{"id":"T12","span":{"begin":443,"end":452},"obj":"SP_7"},{"id":"T13","span":{"begin":592,"end":605},"obj":"GO:0050817"},{"id":"T14","span":{"begin":924,"end":932},"obj":"CL:0000233"},{"id":"T15","span":{"begin":1038,"end":1045},"obj":"CHEBI:24505"},{"id":"T16","span":{"begin":1038,"end":1045},"obj":"CHEBI:24505"},{"id":"T17","span":{"begin":1189,"end":1198},"obj":"SP_7"},{"id":"T18","span":{"begin":1210,"end":1218},"obj":"CL:0000233"},{"id":"T19","span":{"begin":1251,"end":1260},"obj":"SP_7"},{"id":"T20","span":{"begin":1330,"end":1343},"obj":"GO:0050817"}],"namespaces":[{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"}],"text":"Difference of coagulation features between severe pneumonia induced by SARS-CoV2 and non-SARS-CoV2.\nSevere coronavirus disease 2019 (COVID-19) is commonly complicated with coagulopathy, the difference of coagulation features between severe pneumonia induced by SARS-CoV2 and non-SARS-CoV2 has not been analyzed. Coagulation results and clinical features of consecutive patients with severe pneumonia induced by SARS-CoV2 (COVID group) and non-SARS-CoV2 (non-COVID group) in Tongji hospital were retrospectively analyzed and compared. Whether patients with elevated D-dimer could benefit from anticoagulant treatment was evaluated. There were 449 COVID patients and 104 non-COVID patients enrolled into the study. The 28-day mortality in COVID group was approximately twofold of mortality in non-COVID group (29.8% vs. 15.4%, P = 0.003), COVID group were older (65.1 ± 12.0 vs. 58.4 ± 18.0, years, P \u003c 0.001) and with higher platelet count (215 ± 100 vs. 188 ± 98, ×109/L, P = 0.015), comparing to non-COVID group. The 28-day mortality of heparin users were lower than nonusers In COVID group with D-dimer \u003e 3.0 μg/mL (32.8% vs. 52.4%, P = 0.017). Patients with severe pneumonia induced by SARS-CoV2 had higher platelet count than those induced by non-SARS-CoV2, and only the former with markedly elevated D-dimer may benefit from anticoagulant treatment."}

{"project":"LitCovid_AGAC","denotations":[{"id":"p123156s11","span":{"begin":1210,"end":1224},"obj":"MPA"}],"text":"Difference of coagulation features between severe pneumonia induced by SARS-CoV2 and non-SARS-CoV2.\nSevere coronavirus disease 2019 (COVID-19) is commonly complicated with coagulopathy, the difference of coagulation features between severe pneumonia induced by SARS-CoV2 and non-SARS-CoV2 has not been analyzed. Coagulation results and clinical features of consecutive patients with severe pneumonia induced by SARS-CoV2 (COVID group) and non-SARS-CoV2 (non-COVID group) in Tongji hospital were retrospectively analyzed and compared. Whether patients with elevated D-dimer could benefit from anticoagulant treatment was evaluated. There were 449 COVID patients and 104 non-COVID patients enrolled into the study. The 28-day mortality in COVID group was approximately twofold of mortality in non-COVID group (29.8% vs. 15.4%, P = 0.003), COVID group were older (65.1 ± 12.0 vs. 58.4 ± 18.0, years, P \u003c 0.001) and with higher platelet count (215 ± 100 vs. 188 ± 98, ×109/L, P = 0.015), comparing to non-COVID group. The 28-day mortality of heparin users were lower than nonusers In COVID group with D-dimer \u003e 3.0 μg/mL (32.8% vs. 52.4%, P = 0.017). Patients with severe pneumonia induced by SARS-CoV2 had higher platelet count than those induced by non-SARS-CoV2, and only the former with markedly elevated D-dimer may benefit from anticoagulant treatment."}

{"project":"MeasurableQuantitativeAnnotation","denotations":[{"id":"E1","span":{"begin":717,"end":733},"obj":"entity"},{"id":"E2","span":{"begin":922,"end":936},"obj":"entity"},{"id":"N1","span":{"begin":808,"end":812},"obj":"num"},{"id":"N2","span":{"begin":938,"end":947},"obj":"num"},{"id":"U1","span":{"begin":812,"end":813},"obj":"unit"},{"id":"U2","span":{"begin":965,"end":967},"obj":"unit"}],"relations":[{"id":"R1","pred":"associateWith","subj":"E1","obj":"N1"},{"id":"R2","pred":"associateOf","subj":"N1","obj":"U1"},{"id":"R3","pred":"associateWith","subj":"E2","obj":"N2"},{"id":"R4","pred":"associateOf","subj":"N2","obj":"U2"}],"text":"Difference of coagulation features between severe pneumonia induced by SARS-CoV2 and non-SARS-CoV2.\nSevere coronavirus disease 2019 (COVID-19) is commonly complicated with coagulopathy, the difference of coagulation features between severe pneumonia induced by SARS-CoV2 and non-SARS-CoV2 has not been analyzed. Coagulation results and clinical features of consecutive patients with severe pneumonia induced by SARS-CoV2 (COVID group) and non-SARS-CoV2 (non-COVID group) in Tongji hospital were retrospectively analyzed and compared. Whether patients with elevated D-dimer could benefit from anticoagulant treatment was evaluated. There were 449 COVID patients and 104 non-COVID patients enrolled into the study. The 28-day mortality in COVID group was approximately twofold of mortality in non-COVID group (29.8% vs. 15.4%, P = 0.003), COVID group were older (65.1 ± 12.0 vs. 58.4 ± 18.0, years, P \u003c 0.001) and with higher platelet count (215 ± 100 vs. 188 ± 98, ×109/L, P = 0.015), comparing to non-COVID group. The 28-day mortality of heparin users were lower than nonusers In COVID group with D-dimer \u003e 3.0 μg/mL (32.8% vs. 52.4%, P = 0.017). Patients with severe pneumonia induced by SARS-CoV2 had higher platelet count than those induced by non-SARS-CoV2, and only the former with markedly elevated D-dimer may benefit from anticoagulant treatment."}

{"project":"Inflammaging","denotations":[{"id":"T1","span":{"begin":0,"end":99},"obj":"Sentence"},{"id":"T2","span":{"begin":100,"end":311},"obj":"Sentence"},{"id":"T3","span":{"begin":312,"end":533},"obj":"Sentence"},{"id":"T4","span":{"begin":534,"end":630},"obj":"Sentence"},{"id":"T5","span":{"begin":631,"end":712},"obj":"Sentence"},{"id":"T6","span":{"begin":713,"end":1013},"obj":"Sentence"},{"id":"T7","span":{"begin":1014,"end":1146},"obj":"Sentence"},{"id":"T8","span":{"begin":1147,"end":1354},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":99},"obj":"Sentence"},{"id":"T2","span":{"begin":100,"end":311},"obj":"Sentence"},{"id":"T3","span":{"begin":312,"end":533},"obj":"Sentence"},{"id":"T4","span":{"begin":534,"end":630},"obj":"Sentence"},{"id":"T5","span":{"begin":631,"end":712},"obj":"Sentence"},{"id":"T6","span":{"begin":713,"end":1013},"obj":"Sentence"},{"id":"T7","span":{"begin":1014,"end":1146},"obj":"Sentence"},{"id":"T8","span":{"begin":1147,"end":1354},"obj":"Sentence"}],"text":"Difference of coagulation features between severe pneumonia induced by SARS-CoV2 and non-SARS-CoV2.\nSevere coronavirus disease 2019 (COVID-19) is commonly complicated with coagulopathy, the difference of coagulation features between severe pneumonia induced by SARS-CoV2 and non-SARS-CoV2 has not been analyzed. Coagulation results and clinical features of consecutive patients with severe pneumonia induced by SARS-CoV2 (COVID group) and non-SARS-CoV2 (non-COVID group) in Tongji hospital were retrospectively analyzed and compared. Whether patients with elevated D-dimer could benefit from anticoagulant treatment was evaluated. There were 449 COVID patients and 104 non-COVID patients enrolled into the study. The 28-day mortality in COVID group was approximately twofold of mortality in non-COVID group (29.8% vs. 15.4%, P = 0.003), COVID group were older (65.1 ± 12.0 vs. 58.4 ± 18.0, years, P \u003c 0.001) and with higher platelet count (215 ± 100 vs. 188 ± 98, ×109/L, P = 0.015), comparing to non-COVID group. The 28-day mortality of heparin users were lower than nonusers In COVID group with D-dimer \u003e 3.0 μg/mL (32.8% vs. 52.4%, P = 0.017). Patients with severe pneumonia induced by SARS-CoV2 had higher platelet count than those induced by non-SARS-CoV2, and only the former with markedly elevated D-dimer may benefit from anticoagulant treatment."}