PubMed:32073213 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/32073213","sourcedb":"PubMed","sourceid":"32073213","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/32073213","text":"Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia.\nBACKGROUND: In the recent outbreak of novel coronavirus infection in Wuhan, China, significantly abnormal coagulation parameters in severe novel coronavirus pneumonia (NCP) cases were a concern.\nOBJECTIVES: To describe the coagulation feature of patients with NCP.\nMETHODS: Conventional coagulation results and outcomes of 183 consecutive patients with confirmed NCP in Tongji hospital were retrospectively analyzed.\nRESULTS: The overall mortality was 11.5%, the non-survivors revealed significantly higher D-dimer and fibrin degradation product (FDP) levels, longer prothrombin time and activated partial thromboplastin time compared to survivors on admission (P \u003c .05); 71.4% of non-survivors and 0.6% survivors met the criteria of disseminated intravascular coagulation during their hospital stay.\nCONCLUSIONS: The present study shows that abnormal coagulation results, especially markedly elevated D-dimer and FDP are common in deaths with 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