PubMed:31908101 JSONTXT

{"project":"Inflammaging","denotations":[{"id":"T1","span":{"begin":0,"end":84},"obj":"Sentence"},{"id":"T2","span":{"begin":85,"end":96},"obj":"Sentence"},{"id":"T3","span":{"begin":97,"end":205},"obj":"Sentence"},{"id":"T4","span":{"begin":206,"end":228},"obj":"Sentence"},{"id":"T5","span":{"begin":229,"end":344},"obj":"Sentence"},{"id":"T6","span":{"begin":345,"end":352},"obj":"Sentence"},{"id":"T7","span":{"begin":353,"end":449},"obj":"Sentence"},{"id":"T8","span":{"begin":450,"end":470},"obj":"Sentence"},{"id":"T9","span":{"begin":471,"end":594},"obj":"Sentence"},{"id":"T10","span":{"begin":595,"end":774},"obj":"Sentence"},{"id":"T11","span":{"begin":775,"end":953},"obj":"Sentence"},{"id":"T12","span":{"begin":954,"end":1003},"obj":"Sentence"},{"id":"T13","span":{"begin":1004,"end":1040},"obj":"Sentence"},{"id":"T14","span":{"begin":1041,"end":1180},"obj":"Sentence"},{"id":"T15","span":{"begin":1181,"end":1246},"obj":"Sentence"},{"id":"T16","span":{"begin":1247,"end":1353},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":84},"obj":"Sentence"},{"id":"T2","span":{"begin":85,"end":96},"obj":"Sentence"},{"id":"T3","span":{"begin":97,"end":205},"obj":"Sentence"},{"id":"T4","span":{"begin":206,"end":228},"obj":"Sentence"},{"id":"T5","span":{"begin":229,"end":344},"obj":"Sentence"},{"id":"T6","span":{"begin":345,"end":352},"obj":"Sentence"},{"id":"T7","span":{"begin":353,"end":449},"obj":"Sentence"},{"id":"T8","span":{"begin":450,"end":470},"obj":"Sentence"},{"id":"T9","span":{"begin":471,"end":594},"obj":"Sentence"},{"id":"T10","span":{"begin":595,"end":774},"obj":"Sentence"},{"id":"T11","span":{"begin":775,"end":953},"obj":"Sentence"},{"id":"T12","span":{"begin":954,"end":1003},"obj":"Sentence"},{"id":"T13","span":{"begin":1004,"end":1040},"obj":"Sentence"},{"id":"T14","span":{"begin":1041,"end":1180},"obj":"Sentence"},{"id":"T15","span":{"begin":1181,"end":1246},"obj":"Sentence"},{"id":"T16","span":{"begin":1247,"end":1353},"obj":"Sentence"}],"text":"Granulomatous mural folliculitis in a dog treated with ciclosporin and methotrexate.\nBACKGROUND: Canine granulomatous mural folliculitis is a very rare cause of scarring alopecia with unknown pathogenesis.\nHYPOTHESIS/OBJECTIVES: To report a case of granulomatous mural folliculitis in a dog treated with ciclosporin (Cs) and methotrexate (MTX).\nANIMAL: A 13-year-old spayed female Pyrenean shepherd dog with a one month history of scarring alopecia.\nMETHODS AND RESULTS: Histopathological examination revealed a granulomatous and lymphocytic mural and necrotizing folliculitis and furunculosis. Immunochemistry, using antibodies for CD3, CD204, CD206, IBA-1 and CD208, revealed that CD3+ lymphocytes were infiltrating the outer root sheath along with IBA-1+ or CD204+ cells. Ciclosporin (5 mg/kg once daily) and MTX (0.25 mg/kg once weekly then 0.5 mg/kg once weekly) were initiated simultaneously, and Cs was stopped after stabilization of the lesions. The dog's skin disease was stable for six months.\nCONCLUSIONS AND CLINICAL IMPORTANCE: To the best of the authors' knowledge, this is the first report of the long-term management of a granulomatous mural folliculitis in a dog. Ciclosporin and MTX appeared to be an effective treatment option. Additional treated cases are needed to assess the effectiveness of MTX in canine immune-mediated diseases."}