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PubMed:31681295 JSONTXT

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GoldHamster

Id Subject Object Predicate Lexical cue
T1 14-19 D006801 denotes Human
T2 27-37 P42858 denotes Huntingtin
T3 27-37 P42859 denotes Huntingtin
T4 27-37 P51111 denotes Huntingtin
T5 27-37 PR:000008840 denotes Huntingtin
T6 27-37 P51112 denotes Huntingtin
T7 27-45 D000071058 denotes Huntingtin Protein
T9 49-59 2294143 denotes Drosophila
T10 49-59 504603 denotes Drosophila
T11 49-59 2294139 denotes Drosophila
T12 49-59 2294145 denotes Drosophila
T13 49-59 2294141 denotes Drosophila
T14 49-59 2294142 denotes Drosophila
T15 49-59 2294144 denotes Drosophila
T16 49-59 2294140 denotes Drosophila
T17 49-59 D004330 denotes Drosophila
T18 49-59 2080301 denotes Drosophila
T19 128-131 PR:P51111 denotes HTT
T20 128-131 PR:000015189 denotes HTT
T21 128-131 PR:Q76P24 denotes HTT
T22 128-131 PR:P31645 denotes HTT
T23 128-131 PR:P42859 denotes HTT
T24 128-131 PR:Q60857 denotes HTT
T25 128-131 PR:P42858 denotes HTT
T26 128-131 PR:000008840 denotes HTT
T27 133-137 PR:P42859 denotes mHTT
T30 152-170 D006816 denotes Huntington disease
T31 152-170 D006816 denotes Huntington disease
T35 198-212 UBERON:0001016 denotes nervous system
T34 198-212 D009422 denotes nervous system
T36 198-212 D009422 denotes nervous system
T37 365-387 GO:0045087 denotes innate immune response
T39 407-416 D007239 denotes infection
T40 407-416 D007239 denotes infection
T41 448-458 SO:0000781 denotes transgenic
T52 459-482 D004331 denotes Drosophila melanogaster
T53 459-482 7227 denotes Drosophila melanogaster
T54 501-504 PR:P51111 denotes HTT
T55 501-504 PR:000015189 denotes HTT
T56 501-504 PR:Q76P24 denotes HTT
T57 501-504 PR:P31645 denotes HTT
T58 501-504 PR:P42859 denotes HTT
T59 501-504 PR:Q60857 denotes HTT
T60 501-504 PR:P42858 denotes HTT
T61 501-504 PR:000008840 denotes HTT
T66 505-512 SO:0000104 denotes protein
T63 505-512 CHEBI:36080 denotes protein
T64 505-512 CHEBI:11122 denotes protein
T65 505-512 PR:000000001 denotes protein
T62 505-512 GO:0003675 denotes protein
T67 514-518 PR:P42859 denotes mHTT
T68 525-533 897253 denotes hemocyte
T69 589-597 897253 denotes hemocyte
T70 622-626 PR:P42859 denotes mHTT
T71 805-809 PR:P42859 denotes mHTT
T72 870-874 UBERON:0010210 denotes clot
T73 875-884 GO:0009058 denotes formation
T74 931-945 D004198 denotes susceptibility
T75 931-945 D004198 denotes susceptibility
T76 990-994 PR:000017371 denotes wasp
T77 990-994 P42768 denotes wasp
T78 990-994 PR:P70315 denotes wasp
T79 990-994 P70315 denotes wasp
T80 990-994 D014863 denotes wasp
T81 1020-1024 PR:P42859 denotes mHTT
T82 1039-1049 2294143 denotes Drosophila
T83 1039-1049 504603 denotes Drosophila
T84 1039-1049 2294139 denotes Drosophila
T85 1039-1049 2294145 denotes Drosophila
T86 1039-1049 2294141 denotes Drosophila
T87 1039-1049 2294142 denotes Drosophila
T88 1039-1049 2294144 denotes Drosophila
T89 1039-1049 2294140 denotes Drosophila
T90 1039-1049 D004330 denotes Drosophila
T91 1039-1049 2080301 denotes Drosophila
T92 1050-1060 CL:0000235 denotes macrophage
T93 1092-1095 D000255 denotes ATP
T95 1092-1095 CHEBI:30616 denotes ATP
T96 1092-1095 D000255 denotes ATP
T97 1092-1095 CHEBI:15422 denotes ATP
T94 1092-1095 318 denotes ATP
T98 1145-1158 CHEBI:33281 denotes antimicrobial
T99 1145-1167 B3EWR6 denotes antimicrobial peptides
T100 1145-1167 O24006 denotes antimicrobial peptides
T101 1159-1167 D010455 denotes peptides
T102 1159-1167 D010455 denotes peptides
T103 1159-1167 CHEBI:16670 denotes peptides
T104 1197-1201 PR:P42859 denotes mHTT
T105 1254-1263 D016207 denotes cytokines
T106 1254-1263 D016207 denotes cytokines
T107 1282-1285 GO:0004713 denotes JAK
T108 1286-1290 P08457 denotes STAT
T109 1286-1290 PR:P35610 denotes STAT
T110 1286-1290 PR:000015389 denotes STAT
T111 1286-1290 PR:Q24151 denotes STAT
T112 1291-1300 GO:0023052 denotes signaling
T113 1349-1353 PR:P42859 denotes mHTT
T114 1357-1367 2294143 denotes Drosophila
T115 1357-1367 504603 denotes Drosophila
T116 1357-1367 2294139 denotes Drosophila
T117 1357-1367 2294145 denotes Drosophila
T118 1357-1367 2294141 denotes Drosophila
T119 1357-1367 2294142 denotes Drosophila
T120 1357-1367 2294144 denotes Drosophila
T121 1357-1367 2294140 denotes Drosophila
T122 1357-1367 D004330 denotes Drosophila
T123 1357-1367 2080301 denotes Drosophila
T124 1525-1529 PR:P42859 denotes mHTT

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 102-213 DRI_Background denotes thogenic effect of mutant HTT (mHTT) which causes Huntington disease (HD) are not restricted to nervous system.
T2 214-290 DRI_Outcome denotes Such phenotypes include aberrant immune responses observed in the HD models.
T3 291-417 DRI_Challenge denotes However, it is still unclear how this immune dysregulation influences the innate immune response against pathogenic infection.
T4 418-607 DRI_Outcome denotes In the present study, we used transgenic Drosophila melanogaster expressing mutant HTT protein (mHTT) with hemocyte-specific drivers and examined the immune responses and hemocyte function.
T5 608-755 DRI_Outcome denotes We found that mHTT expression in the hemocytes did not affect fly viability, but the numbers of circulating hemocytes were significantly decreased.
T6 756-1006 DRI_Outcome denotes Consequently, we observed that the expression of mHTT in the hemocytes compromised the immune responses including clot formation and encapsulation which lead to the increased susceptibility to entomopathogenic nematode and parasitoid wasp infections.
T7 1007-1168 DRI_Outcome denotes In addition, mHTT expression in Drosophila macrophage-like S2 cells in vitro reduced ATP levels, phagocytic activity and the induction of antimicrobial peptides.
T8 1169-1301 DRI_Approach denotes Further effects observed in mHTT-expressing cells included the altered production of cytokines and activation of JAK/STAT signaling.
T9 1302-1460 DRI_Background denotes The present study shows that the expression of mHTT in Drosophila hemocytes causes deficient cellular and humoral immune responses against invading pathogens.
T10 1461-1550 DRI_Outcome denotes Our findings provide the insight into the pathogenic effects of mHTT in the immune cells.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 440-442 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes we
T2 608-610 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes We
T3 770-772 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes we
T4 1066-1068 CVCL_2500|Cancer_cell_line|Homo sapiens denotes S2
T5 1066-1068 CVCL_4698|Hybridoma|Mus musculus denotes S2
T6 1066-1068 CVCL_4719|Cancer_cell_line|Homo sapiens denotes S2
T7 1066-1068 CVCL_Z232|Spontaneously_immortalized_cell_line|Drosophila melanogaster denotes S2
T8 1115-1123 CVCL_C410|Hybridoma|Mus musculus denotes activity
T9 1268-1278 CVCL_C410|Hybridoma|Mus musculus denotes activation