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PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 98-358 BACKGROUND denotes Neuroblastoma is the main solid extracranial tumor of childhood. The amplification of N-myc oncogene (MYCN) and 1p deletion are the main molecular alterations. These features are what make treatment impossible, especially in high-risk patients with metastases.
T2 382-549 METHODS denotes Our study investigated the processes undergone by CHP-212 neuroblastoma cells, after being treated with Casiopeínas® (Cas) IIgly, IIIEa, and IIIia for 2, 10, and 24 h.
T3 559-1222 RESULTS denotes At 2 h, all the treatments Ied to apoptosis [defined by the presence of B-cell lymphoma 2 (BCL2), BCL2-associated X protein, cytochrome c, and caspase-3]. In addition, autophagy with specific molecules beclin-1 and microtubule-associated protein 1A/1B-light chain 3 (LC3)-II/LC3-I (ratio >1). Later at 10 h, autophagy-associated proteins were observed, and at 24 h, only survival proteins nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-κB), and extracellular signal-regulated kinases (ERK)2/ERK1>1 were found. Another relevant finding was the presence of caspase-10 throughout the study, especially in cells treated with CasIIgly and CasIIIEa.
T4 1235-1327 CONCLUSIONS denotes These relationships indicate a possible mechanism of action of Casiopeínas on neuroblastoma.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 31-38 CVCL_1125|Cancer_cell_line|Homo sapiens denotes CHP-212
T2 432-439 CVCL_1125|Cancer_cell_line|Homo sapiens denotes CHP-212
T3 544-548 CVCL_8262|Cancer_cell_line|Homo sapiens denotes 24 h
T4 559-563 CVCL_L303|Cancer_cell_line|Rattus norvegicus denotes At 2
T5 631-632 CVCL_6480|Finite_cell_line|Mus musculus denotes B
T6 695-696 CVCL_S361|Finite_cell_line|Mus musculus denotes c
T7 861-865 CVCL_N538|Hybridoma|Mus musculus denotes 10 h
T8 919-923 CVCL_8262|Cancer_cell_line|Homo sapiens denotes 24 h
T9 993-1002 CVCL_C410|Hybridoma|Mus musculus denotes activated
T10 1003-1004 CVCL_6480|Finite_cell_line|Mus musculus denotes B
T11 1012-1014 CVCL_W770|Cancer_cell_line|Homo sapiens denotes NF
T12 1016-1017 CVCL_6480|Finite_cell_line|Mus musculus denotes B
T13 1264-1265 CVCL_6479|Finite_cell_line|Mus musculus denotes a

GoldHamster

Id Subject Object Predicate Lexical cue
T1 0-9 GO:0016236 denotes Autophagy
T2 0-9 GO:0006914 denotes Autophagy
T3 31-34 PR:Q2FFF7 denotes CHP
T4 31-34 PR:A6QIG7 denotes CHP
T5 31-34 PR:P61023 denotes CHP
T7 31-34 PR:P61022 denotes CHP
T8 31-34 PR:Q5ZM44 denotes CHP
T9 31-34 PR:P12024 denotes CHP
T10 31-34 PR:Q6GFB3 denotes CHP
T11 31-34 PR:Q99SU8 denotes CHP
T69 500-503 PR:P55060 denotes Cas
T12 31-34 PR:Q99653 denotes CHP
T13 31-34 PR:000005446 denotes CHP
T14 31-34 PR:Q2FWV5 denotes CHP
T15 31-34 PR:000029171 denotes CHP
T6 31-34 CHEBI:78673 denotes CHP
T16 31-38 CVCL_1125 denotes CHP-212
T17 39-52 D009447 denotes Neuroblastoma
T18 39-52 D009447 denotes Neuroblastoma
T19 98-111 D009447 denotes Neuroblastoma
T20 98-111 D009447 denotes Neuroblastoma
T21 143-148 D009369 denotes tumor
T22 143-148 D009369 denotes tumor
T23 186-189 PR:P52160 denotes myc
T24 200-204 PR:Q9PSJ0 denotes MYCN
T25 200-204 PR:000010812 denotes MYCN
T26 200-204 PR:Q63379 denotes MYCN
T27 200-204 PR:P03966 denotes MYCN
T28 200-204 PR:P04198 denotes MYCN
T37 213-221 SO:0000159 denotes deletion
T38 347-357 D009362 denotes metastases
T39 347-357 D009362 denotes metastases
T40 369-372 1481724 denotes AND
T41 409-418 UBERON:0004529 denotes processes
T42 432-435 PR:Q2FFF7 denotes CHP
T43 432-435 PR:A6QIG7 denotes CHP
T44 432-435 PR:P61023 denotes CHP
T46 432-435 PR:P61022 denotes CHP
T47 432-435 PR:Q5ZM44 denotes CHP
T48 432-435 PR:P12024 denotes CHP
T49 432-435 PR:Q6GFB3 denotes CHP
T50 432-435 PR:Q99SU8 denotes CHP
T51 432-435 PR:Q99653 denotes CHP
T52 432-435 PR:000005446 denotes CHP
T53 432-435 PR:Q2FWV5 denotes CHP
T54 432-435 PR:000029171 denotes CHP
T45 432-435 CHEBI:78673 denotes CHP
T55 432-439 CVCL_1125 denotes CHP-212
T56 440-453 D009447 denotes neuroblastoma
T57 440-453 D009447 denotes neuroblastoma
T60 500-503 GO:0005650 denotes Cas
T58 500-503 O60716 denotes Cas
T59 500-503 PR:Q9ZPY7 denotes Cas
T61 500-503 PR:Q7M3M8 denotes Cas
T62 500-503 PR:Q9XZU1 denotes Cas
T63 500-503 PR:000004676 denotes Cas
T64 500-503 P30999 denotes Cas
T65 500-503 P22947 denotes Cas
T66 500-503 O45679 denotes Cas
T67 500-503 PR:Q61140 denotes Cas
T68 500-503 PR:000006012 denotes Cas
T71 500-503 PR:Q9FN48 denotes Cas
T72 500-503 PR:Q63767 denotes Cas
T73 500-503 PR:000005929 denotes Cas
T75 500-503 PR:P56945 denotes Cas
T70 500-503 UBERON:0002920 denotes Cas
T74 500-503 D001072 denotes Cas
T76 500-510 C505569 denotes Cas) IIgly
T77 500-510 C505569 denotes Cas) IIgly
T79 544-548 CVCL_8262 denotes 24 h
T95 593-602 GO:0097194 denotes apoptosis
T96 593-602 GO:0006915 denotes apoptosis
T97 631-637 CL:0000236 denotes B-cell
T98 631-646 D016393 denotes B-cell lymphoma
T99 631-646 D016393 denotes B-cell lymphoma
T103 650-654 PR:P49950 denotes BCL2
T104 650-654 PR:000002307 denotes BCL2
T105 650-654 PR:P10417 denotes BCL2
T106 650-654 PR:Q00709 denotes BCL2
T107 650-654 PR:P10415 denotes BCL2
T102 650-654 GO:0015283 denotes BCL2
T109 657-661 PR:P49950 denotes BCL2
T110 657-661 PR:000002307 denotes BCL2
T111 657-661 PR:P10417 denotes BCL2
T112 657-661 PR:Q00709 denotes BCL2
T113 657-661 PR:P10415 denotes BCL2
T108 657-661 GO:0015283 denotes BCL2
T114 657-682 D051028 denotes BCL2-associated X protein
T115 673-682 P0DOF1 denotes X protein
T116 673-682 P0DOF0 denotes X protein
T117 675-682 GO:0003675 denotes protein
T121 675-682 SO:0000104 denotes protein
T131 684-696 P00064 denotes cytochrome c
T132 684-696 P00142 denotes cytochrome c
T133 684-696 P00002 denotes cytochrome c
T134 684-696 P00065 denotes cytochrome c
T135 684-696 P00062 denotes cytochrome c
T136 684-696 Q6QLW4 denotes cytochrome c
T137 684-696 P00151 denotes cytochrome c
T138 684-696 P00059 denotes cytochrome c
T139 684-696 P00144 denotes cytochrome c
T140 684-696 P68519 denotes cytochrome c
T141 684-696 P00146 denotes cytochrome c
T142 684-696 P00021 denotes cytochrome c
T143 684-696 P00068 denotes cytochrome c
T144 684-696 P00078 denotes cytochrome c
T145 684-696 P00007 denotes cytochrome c
T146 684-696 Q52V08 denotes cytochrome c
T147 684-696 P00041 denotes cytochrome c
T148 684-696 P15451 denotes cytochrome c
T149 684-696 P81280 denotes cytochrome c
T150 684-696 O93863 denotes cytochrome c
T151 684-696 P00025 denotes cytochrome c
T152 684-696 P00032 denotes cytochrome c
T153 684-696 P00039 denotes cytochrome c
T154 684-696 P00071 denotes cytochrome c
T155 684-696 Q52V09 denotes cytochrome c
T156 684-696 P21665 denotes cytochrome c
T157 684-696 Q4HVX7 denotes cytochrome c
T158 684-696 P00066 denotes cytochrome c
T159 684-696 P00029 denotes cytochrome c
T160 684-696 P99998 denotes cytochrome c
T161 684-696 P00035 denotes cytochrome c
T162 684-696 P00054 denotes cytochrome c
T163 684-696 P00008 denotes cytochrome c
T164 684-696 P00063 denotes cytochrome c
T166 684-696 P00046 denotes cytochrome c
T167 684-696 P68517 denotes cytochrome c
T168 684-696 P00145 denotes cytochrome c
T169 684-696 P22342 denotes cytochrome c
T170 684-696 P00076 denotes cytochrome c
T171 684-696 P32556 denotes cytochrome c
T172 684-696 P00138 denotes cytochrome c
T173 684-696 P56205 denotes cytochrome c
T174 684-696 Q52V10 denotes cytochrome c
T175 684-696 P68099 denotes cytochrome c
T176 684-696 P00153 denotes cytochrome c
T177 684-696 P00052 denotes cytochrome c
T178 684-696 P00072 denotes cytochrome c
T179 684-696 P00013 denotes cytochrome c
T180 684-696 P62896 denotes cytochrome c
T182 684-696 P53698 denotes cytochrome c
T183 684-696 Q0DI31 denotes cytochrome c
T184 684-696 P00077 denotes cytochrome c
T185 684-696 P00070 denotes cytochrome c
T186 684-696 P00011 denotes cytochrome c
T187 684-696 P99999 denotes cytochrome c
T188 684-696 P00042 denotes cytochrome c
T189 684-696 P00037 denotes cytochrome c
T190 684-696 P00024 denotes cytochrome c
T192 684-696 B4USV4 denotes cytochrome c
T193 684-696 P00147 denotes cytochrome c
T194 684-696 Q4N594 denotes cytochrome c
T195 684-696 P00012 denotes cytochrome c
T196 684-696 P29380 denotes cytochrome c
T197 684-696 O07091 denotes cytochrome c
T199 684-696 P00020 denotes cytochrome c
T200 684-696 P67881 denotes cytochrome c
T201 684-696 P00060 denotes cytochrome c
T202 684-696 P00031 denotes cytochrome c
T203 684-696 P00074 denotes cytochrome c
T204 684-696 P00079 denotes cytochrome c
T205 684-696 P62773 denotes cytochrome c
T206 684-696 P00053 denotes cytochrome c
T207 684-696 Q6Q4H8 denotes cytochrome c
T208 684-696 P00038 denotes cytochrome c
T209 684-696 P00004 denotes cytochrome c
T210 684-696 P00049 denotes cytochrome c
T211 684-696 P00027 denotes cytochrome c
T212 684-696 Q869N1 denotes cytochrome c
T213 684-696 P00014 denotes cytochrome c
T214 684-696 P00022 denotes cytochrome c
T215 684-696 P00036 denotes cytochrome c
T216 684-696 P00017 denotes cytochrome c
T217 684-696 A2Y4S9 denotes cytochrome c
T218 684-696 P59218 denotes cytochrome c
T219 684-696 P00048 denotes cytochrome c
T220 684-696 P00003 denotes cytochrome c
T221 684-696 P18822 denotes cytochrome c
T222 684-696 Q6WUX8 denotes cytochrome c
T223 684-696 P00069 denotes cytochrome c
T224 684-696 PR:000025635 denotes cytochrome c
T225 684-696 P00057 denotes cytochrome c
T226 684-696 Q6IQM2 denotes cytochrome c
T227 684-696 P68518 denotes cytochrome c
T228 684-696 P62895 denotes cytochrome c
T229 684-696 Q753F4 denotes cytochrome c
T230 684-696 P00152 denotes cytochrome c
T231 684-696 P62894 denotes cytochrome c
T232 684-696 P12831 denotes cytochrome c
T233 684-696 Q9RQB9 denotes cytochrome c
T234 684-696 P00067 denotes cytochrome c
T235 684-696 Q41346 denotes cytochrome c
T236 684-696 Q4UEA0 denotes cytochrome c
T237 684-696 P25400 denotes cytochrome c
T239 684-696 P00143 denotes cytochrome c
T240 684-696 P38091 denotes cytochrome c
T242 684-696 P67882 denotes cytochrome c
T243 684-696 P00149 denotes cytochrome c
T244 684-696 Q5RFH4 denotes cytochrome c
T245 684-696 P00154 denotes cytochrome c
T246 684-696 Q6C9Q0 denotes cytochrome c
T247 684-696 P19681 denotes cytochrome c
T248 684-696 Q4SG99 denotes cytochrome c
T249 684-696 P00058 denotes cytochrome c
T250 684-696 Q7YR71 denotes cytochrome c
T251 684-696 P68097 denotes cytochrome c
T252 684-696 P81459 denotes cytochrome c
T253 684-696 P00047 denotes cytochrome c
T254 684-696 P00040 denotes cytochrome c
T255 684-696 P00043 denotes cytochrome c
T256 684-696 P68096 denotes cytochrome c
T257 684-696 O13393 denotes cytochrome c
T258 684-696 P00051 denotes cytochrome c
T259 684-696 P00030 denotes cytochrome c
T260 684-696 P00056 denotes cytochrome c
T261 684-696 P00019 denotes cytochrome c
T262 684-696 P68098 denotes cytochrome c
T263 684-696 P62772 denotes cytochrome c
T264 684-696 P00018 denotes cytochrome c
T265 684-696 P00148 denotes cytochrome c
T266 684-696 P00073 denotes cytochrome c
T267 684-696 P00061 denotes cytochrome c
T268 684-696 P68100 denotes cytochrome c
T269 684-696 O22642 denotes cytochrome c
T270 684-696 P00028 denotes cytochrome c
T271 684-696 P00075 denotes cytochrome c
T272 684-696 Q96VP3 denotes cytochrome c
T181 684-696 D045304 denotes cytochrome c
T191 684-696 C076615 denotes cytochrome c
T198 684-696 D045305 denotes cytochrome c
T241 684-696 CHEBI:18070 denotes cytochrome c
T165 684-696 GO:0045155 denotes cytochrome c
T238 684-696 GO:0009461 denotes cytochrome c
T275 702-711 P55866 denotes caspase-3
T276 702-711 Q8MJC3 denotes caspase-3
T277 702-711 Q2PFV2 denotes caspase-3
T278 702-711 Q08DY9 denotes caspase-3
T279 702-711 Q5IS54 denotes caspase-3
T280 702-711 Q8MKI5 denotes caspase-3
T281 702-711 PR:000002312 denotes caspase-3
T282 702-711 Q8MJU1 denotes caspase-3
T283 702-711 Q60431 denotes caspase-3
T284 702-711 P42574 denotes caspase-3
T285 702-711 Q5IS99 denotes caspase-3
T286 702-711 Q95ND5 denotes caspase-3
T287 702-711 P70677 denotes caspase-3
T288 702-711 P55213 denotes caspase-3
T274 702-711 D053148 denotes caspase-3
T289 727-736 GO:0016236 denotes autophagy
T290 727-736 GO:0006914 denotes autophagy
T291 751-760 CHEBI:25367 denotes molecules
T292 761-769 O88597 denotes beclin-1
T293 761-769 Q91XJ1 denotes beclin-1
T295 761-769 Q14457 denotes beclin-1
T296 761-769 F1RCP1 denotes beclin-1
T297 761-769 Q4A1L3 denotes beclin-1
T298 761-769 Q5R878 denotes beclin-1
T299 761-769 Q5ZKS6 denotes beclin-1
T300 761-769 Q6GP52 denotes beclin-1
T301 761-769 PR:000004719 denotes beclin-1
T302 761-769 Q4A1L5 denotes beclin-1
T303 761-769 Q4A1L4 denotes beclin-1
T294 761-769 D000071186 denotes beclin-1
T304 774-785 GO:0005874 denotes microtubule
T306 774-806 D008869 denotes microtubule-associated protein 1
T307 774-807 P78559 denotes microtubule-associated protein 1A
T308 774-807 PR:000010116 denotes microtubule-associated protein 1A
T309 774-807 P34926 denotes microtubule-associated protein 1A
T310 774-807 Q9QYR6 denotes microtubule-associated protein 1A
T315 797-804 SO:0000104 denotes protein
T311 797-804 GO:0003675 denotes protein
T317 805-809 CVCL_KR49 denotes 1A/1
T318 817-822 SO:0000419 denotes chain
T319 817-824 Q00285 denotes chain 3
T320 826-829 P82160 denotes LC3
T321 834-837 P82160 denotes LC3
T327 861-865 CVCL_N538 denotes 10 h
T328 867-876 GO:0016236 denotes autophagy
T329 867-876 GO:0006914 denotes autophagy
T330 888-896 CHEBI:36080 denotes proteins
T332 919-923 CVCL_8262 denotes 24 h
T334 939-955 D009687 denotes proteins nuclear
T335 975-980 SO:0000419 denotes chain
T336 981-989 SO:0000165 denotes enhancer
T339 1024-1037 GO:0005576 denotes extracellular
T340 1024-1062 D048049 denotes extracellular signal-regulated kinases
T341 1038-1044 SO:0000725 denotes signal
T342 1038-1044 SO:0000418 denotes signal
T343 1045-1054 SO:0000119 denotes regulated
T347 1064-1069 PR:P63086 denotes ERK)2
T348 1064-1069 PR:P28482 denotes ERK)2
T349 1064-1069 PR:P63085 denotes ERK)2
T350 1064-1069 PR:Q54QB1 denotes ERK)2
T351 1064-1069 P63085 denotes ERK)2
T352 1064-1069 P63086 denotes ERK)2
T353 1064-1069 PR:000000103 denotes ERK)2
T354 1064-1069 P46196 denotes ERK)2
T356 1064-1069 Q54QB1 denotes ERK)2
T357 1064-1069 P28482 denotes ERK)2
T355 1064-1069 GO:0004707 denotes ERK)2
T361 1070-1074 Q63844 denotes ERK1
T362 1070-1074 P27361 denotes ERK1
T363 1070-1074 P21708 denotes ERK1
T364 1070-1074 PR:000000104 denotes ERK1
T365 1070-1074 PR:P42525 denotes ERK1
T366 1070-1074 Q5A1D3 denotes ERK1
T367 1070-1074 P42525 denotes ERK1
T368 1070-1074 PR:P27361 denotes ERK1
T369 1070-1074 PR:P21708 denotes ERK1
T371 1070-1074 PR:Q63844 denotes ERK1
T372 1070-1074 C4YGK0 denotes ERK1
T373 1070-1074 PR:Q5A1D3 denotes ERK1
T370 1070-1074 GO:0004707 denotes ERK1
T375 1134-1144 Q92851 denotes caspase-10
T377 1134-1144 PR:000002310 denotes caspase-10
T376 1134-1144 D053455 denotes caspase-10
T378 1200-1208 C505569 denotes CasIIgly
T379 1200-1208 C505569 denotes CasIIgly
T380 1213-1221 C586191 denotes CasIIIEa
T381 1213-1221 C586191 denotes CasIIIEa
T382 1313-1326 D009447 denotes neuroblastoma
T383 1313-1326 D009447 denotes neuroblastoma