> top > docs > PubMed:31158749 > annotations

PubMed:31158749 JSONTXT

Annnotations TAB JSON ListView MergeView

GoldHamster

Id Subject Object Predicate Lexical cue
T1 20-26 CHEBI:16042 denotes halide
T2 20-26 CHEBI:37578 denotes halide
T3 78-94 D000970 denotes antitumor agents
T4 78-94 D000970 denotes antitumor agents
T5 150-162 MOP:0000797 denotes coordination
T6 300-306 CHEBI:16042 denotes halide
T7 300-306 CHEBI:37578 denotes halide
T8 336-341 CVCL_0027 denotes HepG2
T9 343-346 CHEBI:566274 denotes MDA
T10 343-353 CVCL_0062 denotes MDA-MB-231
T13 355-360 CVCL_0031 denotes MCF-7
T14 365-369 PR:Q54CD8 denotes HeLa
T15 365-369 CVCL_0030 denotes HeLa
T16 389-392 PR:000007123 denotes HEK
T18 389-392 PR:P29320 denotes HEK
T20 389-392 P29320 denotes HEK
T21 389-396 CVCL_0045 denotes HEK-293
T22 564-572 7456 denotes nitrogen
T23 564-572 CHEBI:25555 denotes nitrogen
T24 564-572 CHEBI:29351 denotes nitrogen
T25 648-658 CHEBI:52552 denotes cyclohexyl
T26 662-668 CHEBI:42645 denotes fluoro
T27 844-854 UBERON:2000098 denotes cell cycle
T28 844-854 GO:0007049 denotes cell cycle
T29 947-957 UBERON:2000098 denotes cell cycle
T31 947-964 GO:0007050 denotes cell cycle arrest
T32 979-986 GO:0051320 denotes S phase
T33 992-1000 GO:0019835 denotes necrosis
T34 992-1000 GO:0008219 denotes necrosis
T37 992-1000 GO:0008220 denotes necrosis
T38 992-1000 GO:0001906 denotes necrosis
T39 992-1000 GO:0070265 denotes necrosis
T35 992-1000 D009336 denotes necrosis
T36 992-1000 D009336 denotes necrosis
T45 1036-1047 10878 denotes Trypan blue
T42 1036-1047 CHEBI:78897 denotes Trypan blue
T43 1036-1047 D014343 denotes Trypan blue
T44 1036-1047 D014343 denotes Trypan blue
T46 1048-1051 PR:Q7ZU29 denotes dye
T48 1048-1051 PR:P0A9Q1 denotes dye
T49 1048-1051 PR:000022123 denotes dye
T47 1048-1051 CHEBI:37958 denotes dye
T50 1094-1107 A0A5C1RDA6 denotes dehydrogenase
T51 1094-1107 D010088 denotes dehydrogenase
T52 1109-1112 P29038 denotes LDH
T53 1109-1112 PR:A5I1Z6 denotes LDH
T54 1109-1112 Q99289 denotes LDH
T55 1109-1112 Q27888 denotes LDH
T56 1109-1112 P93052 denotes LDH
T57 1109-1112 Q27797 denotes LDH
T58 1109-1112 P33571 denotes LDH
T59 1187-1200 GO:0005622 denotes intracellular
T60 1201-1224 D017382 denotes reactive oxygen species
T61 1201-1224 CHEBI:26523 denotes reactive oxygen species
T62 1201-1224 D017382 denotes reactive oxygen species
T64 1210-1216 7806 denotes oxygen
T66 1226-1229 CHEBI:26523 denotes ROS
T65 1226-1229 PR:P08922 denotes ROS
T67 1226-1229 PR:000014165 denotes ROS
T68 1234-1237 CHEBI:566274 denotes MDA
T69 1234-1244 CVCL_0062 denotes MDA-MB-231
T72 1405-1408 CHEBI:26523 denotes ROS
T71 1405-1408 PR:P08922 denotes ROS
T73 1405-1408 PR:000014165 denotes ROS
T74 1490-1502 MOP:0000797 denotes coordination
T75 1586-1594 D000965 denotes antimony
T76 1586-1594 CHEBI:30304 denotes antimony
T77 1586-1594 CHEBI:30513 denotes antimony
T78 1586-1594 D000965 denotes antimony
T79 1639-1656 D000970 denotes anticancer agents
T80 1639-1656 CHEBI:35610 denotes anticancer agents
T81 1639-1656 D000970 denotes anticancer agents

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 164-256 DRI_Background denotes The relationship between chemical structure and in vitro cytotoxic activities of a series of
T2 294-440 DRI_Background denotes (III) halide complexes against cancerous (HepG2, MDA-MB-231, MCF-7 and HeLa) and nonmalignant (HEK-293) cell lines was studied for the first time.
T3 441-598 DRI_Approach denotes A positive correlation between cytotoxic activity and the length of N→Sb coordinate bond on azastibocine framework of same nitrogen substituent was observed.
T4 599-828 DRI_Approach denotes By comparison, the organoantimony(III) complex 6-cyclohexyl-12-fluoro-5,6,7,12-tetrahydrodibenzo[c,f][1,5]azastibocine (C4) exhibited the highest selectivity index, giving a IC50(nonmalignant)/IC50(cancerous) ratio of up to 8.33.
T5 829-987 DRI_Outcome denotes The results of cell cycle analysis indicated that the inhibitory effect of C4 on the cellular viability was caused by cell cycle arrest mainly at the S phase.
T6 988-1145 DRI_Approach denotes The necrosis induced by C4 was confirmed by the Trypan blue dye exclusion test and the increase of lactic dehydrogenase (LDH) released in the culture medium.
T7 1146-1409 DRI_Background denotes Furthermore, evaluation of the levels of intracellular reactive oxygen species (ROS) in MDA-MB-231 cells, by quantifying the relative fluorescence units (RFU) using spectrofluorometer, indicated that cytotoxic activity of C4 is dependent on the production of ROS.
T8 1410-1478 DRI_Background denotes This work established the correlation between cytotoxic activity and
T9 1502-1657 DRI_Background denotes , a finding that provided theoretical and experimental basis for in-depth design of antimony-based organometallic complexes as potential anticancer agents.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 126-134 CVCL_C410|Hybridoma|Mus musculus denotes activity
T2 141-143 CVCL_0C95|Cancer_cell_line|Canis lupus familiaris denotes Sb
T3 141-143 CVCL_1860|Cancer_cell_line|Homo sapiens denotes Sb
T4 141-143 CVCL_AQ30|Cancer_cell_line|Homo sapiens denotes Sb
T5 141-143 CVCL_M146|Cancer_cell_line|Homo sapiens denotes Sb
T6 141-143 CVCL_VK76|Spontaneously_immortalized_cell_line|Lates calcarifer denotes Sb
T7 231-241 CVCL_C410|Hybridoma|Mus musculus denotes activities
T8 245-246 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T9 325-334 CVCL_E025|Induced_pluripotent_stem_cell|Homo sapiens denotes cancerous
T10 336-341 CVCL_0027|Cancer_cell_line|Homo sapiens denotes HepG2
T11 343-353 CVCL_0062|Cancer_cell_line|Homo sapiens denotes MDA-MB-231
T12 347-349 CVCL_5M21|Cancer_cell_line|Mesocricetus auratus denotes MB
T13 350-353 CVCL_L524|Hybridoma|Mus musculus denotes 231
T14 355-360 CVCL_0031|Cancer_cell_line|Homo sapiens denotes MCF-7
T15 355-360 CVCL_4Y53|Cancer_cell_line|Homo sapiens denotes MCF-7
T16 355-358 CVCL_E778|Transformed_cell_line|Homo sapiens denotes MCF
T17 365-369 CVCL_0030|Cancer_cell_line|Homo sapiens denotes HeLa
T18 389-396 CVCL_0045|Transformed_cell_line|Homo sapiens denotes HEK-293
T19 389-392 CVCL_M624|Cancer_cell_line|Homo sapiens denotes HEK
T20 435-439 CVCL_0047|Telomerase_immortalized_cell_line|Homo sapiens denotes time
T21 441-442 CVCL_6479|Finite_cell_line|Mus musculus denotes A
T22 482-490 CVCL_C410|Hybridoma|Mus musculus denotes activity
T23 511-513 CVCL_0C95|Cancer_cell_line|Canis lupus familiaris denotes Sb
T24 511-513 CVCL_1860|Cancer_cell_line|Homo sapiens denotes Sb
T25 511-513 CVCL_AQ30|Cancer_cell_line|Homo sapiens denotes Sb
T26 511-513 CVCL_M146|Cancer_cell_line|Homo sapiens denotes Sb
T27 511-513 CVCL_VK76|Spontaneously_immortalized_cell_line|Lates calcarifer denotes Sb
T28 696-697 CVCL_S361|Finite_cell_line|Mus musculus denotes c
T29 719-721 CVCL_1G33|Induced_pluripotent_stem_cell|Pan troglodytes denotes C4
T30 719-721 CVCL_4783|Cancer_cell_line|Homo sapiens denotes C4
T31 719-721 CVCL_5111|Cancer_cell_line|Homo sapiens denotes C4
T32 719-721 CVCL_7311|Finite_cell_line|Homo sapiens denotes C4
T33 719-721 CVCL_H536|Cancer_cell_line|Rattus norvegicus denotes C4
T34 719-721 CVCL_W593|Induced_pluripotent_stem_cell|Homo sapiens denotes C4
T35 771-772 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T36 797-806 CVCL_E025|Induced_pluripotent_stem_cell|Homo sapiens denotes cancerous
T37 904-906 CVCL_1G33|Induced_pluripotent_stem_cell|Pan troglodytes denotes C4
T38 904-906 CVCL_4783|Cancer_cell_line|Homo sapiens denotes C4
T39 904-906 CVCL_5111|Cancer_cell_line|Homo sapiens denotes C4
T40 904-906 CVCL_7311|Finite_cell_line|Homo sapiens denotes C4
T41 904-906 CVCL_H536|Cancer_cell_line|Rattus norvegicus denotes C4
T42 904-906 CVCL_W593|Induced_pluripotent_stem_cell|Homo sapiens denotes C4
T43 1012-1014 CVCL_1G33|Induced_pluripotent_stem_cell|Pan troglodytes denotes C4
T44 1012-1014 CVCL_4783|Cancer_cell_line|Homo sapiens denotes C4
T45 1012-1014 CVCL_5111|Cancer_cell_line|Homo sapiens denotes C4
T46 1012-1014 CVCL_7311|Finite_cell_line|Homo sapiens denotes C4
T47 1012-1014 CVCL_H536|Cancer_cell_line|Rattus norvegicus denotes C4
T48 1012-1014 CVCL_W593|Induced_pluripotent_stem_cell|Homo sapiens denotes C4
T49 1238-1240 CVCL_5M21|Cancer_cell_line|Mesocricetus auratus denotes MB
T50 1356-1364 CVCL_C410|Hybridoma|Mus musculus denotes activity
T51 1368-1370 CVCL_1G33|Induced_pluripotent_stem_cell|Pan troglodytes denotes C4
T52 1368-1370 CVCL_4783|Cancer_cell_line|Homo sapiens denotes C4
T53 1368-1370 CVCL_5111|Cancer_cell_line|Homo sapiens denotes C4
T54 1368-1370 CVCL_7311|Finite_cell_line|Homo sapiens denotes C4
T55 1368-1370 CVCL_H536|Cancer_cell_line|Rattus norvegicus denotes C4
T56 1368-1370 CVCL_W593|Induced_pluripotent_stem_cell|Homo sapiens denotes C4
T57 1466-1474 CVCL_C410|Hybridoma|Mus musculus denotes activity
T58 1481-1483 CVCL_0C95|Cancer_cell_line|Canis lupus familiaris denotes Sb
T59 1481-1483 CVCL_1860|Cancer_cell_line|Homo sapiens denotes Sb
T60 1481-1483 CVCL_AQ30|Cancer_cell_line|Homo sapiens denotes Sb
T61 1481-1483 CVCL_M146|Cancer_cell_line|Homo sapiens denotes Sb
T62 1481-1483 CVCL_VK76|Spontaneously_immortalized_cell_line|Lates calcarifer denotes Sb
T63 1504-1505 CVCL_6479|Finite_cell_line|Mus musculus denotes a