PubMed:31129139 / 1587-1849 JSONTXT

{"project":"PubMed_Structured_Abstracts","denotations":[{"id":"T4","span":{"begin":0,"end":262},"obj":"CONCLUSIONS"}],"text":"Our results suggested that HO could alleviate APAP-induced liver damage through reducing the generation of APAP-protein adducts, which might be mediated by inhibiting the activity of CYP 2E1 and CYP2A1 as well as enhancing the generation of GSH via NRF2 pathway."}

{"project":"Goldhamster2_Cellosaurus","denotations":[{"id":"T13","span":{"begin":27,"end":29},"obj":"CVCL_M698|Cancer_cell_line|Homo sapiens"},{"id":"T14","span":{"begin":171,"end":179},"obj":"CVCL_C410|Hybridoma|Mus musculus"}],"text":"Our results suggested that HO could alleviate APAP-induced liver damage through reducing the generation of APAP-protein adducts, which might be mediated by inhibiting the activity of CYP 2E1 and CYP2A1 as well as enhancing the generation of GSH via NRF2 pathway."}

{"project":"GoldHamster","denotations":[{"id":"T240","span":{"begin":46,"end":50},"obj":"D000082"},{"id":"T241","span":{"begin":46,"end":50},"obj":"D000082"},{"id":"T242","span":{"begin":46,"end":50},"obj":"CHEBI:46195"},{"id":"T243","span":{"begin":59,"end":64},"obj":"UBERON:0002107"},{"id":"T244","span":{"begin":107,"end":111},"obj":"D000082"},{"id":"T245","span":{"begin":107,"end":111},"obj":"D000082"},{"id":"T246","span":{"begin":107,"end":111},"obj":"CHEBI:46195"},{"id":"T251","span":{"begin":112,"end":119},"obj":"SO:0000104"},{"id":"T250","span":{"begin":112,"end":119},"obj":"PR:000000001"},{"id":"T248","span":{"begin":112,"end":119},"obj":"CHEBI:36080"},{"id":"T249","span":{"begin":112,"end":119},"obj":"CHEBI:11122"},{"id":"T247","span":{"begin":112,"end":119},"obj":"GO:0003675"},{"id":"T264","span":{"begin":183,"end":190},"obj":"PR:P05182"},{"id":"T265","span":{"begin":183,"end":190},"obj":"PR:000006122"},{"id":"T267","span":{"begin":183,"end":190},"obj":"PR:Q05421"},{"id":"T268","span":{"begin":183,"end":190},"obj":"PR:P05181"},{"id":"T266","span":{"begin":183,"end":190},"obj":"D019392"},{"id":"T277","span":{"begin":195,"end":200},"obj":"C029009"},{"id":"T278","span":{"begin":195,"end":201},"obj":"PR:P11711"},{"id":"T279","span":{"begin":198,"end":201},"obj":"CVCL_XG57"},{"id":"T280","span":{"begin":198,"end":201},"obj":"CVCL_1930"},{"id":"T282","span":{"begin":241,"end":244},"obj":"CHEBI:16856"},{"id":"T281","span":{"begin":241,"end":244},"obj":"C563177"},{"id":"T286","span":{"begin":249,"end":253},"obj":"PR:Q60795"},{"id":"T287","span":{"begin":249,"end":253},"obj":"PR:O54968"},{"id":"T288","span":{"begin":249,"end":253},"obj":"PR:000011170"},{"id":"T289","span":{"begin":249,"end":253},"obj":"Q16236"},{"id":"T290","span":{"begin":249,"end":253},"obj":"PR:Q16236"},{"id":"T291","span":{"begin":254,"end":261},"obj":"CHEBI:34922"}],"text":"Our results suggested that HO could alleviate APAP-induced liver damage through reducing the generation of APAP-protein adducts, which might be mediated by inhibiting the activity of CYP 2E1 and CYP2A1 as well as enhancing the generation of GSH via NRF2 pathway."}