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PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 131-449 OBJECTIVE denotes Acetaminophen (APAP) overdose is the most frequent cause of drug-induced liver damage. Magnolia officinalis is a traditional hepatoprotective Chinese medicine and Honokiol (HO) is the major active constituent. The present study was to investigate the effect of HO on APAP-induced hepatotoxicity and related mechanisms.
T2 464-1037 METHODS denotes Four groups of mice were subjected to treatment as vehicle, APAP, APAP + HO and APAP + HO + NRF2 inhibitor. The morphological and biochemical assessments were used to evaluate the hepatoprotective effects. The extent of APAP-protein adducts was determined through evaluate the hepatic content 3‑(cystein‑S‑yl)acetaminophen (APAP-Cys), the hydrolysis products of APAP-protein adducts. The activities of CYP2E1, CYP1A2 and CYP3A4 were evaluated by cocktail incubation, and the protein expression levels of NRF2, GCLC, GCLM, GS and GST were evaluated by western blot analysis.
T3 1052-1572 RESULTS denotes Morphological and biochemical assessments clearly demonstrated that HO could alleviate APAP-induced liver damage. The hepatoprotective effect of HO was positively associated with the reduction of APAP-protein adducts. Further investigation suggested that HO induced inhibition of CYP 2E1 and CYP2A1 as well as upregulation of GSH co-contributed to the reduction of APAP-protein adducts. Furthermore, HO induced activations of NRF2 and its target enzymes, such as GCLC, GCLM and GST, gave rise to the upregulation of GSH.
T4 1587-1849 CONCLUSIONS denotes Our results suggested that HO could alleviate APAP-induced liver damage through reducing the generation of APAP-protein adducts, which might be mediated by inhibiting the activity of CYP 2E1 and CYP2A1 as well as enhancing the generation of GSH via NRF2 pathway.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 242-243 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T2 304-306 CVCL_M698|Cancer_cell_line|Homo sapiens denotes HO
T3 321-327 CVCL_C410|Hybridoma|Mus musculus denotes active
T4 392-394 CVCL_M698|Cancer_cell_line|Homo sapiens denotes HO
T5 852-862 CVCL_C410|Hybridoma|Mus musculus denotes activities
T6 986-988 CVCL_S933|Spontaneously_immortalized_cell_line|Epinephelus coioides denotes GS
T7 1120-1122 CVCL_M698|Cancer_cell_line|Homo sapiens denotes HO
T8 1197-1199 CVCL_M698|Cancer_cell_line|Homo sapiens denotes HO
T9 1307-1309 CVCL_M698|Cancer_cell_line|Homo sapiens denotes HO
T10 1382-1384 CVCL_J653|Cancer_cell_line|Homo sapiens denotes co
T11 1452-1454 CVCL_M698|Cancer_cell_line|Homo sapiens denotes HO
T12 1463-1474 CVCL_C410|Hybridoma|Mus musculus denotes activations
T13 1614-1616 CVCL_M698|Cancer_cell_line|Homo sapiens denotes HO
T14 1758-1766 CVCL_C410|Hybridoma|Mus musculus denotes activity

GoldHamster

Id Subject Object Predicate Lexical cue
T1 0-8 C005499 denotes Honokiol
T2 0-8 C005499 denotes Honokiol
T3 0-8 CHEBI:5759 denotes Honokiol
T5 20-33 161 denotes acetaminophen
T4 20-33 D000082 denotes acetaminophen
T6 20-33 D000082 denotes acetaminophen
T7 20-33 CHEBI:46195 denotes acetaminophen
T9 86-99 161 denotes acetaminophen
T8 86-99 D000082 denotes acetaminophen
T10 86-99 D000082 denotes acetaminophen
T11 86-99 CHEBI:46195 denotes acetaminophen
T16 100-107 SO:0000104 denotes protein
T15 100-107 PR:000000001 denotes protein
T13 100-107 CHEBI:36080 denotes protein
T14 100-107 CHEBI:11122 denotes protein
T12 100-107 GO:0003675 denotes protein
T17 119-124 UBERON:0002107 denotes liver
T19 131-144 161 denotes Acetaminophen
T18 131-144 D000082 denotes Acetaminophen
T20 131-144 D000082 denotes Acetaminophen
T21 131-144 CHEBI:46195 denotes Acetaminophen
T22 146-150 D000082 denotes APAP
T23 146-150 D000082 denotes APAP
T24 146-150 CHEBI:46195 denotes APAP
T25 191-195 CHEBI:23888 denotes drug
T26 191-209 D056486 denotes drug-induced liver
T27 191-209 D056486 denotes drug-induced liver
T28 204-209 UBERON:0002107 denotes liver
T30 218-238 85864 denotes Magnolia officinalis
T31 218-238 D031566 denotes Magnolia officinalis
T32 281-289 CHEBI:23888 denotes medicine
T33 294-302 C005499 denotes Honokiol
T34 294-302 C005499 denotes Honokiol
T35 294-302 CHEBI:5759 denotes Honokiol
T36 398-402 D000082 denotes APAP
T37 398-402 D000082 denotes APAP
T38 398-402 CHEBI:46195 denotes APAP
T39 479-483 PR:000005054 denotes mice
T41 479-483 O89094 denotes mice
T40 479-483 D051379 denotes mice
T42 479-483 10095 denotes mice
T43 524-528 D000082 denotes APAP
T44 524-528 D000082 denotes APAP
T45 524-528 CHEBI:46195 denotes APAP
T46 530-534 D000082 denotes APAP
T47 530-534 D000082 denotes APAP
T48 530-534 CHEBI:46195 denotes APAP
T49 544-548 D000082 denotes APAP
T50 544-548 D000082 denotes APAP
T51 544-548 CHEBI:46195 denotes APAP
T52 561-570 CHEBI:35222 denotes inhibitor
T53 684-688 D000082 denotes APAP
T54 684-688 D000082 denotes APAP
T55 684-688 CHEBI:46195 denotes APAP
T60 689-696 SO:0000104 denotes protein
T59 689-696 PR:000000001 denotes protein
T57 689-696 CHEBI:36080 denotes protein
T58 689-696 CHEBI:11122 denotes protein
T56 689-696 GO:0003675 denotes protein
T62 773-786 161 denotes acetaminophen
T61 773-786 D000082 denotes acetaminophen
T63 773-786 D000082 denotes acetaminophen
T64 773-786 CHEBI:46195 denotes acetaminophen
T65 788-792 D000082 denotes APAP
T66 788-792 D000082 denotes APAP
T67 788-792 CHEBI:46195 denotes APAP
T79 793-796 SO:0001447 denotes Cys
T75 793-796 PR:Q945Q1 denotes Cys
T78 793-796 PR:P23779 denotes Cys
T68 793-796 CHEBI:29964 denotes Cys
T69 793-796 CHEBI:32737 denotes Cys
T70 793-796 CHEBI:32740 denotes Cys
T71 793-796 CHEBI:32456 denotes Cys
T72 793-796 CHEBI:15356 denotes Cys
T73 793-796 CHEBI:32448 denotes Cys
T74 793-796 CHEBI:17561 denotes Cys
T76 793-796 CHEBI:29950 denotes Cys
T77 793-796 CHEBI:32447 denotes Cys
T80 803-813 MOP:0000619 denotes hydrolysis
T81 826-830 D000082 denotes APAP
T82 826-830 D000082 denotes APAP
T83 826-830 CHEBI:46195 denotes APAP
T88 831-838 SO:0000104 denotes protein
T87 831-838 PR:000000001 denotes protein
T85 831-838 CHEBI:36080 denotes protein
T86 831-838 CHEBI:11122 denotes protein
T84 831-838 GO:0003675 denotes protein
T103 866-872 D019392 denotes CYP2E1
T101 866-872 PR:P05182 denotes CYP2E1
T102 866-872 PR:000006122 denotes CYP2E1
T104 866-872 PR:Q05421 denotes CYP2E1
T105 866-872 PR:P05181 denotes CYP2E1
T115 874-880 D019388 denotes CYP1A2
T114 874-880 PR:000006102 denotes CYP1A2
T116 874-880 PR:P00186 denotes CYP1A2
T117 874-880 Q92110 denotes CYP1A2
T118 874-880 PR:P05177 denotes CYP1A2
T119 874-880 PR:P04799 denotes CYP1A2
T120 877-880 CVCL_9V12 denotes 1A2
T121 877-880 CVCL_KT11 denotes 1A2
T122 877-880 CVCL_3480 denotes 1A2
T134 885-891 D051544 denotes CYP3A4
T133 885-891 PR:P08684 denotes CYP3A4
T135 885-891 PR:000006130 denotes CYP3A4
T136 885-891 GO:0033780 denotes CYP3A4
T137 888-891 CVCL_XG96 denotes 3A4
T142 939-946 SO:0000104 denotes protein
T139 939-946 CHEBI:36080 denotes protein
T140 939-946 CHEBI:11122 denotes protein
T141 939-946 PR:000000001 denotes protein
T138 939-946 GO:0003675 denotes protein
T146 968-972 PR:Q60795 denotes NRF2
T147 968-972 PR:O54968 denotes NRF2
T148 968-972 PR:000011170 denotes NRF2
T149 968-972 Q16236 denotes NRF2
T150 968-972 PR:Q16236 denotes NRF2
T151 974-978 PR:Q9W3K5 denotes GCLC
T152 974-978 PR:000007897 denotes GCLC
T153 974-978 PR:P48506 denotes GCLC
T154 974-978 PR:P97494 denotes GCLC
T155 974-978 PR:P19468 denotes GCLC
T156 980-984 PR:000007898 denotes GCLM
T157 980-984 PR:P48507 denotes GCLM
T158 980-984 PR:O09172 denotes GCLM
T159 980-984 PR:P48508 denotes GCLM
T160 993-996 Q86UG4 denotes GST
T161 993-996 PR:P20432 denotes GST
T162 993-996 PR:000025821 denotes GST
T163 993-996 PR:Q7REH6 denotes GST
T164 1139-1143 D000082 denotes APAP
T165 1139-1143 D000082 denotes APAP
T166 1139-1143 CHEBI:46195 denotes APAP
T167 1152-1157 UBERON:0002107 denotes liver
T168 1235-1244 MOP:0000569 denotes reduction
T169 1248-1252 D000082 denotes APAP
T170 1248-1252 D000082 denotes APAP
T171 1248-1252 CHEBI:46195 denotes APAP
T175 1253-1260 PR:000000001 denotes protein
T172 1253-1260 GO:0003675 denotes protein
T176 1253-1260 SO:0000104 denotes protein
T173 1253-1260 CHEBI:36080 denotes protein
T174 1253-1260 CHEBI:11122 denotes protein
T189 1332-1339 PR:P05182 denotes CYP 2E1
T190 1332-1339 PR:000006122 denotes CYP 2E1
T192 1332-1339 PR:Q05421 denotes CYP 2E1
T193 1332-1339 PR:P05181 denotes CYP 2E1
T191 1332-1339 D019392 denotes CYP 2E1
T202 1344-1349 C029009 denotes CYP2A
T203 1344-1350 PR:P11711 denotes CYP2A1
T204 1347-1350 CVCL_XG57 denotes 2A1
T205 1347-1350 CVCL_1930 denotes 2A1
T207 1378-1381 CHEBI:16856 denotes GSH
T206 1378-1381 C563177 denotes GSH
T208 1404-1413 MOP:0000569 denotes reduction
T209 1417-1421 D000082 denotes APAP
T210 1417-1421 D000082 denotes APAP
T211 1417-1421 CHEBI:46195 denotes APAP
T212 1422-1429 GO:0003675 denotes protein
T216 1422-1429 SO:0000104 denotes protein
T215 1422-1429 PR:000000001 denotes protein
T213 1422-1429 CHEBI:36080 denotes protein
T214 1422-1429 CHEBI:11122 denotes protein
T220 1478-1482 PR:Q60795 denotes NRF2
T221 1478-1482 PR:O54968 denotes NRF2
T222 1478-1482 PR:000011170 denotes NRF2
T223 1478-1482 Q16236 denotes NRF2
T224 1478-1482 PR:Q16236 denotes NRF2
T225 1515-1519 PR:Q9W3K5 denotes GCLC
T226 1515-1519 PR:000007897 denotes GCLC
T227 1515-1519 PR:P48506 denotes GCLC
T228 1515-1519 PR:P97494 denotes GCLC
T229 1515-1519 PR:P19468 denotes GCLC
T230 1521-1525 PR:000007898 denotes GCLM
T231 1521-1525 PR:P48507 denotes GCLM
T232 1521-1525 PR:O09172 denotes GCLM
T233 1521-1525 PR:P48508 denotes GCLM
T234 1530-1533 Q86UG4 denotes GST
T235 1530-1533 PR:P20432 denotes GST
T236 1530-1533 PR:000025821 denotes GST
T237 1530-1533 PR:Q7REH6 denotes GST
T239 1568-1571 CHEBI:16856 denotes GSH
T238 1568-1571 C563177 denotes GSH
T240 1633-1637 D000082 denotes APAP
T241 1633-1637 D000082 denotes APAP
T242 1633-1637 CHEBI:46195 denotes APAP
T243 1646-1651 UBERON:0002107 denotes liver
T244 1694-1698 D000082 denotes APAP
T245 1694-1698 D000082 denotes APAP
T246 1694-1698 CHEBI:46195 denotes APAP
T251 1699-1706 SO:0000104 denotes protein
T250 1699-1706 PR:000000001 denotes protein
T248 1699-1706 CHEBI:36080 denotes protein
T249 1699-1706 CHEBI:11122 denotes protein
T247 1699-1706 GO:0003675 denotes protein
T264 1770-1777 PR:P05182 denotes CYP 2E1
T265 1770-1777 PR:000006122 denotes CYP 2E1
T267 1770-1777 PR:Q05421 denotes CYP 2E1
T268 1770-1777 PR:P05181 denotes CYP 2E1
T266 1770-1777 D019392 denotes CYP 2E1
T277 1782-1787 C029009 denotes CYP2A
T278 1782-1788 PR:P11711 denotes CYP2A1
T279 1785-1788 CVCL_XG57 denotes 2A1
T280 1785-1788 CVCL_1930 denotes 2A1
T282 1828-1831 CHEBI:16856 denotes GSH
T281 1828-1831 C563177 denotes GSH
T286 1836-1840 PR:Q60795 denotes NRF2
T287 1836-1840 PR:O54968 denotes NRF2
T288 1836-1840 PR:000011170 denotes NRF2
T289 1836-1840 Q16236 denotes NRF2
T290 1836-1840 PR:Q16236 denotes NRF2
T291 1841-1848 CHEBI:34922 denotes pathway