| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
77-245 |
DRI_Background |
denotes |
The nematode Caenorhabditis elegans has emerged as a genetically tractable animal host in which to study evolutionarily conserved mechanisms of innate immune signaling. |
| T2 |
246-404 |
DRI_Outcome |
denotes |
We previously showed that the PMK-1 p38 mitogen-activated protein kinase (MAPK) pathway regulates innate immunity of C. elegans through phosphorylation of the |
| T3 |
419-447 |
DRI_Outcome |
denotes |
transcription factor, ATF-7. |
| T4 |
707-913 |
DRI_Challenge |
denotes |
We observe that PMK-1-ATF-7 activity regulates a majority of all genes induced by pathogen infection, and observe ATF-7 occupancy in regulatory regions of pathogen-induced genes in a PMK-1-dependent manner. |
| T5 |
914-964 |
DRI_Approach |
denotes |
Moreover, functional analysis of a subset of these |
| T6 |
998-1084 |
DRI_Approach |
denotes |
target genes supports a direct role for this transcriptional response in host defense. |
| T7 |
1085-1119 |
DRI_Background |
denotes |
The genome-wide regulation through |
| T8 |
1133-1267 |
DRI_Background |
denotes |
signaling reveals a striking level of control over the innate immune response to infection through a single transcriptional regulator. |
