PubMed:30669833
Annnotations
mondo_disease
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 64-79 | Disease | denotes | Prostate Cancer | http://purl.obolibrary.org/obo/MONDO_0008315 |
T2 | 218-233 | Disease | denotes | prostate cancer | http://purl.obolibrary.org/obo/MONDO_0008315 |
T3 | 235-238 | Disease | denotes | PCa | http://purl.obolibrary.org/obo/MONDO_0008315 |
T4 | 388-391 | Disease | denotes | PCa | http://purl.obolibrary.org/obo/MONDO_0008315 |
T5 | 607-610 | Disease | denotes | PCa | http://purl.obolibrary.org/obo/MONDO_0008315 |
T6 | 617-644 | Disease | denotes | benign prostate hyperplasia | http://purl.obolibrary.org/obo/MONDO_0010811 |
T7 | 646-649 | Disease | denotes | BPH | http://purl.obolibrary.org/obo/MONDO_0010811 |
T8 | 897-900 | Disease | denotes | PCa | http://purl.obolibrary.org/obo/MONDO_0008315 |
T9 | 923-926 | Disease | denotes | BPH | http://purl.obolibrary.org/obo/MONDO_0010811 |
T10 | 1018-1021 | Disease | denotes | PCa | http://purl.obolibrary.org/obo/MONDO_0008315 |
T11 | 1148-1151 | Disease | denotes | PCa | http://purl.obolibrary.org/obo/MONDO_0008315 |
T12 | 1159-1162 | Disease | denotes | BPH | http://purl.obolibrary.org/obo/MONDO_0010811 |
T13 | 1438-1441 | Disease | denotes | PCa | http://purl.obolibrary.org/obo/MONDO_0008315 |
T14 | 1702-1705 | Disease | denotes | PCa | http://purl.obolibrary.org/obo/MONDO_0008315 |
Glycan-GlyCosmos
Id | Subject | Object | Predicate | Lexical cue | image |
---|---|---|---|---|---|
T1 | 830-836 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
GlyCosmos15-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 64-72 | Body_part | denotes | Prostate | http://purl.obolibrary.org/obo/UBERON_0002367 |
T2 | 115-120 | Body_part | denotes | Serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
T3 | 121-129 | Body_part | denotes | prostate | http://purl.obolibrary.org/obo/UBERON_0002367 |
T4 | 218-226 | Body_part | denotes | prostate | http://purl.obolibrary.org/obo/UBERON_0002367 |
T5 | 624-632 | Body_part | denotes | prostate | http://purl.obolibrary.org/obo/UBERON_0002367 |
GlyCosmos15-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T1 | 64-79 | Phenotype | denotes | Prostate Cancer | HP:0012125 |
T2 | 218-233 | Phenotype | denotes | prostate cancer | HP:0012125 |
T3 | 235-238 | Phenotype | denotes | PCa | HP:0012125 |
T4 | 388-391 | Phenotype | denotes | PCa | HP:0012125 |
T5 | 607-610 | Phenotype | denotes | PCa | HP:0012125 |
T6 | 617-644 | Phenotype | denotes | benign prostate hyperplasia | HP:0008711 |
T7 | 646-649 | Phenotype | denotes | BPH | HP:0008711 |
T8 | 897-900 | Phenotype | denotes | PCa | HP:0012125 |
T9 | 923-926 | Phenotype | denotes | BPH | HP:0008711 |
T10 | 1018-1021 | Phenotype | denotes | PCa | HP:0012125 |
T11 | 1148-1151 | Phenotype | denotes | PCa | HP:0012125 |
T12 | 1159-1162 | Phenotype | denotes | BPH | HP:0008711 |
T13 | 1438-1441 | Phenotype | denotes | PCa | HP:0012125 |
T14 | 1702-1705 | Phenotype | denotes | PCa | HP:0012125 |
GlyCosmos15-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 64-79 | Disease | denotes | Prostate Cancer | http://purl.obolibrary.org/obo/MONDO_0008315 |
T2 | 218-233 | Disease | denotes | prostate cancer | http://purl.obolibrary.org/obo/MONDO_0008315 |
T3 | 235-238 | Disease | denotes | PCa | http://purl.obolibrary.org/obo/MONDO_0008315 |
T4 | 388-391 | Disease | denotes | PCa | http://purl.obolibrary.org/obo/MONDO_0008315 |
T5 | 607-610 | Disease | denotes | PCa | http://purl.obolibrary.org/obo/MONDO_0008315 |
T6 | 617-644 | Disease | denotes | benign prostate hyperplasia | http://purl.obolibrary.org/obo/MONDO_0010811 |
T7 | 646-649 | Disease | denotes | BPH | http://purl.obolibrary.org/obo/MONDO_0010811 |
T8 | 897-900 | Disease | denotes | PCa | http://purl.obolibrary.org/obo/MONDO_0008315 |
T9 | 923-926 | Disease | denotes | BPH | http://purl.obolibrary.org/obo/MONDO_0010811 |
T10 | 1018-1021 | Disease | denotes | PCa | http://purl.obolibrary.org/obo/MONDO_0008315 |
T11 | 1148-1151 | Disease | denotes | PCa | http://purl.obolibrary.org/obo/MONDO_0008315 |
T12 | 1159-1162 | Disease | denotes | BPH | http://purl.obolibrary.org/obo/MONDO_0010811 |
T13 | 1438-1441 | Disease | denotes | PCa | http://purl.obolibrary.org/obo/MONDO_0008315 |
T14 | 1702-1705 | Disease | denotes | PCa | http://purl.obolibrary.org/obo/MONDO_0008315 |
GlyCosmos15-MAT
Id | Subject | Object | Predicate | Lexical cue | mat_id |
---|---|---|---|---|---|
T1 | 64-72 | Body_part | denotes | Prostate | http://purl.obolibrary.org/obo/MAT_0000078 |
T2 | 121-129 | Body_part | denotes | prostate | http://purl.obolibrary.org/obo/MAT_0000078 |
T3 | 218-226 | Body_part | denotes | prostate | http://purl.obolibrary.org/obo/MAT_0000078 |
T4 | 624-632 | Body_part | denotes | prostate | http://purl.obolibrary.org/obo/MAT_0000078 |
GlyCosmos15-Sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-114 | Sentence | denotes | Identification of Multisialylated LacdiNAc Structures as Highly Prostate Cancer Specific Glycan Signatures on PSA. |
T2 | 115-299 | Sentence | denotes | Serum prostate-specific antigen (PSA) test is the current gold standard for screening and diagnosis of prostate cancer (PCa), while overdiagnosis and overtreatment are social problems. |
T3 | 300-563 | Sentence | denotes | In order to improve the specificity and exclude a false positive diagnosis in PSA test, PCa-specific glycosylation subtypes of PSA were explored using in-depth quantitative profiling of PSA glycoforms based on mass spectrometric oxonium ion monitoring technology. |
T4 | 564-776 | Sentence | denotes | As a result of analysis using sera from 15 PCa or 15 benign prostate hyperplasia (BPH) patients whose PSA levels were in the "gray zone" (4.0-10.0 ng/mL), 52 glycan structures on PSA were quantitatively observed. |
T5 | 777-933 | Sentence | denotes | We found that abundance of multisialylated LacdiNAc (GalNAcβ1-4GlcNAc) structures were significantly upregulated in the PCa group compared to the BPH group. |
T6 | 934-1061 | Sentence | denotes | A couple of those glycoforms were then extracted and subjected to establish a novel PCa-specific diagnosis model (PSA G-index). |
T7 | 1062-1299 | Sentence | denotes | When the diagnostic power was assessed using an independent validation sample set (15 PCa and 15 BPH patients in the PSA gray zone), an AUC of PSA G-index was 1.00, while that of total PSA or PSA f/T ratio was 0.50 or 0.60, respectively. |
T8 | 1300-1381 | Sentence | denotes | Moreover, both PSA glycoforms showed significant correlation with Gleason scores. |
T9 | 1382-1522 | Sentence | denotes | Lectin histochemical staining analysis also showed that PCa cells overexpressed glycoproteins containing LacdiNAc and sialic acids moieties. |
T10 | 1523-1706 | Sentence | denotes | Thus, PSA G-index could serve as not only an effective secondary screening method to exclude false positive diagnosis in PSA screening, but also a potential grading biomarker for PCa. |
GlyCosmos15-Glycan
Id | Subject | Object | Predicate | Lexical cue | image |
---|---|---|---|---|---|
T1 | 830-836 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
GlyCosmos15-Lectin-Jamboree
Id | Subject | Object | Predicate | Lexical cue | glycosmos_id |
---|---|---|---|---|---|
T1 | 110-113 | Lectin | denotes | PSA | GL_000021 |
T2 | 148-151 | Lectin | denotes | PSA | GL_000021 |
T3 | 378-381 | Lectin | denotes | PSA | GL_000021 |
T4 | 427-430 | Lectin | denotes | PSA | GL_000021 |
T5 | 486-489 | Lectin | denotes | PSA | GL_000021 |
T6 | 666-669 | Lectin | denotes | PSA | GL_000021 |
T7 | 743-746 | Lectin | denotes | PSA | GL_000021 |
T8 | 1048-1051 | Lectin | denotes | PSA | GL_000021 |
T9 | 1179-1182 | Lectin | denotes | PSA | GL_000021 |
T10 | 1205-1208 | Lectin | denotes | PSA | GL_000021 |
T11 | 1247-1250 | Lectin | denotes | PSA | GL_000021 |
T12 | 1254-1257 | Lectin | denotes | PSA | GL_000021 |
T13 | 1315-1318 | Lectin | denotes | PSA | GL_000021 |
T14 | 1529-1532 | Lectin | denotes | PSA | GL_000021 |
T15 | 1644-1647 | Lectin | denotes | PSA | GL_000021 |
Anatomy-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 64-72 | Body_part | denotes | Prostate | http://purl.obolibrary.org/obo/UBERON_0002367 |
T2 | 115-120 | Body_part | denotes | Serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
T3 | 121-129 | Body_part | denotes | prostate | http://purl.obolibrary.org/obo/UBERON_0002367 |
T4 | 218-226 | Body_part | denotes | prostate | http://purl.obolibrary.org/obo/UBERON_0002367 |
T5 | 624-632 | Body_part | denotes | prostate | http://purl.obolibrary.org/obo/UBERON_0002367 |
Anatomy-MAT
Id | Subject | Object | Predicate | Lexical cue | mat_id |
---|---|---|---|---|---|
T1 | 64-72 | Body_part | denotes | Prostate | http://purl.obolibrary.org/obo/MAT_0000078 |
T2 | 121-129 | Body_part | denotes | prostate | http://purl.obolibrary.org/obo/MAT_0000078 |
T3 | 218-226 | Body_part | denotes | prostate | http://purl.obolibrary.org/obo/MAT_0000078 |
T4 | 624-632 | Body_part | denotes | prostate | http://purl.obolibrary.org/obo/MAT_0000078 |
HP-phenotype
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T1 | 64-79 | Phenotype | denotes | Prostate Cancer | HP:0012125 |
T2 | 218-233 | Phenotype | denotes | prostate cancer | HP:0012125 |
T3 | 235-238 | Phenotype | denotes | PCa | HP:0012125 |
T4 | 388-391 | Phenotype | denotes | PCa | HP:0012125 |
T5 | 607-610 | Phenotype | denotes | PCa | HP:0012125 |
T6 | 617-644 | Phenotype | denotes | benign prostate hyperplasia | HP:0008711 |
T7 | 646-649 | Phenotype | denotes | BPH | HP:0008711 |
T8 | 897-900 | Phenotype | denotes | PCa | HP:0012125 |
T9 | 923-926 | Phenotype | denotes | BPH | HP:0008711 |
T10 | 1018-1021 | Phenotype | denotes | PCa | HP:0012125 |
T11 | 1148-1151 | Phenotype | denotes | PCa | HP:0012125 |
T12 | 1159-1162 | Phenotype | denotes | BPH | HP:0008711 |
T13 | 1438-1441 | Phenotype | denotes | PCa | HP:0012125 |
T14 | 1702-1705 | Phenotype | denotes | PCa | HP:0012125 |