PubMed:30535277
Annnotations
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 68-74 | http://purl.obolibrary.org/obo/MAT_0000444 | denotes | Saliva |
| T2 | 194-199 | http://purl.obolibrary.org/obo/MAT_0000097 | denotes | liver |
| T3 | 364-369 | http://purl.obolibrary.org/obo/MAT_0000097 | denotes | liver |
| T4 | 474-480 | http://purl.obolibrary.org/obo/MAT_0000444 | denotes | saliva |
| T5 | 932-938 | http://purl.obolibrary.org/obo/MAT_0000444 | denotes | saliva |
| T6 | 1271-1277 | http://purl.obolibrary.org/obo/MAT_0000444 | denotes | saliva |
| T7 | 1502-1507 | http://purl.obolibrary.org/obo/MAT_0000097 | denotes | liver |
| T8 | 1784-1790 | http://purl.obolibrary.org/obo/MAT_0000444 | denotes | saliva |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| TextSentencer_T1 | 0-149 | Sentence | denotes | Identification of Abnormal Fucosylated-Glycans Recognized by LTL in Saliva of HBV-Induced Chronic Hepatitis, Cirrhosis, and Hepatocellular Carcinoma. |
| TextSentencer_T2 | 150-246 | Sentence | denotes | The hepatitis B virus (HBV)-induced chronic liver diseases are serious health threats worldwide. |
| TextSentencer_T3 | 247-379 | Sentence | denotes | There is evidence to display the alterations of salivary N-linked glycans related to the development of HBV-infected liver diseases. |
| TextSentencer_T4 | 380-704 | Sentence | denotes | Here, we further investigated the alterations of fucosylated N/O-glycans recognized by LTL in saliva from 120 subjects (30 healthy volunteers (HV), 30 patients with hepatitis B (HB), 30 patients with hepatic cirrhosis (HC), and 30 patients with hepatocellular carcinoma (HCC)) using salivary microarrys and MALDI-TOF/TOF-MS. |
| TextSentencer_T5 | 705-866 | Sentence | denotes | The results showed that the expression level of fucosylated glycans recognized by LTL was significantly increased in HCC compared with other subjects (p<0.0001). |
| TextSentencer_T6 | 867-998 | Sentence | denotes | Besides, the fucosylated glycoproteins were isolated from pooled saliva of HV, HB, HC, and HCC by LTL-magnetic particle conjugates. |
| TextSentencer_T7 | 999-1139 | Sentence | denotes | Then, N/O- glycans were released from the isolated glycoproteins with PNGase F and NaClO, and were identified by MALDI-TOF-MS, respectively. |
| TextSentencer_T8 | 1140-1301 | Sentence | denotes | Totally, there were 21/20, 25/18, 29/19, and 28/24 N/O-glycan peaks that were identified and annotated with proposed structures in saliva of HV, HB, HC, and HCC. |
| TextSentencer_T9 | 1302-1517 | Sentence | denotes | Among the total, there were 8 N-glycan peaks (e.g., m/z 1905.634, 2158.777 and 2905.036) and 15 O-glycan peaks (e.g., 1177.407, 1308.444 and 1322.444) that only presented in patients with HBV-induced liver diseases. |
| TextSentencer_T10 | 1518-1653 | Sentence | denotes | One N-glycan peak (m/z 2205.766) was unique in HC, and 9 O-glycan peaks (e.g., m/z 1157.420, 1163.417 and 1193.402) were unique in HCC. |
| TextSentencer_T11 | 1654-1791 | Sentence | denotes | This study could facilitate the discovery of biomarkers for HC and HCC based on precise alterations of fucosylated N/O-glycans in saliva. |
| T1 | 0-149 | Sentence | denotes | Identification of Abnormal Fucosylated-Glycans Recognized by LTL in Saliva of HBV-Induced Chronic Hepatitis, Cirrhosis, and Hepatocellular Carcinoma. |
| T2 | 150-246 | Sentence | denotes | The hepatitis B virus (HBV)-induced chronic liver diseases are serious health threats worldwide. |
| T3 | 247-379 | Sentence | denotes | There is evidence to display the alterations of salivary N-linked glycans related to the development of HBV-infected liver diseases. |
| T4 | 380-704 | Sentence | denotes | Here, we further investigated the alterations of fucosylated N/O-glycans recognized by LTL in saliva from 120 subjects (30 healthy volunteers (HV), 30 patients with hepatitis B (HB), 30 patients with hepatic cirrhosis (HC), and 30 patients with hepatocellular carcinoma (HCC)) using salivary microarrys and MALDI-TOF/TOF-MS. |
| T5 | 705-866 | Sentence | denotes | The results showed that the expression level of fucosylated glycans recognized by LTL was significantly increased in HCC compared with other subjects (p<0.0001). |
| T6 | 867-998 | Sentence | denotes | Besides, the fucosylated glycoproteins were isolated from pooled saliva of HV, HB, HC, and HCC by LTL-magnetic particle conjugates. |
| T7 | 999-1139 | Sentence | denotes | Then, N/O- glycans were released from the isolated glycoproteins with PNGase F and NaClO, and were identified by MALDI-TOF-MS, respectively. |
| T8 | 1140-1301 | Sentence | denotes | Totally, there were 21/20, 25/18, 29/19, and 28/24 N/O-glycan peaks that were identified and annotated with proposed structures in saliva of HV, HB, HC, and HCC. |
| T9 | 1302-1517 | Sentence | denotes | Among the total, there were 8 N-glycan peaks (e.g., m/z 1905.634, 2158.777 and 2905.036) and 15 O-glycan peaks (e.g., 1177.407, 1308.444 and 1322.444) that only presented in patients with HBV-induced liver diseases. |
| T10 | 1518-1653 | Sentence | denotes | One N-glycan peak (m/z 2205.766) was unique in HC, and 9 O-glycan peaks (e.g., m/z 1157.420, 1163.417 and 1193.402) were unique in HCC. |
| T11 | 1654-1791 | Sentence | denotes | This study could facilitate the discovery of biomarkers for HC and HCC based on precise alterations of fucosylated N/O-glycans in saliva. |
NGLY1-deficiency
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-NGLY1-deficiency-B_T1 | 1069-1075 | hgnc:17646 | denotes | PNGase |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 98-107 | Disease | denotes | Hepatitis | http://purl.obolibrary.org/obo/MONDO_0002251 |
| T2 | 109-118 | Disease | denotes | Cirrhosis | http://purl.obolibrary.org/obo/MONDO_0005155 |
| T3 | 124-148 | Disease | denotes | Hepatocellular Carcinoma | http://purl.obolibrary.org/obo/MONDO_0007256 |
| T4 | 154-165 | Disease | denotes | hepatitis B | http://purl.obolibrary.org/obo/MONDO_0005344 |
| T5 | 194-208 | Disease | denotes | liver diseases | http://purl.obolibrary.org/obo/MONDO_0005154 |
| T6 | 364-378 | Disease | denotes | liver diseases | http://purl.obolibrary.org/obo/MONDO_0005154 |
| T7 | 545-556 | Disease | denotes | hepatitis B | http://purl.obolibrary.org/obo/MONDO_0005344 |
| T8 | 558-560 | Disease | denotes | HB | http://purl.obolibrary.org/obo/MONDO_0005344 |
| T9 | 588-597 | Disease | denotes | cirrhosis | http://purl.obolibrary.org/obo/MONDO_0005155 |
| T10 | 625-649 | Disease | denotes | hepatocellular carcinoma | http://purl.obolibrary.org/obo/MONDO_0007256 |
| T11 | 651-654 | Disease | denotes | HCC | http://purl.obolibrary.org/obo/MONDO_0007256 |
| T12 | 822-825 | Disease | denotes | HCC | http://purl.obolibrary.org/obo/MONDO_0007256 |
| T13 | 946-948 | Disease | denotes | HB | http://purl.obolibrary.org/obo/MONDO_0005344 |
| T14 | 958-961 | Disease | denotes | HCC | http://purl.obolibrary.org/obo/MONDO_0007256 |
| T15 | 1285-1287 | Disease | denotes | HB | http://purl.obolibrary.org/obo/MONDO_0005344 |
| T16 | 1297-1300 | Disease | denotes | HCC | http://purl.obolibrary.org/obo/MONDO_0007256 |
| T17 | 1502-1516 | Disease | denotes | liver diseases | http://purl.obolibrary.org/obo/MONDO_0005154 |
| T18 | 1649-1652 | Disease | denotes | HCC | http://purl.obolibrary.org/obo/MONDO_0007256 |
| T19 | 1721-1724 | Disease | denotes | HCC | http://purl.obolibrary.org/obo/MONDO_0007256 |
Lectin-Jamboree-small
| Id | Subject | Object | Predicate | Lexical cue | glycosmos_id |
|---|---|---|---|---|---|
| T1 | 61-64 | Lectin | denotes | LTL | GL_000384 |
| T2 | 467-470 | Lectin | denotes | LTL | GL_000384 |
| T3 | 787-790 | Lectin | denotes | LTL | GL_000384 |
| T4 | 965-968 | Lectin | denotes | LTL | GL_000384 |
Lectin-Jamboree-Sentence
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-149 | Sentence | denotes | Identification of Abnormal Fucosylated-Glycans Recognized by LTL in Saliva of HBV-Induced Chronic Hepatitis, Cirrhosis, and Hepatocellular Carcinoma. |
| T2 | 150-246 | Sentence | denotes | The hepatitis B virus (HBV)-induced chronic liver diseases are serious health threats worldwide. |
| T3 | 247-379 | Sentence | denotes | There is evidence to display the alterations of salivary N-linked glycans related to the development of HBV-infected liver diseases. |
| T4 | 380-704 | Sentence | denotes | Here, we further investigated the alterations of fucosylated N/O-glycans recognized by LTL in saliva from 120 subjects (30 healthy volunteers (HV), 30 patients with hepatitis B (HB), 30 patients with hepatic cirrhosis (HC), and 30 patients with hepatocellular carcinoma (HCC)) using salivary microarrys and MALDI-TOF/TOF-MS. |
| T5 | 705-866 | Sentence | denotes | The results showed that the expression level of fucosylated glycans recognized by LTL was significantly increased in HCC compared with other subjects (p<0.0001). |
| T6 | 867-998 | Sentence | denotes | Besides, the fucosylated glycoproteins were isolated from pooled saliva of HV, HB, HC, and HCC by LTL-magnetic particle conjugates. |
| T7 | 999-1139 | Sentence | denotes | Then, N/O- glycans were released from the isolated glycoproteins with PNGase F and NaClO, and were identified by MALDI-TOF-MS, respectively. |
| T8 | 1140-1301 | Sentence | denotes | Totally, there were 21/20, 25/18, 29/19, and 28/24 N/O-glycan peaks that were identified and annotated with proposed structures in saliva of HV, HB, HC, and HCC. |
| T9 | 1302-1517 | Sentence | denotes | Among the total, there were 8 N-glycan peaks (e.g., m/z 1905.634, 2158.777 and 2905.036) and 15 O-glycan peaks (e.g., 1177.407, 1308.444 and 1322.444) that only presented in patients with HBV-induced liver diseases. |
| T10 | 1518-1653 | Sentence | denotes | One N-glycan peak (m/z 2205.766) was unique in HC, and 9 O-glycan peaks (e.g., m/z 1157.420, 1163.417 and 1193.402) were unique in HCC. |
| T11 | 1654-1791 | Sentence | denotes | This study could facilitate the discovery of biomarkers for HC and HCC based on precise alterations of fucosylated N/O-glycans in saliva. |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 154-177 | OrganismTaxon | denotes | hepatitis B virus (HBV) | 10407 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 68-74 | Body_part | denotes | Saliva | http://purl.obolibrary.org/obo/MAT_0000444 |
| T2 | 194-199 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T3 | 364-369 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T4 | 474-480 | Body_part | denotes | saliva | http://purl.obolibrary.org/obo/MAT_0000444 |
| T5 | 932-938 | Body_part | denotes | saliva | http://purl.obolibrary.org/obo/MAT_0000444 |
| T6 | 1271-1277 | Body_part | denotes | saliva | http://purl.obolibrary.org/obo/MAT_0000444 |
| T7 | 1502-1507 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T8 | 1784-1790 | Body_part | denotes | saliva | http://purl.obolibrary.org/obo/MAT_0000444 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 68-74 | Body_part | denotes | Saliva | http://purl.obolibrary.org/obo/UBERON_0001836 |
| T2 | 194-199 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T3 | 364-369 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T4 | 474-480 | Body_part | denotes | saliva | http://purl.obolibrary.org/obo/UBERON_0001836 |
| T5 | 932-938 | Body_part | denotes | saliva | http://purl.obolibrary.org/obo/UBERON_0001836 |
| T6 | 1271-1277 | Body_part | denotes | saliva | http://purl.obolibrary.org/obo/UBERON_0001836 |
| T7 | 1502-1507 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T8 | 1784-1790 | Body_part | denotes | saliva | http://purl.obolibrary.org/obo/UBERON_0001836 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 90-107 | Phenotype | denotes | Chronic Hepatitis | HP:0200123 |
| T2 | 109-118 | Phenotype | denotes | Cirrhosis | HP:0001394 |
| T3 | 124-148 | Phenotype | denotes | Hepatocellular Carcinoma | HP:0001402 |
| T4 | 154-163 | Phenotype | denotes | hepatitis | HP:0012115 |
| T5 | 194-208 | Phenotype | denotes | liver diseases | HP:0001392 |
| T6 | 364-378 | Phenotype | denotes | liver diseases | HP:0001392 |
| T7 | 545-554 | Phenotype | denotes | hepatitis | HP:0012115 |
| T8 | 580-597 | Phenotype | denotes | hepatic cirrhosis | HP:0001394 |
| T9 | 599-601 | Phenotype | denotes | HC | HP:0001394 |
| T10 | 625-649 | Phenotype | denotes | hepatocellular carcinoma | HP:0001402 |
| T11 | 651-654 | Phenotype | denotes | HCC | HP:0001402 |
| T12 | 822-825 | Phenotype | denotes | HCC | HP:0001402 |
| T13 | 950-952 | Phenotype | denotes | HC | HP:0001394 |
| T14 | 958-961 | Phenotype | denotes | HCC | HP:0001402 |
| T15 | 1289-1291 | Phenotype | denotes | HC | HP:0001394 |
| T16 | 1297-1300 | Phenotype | denotes | HCC | HP:0001402 |
| T17 | 1502-1516 | Phenotype | denotes | liver diseases | HP:0001392 |
| T18 | 1565-1567 | Phenotype | denotes | HC | HP:0001394 |
| T19 | 1649-1652 | Phenotype | denotes | HCC | HP:0001402 |
| T20 | 1714-1716 | Phenotype | denotes | HC | HP:0001394 |
| T21 | 1721-1724 | Phenotype | denotes | HCC | HP:0001402 |